low-dose aspirin improves endothelial function in hypertension

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Inpharma 1320 - 12 Jan 2002 Low-dose aspirin improves endothelial function in hypertension Low-dose aspirin may restore endothelium- dependent vasodilation in patients with hypertension, according to researchers from Japan. The researchers studied 18 patients with essential hypertension and 10 volunteers without hypertension, before and 8 weeks after administration of aspirin [acetylsalicylic acid] 162 mg/day. Flow-mediated vasodilation was lower in the patients with hypertension than in the control group (6.4 vs 11.3%), but glyceryl trinitrate-induced (endothelium- independent) vasodilation was similar in the two groups. Aspirin significantly increased flow-mediated vasodilation in the patients with hypertension from 6.4 to 10.4%, and also increased production of cyclic guanosine monophosphate. These findings suggest that increased nitric oxide production, resulting from cyclo-oxygenase inhibition, may be involved in the improvement of endothelial function seen with low-dose-aspirin, comment the researchers. Monobe H, et al. Effects of low-dose aspirin on endothelial function in hypertensive patients. Clinical Cardiology 24: 705-709, Nov 2001 800886418 1 Inpharma 12 Jan 2002 No. 1320 1173-8324/10/1320-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Page 1: Low-dose aspirin improves endothelial function in hypertension

Inpharma 1320 - 12 Jan 2002

Low-dose aspirin improvesendothelial function in

hypertensionLow-dose aspirin may restore endothelium-

dependent vasodilation in patients with hypertension,according to researchers from Japan.

The researchers studied 18 patients with essentialhypertension and 10 volunteers without hypertension,before and 8 weeks after administration of aspirin[acetylsalicylic acid] 162 mg/day.

Flow-mediated vasodilation was lower in the patientswith hypertension than in the control group (6.4 vs11.3%), but glyceryl trinitrate-induced (endothelium-independent) vasodilation was similar in the twogroups. Aspirin significantly increased flow-mediatedvasodilation in the patients with hypertension from 6.4to 10.4%, and also increased production of cyclicguanosine monophosphate.

These findings suggest that increased nitric oxideproduction, resulting from cyclo-oxygenase inhibition,may be involved in the improvement of endothelialfunction seen with low-dose-aspirin, comment theresearchers.Monobe H, et al. Effects of low-dose aspirin on endothelial function inhypertensive patients. Clinical Cardiology 24: 705-709, Nov 2001 800886418

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Inpharma 12 Jan 2002 No. 13201173-8324/10/1320-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved