karl friedrich meyer: 1884–1974 - national academy of ... friedrich meyer may 19, 1884-april 27,...

Download Karl Friedrich Meyer: 1884–1974 - National Academy of ...  FRIEDRICH MEYER May 19, 1884-April 27, 1974 BY ALBERT D. SABIN* KF MEYER (henceforth KF, as he was affectionately called by

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  • n a t i o n a l a c a d e m y o f s c i e n c e s

    Any opinions expressed in this memoir are those of the author(s)and do not necessarily reflect the views of the

    National Academy of Sciences.

    k a r l f r i e d r i c h m e y e r

    18841974

    A Biographical Memoir by

    a lB ert d . sa B in

    Biographical Memoir

    Copyright 1980national aCademy of sCienCes

    washington d.C.

  • KARL FRIEDRICH MEYERMay 19, 1884-April 27, 1974

    BY ALBERT D. SABIN*

    KF MEYER (henceforth "KF," as he was affectionately calledby his colleagues) was an outstanding bacteriologist,experimental pathologist, virologist, epidemiologist, ecolo-gist, brilliant and inspiring teacher, and a prototype of thescientist in the service of society. In the tradition of Pasteurand Koch, his scientific studies invariably involved theacquisition of knowledge for the understanding and solutionof important practical problems in the field of human andanimal diseases. In 1951, when KF was sixty-seven yearsyoung, the American Public Health Association presentedhim a Lasker Award with the following citation that aptlyexpressed the esteem of his colleagues and summarized hismajor contributions to science and public health:

    Brilliant scientist, dynamic teacher, inspired humanitarian. His influ-ence now extends over two generations of students of medicine, biology,

    *In writing this biographical memoir, I tried whenever possible to let K. F. Meyertalk for himself in his own colorful, inimitable manner. I am indebted to the directorof the Bancroft Library of the University of California, Berkeley, for permission toquote from Dr. Meyer's oral history memoir entitled Medical Research and PublicHealth (Berkeley: University of California, 1976), a transcript of a 1961-1962unedited tape-recorded oral interview by Edna Tartaul Daniel, Regional OralHistory Office, The Bancroft Library. This oral history was also the source of muchof my information that is not available elsewhere. Since Dr. Meyer continued to betoo busy to read this transcript, I corrected the spelling of some of the names andchecked the dates of certain events.

    269

  • 270 BIOGRAPHICAL MEMOIRS

    and the allied health sciences. His research and leadership have benefitedall classes of people for four decades. . . .

    Among his accomplishments is a major share of responsibility for thecontrol of botulism, and for a classification and international identificationcenter for the clostridia; for our recognition that plague is sylvatic, notmerely rat-borne; for understanding of the broad spectrum of brucellosisrather than restricted goat-borne Malta-fever; for the concept of ornithosisrather than psittacosis; for elucidating the role of the arthropod vector inwestern equine encephalomyelitis; for showing that western ticks are alsoresponsible for relapsing fever; for studying the dinoflagellate causingmussel poisoning; for increasing our knowledge of leptospirosis; for valu-able assistance with investigations of Q fever.

    No ivory tower recluse, Karl Meyer has responded promptly and gratisto calls for help from physicians, scientists, health officers, farmers, fisher-men, canners, the Military and the United States Government.

    Inherent in his research is its application. To both he has appliedhimself with boundless energy and humanitarian generosity, to the greatgood of mankind.

    KF continued his important work and enjoyment of life inhis inimitable manner until a brief illness ended his life onlytwenty-two days before his ninetieth birthday.

    FAMILY BACKGROUND AND EARLY LIFE

    IN SWITZERLAND

    KF was born in Basel, Switzerland, the son of Theodorand Sophie (Lichtenhahn) Meyer zum Pfeil van Biiren. Bothparents were members of old, upper-middle-class Basel fami-lies, and KF noted that he traced his family tree back to thefourteenth century. His father was a relatively affluent mer-chant who imported fine cigars from Cuba and Indonesia forsale throughout Central Europe. His father's hobbiesincluded reading, hunting, fencing, and long walks in theSwiss Alps. His mother taught in elementary school beforeher marriage, and did much to develop KF's intellectualcuriosity in his pre-school years. KF had two sisters, both

  • KARL FRIEDRICH MEYER 271

    younger than he. His early years were spent in a large, well-appointed old house overlooking the Rhine River, just off theprincipal Basel Cathedral Square.

    KF attended a private elementary Evangelische Volk-schule of the Swiss Zwingli reformed church. After four yearsof elementary school, he entered Gymnasium where lan-guages (Latin, Greek, classical German, French, andEnglish), history, mathematics, and, to a lesser extent, thesciences were the main components of the curriculum. KF'sspecial interest in the natural sciences led him to spend thelast two years in the Realgymnasium where there was greateremphasis on and better teaching of the sciences, especiallychemistry, physics, and biology. According to KF's own recol-lection, he was a pain in the neck to his teachers and a "betenoir," full of mischief and tricks in the classroom right up tothe end of his Realgymnasium days. His lifelong impatiencewith what he regarded as "nonsense," illogical, or factuallyunproven was already fully developed in his late Gymnasiumyears, and he apparently never let his teachers get away withwhat he regarded as questionable statements. Despite thisand his propensity for neglecting homework, he graduatedsecond in his Realgymnasium class in 1902 when he waseighteen years old.

    KF recalled that physically he was in "fantastic shape"during those years. He fenced, rode horseback, rowed on theRhine River, and walked a lot. He did not share his father'slove for hunting. KF was very popular with his classmates andhe put on school plays such as Moliere's Le Malade Imaginaireand Rostand's Cyrano de Bergerac. His extracurricular readingduring those days included mostly adventure books, the Illus-trated London Times, the Swiss daily newspapers, with their"superb editorials," and the German encyclopedia Conversa-tions Lexicone.

  • 272 BIOGRAPHICAL MEMOIRS

    UNIVERSITY EDUCATION

    KF's university education included one-half year (1902) inBasel, two years (1903, 1904) in Zurich, one year (1905) inMunich, and about two and one-half years (1906-1908) ofcourse and thesis work in Bern. At Basel, he was tremen-dously attracted to zoology, more to the abnormal than to thenormal, and was particularly fascinated by the newly emer-ging protozoology with the recent discoveries of the malarialparasites and the flagellated trypanosomes. KF's recollectionsof Professor Friedrich Zschokke, the "topnotch" zoologyteacher in Switzerland at the time, included all those at-tributes that later characterized KF's own teachingmethodsthe "fantastically" prepared and orderly pre-sented lectures followed by dissections and gross and micro-scopic demonstrations in the laboratory, the Saturday fieldtrips that ended in vivid discussions over steins of beer in anoutdoor beer garden. "Bon vivant" KF first joined the Helve-tia Fencing Club, where the rapier fencing was too much ofa bloody affair for him, and, ultimately, the extensive alcoholconsumption also became too much. He then switched to oneof the oldest color fraternities, the Zofingia. The indepen-dent KF's dislike of being pushed around by the oldermembers of the Zofingia corps, and the heavy beer-drinkingand all-night parties, strongly disapproved by his father, ledto the decision to move away from Basel.

    His move to the University of Zurich was influenced notonly by his desire to "get away from the house," but also bythe fact that there were many more good departments inZurich, especially the great departments of comparative anat-omy and chemistry. Although his great interest was in zool-ogy, he also worked hard in botany, chemistry, and physics,in which he had to pass examinations for admission to thesubsequent studies he wished to pursue. KF recalled that

  • KARL FRIEDRICH MEYER 273

    his later career was determined by the recommendation ofhis professor of comparative anatomy that he continue hisstudies with Heinrich Zangger, a professor of comparativephysiology and pathology at the Veterinary School. KFdescribed Zangger as a "perfectly fabulous individual fromthe standpoint of what he knew in chemistry and the way helooked at life."* Zangger treated KF as if he were a graduatestudent and gave him a corner in his laboratory where hecould work in his spare time.

    KF accepted Zangger's recommendation that he enroll inthe Veterinary School where he could learn a great dealabout animals. KF also studied human anatomy, physiology,and biochemistry in the medical section of the University.After two years at the University of Zurich, KF passed hisexaminations with "flying colors." Zangger then steered himto the University of Munich and continued to have a mostimportant influence on KF's career and general outlook onlife. KF later said about Zangger: "In my life, he was the man."Zangger's concern about human beings and what happenedin society, evidenced by his subsequent activities in forensicmedicine, in industrial hygiene in the rapidly evolving Swisschemical industry, and in preventive medicine in industry,led KF to say: "This gave me my social consciousness whichI always try to hammer homesocial consciousness. You arepart of the society and you have to make your contribution."t

    KF spent his year in Munich working in the laboratory ofProfessor Friedrich von Miiller in the University's Depart-ment of Medicine and in the pathological institute of Her-mann Diirck. During the first weeks in Munich, KF againindulged in a great deal of heavy drinking and carousing,often without a stop from Friday night to Monday morning.

    *Medical Research and Public Health,