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LOGO Longer Life, Better Life

The third group 陈昊

——Current research progress on Alzheimer Disease

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21st century--time for the aged

Number of the aged is so huge!

October 31st, 2011

7 billion people on the world?

0.7 billion is the old!Almost 1 in 10 on the world

is over 60!

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Aging is everywhere

Number of the aged (current and predicted) of some continent

4-5 times increasing in 50 years, just like a

rocket!

What about China?

The pace is faster.

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The Result: Enjoy a longer life

Life expectancy worldwide on 2007

From Wikipedia

CIA World Fact book 2007 :Over 100 nations or regions enjoy the life expectancy over 70!

Quality

of life?

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Living quality---A better life as well?

Economic influence

Social problems

Health and diseases

Aging is good Aging is good or not? This is or not? This is

a question.a question.

The tragedy of aging:

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Diseases of the aged

diabetes

CHF Stroke

Neurodegenerativedisease hypertension

Aged diseases

When we become old……

Cancer

Alzheimer

The position of Alzheimer

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Contents

1 The characters of Alzheimer

2 Alzheimer----the killer of life quality

3 Research on Mechanism of Alzheimer

4 Current drug and therapy

5 Can Alzheimer be prevented?

Fight against

Alzheimer!

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1 Alzheimer--- four stages characters

Early Middle Severe Final

1. slow, progressive loss of intellectual ability

2. difficulty learning

3. mild depression

1. an increase in memory loss

2. Decrease losing of daily living ability

1. unable to recognize objects and family members

1. cannot speak or walk, even breathe

2. has profound memory loss

Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30

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Epidemiology from a point: a large market in AD therapy

•Drugs for AD have a large market.

•AD is very popular in the aged.

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2. Alzheimer destroys the quality of life

Danger of the patients

1. They can’t remember what they have done.

2. They can’t remember their family members.

3. Finally, they will not know who they are.

4. They will die because of breath problem!

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Alzheimer destroys the quality of life

Social problems

TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661

Have you remembered or not? !

Mercy killing!

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3.The mechanism of Alzheimer—so many hypothesis

Cholinergic hypothesis

The mechanismOf Alzheimer

Amyloid hypothesis

imbalance

Acetylcholine (ACh)

production elimination

11C-PIB PET images characteristicChristiane Reitz. Epidemiology of Alzheimer disease. Nat.

Rev. Neurol. 7, 137–152 (2011)

amyloid deposits

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New research: The interaction between these hypothesis

MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111

Amyloid hypothesis to Cholinergic hypothesis

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New research: The interaction between these hypothesis

MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111

Cholinergic hypothesis to Amyloid hypothesis

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4.Current Drug and therapy

CurrentDrug H3

antagonist

5-HTreceptor

ACEIs

NewACEIs

Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210

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5. Can Alzheimer be prevented?

EmotionalTherapy?

AntibodyTherapy?

DietTherapy?

Anti-oxidation?

Virus-likeVaccine?

PreventionOf AD

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---Longer life, better lifeConclusion

Our loveTo the old?

Better prevention

More drugs

Mechanismclearer

live longer, live better.

It’s not only for the old, but also for our

future!

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F0917101TM Scientific