k. van liempt faculty of medicine

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K. Van Liempt

Faculty of Medicine

The University of AntwerpThe University of AntwerpFaculty of MedicineFaculty of Medicine

University Hospital AntwerpUniversity Hospital Antwerp

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The Antwerp Region

• 470.000 people in the City of Antwerp• Most important economic region in Flanders• Strong economic assets:

- Port of Antwerp 2nd largest in Europe; 4th world-wide- Largest cluster of petrochemical industry in the world- Diamond trade- Logistics

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The University of Antwerp

• Founded in 2003 upon the merger of three independent University Institutions

• Roots dating back to 1852

UIA

RUCA UFSIA

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The University of Antwerp in Flanders

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The University of Antwerp in the World

• University Rankings- QS World University ranking : 179

worldwide- ARWU (“Shanghai”) : 201-300 worldwide

• Consistently in the top 250 worldwide

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Facts and Figures

• Main partner in the Antwerp University Association- 1 university (UA)- 4 university colleges

• 30 000 students in total• 400 FTE UA-faculty staff• 1200 UA-research staff• 1100 UA-PhD students

• Around 3500 scientific works published/year- 1500 articles in Web of Science/year

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Organisational Structure

Natural SciencesNatural Sciences

SciencesSciences

Humanities and Social SciencesHumanities and Social Sciences

Applied EconomicsApplied Economics

Arts and PhilosophyArts and Philosophy

LawLaw

Political and Social SciencesPolitical and

Social Sciences

Pharmaceutical, Biomedical and

Veterinary Sciences

Pharmaceutical, Biomedical and

Veterinary Sciences

MedicineMedicine

Life SciencesLife Sciences

7 Faculties7 Faculties

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Front Line Research Domains

Urban History and Contemporary Urban Policy


Social Economic Policy and

Organisation


Organisation

Ecology and Sustainable

Development


Development

Materials Characterisation


Drug Discovery and DevelopmentDrug Discovery

and Development

Infectious Diseases

Infectious Diseases

NeurosciencesNeurosciences

ImagingImaging

Harbour, Transport and

Logistics


Logistics

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Organisation


Organisation


Development


Development




and Development

Infectious Diseases

Infectious Diseases


ImagingImaging


Logistics


Logistics

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Imaging

• EGAMI: Expert Group Antwerp Molecular Imaging- Network of research labs

• Biomedical Microscopic Imaging• Bioimaging Lab• Molecular Imaging Center Antwerp (MICA)• MicroCT Lab• Vision Lab

- Links with Antwerp University Hospital (UZA)• Radiology• Nuclear Medicine

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Imaging

Molecular and Cellular Imaging

Molecular and Cellular Imaging Small Animal Imaging Small Animal Imaging Clinical Imaging Clinical Imaging

Light MicroscopyLight Microscopy

(Scanning) Electron Microscopy

(Scanning) Electron Microscopy

Fluorescence Microscopy

Fluorescence Microscopy μCTμCT

μMRIμMRI

μPETμPET

In Vivo Biolumi-nescence and Fluorescence

Camera

In Vivo Biolumi-nescence and Fluorescence

Camera

CTCT

MRIMRI

PET/SPECTPET/SPECT

Image Processing

Image Processing

Confocal MicroscopyConfocal Microscopy

Confocal Live Cell Imaging

Confocal Live Cell Imaging

ElectrophysiologyElectrophysiology

Advanced Immuno-histochemistry

Advanced Immuno-histochemistry

Image ProcessingImage Processing

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Imaging

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• Molecular Imaging Center Antwerp (MICA)- Partnership between UA – UZA – Janssen

Pharmaceutica• Cyclotron + μPET/CT: micro-radiotherapy (320 keV),

autoradiography, direct access to FDG, FLT, FET and possibility to produce research tracers, kinetic modeling, multimodal image registration

- Fully operational spring 2011

Imaging - Highlight

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Organisation


Organisation


Development


Development




and Development

Infectious Diseases

Infectious Diseases


ImagingImaging


Logistics


Logistics

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Neurosciences

Neuronal Degeneration

Neuronal Plasticity

Neuronal Repair/ Replacement

Cognition and Behaviour

Stem CellsStem Cells Stem CellsStem Cells

Neuronal Tissue

Engineering

Neuronal Tissue

Engineering

NeurogeneticsNeurogeneticsNeurogeneticsNeurogenetics

Rodent ModelsRodent Models

NeurobiologyNeurobiology

Neuro-pathology

Neuro-pathology

Biobank/ BiomarkersBiobank/

Biomarkers

Psychiatric Disorders/ Dementia

Psychiatric Disorders/ Dementia

Song BirdsSong Birds

Nano-technology

Nano-technology

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Neurosciences

in vivo

< cell cell tissue organism

ex vivo / in vitro

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Neurosciences - Highlight

• VIB Department of Molecular Genetics (VIB8) (Director: Prof. Dr. Christine Van Broeckhoven)- Genetic analysis of complex neurological and

neuropsychiatric diseases• To identify novel molecular mechanisms for disease causation

and effective drug treatment for these diseases

- 4 research groups• Neurodegenerative Brain Diseases• Peripheral Neuropathies • Neurogenetics• Applied Molecular Genomics

- 2 centralized service facilities • Diagnostic Service Facility• Genetic Service Facility

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Organisation


Organisation


Development


Development




and Development

Infectious Diseases

Infectious Diseases


ImagingImaging


Logistics


Logistics

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Infectious Diseases

• Multidisciplinary research on infectious diseases and vaccines- Focused on microbiology and immunology, with

contributions of other disciplines• Epidemiology• Statistics/Mathematical modeling• Sociology• Economics

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2020

Infectious Diseases

Basic Research Preclinical Research

Clinical Research

Immune System

Immune System

Disease Mechanisms

Disease Mechanisms

Antibiotic ResistanceAntibiotic

Resistance

BiomarkersBiomarkers

VaccinesVaccines

Injection Devices

Injection Devices PreventionPrevention

Diagnostic Tests

Diagnostic Tests

VaccinesVaccines

EpidemiologyEpidemiology

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Infectious Diseases - Highlights

• Antibiotic use and resistance- European Surveillance of Antimicrobial

Consumption (ESAC)• European project coordinated by Prof. Dr. Herman

Goossens of the UA- Funded by the European Centre for Disease Prevention and

Control (ECDC) - 34 participating countries

• Study of the use of antibiotics, antivirals and antimycotics and occurrence of resistance

• A vaccine against leukemia?- Wilms’ tumor 1 antigen-targeted dendritic cell

vaccination against acute myeloid leukemia • Van Tendeloo et al., PNAS, 2010

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Organisation


Organisation


Development


Development




and Development

Infectious Diseases

Infectious Diseases


ImagingImaging


Logistics


Logistics

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BiomarkersBiomarkers

ToxicityToxicity

ImagingImaging

Drug Discovery and Development

Target DiscoveryTarget Discovery Drug DiscoveryDrug Discovery Preclinical Drug Development

Preclinical Drug Development

End point: Clinical Trials

End point: Clinical Trials

Disease PathologyDisease

Pathology

Disease Mechanism

Disease Mechanism

Animal ModelsAnimal Models

In vitro ScreensIn vitro Screens

Medicinal ChemistryMedicinal Chemistry

Small Molecules

Small Molecules

Medicinal Plants

Medicinal Plants

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Drug Discovery and Development

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• Major Focus of Disease Areas:- Bone disease

• Osteoporosis

- Cancer- Cardiovascular disease

• Atherosclerosis

- Infectious disease• Bacterial, fungal and parasitic infections

- Kidney disease- Metabolic disease

• Diabetes

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Drug Discovery and Development - Highlight

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• Antwerp Drug Discovery Network- Integrated Platform for early drug discovery from

hit to lead optimisation- Protease Inhibitors

• Urokinase Plasminogen Activator (uPA) inhibitors in Oncology

• Molecular Probes as drug discovery tools

- Infectious Diseases• In vitro screening panels for antifungals and drugs against tropical diseases• Reference Center World Health Organization (WHO)

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Faculty of Medicine

• Overview number of students- Medecine BA-MA 750- Nursing MA 194- Specialisation 250- Doctoral School 210- Physiotherapy 520

- Total 1924

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Faculty of Medicine

• Features of medical education- BA / MA structure- Competence driven and student

oriented teaching- Integration of CANMEDS roles in the

curriculum aimed at transforming students into medical experts

- English semester, Spring, 4th year

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University Hospital Antwerp

• Features of University Hospital- 600 beds- 520.000 consultations and technical

activities- 300 MIO € yearly budget- Legally independent from University,

but connected with several links, especially with the faculty of medicine

- Close collaboration with regional hospitals

k. van liempt faculty of medicine

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