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Limulus J Test Wako 50

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Table 3 JPSE m EU/ml g Tg min.

JPSE (EU/ml ) Tg (min.)

0.0625 50.8 49.2 0.0125 42.8 42.2 0.025 35.0 34.8 0.5 30.0 29.8 1.0 24.8 24.4 2.0 21.0 21.4

log (Tg (min.) ) 0.251 log (JPSE conc. (EU/ml ) ) 1.397 r 0.9989

Table 4 CSE m ng/ml g Tg mean min.

CSE (ng/ml ) Tg mean (min)

vial 1 vial 2 vial 3 vial 4

0.00625 49.5 50.1 57.8 51.3 0.0125 40.2 42.2 43.1 42.0 0.025 34.8 35.4 36.3 36.7 0.05 29.9 31.2 31.2 30.0 0.1 24.6 24.2 24.8 24.5

Table 5 CSE m EU

CSE d86!m Tg EU EU (ng/ml ) (min) (EU/ml ) (EU/ng)

0.00625 52.1 0.0532 8.51 0.0125 41.9 0.1268 10.14 0.025 35.8 0.2375 9.50 0.05 30.6 0.4439 8.88 0.1 24.5 1.0772 10.77

EU 9.56 (EU/ng)

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$Bang, F. B. : Bull. Johns Hopkins Hosp., 98, 325 (1956).

$Levin, J. and Bang, F. B. : Bull. Johns Hopkins Hosp., 115,

265 (1964).

$Westphal, O., L ›uderitz, O., Eichenberger, E. and Keiderling,

W. : Z. Naturforsch., 7b, 536 (1952).

$Akama, K., Kuratsuka, K., and Homma, R., Kanoh, S.,

Niwa, M., Iwanaga, S. and Nakahara, C. : Bacterial En-

dotoxin, eds. Homma, J.Y. et al., p395, Verlag Chemie (1984).

$ # # # #

#38 (6), 781 (1983).

$The United States Parmacopeia 22th, The National Formulary

17th, p1493, U.S. Pharmacoperial Conversion Inc (1990).

$Oishi, H., Takaoka, A., Hatayama, Y., Matsuo, T. and

Sakata, Y. : J. Parenter. Sci. Technol., 39 (5), 194 (1985).

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