lecture 1 biomaterials introduction

Course Code : MSE-338 [3-0]

Course Title : Biomaterials

• “Biomaterials: The Intersection of Biology and Materials Science” by J. S. Temenoff and A. G. Mikos, 1st Edition, Pearson Education India, 2008.

• “Biomaterials: An Introduction” by Joon Park and R. S. Lake, 3rd Edition, Springer, 2007.

Dr. Saima Shabbir, MS&E, IST

Course Outline• Introduction to materials used in medicine, trace elements

in blood and their importance, surface properties characterization of Bio materials, surface & protein interactions, biological and biochemical properties of proteins, cells & tissues, biocompatibility & host reactions to bio implants, implementation & degradation of implant materials, sterilization and implants associated infections, testing & bio materials surface coating, elastomers, hydrogels and their applications. Ceramics & bioglasses, adhesives & sealants, degradable materials application in drug delivery.


OBE

CLO # CLO PLOLearning domain

and level

CLO-1 Student will be able to discuss various classes of biomaterials on the basis of structure and function. PLO-1 C-2

CLO-2 Student will be able to explain the role of adsorbed proteins in the tissue response to different kinds of biomaterials. PLO-1 C-2

CLO-3 Student will be able to analyze events that lead to the degradation of materials in the biological environment. PLO-2 C-4

CLO-4 Student will be able to propose a biomaterial for a specified application in drug delivery or implant material. PLO-3 C-5


BiomaterialsModule 1 – PLO-1/CLO-1/C-2

Introduction


What is a biomaterial?


Definition: Biomaterial

• Any material (other than a drug) of natural or of synthetic origin that comes in contact with tissue, blood or biological fluids.

• Intended for use in prosthetic, diagnostic, therapeutic or storage applications without adversely affecting the living organism and its components.


Therapeutic Devicesin Orthopedics

Knee replacements


Applications in Dentistry


Catheters

Catheters allow drainage, injection of fluids, or access by surgical instruments.


In Ophthalomolgy


In Drug Delivery


Future Applications-Tissue Replacement


Implant

• Any medical device, made from one or more biomaterials, intentionally placed within the body, either totally or partially buried beneath an epithelial surface, where it is intended to remain for a significant period.


The Food and Drug Administration(www.fda.gov)

Regulates:• Food-Food borne Illness, Nutrition, Dietary

Supplements… • Drugs-Prescription, Generic….• Medical Devices -Pacemakers, Contact Lenses,

Hearing Aids… • Animal Feed and Drugs-Livestock, Pets …• Cosmetics-Safety, Labeling…..• Radiation Emitting Products-Cell Phones, Lasers,

Microwaves…..


Definition: Biomaterial -FDA

• Find it………………..


Drugs Control Organization, Ministry of Health, Pakistan

(www.dcomoh.gov.pk/)

• Responsible for regulating firms who manufacture, repackage, relabel, and/or import medical devices sold in Pakistan.

• Also regulates radiation emitting electronic products (medical and non-medical) such as lasers, X-ray systems, ultrasound equipment, microwave ovens and color televisions.


Basics

•A biomaterial – is a material used in a medical device,

intended to interact with biological systems.1 – is used to make devices to replace a part of a

function of the body in a safe, reliable, economic, and physiologically acceptable manner.

1 Williams, D.F. (1987) Definitions in Biomaterials. Proceedings of a Consensus Conference of the European Society For Biomaterials, England, 1986, Elsevier, New York.Dr. Saima Shabbir, MS&E, IST

General Applications of Biomaterials

• Storage of fluids, tissues, and other biological products

• Diagnosis• Monitoring• Therapy


Drugs Control Organization, Ministry of Health, Pakistan

(www.dcomoh.gov.pk/)

• Responsible for regulating firms who manufacture, repackage, relabel, and/or import medical devices sold in Pakistan.

• Also regulates radiation emitting electronic products (medical and non-medical) such as lasers, X-ray systems, ultrasound equipment, microwave ovens and color televisions.


Relevant Websites• Biomaterials Network (www.biomat.net)• Medical Device Information

(www.devicelink.com)• Medical Materials Engineering reference

(www.engineeringreference.com)• United States Patents and Trademarks Office

(www.uspto.gov)• MEDLINE-(www.ncbi.nih.gov/entrez/

query.fcgi)


Where can you find information about medical devices?

• www.nlm.nih.gov/services/meddevice.html

• - Medical Device Link's Suppliers Page at http://www.devicelink.com/company/

• - MEDMarket Network's Internet Medical Products Guide at http://www.medmarket.com/index.cfm?id=product_guide


lecture 1 biomaterials introduction

Documents

saima shabbir

degradation of materials

materials science

drug of natural

istin drug deliverydr

bio implants

epithelial surface

biological fluids