lectures+67 68+emerging+infections+1+slide+pp

7/27/2019 Lectures+67 68+Emerging+Infections+1+Slide+Pp

http://slidepdf.com/reader/full/lectures67-68emerginginfections1slidepp 1/46

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203314564 4



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203314564 EI"



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203314564 G



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203314564 H

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203314564 O


anything that makes the disease "new"



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203314564 P




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203314564 Q

originated from poultry



8,$#1RS#BT1/&.#0.#.I

2+,)$3+$'0$0-1%4-(%15)106'0$0 3CCD E0/( -(F.;.%.&;2

>BRU"C$,'*'$("B*2*/?/(*"d+?6/%E"8<O:TO9g

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0$($)3*') U=%D')='$,', iY0Uja Ehrlichia ewingii '(@/)*'$("^@$%?/%D3"U=%D')='$,',

+(,-/) / 4"$%"$ /%"2./(

Anaplasma phagocytophilum '(@/)*'$("^@$%?/%D3"

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203314564 65

http://www.cdc.gov/ncphi/disss/nndss/casedef/ehrlichiosis_2008.htm



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203314564 66


not specif ic symptoms!



!;$3&*;&01*;0))&#'.&.

819-!$1*%'0$0 B+--$%*'H/E"

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:1/(*'@')2*'$("$@"?$%+D2/"'("*=/")3*$-D2,?"$@"?$($)3*/,"$%"?2)%$-=2./,"63"?')%$,)$-')"/Q2?'(2*'$("

>$(@'%?/1E" B/%$D$ ')2D /H'1/()/ $@ 2 @$+%@$D1 )=2( / '( '??+($ D$6+D'( X : X O, /)'@')" " " " " " " " "

2(*'6$13"*'*/%"*$"E. chaffeensis 2(*'./("63"'(1'%/)*"'??+($@D+$%/,)/()/"2,,23"^:l!a"6/*#//("-2'%/1",/%+?",2?-D/,"^$(/"*2&/("'("@'%,*"#//&"$@"'DD(/,,"2(1"2",/)$(1"7O\"#//&,"D2*/%a4"5h"

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T/?$(,*%2*'$("$@"/=%D')='2D"2(*'./("'("2"6'$-,3"$%"2+*$-,3",2?-D/"63"'??+($=',*$)=/?')2D"?/*=$1,4"5h"

:,$D2*'$("$@"E. chaffeensis @%$?"2")D'(')2D",-/)'?/("'(")/DD")+D*+%/"

203314564 64


retrospect



!"#$%&"%'()*%+,%% &')#*+&,'1U),$"#$3:1

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2(*'./(,"2%/"($*"2H2'D26D/I"R=+,4"Ehrlichia ewingii

'(@/)*'$(,"?23"$(D3"6/"1'2.($,/1"63"?$D/)+D2%"

" " . " " " ")D'(')2D",-/)'?/("H'2"2?-D'@')2*'$("$@"2",-/)'@')"

*2%./*"63"-$D3?/%2,/")=2'("%/2)*'$("^C>ha"2,,23I"

203314564 6<




-+'.$'/0'(."',1&231."%$40 &')#*+&,'1U),$"#$3:1

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819-!$1*%'0$0 2

J(*&$&'.80$2(K.5(;8(2&F2($(K0%(52@'L2&*2@'M20;%.H&5I2*(08%.K(2,.%)2#"2>)0'&8I%&>).$<N20;%.'(;2HI2@O#62(;PIN(Q$.;R(52.NN<;&/&*H(;%2#//0I2STG@J#U625&%QTG@J#62&*20//0I/2.;2&%)(*2F&*N0%/2SE-E2</(/20;2@O#2@'L28<%&FF2&F2!1B=20;525&(/2;&%2</(2@'M2%(/%2*(/<$%/2.;5(>(;5(;%$I20/25.0';&/%.82

/<>>&* 28* (* 0" 62 2 @5(;%.F.80%.&;2&F2N&*<$0(2.;2%)(28I%&>$0/N2&F2;(<%*&>).$/2&*2(&/.;&>).$/2HI2

N.8*&/8&>.82(V0N.;0%.&;2

E&;F.*N(512 J(*&$&'.80$2(K.5(;8(2&F202F&<*F&$528)0;'(2.;2@'LQ/>(8.F.820;%.H&5I2%.%(*2%&2 A.

phagocytophilum 0;%.'(;2HI2.;5.*(8%2.NN<;&F$<&*(/8(;8(20//0I2S@O#U2.;2>0.*(52/(*<N2/0N>$(/2S&;(2%0R(;2.;2F.*/%2,((R2&F2.$$;(//20;5202/(8&;523Q=2,((R/2$0%(*U624:2

2 2 . 2 2 2 2 2 20N>$.F.80%.&;2&F202/>(8.F.82%0*'(%2HI2>&$IN(*0/(28)0.;2*(08%.&;2S7E:U20//0I624:2

-(N&;/%*0%.&;2&F20;0>$0/N0$20;%.'(;2.;202H.&>/IW0<%&>/I2/0N>$(2HI2.NN<;&)./%&8)(N.80$2N(%)&5/624:2

203314564 6E

@/&$0%.&;2&F2 A. phagocytophilum F*&N2028$.;.80$2/>(8.N(;2.;28($$28<$%<*(


retrospecti ve analysis- hence toolate for diagnosis of patient



!;$3&*;&,.&.J7'0A30.",.&.W1;-"0'W1

-' #+#$" '#710"-7)100$#$31&$'%

TV>&/<*( X./%&*I2&F2)0K.;'2H((;2.;2>&%(;%.0$2%.8R2)0H.%0%2.;2%)(2!=250I/2>*.&*2%&2%)(2

&;/(%2&F2.$$;(//2&*2)./%&*I2&F2%.8R2H.%(2&*2)./%&*I2&F2%.8R2H.%("

E0/(2E$0//.F.80%.&;1. Suspected: #280/(2,.%)2$0H&*0%&*I2(K.5(;8(2&F2>0/%2&*2>*(/(;%2.;F(8%.&;2H<%2

;&28$.;.80$2.;F&*N0%.&;20K0.$0H$(2S("'"202$0H&*0%&*I2*(>&*%U"

2. Probable: #28$.;.80$$ 28&N 0%.H$(280/(2 N((%/28$.;.80$2(K.5(;8(28*.%(*.0 2%)0%2)0/2/<>>&*%.K(2$0H&*0%&*I2*(/<$%/"2O&*2()*$.8).&/./W0;0>$0/N&/./2Y 0;2<;5(%(*N.;(5280/(280;2&;$I2H(28$0//.F.(520/2>*&H0H$("2Z)./2&88<*/2,)(;20280/(2)0/28&N>0%.H$(28$.;.80$28*.%(*.02,.%)2$0H&*0%&*I2(K.5(;8(2%&2/<>>&*%2T)*$.8).0W#;0>$0/N02.;F(8%.&;62H<%2;&%2,.%)2/<FF.8.(;%28$0*.%I2%&25(F.;.%.K($I2

2 2 2 2 2 2 2 2 "2 2 2 2 2.5(;%.F.80%.&;2&F2N&*<$0(2.;2,).%(28($$/2HI2N.8*&/8&>.82(V0N.;0%.&;2.;2%)(20H/(;8(2&F2&%)(*2/<>>&*%.K(2$0H&*0%&*I2*(/<$%/"

3. Confirmed: #28$.;.80$$I28&N>0%.H$(280/(2SN((%/28$.;.80$2(K.5(;8(28*.%(*.0U2%)0%2./2$0H&*0%&*I28&;F.*N(5"

203314564 6G




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)=2(./

203314564 6H

MOST COMMONLY WHEN PPL STOP

VACCINATIONS B/C THEY THINK THE

RISK OF VACCINATION IS GREATER

THAN THE DISEASE ITSELF!



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203314564 6O



203314564 6P

DISCONTINUED -->

RISE IN WHOOPING

COUGH (SEASONAL)



[#=!"#$%&'%1/&.#0.#.11

\;0'%#.1&'1L,*&031,$1!'_&$,'"#'+031N$0*+&*#.

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+,'( ")$??+('*'/, "+(*'D"'*" $*"2"*'?/D "6$$,*"@%$?"*=/"/?/% /()/"

$@"Y:S

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h/D/2,/"$@"-%',$(/%,"2@*/%"@2DD"$@"*=/"!-2%*=/'1".$H/%(?/(*"'("

B$+*="!@%')2I

203314564 6Q

RESISTANCE TO TB DRUGS



[#=!"#$%&'%1/&.#0.#.11

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M0$0*.0 #2,"6%$+.=*"#/DD"+(1/%")$(*%$D"

*=%$+.=$+*"*=/"#$%D1"63"*=/"D2*/"9<g8,4"2@*/%"

98"*$"9g""3/2%,"$@"TTR"+,/I"" B'()/"TTR"#2,"1',)$(*'(+/14"?2D2%'2"=2,"%/O

/?/%./1"2,"*=/"o9"'(@/)*'$+,"1',/2,/"&'DD/%"'("

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0$%/"%/)/(*"'(,/)*')'1/,"=2H/"@2'D/1"*$"F1/(*V"

*=/"?$,m+'*$"H/)*$%"-$-+D2*'$(

203314564 45

DDT AFFECTED THE FOOD CHAIN-

BIRDS/FISH/ETC



`391/&.#0.#.1&'1'#B1N30*#.

S#B1Z,.+1N,A-30+&,'." " " " " " " "

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*=

203314564 46

" "

GREAT POX =>SYPHILLIS

COMMONLY OCCUR IN NAIVE

POPULATIONS!



`391/&.#0.#.1&'1'#B1`$&)&*#.

+;#1RS#BT1LF(.>/%*2'( FB2@/ B/Q V9 !(2DO5%2D %2)*')/,7 =2H/" " " "

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* /" +?- "*$" /)$?/"%/2 " , Giardia lamblia - C%$*$f$2(

. - f

Shigella sp. – R%+/"N2)*/%'2

–. " 5*=/%,` – Y/-2*'*',"!4"NI"2(1">"`

F V

203314564 44

" " " " "

7"B$?/*'?/,")2DD/1"Fh'??'(.V



`391@-%.1B&+;

('*$#0.#91a&$-3#'*# Y9d9":(@D+/(f24"9<9;"#$%D1#'1/"-2(1/?')"

Ygd9"'(@D+/(f24""9<WP"Y$(."e$(."

Staph aureus UQ$*$Q'("RBBRO9"O9<;8,"AB!

R=/"FlD/,="U2*'( V"Stre [ 9<<8,"AB!

E. coli 59gPEYP4"9<<8,"AB!

203314564 4<

ALMOST WORLDWIDE

PANDEMIC! VERY SEVERE



/$-%1[#.&.+0'*#

CCdX C/(')'DD'(2,/"-$,'*'H/"Neisseria

0Th"RN 0+D*'-D/OT%+."%/,',*2(*"

0hB! 0/*=)'DD'("h/,',*2(*"Staph aureus

?/%./()/"$ " %+." /, ,*2()/"- 2,? ,"# ) "

2%/",-%/21'(."*=%$+.="*=/"Enterobacteriaceae 2(1"

O" "

203314564 4E

EARLY IN WW2 GONORRHEA COULD BE TREATED

WITH SULFONAMIDES

NOSOCOMIAL INFECTIONS



N0++#$'.1,)1!"#$%#'*#

!" #$%& (%)(* +(, -./(0/(12

3" 4$52-./(0/(62+(,27$08(1

" 2 2

=" 4$52-./(0/(62+(,27&><$0%.&;1

" 2

B" -*<'2:(/./%0;8(1

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203314564 4G;++AIJJBBBD%#&.D);AD,.9D"&3JK!(LJ0@,-+K!(LJ27M.J27M<D0.A



F;#1\30..&*I

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203314564 4H

and gave himself ulcers



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%/*%$H'%+,I""T',-%$H/("``

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and the Montefiore Medical Center, Bronx, New York)

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bieneusi

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203314564 E5



SERRATIA MARCESCENS 62E4+Z#M@+#ZT-2J4G]Z@4+

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203314564 E6

normally harmless organism -->harmful in another part of the body --> bypass BBB and cause

major symptoms!



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203314564 E4



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203314564 E<



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203314564 EE



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203314564 EH

lectures+67 68+emerging+infections+1+slide+pp

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