jeffrey l. curtis, m.d. professor of internal medicine division of … · 2015-11-30 · jeffrey l....

Jeffrey L. Curtis, M.D.

Professor of Internal Medicine Division of Pulmonary & Critical Care Medicine

University of Michigan Health System

Pulmonary & Critical Care Medicine Section VA Health System (506/111G)

2215 Fuller Road Ann Arbor, MI 48105-2303

(734) 845-3457 (734) 845-3257 (fax) [email protected]

http://sitemaker.umich.edu/curtis.lab/home

mailto:[email protected]


Jeffrey L. Curtis, MD revised 11/30/15 1

Jeffrey L. Curtis, M.D. Professor of Internal Medicine

Division of Pulmonary & Critical Care Medicine University of Michigan Health System

Pulmonary & Critical Care Medicine Section

VA Health System (506/111G) 2215 Fuller Road

Ann Arbor, MI 48105-2303 (734) 845-3457

(734) 845-3257 (fax) [email protected]


Title and Contents Page 1

Education and Training

Certification and Licensure Page 2

Academic, Administrative and Clinical Appointments Page 3

Research Interests Page 3

Grants Page 4

Honors and Awards Page 7

Memberships in Professional Societies Page 7

Editorial Positions, Boards and Peer-Review Service Page 8

Teaching Page 10

Committee, Organizational, and Volunteer Service Page 19

Consulting Positions NA

Visiting Professorships, Seminars, and Extramural Invited Presentations Page 21

Patents NA

Bibliography Page 28



Jeffrey L. Curtis, M.D. Professor of Internal Medicine

Division of Pulmonary & Critical Care Medicine University of Michigan Health System

Pulmonary & Critical Care Medicine Section

VA Health System (506/111G) 2215 Fuller Road

Ann Arbor, MI 48105-2303 (734) 845-3457

(734) 845-3257 (fax) [email protected]


Education and Training

9/1965-6/1969 Trinity High School; Shiremanstown, PA (summa cum laude) 9/1969-5/1973 University of Scranton, Scranton, PA; Bachelor of Science, Biology

(magna cum laude) 9/1973-5/1977 Georgetown University School of Medicine, Washington, DC; Doctor of

Medicine 6/1977-6/1980 Internal Medicine Residency, Johns Hopkins Bayview Medical Center

(formerly Baltimore City Hospitals), Baltimore, MD 7/1980-6/1981 Chief Medical Resident, Johns Hopkins Bayview Medical Center, Baltimore,

MD (Dr. Philip D. Zieve) 7/1981-6/1983 Clinical Immunology fellow, Gerontology Research Center, NIH/NIA

(Laboratories of Drs. William H. Adler & Albert A. Nordin); and Sarcoidosis Clinic (Dr. Carol Johns), The Johns Hopkins Hospital, Baltimore, MD

7/1983-6/1984 Postdoctoral Pulmonary Immunology Research Trainee, VA Medical Center & Cardiovascular Research Institute (CVRI), University of California San Francisco (UCSF) (Laboratory of Dr. H. Benfer Kaltreider)

7/1984-6/1985 Clinical Pulmonary Fellow, Pulmonary Training Program, UCSF (Drs. John F. Murray & Jay A. Nadel)

Certification and Licensure

1979-present Federal Drug Enforcement Administration Registration - AC9064508 2007-present National Provider Identifier - 1578649018 Board Certification 1980-lifetime American Board of Internal Medicine, Diplomate in Internal Medicine 1983 American College of Surgeons Instructor, Advanced Trauma Life Support 1986-lifetime American Board of Internal Medicine, Diplomate in Pulmonary Diseases 1989 -1999 American Board of Internal Medicine, Diplomate in Critical Care Medicine



State Licensure 1979-1991 Maryland Medical Licensure - License D24373 1983-1990 California Medical Licensure - License G50052 1990-present Michigan Medical Licensure - License 4301056149

Academic, Administrative, and Clinical Appointments

Academic Appointments 7/1985-9/1988 Assistant Research Immunologist, Department of Medicine, University of

California, San Francisco, CA 10/1988-6/1990 Assistant Professor in Residence, Department of Medicine, University of

California, San Francisco, CA 7/1990-8/1996 Assistant Professor, Department of Internal Medicine, University of Michigan

Health System, Ann Arbor, MI 9/1996-8/2002 Associate Professor with tenure, Department of Internal Medicine, University

of Michigan Health System, Ann Arbor, MI 7/2000-present Member, Graduate Program in Immunology, University of Michigan Health

System, Ann Arbor, MI 9/2002-present Professor, Department of Internal Medicine, University of Michigan Health

System, Ann Arbor, MI Administrative Appointments 7/1990-12/2014 Chief, Pulmonary & Critical Care Section, VA Ann Arbor Healthcare System,

Ann Arbor, MI Clinical Appointments 7/1985-10/1988 Attending Physician, Respiratory Care Section, Veterans Administration (VA)

Medical Center, San Francisco, CA 10/1988-6/1990 Staff Physician, VA Medical Center, San Francisco, CA 7/1990-present Attending Physician, Pulmonary & Critical Care Medicine Division, UMHS,

Ann Arbor, MI 7/1990-present Staff Physician, Pulmonary & Critical Care Medicine Section, Department of

Veterans Affairs Health System, Ann Arbor, MI

Research Interests 1. Regulation of pulmonary immunity, especially though control of lung

lymphocyte recruitment and apoptosis, using multiple murine models of lung inflammation, auto-immunity, infection, and tobacco-smoke exposure.

2. Efferocytosis and its immunological consequences. 3. Immunopathogenesis and treatment of chronic obstructive pulmonary disease

in human subjects. 4. Ontogeny, phagocytosis, and signal transduction by lung mononuclear cells

(including both alveolar macrophages and dendritic cells). 5. Interactions of lung microbiome and lung innate immune cells.


Grants Current:

Department of Veterans Affairs Merit Review, I01 CX000911 “Modulation of steroid immunosuppression by alveolar efferocytosis” (20% P.I.: Jeffrey L. Curtis, M.D. (20% VA effort/15% total professional effort; 2.4 calendar months/year). 04/01/2015 to 03/31/2019 ($594,951 total direct costs; $147, 375 first-year annual direct costs).

MedImmune Corporation “Characterization of NK involvement in COPD Pathogenesis”, P.I.: Christine Freeman, PhD| Role: Co-Investigator; 07/01/2014-06/30/2015 ($100,000 total direct costs).

NIH/NHLBI, R01 HL089856 & R01 HL089857 “Genetic Epidemiology of COPD (COPDGene®)” P.I.: James D. Crapo, M.D. and Edwin K. Silverman, M.D., Ph.D. Role: Co-Investigator & VA Site P.I.; 0.24 calendar months/year. 10/31/2007-7/31/2017 (Annual Direct Funds to UMHS: $205,408).

NIH/NHLBI, Contract No. HHSN26820090016C “Subpopulations and Intermediate Outcome Measure in COPD Study (SPIROMICS): Clinical Centers” P.I.: Fernando J. Martinez, M.D., M.S. Role: Co-Principal Investigator, VA site-P.I., (0.60 calendar months/year) 02/01/2009-01/31/2016 ($1,961,990 total direct costs; $$386,261 annual direct costs).

NIH/NHLBI, Subcontract of Contract No. HHSN268200900016C “Subpopulations and Intermediate Outcome Measure in COPD Study (SPIROMICS): Immunophenotyping Sub-study” P.I.: Jeffrey L. Curtis, M.D. 09/01/2011-12/31/2015 ($1,200.00 total direct costs; $400,000 annual direct costs).

Pending: none


Recent: NIH/NHLBI, U01 HL098961 “Understanding the Lung Microbiome in HIV-Infected & HIV-Uninfected Individuals” MPIs: Jeffrey L. Curtis, M.D., James M. Beck, M.D. & Vincent B. Young, M.D., Ph.D. Role: Contact Principal Investigator (25% UMHS effort, 15% total professional effort; 3.0 calendar months/year). 10/01/2009-04/30/2015 ($525,000 direct cost annually) NIH/NHLBI, U10 HL074422 “Strategies to Prevent Chronic Obstructive Pulmonary Disease (COPD) Exacerbation” (COPD Clinical Research Network)” P.I.: Fernando J. Martinez, M.D., M.S. Role: Co-Principal Investigator & VA Site P.I. (5% UMHS effort; 3% total professional effort); 10/01/2004-07/31/2014 ($1,047,083 total direct costs). Department of Veterans Affairs Research Enhancement Award Program (REAP) “Pulmonary Innate Immunity in the Pathogenesis of Tobacco-induced Lung Diseases” (renewal years 05-11) P.I.: Jeffrey L. Curtis, M.D. (20% VA effort/15% total professional effort; 0.80 calendar months/year); 01/01/2005-12/31/2012 ($1,625,000 total direct costs; $250,000 annual direct costs). NIH/NHLBI, Contract No. HHSN2682011008C “Lung Tissue Research Consortium (LTRC): Clinical Centers” P.I.: Fernando J. Martinez, M.D., M.S. Role: Project Director, Project 1: “CD8 Tc1 cells & Macrophages in COPD pathogenesis” (20% UMHS effort; 14% total professional effort; 0.60 calendar months/year). 02/01/2004-01/31/2014 ($707,779 direct annual costs). NIH/NHLBI, N01 HR76192 “Long-term Oxygen Treatment Trial (LOTT) – Regional Clinic Centers” P.I.: Fernando J. Martinez, M.D., M.S. Role: Co-Investigator & VA site-P.I. (10% UMHS effort; 7% total professional effort);10/31/2006-10/30/2012 ($179,579 annual direct costs).

NIH/NHLBI, R01 HL082480-6 “Innate and adaptive immunity in COPD exacerbations” P.I.: Jeffrey L. Curtis, M.D. (30% UMHS effort; 20% total professional effort); 09/26/2005-07/31/2011 ($1,992,543 total direct costs). NIH/NHLBI, R01 HL056309-13 “Apoptotic T cell Clearance from Murine Lungs” (renewal years 06-13) P.I.: Jeffrey L. Curtis, M.D. (20% University effort/14% total professional effort); 05/01/1996-03/31/2011 ($2,268,000 total direct costs). NIH/NIAM, R01 AT004793


“Quercetin and innate immune modulation in COPD” P.I. Umadevi S. Sajjan, Ph.D. Role: Co-I. (5% UMHS effort, cost-shared with VA.; 0.60 calendar months/year); 7/1/2008-6/30/2013 ($1,447,681 total direct costs; $373,957 annual direct costs). Boehringer Ingelheim Protocol 205.325 “A Randomized, Double-blind, Double-dummy, Parallel Group Trial comparing 12 weeks Treatment with Tiotropium Inhalation Capsules 18 mcg via the HandiHaler® Once Daily to Combivent® Inhalation Aerosol CFC MDI 2 Actuations q.i.d., in COPD patients currently prescribed Combivent® Inhalation Aerosol CFC MDI”. Role: VA site-P.I. (0% UMHS effort; 0% total professional effort) 10/31/2006-9/30/2008.

Department of Veterans Affairs Merit Review Award (renewal years 14-19)

“Recruitment and Activation of Pulmonary Lymphocyte Subsets” P.I.: Jeffrey L. Curtis, M.D. (35% VA effort; 26% total professional effort)

10/01/2002-09/30/2007 ($675,000 total direct costs)

Department of Veterans Affairs Research Enhancement Award Program “Molecular Mechanisms in Lung Host Defense” Program Director: Jeffrey L. Curtis, M.D. (20% effort); 07/01/1999-12/31/2004 ($1,350,000 total direct costs). Michigan Life Sciences Initiative “Novel Strategy for Mucosal Vaccine Development” P.I.: Ellen Zimmerman, M.D. Role: Co-investigator (5% effort) 01/01/2001-12/31/2003 ($327,321 annual direct costs) NHLBI, R01 HL059823 “Cytokine control of host susceptibility to Pneumocystis” P.I.: James M. Beck, M.D. Role: Co-Investigator (10% effort) 9/30/1997-8/31/2002 ($1,000,000 direct costs). Department of Veterans Affairs Merit Review Award (renewal years 09-13), “Recruitment and Activation of Pulmonary Lymphocyte Subsets” P.I.: Jeffrey L. Curtis, M.D. (35% effort) 10/1/97-9/30/02 ($398,000 direct costs) NIH/NHLBI, R01 HL061577 “T cell adhesion molecules in murine lupus pneumonitis” P.I.: Jeffrey L. Curtis M.D. (20% effort) Novartis Protocol CFOR258D US06 “A randomized, multicenter, open-label, parallel group study comparing the efficacy and safety of Foradil® Aerolizer (formoterol fumarate inhalation


powder) 12 µg B.I.D. to Serevent® MDI (salmeterol xinafoate) 50 µg B.I.D. in patients with COPD” P.I. : Jeffrey L. Curtis, M.D. (1% effort) 3/30/2002-10/30/2003 Pfizer Protocol #A0661087 “A randomized, multicenter, third-party blinded study comparing the efficacy and safety of Zithromax® (Azithromycin) for 3 days (1.5 grams) versus Avelox® (Moxifloxacin Hydrochloride) for 5 days (2.0 grams) in the outpatient treatment of acute exacerbations of chronic bronchitis (AECB)”; P.I. : Jeffrey L. Curtis, M.D. (1% effort) 01/01/2002-12/31/2002

Honors and Awards

1969 National Merit Scholarship, semi-finalist 1969 - 1973 Presidential Scholarship (Full Tuition); University of Scranton 1969 Scholar-Athlete Award, University of Scranton 1973 B. S., Magna cum laude, University of Scranton 1983 - 1985 Research Fellowship; American Lung Association 1987 Parker B. Francis Fellowship in Pulmonary Research (declined to accept VA Career Development Award) 1988 Edward Livingston Trudeau Scholar Award; American Lung Association

(declined to accept VA Career Development Award) 1988 - 1990 Research Associate, Career Development Program, Dept. of Veterans Affairs 1995 Pulmonary Faculty & Staff Appreciation Award 1996 - 1999 Career Investigator Award, American Lung Association of Michigan 1999 Margaret Epp Weber Provider of Choice Award, VISN 11, Dept. of Veterans

Affairs 2010 Federal Employee of the Year Award, Federal Executive Board for Southeast

Michigan. 2010 Administrative Excellence Award, Pulmonary Fellowship. 2014 Elected Fellow, European Respiratory Society

Memberships in Professional Societies 1985 - present American Association for the Advancement of Science (AAAS) 1993 - present American Association of Immunologists (AAI) 1983 - 1994 American College of Chest Physicians (ACCP) 1989 elected Fellow 1980 - 2009 American College of Physicians (ACP) 1989 elected Fellow 1989 - 1995 American Society for Cell Biology (ASCB) 1984 - present American Federation for Medical Research (AFMR) 1983 - present American Thoracic Society (ATS) 1993 - present Central Society for Clinical Research (CSCR) 1983 - 1990 California Thoracic Society (CTS) 1998 - present European Respiratory Society (ERS) 1997 - present Michigan Thoracic Society (MTS)


1994 - present National Association of VA Physicians & Dentists (NAVAPD) 1987 - present Physicians for Social Responsibility (PSR) 1988 - 2000 Leadership Circle 2000 - present Society for Leukocyte Biology (SLB) Editorial Positions, Boards, and Peer-Review Service Editorial Board 2009-present American Journal of Respiratory & Critical Care Medicine Ad Hoc Reviewer (alphabetical by journal) 1999 American Journal of Medicine 2015 American Journal of Medical Sciences 1993-6, 2003-4 2008-2015 American Journal of Pathology 1995, 2003-4, 2006-07 American Journal of Physiology: Lung Cell & Molecular Biology 1989, 91, 1993-2013 American Journal of Respiratory Cell & Molecular Biology 1988, 1991-4 1997-98, 2001-15 American Review of Respiratory Diseases /American Journal of Respiratory

& Critical Care Medicine 2000 Anatomic Record 1988, 1996 Annals of Internal Medicine 2007, 2015 Annals of the American Thoracic Society/Proceedings of the American

Thoracic Society 1996, 2005-7 Blood 2008 BMC Infectious Diseases 2014 BMC Res Notes 2010, 2014 Clinical & Experimental Immunology 2014 Clinical & Experimental Medicine 2006-2012 CHEST 2002 Circulation Research 2009 COPD 2006, 2009-11 2013 European Respiratory Journal 2005 Experimental Haematology 1997, 2008 Experimental Lung Research 2008 Frontiers in Bioscience 2008 Immunological Letters 2010 Inflammation Research 2007-08, 2015 International Journal of COPD 2009 International Journal of Medicine & Medical Sciences 1989, 1994, 1998 2002–2005, 2007-15 Journal of Clinical Investigation 1992, 95, 1997-2014 Journal of Immunology 2009 Journal of Innate Immunity


2000 Journal of Infectious Diseases 2013 Journal of Interferon & Cytokine Research 1997 Journal of Investigative Medicine 1988, 1994-1995 Journal of Laboratory & Clinical Medicine 1994, 1999-00, 2003-4, 2008-09 2011, 2015 Journal of Leukocyte Biology 1996 Lung 2011-13 Molecular Medicine 2012 Mucosal Immunity 2006 Oncogene 2012, 2014-15 PLOS One 1993 Regional Immunology 2008-13 Respiratory Research 2015 Respirology Case Reports 1999 The Lancet 2007, 2009-10 Thorax Study Sections

Chair 2000 - 2001 Respiration Study Section, Merit Review Board, DVA. 2004 - 2006 Research Career Development Award Committee (CADE 1), DVA.

Member

1989 Peer Review Panel of Chemical Toxicology Projects, Department of Energy. 1995 - 1997 Grant Review Board - American Lung Association. 1998 - 2001 Respiration Study Section, Merit Review Board, DVA. 1999 Research Enhancement Award Program (REAP) review board, DVA. 2002 Site visit review board, 2PO1 CA073743-06, University of Pittsburgh;

Pittsburgh, PA; National Cancer Institute (NCI). 2003 Site visit review board, 2M01 RR000073-42, General Center for Clinical

Research, UTMB Galveston, TX; National Center for Research Resources, NIH.

2003 Site visit review board, 1P01 HL075385-01; Baltimore, MD; National Heart Lung and Blood Institute (NHLBI), NIH.

2003 Site visit review board, 2PO1 CA073743-06 (appeal); NCI. 2005 Gulf War Syndrome Study Section, DVA. 2006 Special Emphasis Panel ZHL1 CSR-A(M1), Specialized Centers of Clinical

Research (SCCOR) in Chronic Obstructive Pulmonary Disease, NHLBI/NIH. 2007 Review panel, 2P01 HL071659, Div. of Lung Diseases, NHLBI, NIH. 2007 - 2009 BLRD/CSRD Non-Clinician Eligibility Review Board, DVA. 2007 - 2009 Data Safety Monitoring Board (DSMB), Specialized Centers of Clinical

Research, Division of Lung Diseases, NHLBI, NIH. 2007 - 2013 Scientific Advisory Committee, American Thoracic Society. 2011 Review panel, ZHL1 CSR-S (F3), NHLBI, NIH. 2011 Review panel, John B. Barnwell & William S. Middleton Awards, DVA. 2010 Workgroup HLBP (25) 1, 1PO1 HL107226, Div. of Lung Diseases, NHLBI,

NIH.


2013 Scientific Review Group 2013/10 HLBP-I 1: 1 PO1 HL120848, Div. of Lung Diseases, NHLBI, NIH.

2013 Review panel, John B. Barnwell & William S. Middleton Awards, DVA. 2015 - present Career Scientist Promotion Committee, DVA. 2015 - present DSMB, VA Cooperative Trials.

Ad hoc reviewer

1988 - 1989 Merit Review Committee, DVA. 1991 Merit Review Committee, DVA. 1993 Research Advisory Group, DVA. 1993 Grayson-Jockey Club Research Foundation Grants. 1995 - 1996 Merit Review Committee, DVA. 1997 Study Section Lung Biology and Pathology A (LBPA), Center for Scientific

Review (CSR), NIH. 1998 Alberta Heritage Foundation, Canada. 2000 Health Excellence Fund Program, Louisiana State Board of Regents. 2001 - 2002 Career Development Award Committee, DVA. 2002 National Health & Medical Research Council in Australia. 2003 Ad hoc reviewer (appeal), VA Merit Review Board. 2003 Ad hoc Council Subcommittee D (Clinical Studies); NCI. 2003 Intermediate Research Fellowship (Clinical Scientist), The Wellcome Trust,

UK. 2005 Lung Cellular and Molecular Immunology (LCMI), CSR, NIH. 2005 Senior Research Fellowship, The Wellcome Trust, UK. 2005 Canadian Lung Association. 2005 - 2006 Scientific Advisory Committee, American Thoracic Society. 2006 “Elise-Richter-Position” Fonds zur Förderung der wissenschaftlichen

Forschung (Austrian Science Fund). 2006 Respiratory Integrative Biology and Translational Research (RIBT),

NIH/CSR. 2006 Section 4, Cardiovascular Issues, Flight Attendants Medical Research Institute

(FAMRI) Study Section. 2007 Research Career Development Award Committee

(CADE 1), DVA. 2008 - 2010 Programme Grant, The Wellcome Trust, UK. 2008 Clinical Research 2 Integrated Review Group Study Section, DVA. 2009 Ad hoc Scientific Advisory Committee, Parker B. Francis Foundation. 2010 Gulf War Syndrome Study Section (SPLD1), DVA. 2010 Lung Cellular and Molecular Immunology (LCMI), CSR, NIH. 2011 Project Grant, The Wellcome Trust, UK. 2012 Immunology Merit Review (IMMA) DVA. 2012 Infectious, Reproductive, Asthma and Pulmonary Conditions (IRAP), CSR,

NIH. 2012 European Research Council Immunity & Infection LS6 Advanced Grant

Panel. 2014 Biotechnology & Biological Science Research Council (BBSRC), UK. 2014 AA-1 Biomedical Research study section, NIAAA, NIH 2015 External reviewer of programme grant, Medical Research Council, UK.


Teaching University of California San Francisco (selected)

1985 Instructor, M2 Introduction to Clinical Medicine course. 1986 Instructor, M2 Introduction to Clinical Medicine course. 1988 Lecturer, “Interstitial lung disease: advances in immunopathogenesis”.

Seventh Annual Recent Advances in Pulmonary & Critical Care Medicine. 1988 Instructor, M2 Introduction to Clinical Medicine course. 1989 Lecturer, “Endothelial cell activation during an experimental pulmonary

immune response in mice”. Pulmonary Staff Research Conference, Cardiovascular Research Institute, San Francisco, CA.

1989 Instructor, M2 Introduction to Clinical Medicine course. 1989 Supervision of postdoctoral fellow in manuscript preparation: Elaine Imoto,

M.D. 05/18/1989 Lecturer, “Endothelial activation and lymphocyte recruitment to the lungs”.

VA Care AIDS Research Conference; VAMC, San Francisco, CA. 1990 Lecturer, “Hypersensitivity pneumonitis”. Occupational and Environmental

Medicine Course, San Francisco, CA.

Ann Arbor Department of Veterans Affairs Health System 1990-1995 Attending Physician, Internal Medicine Service, Ann Arbor Veterans

Administration Medical Center, 1 month/year. 11/08/1990 Lecturer, “Airway management”. Grand Rounds. 12/06/1990 Lecturer, “Modes of mechanical ventilation”. Critical Care Staff Meeting. 01/14/1991 Lecturer, “Pressure-support ventilation”. Critical Care Staff Meeting. 05/03/1994 Lecturer, “Fundamentals of airway management”. Grand Rounds. 09/19/1995 Lecturer, “Airway management”. Grand Rounds. 05/07/1996 Lecturer, “Steroids in COPD”. Grand Rounds. 09/18/1996 Lecturer, “Management of COPD exacerbations”. Ambulatory Care Medicine

Group. 10/30/1996 Lecturer, “Community-acquired pneumonia”. Ambulatory Care Medicine

Group. 10/11/2006 Lecturer, “On the horizon: new research on COPD pathogenesis & treatment

at the AAVAHS”. Ambulatory Care Medicine Group.

Noon Medical Housestaff Conference, VA Medical Center 05/03/1994 Lecturer, “Disseminated histoplasmosis”. 01/06/1999 Lecturer, “How to think like a Critical Care Doc”. 01/12/1999 Lecturer, “Basics of ventilator management”. 06/05/2000 Lecturer, “Massive hemoptysis”. 12/18/2002 Lecturer, “Thinking critically: holistic care of the critically ill patient”. 02/18/2004 Lecturer, “COPD: time for a therapeutic change”. 06/02/2004 Lecturer, “Community-acquired pneumonia in adults – 2004”. 08/18/2004 Lecturer, “Thinking critically: holistic care of the critically ill patient”. 08/22/2004 Lecturer, “Basics of ventilator management”. 11/03/2004 Lecturer, “Thinking critically: holistic care of the critically ill patient”. 08/08/2005 Lecturer, “Thinking critically: holistic care of the critically ill patient”. 08/22/2005 Lecturer, “Community-acquired pneumonia in adults – 2005”. 08/02/2006 Lecturer, “COPD: management in the VA setting”. 10/18/2006 Lecturer, “Thinking critically: holistic care of the critically ill patient”.


06/06/2007 Lecturer, “COPD: management in the VA setting”. 08/15/2007 Lecturer, “What’s new in community-acquired pneumonia?: the 2007

IDSA/ATS guidelines”. 04/09/2009 Lecturer, “Current concepts in COPD” 06/11/2009 Lecturer, “Community-acquired pneumonia: IDSA/ATS guidelines”. 08/27/2009 Lecturer, “Reducing mortality in community-acquired pneumonia (CAP)”. 12/09/2010 Lecturer, “Reducing mortality in community-acquired pneumonia (CAP)”. 09/10/2014 Lecturer, “COPD case studies: what actually works”

Medical Housestaff Noon Conferences, Department of Internal Medicine. UMHS

09/02/1992 Lecturer, “Workup of the solitary pulmonary nodule”. 06/15/1994 Lecturer, “Workup of the solitary pulmonary nodule”. 09/14/1995 Lecturer, “Nosocomial pneumonia”. 10/19/1995 Lecturer, “Idiopathic pulmonary fibrosis. 09/23/1996 Lecturer, “Workup of the solitary pulmonary nodule”. 05/14/1998 Lecturer, “How to think like a Critical Care Doc”. 05/08/2002 Lecturer, “COPD management”. 02/13/2003 Lecturer, “COPD, the silent killer”.

University of Michigan Medical School, M1 Class 1991-1992 Preclinical Advisor, M1 student, Jared Levin. 04/29/1993 Instructor, M1 Clinical Skills course (Pulmonary module). 03/10/1994 Instructor, M1 Clinical Skills course (Pulmonary module). 02/16/1995 Instructor, M1 Clinical Skills course (Pulmonary module). Fall 1995 Discussion Group Leader, M1 Introduction to the Patient (ITTP) course. 02/13/1996 Instructor Chest exam M1 ITTP. 03/21/1996 Instructor, M1 Breast & cardiac exam M1 ITTP. 05/02/1996 Instructor, M1 ITTP final exam. 02/20/1997 Instructor, Chest exam M1 ITTP. 03/20/1997 Instructor, Neurology exam M1 ITTP. 04/22/1997 Instructor, M1 ITTP final exam. 04/29/1997 Instructor, M1 ITTP final exam. 10/30/1997 M1 ITTP Small Group Leader 11/13/1997 M1 ITTP Small Group Leader 01/13/2000 Instructor, Chest exam M1 ITTP. 01/21/2000 Instructor, Chest exam M1 ITTP. 10/04/2001 Instructor, Chest exam M1 ITTP. 10/03/2002 Instructor, Chest exam M1 ITTP.

University of Michigan Medical School, M2 Class 1991-1992 Instructor, M2 Clinical Skills: Raj Makim and Emily Lin. 1992-1993 Instructor, M2 Clinical Skills: Richard Fiscor-Jacobs and Scott Paluska. 1993-1994 Instructor, M2 Clinical Skills: Gregory Lara and Rahel Gherbre. 1995-1996 Instructor, M2 Clinical Skills: Wilmer Baalaoing and Michael Hong. 11/18/1994 Lecturer, “Medical aspects of bronchogenic carcinoma”, M2 Introduction to

the Patient Cardiothoracic core curriculum. 11/13/1995 Instructor, Pulmonary Physical Diagnosis M2 ITTP.


11/09/1995 Lecturer, “Medical aspects of bronchogenic carcinoma”, M2 Introduction to the Patient Cardiothoracic core curriculum.

11/11/1996 Instructor, Pulmonary Physical Diagnosis M2 ITTP. 11/11/1996 Small Group Leader, M2 Respiratory core curriculum. 11/15/1996 Lecturer, “Bronchogenic carcinoma”, M2 Respiratory core curriculum. 11/18/1996 Instructor, Pulmonary Physical Diagnosis M2 ITTP. 11/06/1997 Lecturer, “Chronic Obstructive Pulmonary Disease”, M2 Respiratory core

curriculum. 11/10/1997 Instructor, Classic Pulmonary Physical Findings, M2 ITTP. 11/12/1997 Instructor, Classic Pulmonary Physical Findings, M2 ITTP. 11/14/1997 Lecturer, “Lung Cancer”, M2 Respiratory core curriculum. 11/14/1997 Small Group Leader, M2 Respiratory core curriculum. 1997-1998 Instructor, M2 Clinical Skills Course: Dennis Wu and Michael Evers. 11/08/1999 M2 Respiratory Sequence, Small Group Leader 11/12/1999 M2 Respiratory Sequence, Small Group Leader

University of Michigan Medical School, M3 Class 1992-1993 Tutor: Lance Washington.

University of Michigan Medical School, M4 Class 03/23/1994 Instructor, Problem Solving Session for Internal Medicine Subinterns,

“Management of solitary pulmonary nodule”.

Research Conferences, Division of Pulmonary & Critical Care Medicine, UMHS

09/21/1990 Lecturer, “Mechanisms of lymphocyte recruitment to the lungs”. 04/18/1991 Lecturer, “Regulation of pulmonary inflammation by CD4 + T lymphocytes”. 05/21/1992 Lecturer, “Anabasis: the lymphocyte’s march to the lungs”. 01/29/1993 Lecturer, “Adhesion receptor phenotypes of pulmonary CD4+ T cell subsets”. 10/15/1993 Lecturer, “Birth, life and death in the alveolar space: lymphocyte proliferation

and apoptosis”. 08/12/1994 Lecturer, “The Song of the wandering lymphocyte”. 01/24/1997 Lecturer, “Rolling, Sticking, Diving: Adhesive interactions between

lymphocytes and lung endothelial cells”. 02/13/1998 Lecturer, “Regulation of lung lymphocyte numbers during pulmonary

inflammation: lessons from a murine model system”. 08/26/1998 Lecturer, “Adhesion Molecules”, Pulmonary Fellows Conference. 01/08/1999 Lecturer, “Regulation of lung lymphocyte numbers during pulmonary immune

responses: apoptosis, recruitment and a little proliferation”. 12/10/1999 Lecturer, “Lymphocyte-endothelial cell adhesive interactions in lung

lymphocyte recruitment”. 02/08/2002 Lecturer, “Recognizing death: clearance of apoptotic leukocytes by murine

tissue macrophages”. 01/16/2004 Lecturer, “Bring out your dead: clearance of apoptotic leukocytes by murine

tissue macrophages”. 05/06/2005 Lecturer, “A second look at the molecular mechanisms of apoptotic cell

recognition”. 12/21/2006 Lecturer, “Resident and recruited mononuclear phagocytes in the defense of

the lung parenchyma”.


03/25/2010 Lecturer, “Neighbors with differing agendas: the contrasting effector states of lung CD8+ versus CD4+ T cells in COPD”.

03/27/2013 Lecturer, “Sensing danger, dealing with death: Investigating how smoking & glucocorticoids modulate alveolar macrophage functions”.

Clinical Conference, Division of Pulmonary & Critical Care Medicine, UMHS

08/01/1991 Lecturer, “Staging and surgical management of bronchogenic carcinoma”. 09/01/1992 Lecturer, “Tuberculosis in the 1990’s”. 02/25/1993 Lecturer, “Workup of the solitary pulmonary nodule”. 02/13/1997 Lecturer, “Is there a role for immunotherapy in the therapy of adult

asthmatics?”. 10/16/1997 Lecturer “From the polders to the malls: airways hyper-responsiveness in the

progression of COPD”. 09/03/1998 Lecturer, “ ‘But what if he doesn't wake up?’: Prognosis and management of

non-traumatic coma in the adult for the Intensivist”. 01/11/2001 Lecturer, “Can pulmonary complications of CABG be reduced?”. 10/18/2001 Lecturer, “Can we learn to prevent or reverse emphysema?”. 10/31/2002 Lecturer, “The rationale for studying novel actions of macrolides in COPD”. 12/04/2003 Lecturer, “Burning the candle at both ends: is COPD a systemic disease?”. 12/02/2004 Lecturer, “Acute exacerbations of COPD – what’s up with that?”. 10/04/2005 Lecturer, “Innate & adaptive immunity in COPD exacerbations”. 02/02/2006 Lecturer, “Projects of the UMHS/AAVAHS COPD Studies Group”. 04/24/2007 Lecturer, “Home O2 improves survival in COPD…or does it? Designing

LOTT”. 09/08/2009 Lecturer, “Current concepts in COPD”.

University of Michigan (miscellaneous) 07/26/1993 Lecturer, “Slippery, wily & inhalable: C. neoformans versus pulmonary host

defenses”; Department of Internal Medicine Grand Rounds. 1995-1997 Member, Lung Volume Reduction Surgery (LVRS) Working Group. 01/10/1997 Lecturer, “Lung Volume Reduction Surgery for emphysema”; School of

Public Health: Biostatistics/ Epidemiology 557, Clinical Research Seminar, 06/26/1998 Lecturer, “From the polders to the malls: airways inflammation and hyper-

responsiveness in the progression of COPD”; Department of Internal Medicine Grand Rounds.

05/10/1999 Lecturer, “Adhesive interactions in lung lymphocyte recruitment”, Comprehensive Cancer Center Program in Tumor Immunology.

01/21/2002 Lecturer, “Recognizing death: clearance of apoptotic leukocytes by murine tissue macrophages”. Research Conference, Division of Hematology & Oncology.

03/02/2004 Guest Reviewer, K30 Research Project Presentation; Peter Higgins, M.D., “Validation of disease activity indices in ulcerative colitis”.

01/2004-05/2007 Scientific Director, UMHS COPD Study Group. 12/07/2006 Evaluator, Scientific Poster session, Physiology 510. 01/18/2008 “Guaifenesin, germinal centers & Goldilocks: re-thinking the pathogenesis of

COPD”; Department of Internal Medicine Grand Rounds. 09/09/2008 Lecturer, “Grants, Grant Writing & Grant Reviewing”, T32 HL07749 Training

Grant Core lecture.


12/10/2008 Lecturer, “Tips on the tenure and promotions process”, Noon Seminar, Department of Molecular Physiology.

10/26/2009 Lecturer, “Lung T cell-dendritic cell interactions in the pathogenesis of COPD: an emerging story”, Immunopathogenesis of Pulmonary Diseases, Department of Pathology.

01/06/2011 Lecturer, “Grants, Grant Writing & Grant Reviewing”, T32 HL07749 Training Grant Core lecture.

05/05/2011 Lecturer, “Lung CD8+ versus CD+ T cells in COPD: Why Such Different Functional States?” Research in Inflammation Interest Group.

10/05/2012 Lecturer, “So many misconceptions: rethinking COPD immunopathogenesis”; Department of Internal Medicine Grand Rounds.

11/24/2015 Invited Speaker: “What outpatient therapies actually work in COPD?”, General Medicine Division Clinical Conference.

University of Michigan-sponsored CME Courses

09/10/1993 Lecturer, “Management of pneumonia in the elderly”. Towsley Symposium on “Critical clinical issues in the care of the elderly: Oral health, swallowing and pneumonia”.

04/28/1992 Lecturer, “Solitary pulmonary nodule”. 20th Annual Spring Update on Advances in Internal Medicine.

09/20/1993 Lecturer, “Immune complications of asthma (including allergic bronchopulmonary aspergillosis and Churg-Strauss angitis)”. Update on Pulmonary & Critical Care Medicine.

03/17/1994 Lecturer, “Management of pneumonia in the elderly”. 18th Annual Spring Family Practice Review Course.

09/26/1994 Lecturer, “Approach to the solitary pulmonary nodule”. Update on Pulmonary & Critical Care Medicine.

05/09/1998 Lecturer, “Advances in the medical therapy of COPD” Global airway management course, Livonia, MI.

04/22/1999 Lecturer, “Pulmonary nodules: thoughtful approach” 27th Annual Update in Internal Medicine.

10/10/2005 Lecturer, “On the horizon: recent research on COPD pathogenesis & treatment”, 18th Annual Updates in Pulmonary & Critical Care Medicine, Division of Pulmonary and Critical Care Medicine.

09/27/2012 Lecturer, “COPD Phenotypes: Clinical Implications from the COPDGene® Study”, 25th Annual Updates in Pulmonary & Critical Care Medicine, Division of Pulmonary and Critical Care Medicine.

11/14/2014 Invited Speaker: “COPD Update 2014: What actually works?”, 27th Annual UMHS Updates in Pulmonary & Critical Care Medicine.

11/13/2015 Invited Speaker: “Update on COPD 2015”, 28th Annual UMHS Updates in Pulmonary & Critical Care Medicine.

Faculty Research Trainees

1995-1998 Faculty Mentor for James Beck, M.D., Research Associate Career Development Award, Department of Veterans Affairs (DVA). Currently Associate Professor, Department of Internal Medicine, UMHS and AAVAHS.

1997-2001 Faculty Mentor for Paul J. Christensen, M.D., Research Associate Career Development Award, DVA. Currently Associate Professor, Department of Internal Medicine, UMHS & VAAAHS.


2001-2002 Faculty Mentor for Michal Olszewski, D.V.M., Ph.D., Research Associate Career Development Award, DVA.

2002-2005 Faculty Mentor for Michal Olszewski, D.V.M., Ph.D., Merit Review Entry Program (MREP), DVA. Currently Research Investigator (faculty), Depart-ment of Internal Medicine, UMHS & VAAAHS.

2002-2003 Faculty Mentor for Steven Gay, M.D., K30 Award, National Heart Lung and Blood Institute. Currently Clinical Assistant Professor, Department of Internal Medicine, UMHS.

2007-2012 Faculty Mentor for John J. Osterholzer, M.D., Career Development Award II, DVA. Currently Assistant Professor, Department of Internal Medicine, UMHS & VAAAHS.

2009-2012 Faculty Mentor for Christine Freeman, Ph.D., Career Development Award II, DVA. Recipient of the Presidential Early Career Award for Scientists & Engineers (PECASE), 2010. Currently Assistant Research Investigator, Department of Internal Medicine, UMHS & VAAAHS.

2009-2014 Faculty Mentor for Nicholas Giardino, Ph.D., Career Development Award II, DVA. Currently Assistant Professor, Department of Psychiatry, UMHS & VAAAHS.

Sabbatical sponsor

2010-2011 Yahong Chen, M.D., Ph.D., Associate Professor, Peking University Third Hospital.

2015 Lu Guo, M.D. 2015 Chunhong, Peng, D.D.S., Ph.D.

Postdoctoral Research Trainees 1987-1988 Philip F. Michael, M.D., Research Fellow (UCSF, with HB Kaltreider, M.D.).

Currently engaged in private practice of Pulmonary Medicine. 1988-1990 James M. Beck, M.D., Research Fellow supported by Research Associate

Career Development Award, DVA (UCSF, with JE Shellito, M.D.). Currently Associate Professor, Department of Internal Medicine, UMHS.

1990-1994 Sucha Kim, M.D., Research Fellow supported by Individual NRSA, NHLBI. Currently engaged in private Practice of Pulmonary Medicine.

1993-1995 Virginia B. Maxwell, D.V.M., Research Fellow. Currently Associate Professor, Maryland-Virginia Regional College of Veterinary Medicine.

1994-1996 Alicja M. Milik, M.D., Research Fellow. Left to enter Ph.D. program, National Tuberculosis Hospital, Warsaw, Poland.

1998-2001 Bin Hu, M.D., Ph.D., Research fellow. Currently Research Investigator (faculty), Department of Internal Medicine (Cardiovascular Div.), UMHS.

2001-2004 Jeffery H. Jennings, M.D., Research fellow. supported by Institutional Training grant in Pulmonary Diseases (T32 HL07749). Currently Staff Physician, Henry Ford Health System, Detroit Michigan.

2002-2003 John J. Osterholzer, M.D., Research fellow supported by Research Associate Career Development Award, DVA. Subsequently Pulmonary Fellow, University of Michigan 2004-2007.

2003-2004 Derek J. Linderman, M.D., Research fellow supported by Research Associate Career Development Award, DVA. Subsequently Pulmonary Fellow, University of Colorado 2004-2007.


2006-2009 Christine M. Freeman, Ph.D. Research fellow supported by Institutional Training grant in Pulmonary Diseases (T32 HL07749).

2010-2012 Carlos H. Martinez, M.D., M.P.H. Research fellow in Pulmonary Diseases, supported by Divisional Funds.

2012-present Jeanette P. Brown, M.D., Ph.D., Research fellow in Pulmonary Diseases. (T32 HL07749)

2012- 2015 Carlos H. Martinez, M.D., M.P.H. Research fellow in Pulmonary Diseases, (T32 HL07749).

Doctoral Research Trainees

2009-2014 Alexandra McCubbrey, Doctoral Candidate, Graduate Program in Immunology.

Thesis Committees

2003-2005 Matthew Schaller, Doctoral Candidate, Graduate Program in Immunology: “CD8+ T cell responses in allergic airway disease”.

2003-2006 Christine Freeman, Doctoral Candidate, Graduate Program in Cellular & Molecular Pathology: “Understanding the functional role of CCR4 & CCR8 in type-I and type-2 granulomatous immune responses”.

2005-2007 Lynn Kamen, Doctoral Candidate, Graduate Program in Immunology: “3’-phosphatide dynamics during phagosome formation and maturation in macrophages”.

2005-2009 John Phillips, Doctoral Candidate, School of Public Health: “Cigarette smoke-exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of S. pneumoniae”.

2006-2008 Martha Hutchens, Doctoral Candidate, Graduate Program in Immunology: “The role of Toll-like receptors 3 & 4 in pulmonary vaccinia infection”.

2007-2011 Robert Peters, Doctoral Candidate, Graduate Program in Immunology. 2009-2014 Rachel Morgan, Doctoral Candidate, Graduate Program in Immunology:

“Expression of CD13/Aminopeptidase N by Synovial Fibroblasts: Novel Roles in the Pathogenesis of Rheumatoid Arthritis”

Graduate Research Rotation Trainees, University of Michigan

1995 - 1996 Frances Wolber, Doctoral Candidate, Graduate Program in Cellular & Molecular Pathology.

1996, 1998 Gerami D. Seitzman, Doctoral Candidate, School of Medicine. 1998-2000 Kevin Fajardo, M.P.H. Candidate, School of Public Health. 2001 Christine Freeman, Doctoral Candidate, Graduate Program in Cellular &

Molecular Pathology. 2002 Dawn Newcomb, Doctoral Candidate, Graduate Program in Molecular

Physiology. 2008 Alexandra McCubbrey, Doctoral Candidate, Graduate Program in

Immunology. 2010 Payal Attawal, College of Human Medicine, Michigan State University at

Grand Rapids. 2011 Travis Kruger, University of Michigan School of Medicine. 2011 Nisha Nagarseth, Doctoral Candidate, Graduate Program in Immunology. 2012 Alison Eastman, Doctoral Candidate, Graduate Program in Immunology. 2012 Sarah Brown, University of Michigan School of Medicine.


2013 Sophina Taitano, Doctoral Candidate, Graduate Program in Immunology.

Pulmonary Fellowship/T32 Training Grant 2004-2007 John Osterholzer, M.D., T32 Research Advisory Committee 2005-2007 Dennis Lindell, Ph.D., T32 Research Advisory Committee 2005-2007 Tracy McMillan, M.D., Fellowship Research Advisory Committee 2006-2009 Steven Huang, M.D., Fellowship Research Advisory Committee 2006-2008 Brad Fields, M.D., Fellowship Research Advisory Committee 2007-2010 Urvashi Bhan, M.D., KO8 Advisory Committee 2008-2010 Dina Schneider, Ph.D., T32 Research Advisory Committee 2009-2010 Mary Pat Craver, Ph.D., T32 Research Advisory Committee 2009-2011 Shelley Schmidt, M.D., T32 Research Advisory Committee 2010-2015 Carlos H. Martinez, M.D., M.P.H., Fellowship & T32 Research Advisory

Committees 2012-2014 Michael J. Davis, Ph.D., T32 Research Advisory Committee 2013-2015 Robert Dickson, M.D., Fellowship Research Advisory Committee 2015-2017 Daniel Schneider, M.D., Ph.D., Fellowship Research Advisory Committee 2015-2017 Jonathan Roussey, PhD, T32 Research Advisory Committee

Senior Medical Resident Research Projects 1993-1994 Hazem Raslan, M.D., subsequently Pulmonary Fellow, Wayne State

University 1995-1997. 1995-1996 Wanda Choy, M.D., subsequently Pulmonary Fellow, Columbia University

1997-2000. 2001-2002 Naveen Gupta, M.D., subsequently Pulmonary Fellow, UCSF 2003-2006. 2008-2010 Kelly Sweerus, M.D., subsequently Pulmonary Fellow, UCSF 2011-2014. 2015-present Sara Xiaoxin Li, M.D.

Undergraduate Research Trainees 1990-1993 Chan Park, B.S., Undergraduate Honors Biology thesis, College of Literature,

Arts & Science, University of Michigan; Subsequently Graduate, School of Medicine, University of Michigan.

1991-1994 Gerami D. Seitzman, B.S., Undergraduate Honors Biology thesis (summa cum laude), Residential College, University of Michigan; Currently, Clinical Assistant Professor of Ophthalmology, Johns Hopkins School of Medicine.

1993-1994 Margaret Morris, B.S.; Subsequently Graduate, Doctoral Program in Immunology, University of Texas Southwestern School of Medicine.

1994-1995 Caroline Bettinger, College of Literature, Arts & Science, University of Michigan.

1994-1995 Jodi Kauffman, College of Literature, Arts & Science, University of Michigan. 1996-1998 Kevin Fajardo, College of Literature, Arts & Science, University of Michigan.

Subsequently Graduate, Uniformed Services Medical School. 2000-2002 Heena D. Shah, College of Literature, Arts & Science, University of

Michigan. 2014 Bridget L. Saxton, Kalamazoo College.

Current Activities 1990-present Attending Physician, Pulmonary Consult Service, Ann Arbor Veterans Affairs

Health System, 1-2 months/year.


1990- present Chief’s Rounds & Morning report, Ann Arbor VA Health System 1990- present Supervision and teaching of postdoctoral fellows in Pulmonary Function

Testing interpretation, 1 week/month. 1990- present Supervision and teaching of postdoctoral fellows in bronchoscopy procedures,

approximately weekly. 1992-2003 Attending Physician, Critical Care Medicine Unit or Inpatient Pulmonary

Ward, University of Michigan Hospital, 1 month/year. 1997- 2011 Member, Comprehensive Cancer Center (Thoracic Oncology) 2000- present Member, Graduate Program in Immunology 2006- present Member, UM Tobacco Research Network

Committee, Organizational and Volunteer Service Institutional

University of California, San Francisco 1989 - 1990 Medical Director, Bronchoscopy Service 1989 - 1990 Member, Pulmonary Fellowship Selection Committee

University of Michigan 1990- present Internal Medicine Residency Interviewer 1990 - 2013 Member, Fellowship Education Committee 1992 - 1999 Conference Coordinator, Pulmonary & Critical Care Medicine Division 1993 Planning Committee, Towsley Center course: “Critical clinical issues in the

care of the elderly: Oral health, swallowing and pneumonia” 1995 - 1997 Co-Director, Pulmonary Fellowship 1997 - 1999 Member, Student Biomedical Research Committee 2003 - 2007 Member, Resident Retention and Promotion Committee, Department of

Internal Medicine. 2003 - 2007 Member, Sabbatical Review Committee, Department of Internal Medicine. 2004 - present Member, Graduate Student Affairs Committee, Immunology Doctoral

Program, Rackham Graduate School. 2004 - 2005 Chair, Research Training Committee, Pulmonary Fellowship Program. 2005 - 2009 Member, Academic Promotion & Tenure Committee, Department of

Internal Medicine 2007 - 2009 Chair 2010 – 2013 Member, UM-China Lung Task Force

Veterans Affairs Health System, Ann Arbor, MI 1990 - 2014 VA Section Chief 1990 - 2014 Medical Director, Respiratory Therapy Department 1990 - 1995, 2003 - 2014 Medical Director, Pulmonary Function Laboratory 1990 - 1991 Member, Equipment Committee 1990 - 1995 Member, Critical Care Committee 1990 - 1995 Medical Director, Home Oxygen Program 1992 - 1993 Member, Automated Data Processing Committee 1992 - 1993 Member, Intermediate Care Unit Task Force 1992 - 1995 Member, Research & Development Committee 1994 - 1998 Member, Multispecialty Swallowing Disorder group


1994 – 1995, 1999 – 2001, 2009 - 2014 Medical Director, Pulmonary Outpatient Clinic 1994 - 2002 Member, Patient Education Task Force (Chronic Obstructive Pulmonary

Disease) 1994 - 1999 Member, Cancer Committee 1995 Member, VA Mission Statement Task Force 1997 - 1999 Elected, Member-at-large, Clinical Executive Board 1997 - 2001 Member, Critical Care Oversight Committee 1997 - 1998 Chair 1998 - 2001 Medical Director, Medical Intensive Care Unit 1999 - 2001 Member, Executive Committee, Cardiothoracic Center of Excellence 1999 - 2001 Member, Ambulatory Care Committee 2003 - 2014 Medical Director, Home Oxygen & Home Non-invasive Ventilation Programs 2004 - 2006 Member, Information Technology Projects & Budget Committee 2007 - 2009 Member, Pandemic Influenza Preparedness Committee 2011 - 2014 Elected, Member-at-large, Clinical Executive Board 2013 Member, Interconnection Security Agreement Task Force Regional 1997-1998 Member, Long-Range Lung Cancer Control Plan Advisory Committee,

Michigan Department of Community Health National

American Thoracic Society 1992-1996 Member, Program Committee, Annual Scientific Meeting, Assembly on

Allergy, Immunology and Inflammation (AII). 05/15/1993 Organizer & Co-chair, Postgraduate course on “Laboratory techniques in

pulmonary immunology”, ATS International Conference, San Francisco, CA. 05/16/1993 Organizer & Co-chair, Mini-symposium on “T lymphocytes and lung

inflammation” ATS International Conference, San Francisco, CA. 05/18/1993 Organizer & Co-chair, Symposium on “Respiratory Disease in the

Immunocompromised host, part I: generation of pulmonary inflammatory and immune responses”, ATS International Conference, San Francisco, CA.

05/24/1994 Organizer & Co-chair, Symposium on “T cells in lung disease”, ATS International Conference, Boston, MA.

1995 Nominee, Chair-Elect, Program Committee (AII) 05/23/1995 Organizer, Symposium on “Initiation and regulation of pulmonary immune

responses: specialized antigen-presenting cells of the lungs”, ATS International Conference, Seattle, WA.

05/13/1996 Organizer, Symposium on “Apoptosis and resolution of pulmonary inflammation”, ATS International Conference, New Orleans, LA.

1996-1999 Member, AII Long Range Planning Committee. 1996-1998 Chair, AII Long Range Planning Committee. 04/25-26/1997 Invited participant, American Thoracic Society Planning Retreat. 1999-2000 Member, AII Assembly Communication Committee 05/08/2000 Organizer and Co-chair, Symposium on “Dendritic cells & T-cells: recent

developments in lung diseases and new technologies”, ATS International Conference, Toronto, ON.

2000-2002 Chair-elect/Chair, AII Assembly Program Committee.


2000-2003 Member, AII Assembly Planning Committee 05/21/2001 Organizer and co-chair, Symposium on “Deciphering and controlling immune

responses: the best of immunology by the Bay”, ATS International Conference, San Francisco, CA.

2002-2003 Member, Program & Budget Committee (AII) 5/21/2002 Organizer and co-chair, Mini-Symposium “Macrophages and apoptosis: eat to

live, live to eat”, ATS International Conference, Atlanta, GA. 2005-2007 Ad hoc member, Scientific Advisory Committee 05/17/2008 Organizer and co-chair, Post-graduate Course “COPD: Evolving concepts in

2008”. 2007-2013 Member, Scientific Advisory Committee 05/17/2008 Organizer and co-chair, Post-graduate Course “COPD: Evolving concepts in

2008”, ATS International Conference, Toronto, ON. 2008-2010 Member, Program Committee, Assembly on Clinical Problems (CP). 2010-2013 Elected, Chair-elect/Chair, AII Assembly. 2011-2013 Member, Board of Directors. 2011-2013 Member, Subcommittee on ATS Documents 05/19/2014 Organizer and co-chair, Symposium on “The Lung Microbiome in 2014: State

of the Art & Science”, ATS International Conference, San Diego, CA. National Institutes of Health/National Heart Lung & Blood Institute (NHLBI)

8/26-27/1999 Invited Participant, NHLBI workshop on “Pulmonary Immunobiology and Inflammation”, Bethesda, MD.

01/19-20/2003 Invited participant, SPARK II conference, Bethesda, MD. 09/28-9/29/2004 Invited Participant, NHLBI workshop on “Critical Issues in COPD Research”,

Bethesda, MD. 05/01-02/2006 Invited Participant, NIOSH/NHLBI Workshop on “COPD in the Never

Smoker”, Bethesda, MD. 09/25-26/2008 Invited Participant, NHLBI Workshop on “Basic and clinical immunological

aspects that characterize Asthma, COPD and IPF patients”; lecturer, “Things we should know, but don’t”; Bethesda, MD.

06/29-30/2009 Invited Participant, NHLBI Workshop on “COPD 2009: Assessment of the current state-of-the-art for basic and clinical research and shaping the future” , Bethesda, MD.

10/23-25/2011 Invited Participant, 5th Annual NHLBI Global Health Initiative meeting, Bethesda, MD.

7/31-8/01/2012 Invited Participant, NHLBI Global Health Think Tank, Bethesda, MD.

Society for Leukocyte Biology 2003-2008 Member, Rules Committee

COPDGene® 2008-present Member, Executive Committee International

European Respiratory Society 2003-2009 Member, Program Committee, Assembly 5:, Inflammatory Airway Diseases

and Clinical Allergy.


Visiting Professorships, Seminars, and Extramural Invited Presentations

International 10/29/1998 Visiting Professor, “Regulation of lung lymphocyte numbers during

pulmonary inflammation: recruitment, apoptosis, and a little proliferation”. Medizinische Hochschule; Hannover, Germany.

11/3/1998 Co-Chair, “Mucosal immunology of the respiratory tract”; Lecturer, “Controversial aspects in mucosal immunology of the respiratory tract”. 10th International Congress of Immunology; New Delhi, India.

09/20-27/1999 Invited Participant, Society for Leukocyte Biology Conference on “Innate Resistance to Infection”; Cambridge, UK.

09/02/2004 Visiting Professor, “Bring out your dead: clearance of apoptotic leukocytes by murine tissue macrophages”. Division of Pulmonary & Critical Care Medicine, University College; London, UK.

09/06-07/2004 Coordinator, Thematic Poster Session “Animal models of airway diseases”, Co-chair, Oral presentations on “Pulmonary fibrosis – new insights”, 14th Annual Congress, European Respiratory Society; Glasgow, Scotland.

09/10/2004 Visiting Professor, “A central role for MerTK in clearance of apoptotic leukocytes by tissue macrophages”. MRC Centre for Inflammation Research; University of Edinburgh Medical School; Edinburgh, Scotland.

09/18/2005 Co-chair, Poster Discussion Session “Regulation of immunologic and inflammatory reactions in asthma and COPD”, 15th Annual Congress, European Respiratory Society; Copenhagen, Denmark.

06/28-30/2006 Invited Participant, COPD5; Birmingham, United Kingdom. 09/06-08/2006 Visiting Professor, “Resident and recruited mononuclear phagocytes in the

defense of the lung parenchyma”, University of Sheffield School of Medicine & Biomedical Sciences, Sheffield, United Kingdom.

02/09-10/2007 Invited Discussant, European Respiratory Society Research Seminar “Complexity of patients with multiple chronic diseases”, Rome, Italy.

09/18-19/2007 Chair, Mini-symposium on “Regulation of allergic airway inflammation in animal models of asthma”; Chair, Electronic Poster Discussion “Mouse models of allergic airway inflammation”, 16th Annual Congress, European Respiratory Society, Stockholm, Sweden.

11/02/2007 Invited Speaker, “Seasonality of exacerbations in COPD”, in Symposium on “The challenge of COPD – relief from breathlessness and fear of exacerbat-ion”, 4th International Symposium on Respiratory Diseases/15th Congress of the Asia Pacific Association for Respiratory Care; Shanghai, People’s Republic of China.

06/11-13/2008 Invited Speaker, “Why treatment reduces mortality” in Symposium “Realising the benefits of new therapeutic developments”, COPD6, Birmingham, UK.

04/07-11/2010 Invited Speaker, “Research at the University of Michigan on the pathogenesis and treatment of COPD”. University of Michigan Medical School Delegation, Pulmonary Division, Peking University Third Hospital; Beijing, People’s Republic of China.

04/05/2014 Keynote speaker, “What happens when the immune system goes wrong? An insight into COPD”. Australia & New Zealand Society of Respiratory Science (ANZSRS) Plenary Session on “Immunology & Lung Disease”. Adelaide, SA, Australia.


04/06/2014 Invited Speaker, “Role of immunobiology in COPD” at the Thoracic Society of Australia & New Zealand (TSANZ)/ANZSRS Joint Plenary: “Immuno-biology, the Origins and Development of Asthma and COPD”. Adelaide, SA, Australia.

04/08/2014 Invited Speaker, “Alveolar macrophage uptake of apoptotic cells & lung host defense” in Immunology and Cell Biology special interest group session “Progress in macrophage biology in chronic lung disease”, TSANZ meeting. Adelaide, SA, Australia.

04/09/2014 Participant, Closing Pro/Con Debate on research on rare lung diseases, TSANZ meeting. Adelaide, SA, Australia.

04/10/2014 Invited Speaker, “Use of bronchoalveolar lavage to analyze the human lung microbiome”. Lung Health Centre 2nd Annual Airway, Inflammation & Remodeling Scientific Meeting (AIR II); University of Melbourne. Melbourne, VC, Australia.

01/05-10/2015 Faculty Member, Methods in Epidemiologic, Clinical, and Operations Research (MECOR) China Level One Course; Chengdu, China.

10/02/2015 Invited Speaker, “Regulation & consequences of apoptotic cell uptake by alveolar macrophages”, University of Edinburgh, Scotland.

Annual International Scientific Conference of the American Thoracic Society

05/15/1991 Lecturer, “Lymphocyte traffic to the lungs”. Symposium on “Respiratory Tract Immunoglobulins: Current Concepts”, Anaheim, CA.

05/19/1992 Lecturer, “Bidirectional interactions between lymphocytes and endothelial cells”. Symposium on “Pulmonary Immune Responses: Regulation by Accessory Cells”, Miami Beach, FL.

05/15-16/1993 Lecturer, “Overview of animal models of immunologic lung disease and comments on the use of animals”; Lecturer, “CD4+ T-cell trafficking during pulmonary immune responses”, San Francisco, CA.

05/24/1994 Organizer & Co-chair, Symposium on “T cells in lung disease”; Lecturer, “Birth and death in the alveolus: pulmonary lymphocyte proliferation and apoptosis”, Boston, MA.

05/13/1996 Lecturer, “Lung lymphocyte apoptosis in the regulation of pulmonary immunity”, New Orleans, LA.

05/20/1997 Co-Chair, Poster Discussion Session “New Directions in Lymphocyte Biology”, San Francisco, CA.

04/25/1998 Lecturer, “Roles of lung lymphocytes in inflammatory lung diseases” in Postgraduate course on “Cells of the lung: structure, function and cross-talk”, Chicago, IL.

04/28/1999 Invited Speaker, “Lymphocyte apoptosis and lung disease”, San Diego, CA. 05/8/2000 Invited Speaker, “Determinants of lymphocyte recruitment to the lungs”,

Toronto, ON. 05/19-21/2001 Invited Speaker, “Overview of lymphocyte function” Postgraduate course on

“Inflammatory mechanisms in the lungs & airways: cells, cytokines and mediators”; Organizer and co-chair, “Deciphering and controlling immune responses: the best of immunology by the Bay”, San Francisco, CA.

05/21/2002 Lecturer, “Recognizing death: clearance of apoptotic leukocytes by murine tissue macrophages”, Atlanta, GA.

05/19-21/2003 Co-chair, Mini-Symposium “Apoptosis and inflammation”, Invited Speaker, “PPIs & PLCs: controlling membrane shape”; Moderator, Poster Discussion


Session “Signaling pathways: pulmonary effects”; Co-Chair, Symposium “Alveolar macrophage: the center of the world”; Invited Speaker, “Orchestrating signals during macrophage phagocytosis”, Seattle, WA.

05/23-26/2004 Co-chair, Mini-symposium on “Animal models of COPD”; Co-chair & Featured Speaker, “In the center of it all: macrophage and apoptotic cell clearance”, Mini-symposium on “Mechanisms of Immune Survival in Apoptosis”; Facilitator, Thematic Poster Session “COPD: Animal Models of Disease”, Orlando, FL.

05/18-21/2007 Co-chair & Invited Speaker, “Primary role of inflammation in disease pathogenesis & progression”, Postgraduate course “COPD – Update for the clinician and researcher”; Facilitator, Thematic Poster Session “COPD Patho-genesis II: cell signaling and inflammatory mediators, San Francisco, CA.

5/17/2008 Co-chair & Invited Speaker, “The inflammatory response in stable and exacerbated disease: a crucial link”, Postgraduate course “Chronic Obstructive Pulmonary Disease – Evolving concepts in 2008”, Toronto, ON.

05/15/2009 Invited Speaker, “Adaptive immune mechanisms in COPD”, Postgraduate course “COPD – Progress in 2009”, San Diego, CA.

05/14-17/2010 Invited Speaker, “Con: Autoimmunity is a key biological process in the development and progression of COPD”, Postgraduate course “State of the art controversies in COPD – a Pro-Con Debate”, New Orleans, LA. Invited Speaker, “Role of the alveolar macrophage in the removal of apoptotic cells”, Symposium, “Coins for the boatman: is there a relationship between cell death, removal and disease”, New Orleans, LA.

05/23/2012 Invited Speaker, “Defining how lung CD8+ T cells drive COPD progression”, Symposium, “Pulmonary Research at the VA”, San Francisco, CA.

National 09/23/1987 Lecturer, “Regulation of lymphocyte recruitment and activation studied in an

experimental pulmonary immune response”. Research Conference of the Pulmonary Immunology Group, University of Kentucky, Lexington, KY.

9/28/1987 Lecturer, “Regulation of lymphocyte recruitment and activation studied in an experimental pulmonary immune response”. Division of Pulmonary & Critical Care Medicine, University of Maryland, Baltimore, MD.

12/17/1987 Lecturer, “Regulation of lymphocyte recruitment and activation studied in an experimental pulmonary immune response”. Research Conference of the Pulmonary Immunopathology & Lung Transplantation Group, University of Pittsburgh, PA.

03/14/1989 Lecturer, “Endothelial cell activation during an experimental pulmonary immune response in mice”. Inhalational Toxicology Research Institute (ITRI); Lovelace Biomedical and Environmental Research Institute; Albuquerque, NM.

03/30/1989 Lecturer, “Endothelial cell activation during an experimental pulmonary immune response in mice”. Conjoint Allergy/Pulmonary Research Conference, Johns Hopkins Hospital, Baltimore, MD.

05/05/1989 Lecturer, “Generation and regulation of pulmonary immune responses”. Genentech, S. San Francisco, CA.

10/31/1989 Invited Speaker, “Update on the diagnosis and management of interstitial lung diseases”. Medical Grand Rounds, Holy Cross Medical Center, Mission Hills, CA.


04/25/1991 Lecturer, “Normal aspects and disorders of the respiratory system”. Symposium on “Management of Dysphagia in Ventilator-dependent Adults”, sponsored by the Great Lakes Regional Office, Department of Veterans Affairs, Ann Arbor, MI.

01/10/1992 Lecturer, “CD4+ T cell subsets in pulmonary lymphocyte recruitment”. Pulmonary Immunology Research Conference, VA Medical Center, San Francisco, CA.

03/27-29/1992 Invited Speaker, Eleventh Annual Montana Thoracic Society Pulmonary Conference, “Management of non-small cell bronchogenic carcinoma”. “Clinical approach to interstitial lung diseases”, Big Sky, MT.

04/23/1993 Invited Speaker, “Workup of the solitary pulmonary nodule”. Medical Housestaff Noon Conference, Flint Osteopathic Hospital, Flint, MI.

05/02/1993 Lecturer, “Respiratory anatomy & physiology”. Postgraduate Dysphagia Training Conference, co-sponsored by the University of Iowa and the Department of Veterans Affairs; Iowa City, IA.

11/29/1993 Visiting Professor, “The Spectrum of Cryptococcal Disease”. Medical Grand Rounds, William Jennings Bryan Dorn VA Hospital and University of South Carolina, Columbia, SC; November, 29. 1993.

11/20/1994 Invited Speaker, “Aspiration pneumonia” in Symposium on “Risk factors for aspiration pneumonia in the elderly”, Annual Convention of the American Speech & Hearing Association, New Orleans, LA.

11/22/1994 Amgen Visiting Professor of Medicine, “There & back again: lymphocyte trafficking during protective pulmonary immune responses” Pulmonary & Critical Care Medicine Division, Louisiana State University School of Medicine, New Orleans, LA.

01/25/1995 Invited Speaker, “Management of community-acquired pneumonia in the elderly”. Lord Fox Inn, Dixboro, MI.

06/24-25/1996 Invited Participant, Workshop on Immunization of the Pulmonary Mucosa Assembly on Allergy, Immunology and Inflammation, American Thoracic Society, Ann Arbor, MI.

04/12//1997 Invited Speaker, “Medical Therapy” in Advances in COPD, Division of Pulmonary & Critical Care Medicine, UMHS. Livonia, Michigan.

07/28/1997 Invited Speaker, “Management of chronic obstructive lung disease”. Genesys Regional Medical Center, Flint, MI.

02/27/1998 Visiting Professor, “Regulation of lung lymphocyte numbers: lessons from a murine model system”. Pulmonary & Critical Care Medicine Division, St. Louis University School of Medicine, St. Louis, MO.

07/11/1998 Invited Speaker, “Efficacy and safety of inhaled steroids COPD” and “Rationale for long-acting beta agonist therapy in COPD”, Traverse City, MI.

02/11/1999 Visiting Professor, “Regulation of lung lymphocyte numbers during pulmonary immune responses: the relative roles of proliferation, apoptosis and recruitment”. Asthma Conference, Washington University School of Medicine, St. Louis, MO.

03/06/1999 Invited Speaker, “Recruitment of immune cells into the lungs during pulmonary immune responses” at Keystone Symposium on “Immunologic & biological aspects of therapeutic protein delivery to the lungs”, Durango, CO.

08/26-27/1999 Invited Speaker, “CD8+ T cell responses”, NHLBI workshop on “Pulmonary Immunobiology and Inflammation”, Bethesda, MD.


06/11-12/1999 Participant, ATS Conference on “Genetics and the Inflammatory Response”, Seattle, WA.

10/10/1999 Invited participant, “Adhesive interactions in lung lymphocyte recruitment in pulmonary immunity”, Second Lovelace Respiratory Research Institute International Symposium on Respiratory Immunology, Santa Fe, NM.

10/24-25/2000 Visiting Professor, “ ‘Watch what you eat’ – alveolar macrophages and phagocytosis of apoptotic cells”, Heart & Lung Research Institute, Ohio State University, Columbus, OH.

09/06/2002 Invited Speaker, “Community-acquired pneumonia in adults – 2002”. Medical Grand Rounds, St. Joseph Mercy Hospital, Pontiac, MI.

08/03-08/2003 Invited participant, Gordon Research Conference on “Phagocytosis and clearance of apoptotic cells”; New London, CT.

10/28-29/2003 Visiting Professor, Division of Allergy, Pulmonary & Critical Care Medicine, Duke University, “The rationale for studying novel actions of macrolides in COPD" and “Bring out your dead: clearance of apoptotic leukocytes by murine tissue macrophages”.

09/28-29/2004 Participant, “Critical Issues in COPD Research”; NIH/NHLBI; Bethesda, MD. 01/25/2005 Invited Speaker, “COPD: management in the VA setting”. VA Health

System, Spokane, WA. 03/02/2005 Invited Speaker, “COPD: management in the VA setting”. Northern Indiana

VA Health System, Marion IN. 06/21/2005 Invited Speaker, “The alveolar macrophage, lonely sentinel of the lungs”;

Gordon Research Conference on “Apoptotic cell recognition & clearance”; New London, CT.

05/01-02/2006 Invited Speaker, “So what have we learned (summation)?”, NIOSH/NHLBI Workshop on “COPD in the Never Smoker”.

06/21-22/2006 Visiting Professor, “Resident and recruited mononuclear phagocytes in the defense of the lung parenchyma”, Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham, AL.

09/25/2006 Invited Speaker, “Early identification of bacterial airway infection in AE-COPD”, NHLBI COPD Clinical Research Network Retreat, Baltimore, MD.

10/13/2006 Invited Speaker, “Pathogenesis of COPD: inflammation and infection”, Sepracor conference on “Special issues in chronic obstructive pulmonary disease”, Boston, MA.

06/18-21/2007 Invited Speaker, “Interplay between Scavenger Receptors & Mer-TK during apoptotic cell clearance”, Gordon Research Conference on “Apoptotic Cell Recognition & Clearance”, Lewiston, ME.

09/25-26/2008 Invited Speaker, “Initiation of lung inflammation: some things we don’t know, but should”, NHLBI Workshop on “Basic and clinical immunological aspects that characterize Asthma, COPD and IPF patients”, Bethesda, MD.

11/24-25/2008 Visiting Professor, “Insights into the immunopathogenesis of COPD”; and “Apoptotic cell uptake by tissue macrophages: the roles of TAM family receptor tyrosine kinases & scavenger receptor A”; Oregon Health Sciences University, Portland, OR.

04/25-26/2009 Invited Participant, NHLBI Workshop “Immunogenetics and Immunopheno-types of Chronic Lung Disease”, Bethesda, MD.

06/29-30/2009 Invited Participant, NHLBI Workshop “COPD 2009: Assessment of the current state-of-the-art for basic and clinical research and shaping the future”, Bethesda, MD.


05/14/2011 Invited Speaker, “Steroids, efferocytosis & alveolar macrophage innate immune function”. Third International Conference on Lung Innate Immunity and Pulmonology (iCLIIP 2011); Denver, CO.

07/17-22/2011 Invited Speaker, “Modulation of efferocytosis by human alveolar macro-phages”, Gordon Research Conference on “Apoptotic Cell Recognition & Clearance”, Lewiston, ME.

08/01-2012 Featured Speaker, 2nd Annual NHLBI Global Health Symposium Initiative, “Defining diversity: controversies & opportunities to use pulmonary micro-biome analysis to combat the global rise in lung diseases”, Bethesda, MD.

10-02-2013 Invited Speaker, “Progress in COPD Treatment”, Grand Rounds, St. Josephs Mercy Health System, Ypsilanti, MI.


Bibliography Peer-Reviewed Journals and Publications 1. Johns CJ, Zachary JB, MacGregor MI, Curtis JL, Scott PP, Terry PB. The longitudinal

study of chronic sarcoidosis. Trans Am Clin Climatol Assoc 94:173-181, 1982. PMID: 7186230. PMCID: PMC2279583.

2. Curtis JL, Nordin AA. Primary in vitro plaque forming cell response to DAGG-Ficoll: LPS-enhancement mediated by Interleukin-1. Immunology 52:711-719, 1984. PMID: 6378771. PMCID: PMC1454635.

3. Bender BS, Curtis JL, Nagel JE, Chrest FJ, Krause ES, Briefel GB, Adler WH. Analysis of immune status of hemodialyzed adults: Association with prior transfusion. Kidney Int 26:436-443, 1984. PMID: 6241271. PMCID: PMC1454635.

4. Pierce NF, Millan JC, Bender BS, Curtis JL. Disseminated Curvularia infection: Additional therapeutic and clinical considerations with evidence of medical cure. Arch Pathol Lab Med 110:959-961, 1986. PMID: 3767613.

5. Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley KL, Hopewell PC. The usefulness of induced sputum in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. Am Rev Respir Dis 133:515-518, 1986. PMID: 3485945.

6. Curtis JL, Mahlmeister M, Stulbarg MS, Fink JB, Lampe G, Matthay MA. Helium-oxygen gas therapy: Use and availability for the emergency treatment of inoperable airway obstruction. CHEST 90:455-457, 1986. PMID: 3743166.

7. Kaltreider HB, Curtis JL, Arraj SM. The mechanism of appearance of specific antibody-forming cells in lungs of inbred mice after immunization with sheep erythrocytes intratracheally. II: Dose-dependence and kinetics of appearance of antibody-forming cells in hilar lymph nodes and lungs of unprimed and primed mice. Am Rev Respir Dis 135:87-92, 1987. PMID: 3800157.

8. Kaltreider HB, Byrd PK, Curtis JL. Expression of Ia by murine alveolar macrophages is up-regulated during the evolution of a specific immune response in pulmonary parenchyma. Am Rev Respir Dis 137:1411-1416, 1988. PMID: 2462375.

9. Curtis JL, Kaltreider HB. Characterization of bronchoalveolar lymphocytes during a specific antibody-forming cell response in the lungs of mice. Am Rev Respir Dis 139:393-400, 1989. PMID: 2464296.

10. Curtis JL, Warnock ML, Arraj-Peffer SM, Kaltreider HB. Histologic analysis of an immune response in the lung parenchyma of mice: angiopathy accompanies inflammatory cell influx. Am J Pathol 137:689-699, 1990. PMID: 2399937. PMCID: PMC1877521.

11. Imoto EM, Stein RM, Shellito JE, Curtis JL. Central airway obstruction due to cytomegalovirus-induced necrotizing tracheitis in a patient with AIDS. Am Rev Respir Dis 142:884-886, 1990. PMID: 2171387.

12. Beck JM, Warnock ML, Curtis JL, Sniezek MJ, Arraj-Peffer SM, Kaltreider HB, Shellito JE. Inflammatory responses to Pneumocystis carinii pneumonia in mice selectively depleted of helper T lymphocytes. Am J Respir Cell Mol Biol 5:186-197, 1991. PMID: 1679991.

13. Curtis JL, Byrd PK, Warnock ML, Kaltreider HB. Requirement of CD4+ T cells for cellular recruitment to the lungs of mice in response to a particulate intratracheal antigen. J Clin Invest 88:1244-1254, 1991. PMID: 1680880. PMCID: PMC1877521.

14. Curtis JL, Warnock ML, Conrad D, Helfend LK, Boushey HA. Intravascular angiotropic large cell lymphoma (“malignant angioendotheliomatosis”) with small vessel pulmonary angitis and hypercalcemia. West J Med 155:72-76, 1991. PMID: 1877242. PMCID: PMC1002926.


15. Jacques C, Richmond G, Tierney L, Curtis JL, McKerrow J, Warnock ML. Primary pulmonary hypertension and human immunodeficiency viral infection in a non-hemophiliac man. Hum Pathol 23:191-194, 1992. PMID: 1740304.

16. Curtis JL, Byrd PK, Warnock ML, Beck JM, Kaltreider HB. Pulmonary lymphocyte recruitment: depletion of CD8+ T cells does not impair the pulmonary immune response to intratracheal antigen. Am J Respir Cell Mol Biol 9:90-98, 1993. PMID: 8338679.

17. Kim S, Scott PJ, Curtis JL. CD4+ T cell subsets in pulmonary lymphocyte recruitment. CHEST 103:94S, 1993. PMID: 8094049.

18. Mody CH, Chen GH, Jackson C, Curtis JL, Toews GB. Depletion of murine CD8+ T cells in vivo decreases pulmonary clearance of a moderately virulent strain of Cryptococcus neoformans. J Lab Clin Med 121:765-773, 1993. PMID: 7685044.

19. Chen G-H, Curtis JL, Mody CH, Christensen PJ, Armstrong LR, Toews GB. Effect of granulocyte-macrophages colony-stimulating factor (GM-CSF) on rat alveolar macrophage anti-cryptococcal activity. J Immunol 152:724-734, 1994. PMID: 8283047.

20. Curtis JL, Huffnagle, GB, Chen G-H, Warnock ML, Gyetko MR, McDonald RA, Scott PJ, Toews GB. Experimental pulmonary cryptococcosis: differences in pulmonary inflammation and lymphocyte recruitment induced by two encapsulated strains of C. neoformans. Lab Invest 170:113-126, 1994. PMID: 8041111.

21. Mody CH, Chen G-H, Jackson C, Curtis JL, Toews GB. In vivo depletion of murine CD8+ T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans. Mycopathologia 125:7-17, 1994. PMID: 8028643.

22. Curtis JL, Kim S, Scott PJ, Buechner-Maxwell VA. Adhesion receptor phenotypes of murine lung CD4+ T cells during the pulmonary immune response to sheep erythrocytes. Am J Respir Cell Mol Biol 12:520-530, 1995. PMID: 7537969.

23. Huffnagle GB, Chen G-W, Curtis JL, McDonald RA, Strieter RM, Toews GB. Down-regulation of T cell-mediated immunity and inflammation by a high melanin-producing strain of Cryptococcus neoformans. J Immunol 155: 3507-3516, 1995. PMID: 7561046.

24. Orens JB, Kazerooni EA, Martinez FJ, Curtis JL, Gross BH, Whyte RI, Flint A, Toews GB, Lynch JP III. The sensitivity of high resolution computed tomography in detecting biopsy-proven idiopathic pulmonary fibrosis: a prospective study. CHEST 108:109-115, 1995. PMID: 7606943.

25. Milik AM, Beuchner-Maxwell VA, Sonstein J, Kim S, Seitzman GD, Beals TF, Curtis JL. Lung lymphocyte elimination by apoptosis in the murine response to intratracheal particulate antigen. J Clin Invest 99:1082-1091, 1997. PMID: 9062367. PMCID: PMC507917.

26. Ojo TC, Martinez F, Paine R, III, Christensen PJ, Curtis JL, Weg JG, Kazerooni EA, Whyte R. Lung volume reduction surgery alters management of pulmonary nodules in patients with severe COPD. CHEST 112:1494-1500, 1997. PMID: 9404744.

27. Wolber FM, Curtis JL, Milik AM, Seitzman GD, Fields KL, Kim S, Sonstein J, Stoolman LM. Lymphocyte recruitment and the kinetics of adhesion receptor expression during the pulmonary immune response to particulate antigen. Am J Pathol 151:1715-1727, 1997. PMID: 9403722. PMCID: PMC1858353.

28. Bach DS, Curtis JL, Christensen, PJ, Lewis PD, Iannettoni MD, Kazerooni EA, Martinez FJ. Pre-operative echocardiographic evaluation of patients referred for lung volume reduction surgery. CHEST 114: 972-980, 1998. PMID: 9792564.

29. Seitzman GD, Sonstein J, Choy W, Kim S, Curtis JL. Lung lymphocytes proliferate minimally in the murine pulmonary immune response to intratracheal sheep erythrocytes. Am J Respir Cell Mol Biol 18:800-812, 1998. PMID: 9618385. PMCID: PMC4123639.

https://email.med.umich.edu/owa/redir.aspx?C=A4YmGqrUW0in7o9gkb4RC3dJb5YIh9EIIH3QrtdShXcTtTE4o-rAQhXz-JkNHdIz2bbkR-4h2m4.&URL=http%3a%2f%2fwww.ncbi.nlm.nih.gov%2fpmc%2farticles%2fPMC4123639%2f


30. Wolber FM, Curtis JL, Mály P, Kelly RJ, Smith P, Yednock TA, Lowe JB, Stoolman LM. Endothelial selectins and alpha4 integrin regulate independent pathways of T lymphocyte recruitment in the pulmonary immune response. J Immunol 161: 4396-4403, 1998. PMID: 9780218.

31. Christensen PJ, Paine R III, Curtis JL, Kazerooni EA, Iannettoni MD, Martinez FJ. Weight gain after lung volume reduction surgery is not correlated with improvements in pulmonary mechanics. CHEST 116:1601-7, 1999. PMID: 10593783.

32. Warmington KS, Boring L, Ruth JH, Sonstein J, Hogaboam CM, Curtis JL, Kunkel SL, Charo IR, Chensue SW. Effect of C-C chemokine receptor 2 (CCR2) knockout on Type-2 (Schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responses. Am J Pathol 154:1407-1416, 1999. PMID: 10329593. PMCID: PMC1866581.

33. Curtis JL, Wolber FM, Sonstein J, Craig RA, Polak T, Knibbs RN, Todt J, Seitzman GD, Stoolman LM. Lymphocyte-endothelial cell adhesive interactions in lung immunity: lessons from the murine response to particulate antigen. Immunopharmacology 48:223-229, 2000. PMID: 10960661.

34. Hu B, Sonstein J, Christensen PJ, Punturieri A, Curtis JL. Deficient in vitro and in vivo phagocytosis of apoptotic T cells by resident murine alveolar macrophages. J Immunol 165:2124-2133, 2000. PMID: 10925298. PMCID: PMC4513940.

35. Shang X, Qui B, Frait KA, Hu JS, Sonstein J, Curtis JL, Lu B, Gerard C, Chensue SW. Chemokine receptor 1 (CCR1) knockout abrogates NK cell recruitment and impairs type-1 cytokines in lymphoid tissue during pulmonary granuloma formation. Am J Pathol 157;2055-2063, 2000. PMID: 11106578. PMCID: PMC1885763.

36. Todt J, Sonstein J, Polak T, Seitzman GD, Hu B, Curtis JL. Repeated intratracheal challenge with particulate antigen modulates murine lung cytokines. J Immunol 164; 4037-4047, 2000. PMID: 10754296.

37. Flaherty KR, Kazerooni EA, Curtis JL, Iannettoni M, Lange L, Schork MA, Martinez FJ. Short and long-term outcome after bilateral lung volume reduction surgery: Prediction by quantitative computed tomography. CHEST 119; 1337-1346, 2001. PMID: 11348937.

38. Gyetko MR, Sud S, Sonstein S, Polak T, Sud A, Curtis JL. Cutting Edge: Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, but is independent of uPA. J Immunol 167: 5539-5542, 2001. PMID: 11698423.

39. Curtis JL, Sonstein J, Craig RA, Todt JC, Knibbs RN, Polak T, Bullard DC, Stoolman LM. Subset-specific reductions in lung lymphocyte accumulation following intratracheal antigen challenge in endothelial selectin-deficient mice. J Immunol 169: 2570-9, 2002. PMID: 12193727. PMCID: PMC4371789.

40. Hu B, Punturieri A, Todt J, Sonstein J, Polak T, Curtis JL. Recognition and phagocytosis of apoptotic T cells by resident murine tissue macrophages requires multiple signal transduction events. J Leukocyt Biol 71;881-889, 2002. PMID: 11994514. PMCID: PMC4371852.

41. Todt JC, Hu B, Punturieri A, Sonstein J, Polak T, Curtis JL. Activation of Protein Kinase C beta II by the stereo-specific phosphatidylserine receptor is required for phagocytosis of apoptotic thymocytes by resident murine tissue macrophages. J Biol Chem 277:35906-14, 2002. PMID: 12114511. PMCID: PMC2640489.

42. Canetti C, Hu B, Curtis JL, Peters-Golden M. Syk activation is a leukotriene B4-regulated event involved in macrophage phagocytosis of IgG-coated targets but not apoptotic cells. Blood 102:1877-1883, 2003. PMID: 12730109.


43. Mo R-R, Eisenbraun JK, Sonstein J, Craig RA, Curtis JL, Stoolman LM, Yung RL. CD49d overexpression and T cell autoimmunity. J Immunol 171: 745–753, 2003. PMID: 12847241.

44. Hu B, Jennings JH, Sonstein J, Floros J, Todt JC, Polak T, Curtis JL. Resident murine alveolar and peritoneal macrophages differ in adhesion of apoptotic thymocytes. Am J Respir Cell Mol Biol 30: 687-93, 2004. PMID: 14527926. PMCID: PMC4138126.

45. Punturieri A, Alviani RS, Polak T, Cooper P, Sonstein J, Curtis JL. Specific engagement of TLR4 or TLR3 does not lead to IFN-b-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages. J Immunol 173: 1033-1043, 2004. PMID: 15240691. PMCID: PMC2701405.

46. Todt JC, Hu B, Curtis JL. The receptor tyrosine kinase MerTK (Tyro12) activates phospholipase C g2 during recognition of apoptotic thymocytes by resident murine macrophages. J Leukocyt Biol 75:705-713, 2004. PMID: 14704368. PMCID: PMC2441598.

47. Jennings JH, Linderman DJ, Hu B, Sonstein J, Polak T, Curtis JL. Monocytes recruited to the lungs of mice during immune inflammation ingest apoptotic cells poorly. Am J Respir Cell Mol Biol 32:108-117, 2005. (Cover Article). PMID: 15563692. PMCID: PMC2267037.

48. Osterholzer JJ, Ames T, Polak T, Sonstein J, Moore BB, Chensue SW, Toews GB, Curtis JL. CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs in response to particulate antigen. J Immunol 175: 874-883, 2005. PMID: 16002685. PMCID: PMC2396199.

49. Martinez FJ, Foster G, Curtis JL, Criner G, Weinmann G, Fishman A, DeCamp MM, Benditt J, Sciurba F, Make B, Mohsenifar Z, Diaz P, Hoffman E, Wise R for the NETT Research Group. Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med 173:1326-1334, 2006. PMID: 16543549. PMCID: PMC2662972.

50. Punturieri A, Copper P, Polak T, Christensen PJ, Curtis JL. Conserved non-typeable Haemophilus influenzae-derived TLR2-binding lipopeptides synergize with IFN-b to increase cytokine production by resident murine and human alveolar macrophages. J Immunol 177:673-680, 2006. PMID: 16785566. PMCID: PMC2373263.

51. Fan VS, Ramsey SD, Giardino ND, Make BJ, Emery CF, Diaz PT, Benditt JO, Mosenifar Z, McKenna R, Jr., Curtis JL, Fishman AP, Martinez FJ for the NETT Research Group. Sex, depression and risk of hospitalization and mortality in COPD. Arch Intern Med 167; 2345-2353, 2007. PMID: 18039994.

52. Freeman CM, Curtis JL, Chensue SW. CCR5 and CXCR6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity. Am J Pathol 171: 767-76, 2007. PMID: 17640964. PMCID: PMC1959492.

53. Martinez FJ, Curtis JL, Sciurba F, Mumford J, Giardino ND, Weinmann G, Kazerooni E, Murray S, Criner GJ, Sin DD, Hogg J, Ries AL, Han ML, Fishman AP, Make B, Hoffman EA, Mohsenifar Z, Wise R for the NETT Research Group. Sex differences in severe pulmonary emphysema. Am J Respir Crit Care Med 176:243-252, 2007. PMID: 17431226. PMCID: PMC1994221.

54. Rivera R, Hutchens M, Luker KE, Sonstein J, Curtis JL, Luker GD. Alveolar macrophages limit replication of vaccinia virus. Virology 363:48-58, 2007. PMID: 17331554. PMCID: PMC1939814.

55. Christensen PJ, Preston AM, Ling T, Ming D, Fields WB, Curtis JL, Beck JM. Pneumocystis murina infection and cigarette smoke exposure interact to cause increased


organism burden, development of airspace enlargement, and pulmonary inflammation in mice. Infect Immun 76: 3481-3490, 2008. PMID: 18490462. PMCID: PMC2493196.

56. Hutchens M, Luker KE, Sottile P, Sonstein J, Lukacs NW, Nuñez G, Curtis JL, Luker GD. TLR3 increases disease morbidity and mortality from vaccinia infection. J Immunol 180; 483-491, 2008. PMID: 18802464.

57. Hutchens M, Luker KE, Sonstein J, Nuñez G, Curtis JL, Luker GD. Protective effect of Toll-like Receptor 4 in pulmonary vaccinia infection. PLoS Pathogens 4:e1000153, 2008. PMID: 18802464. PMCID: PMC2529451.

58. Martinez FJ, Han M-LK, Andrei A-C, Wise R, Murray S, Curtis JL, Sternberg A, Criner G, Gay SE, Reilly J, Make B, Ries AL, Sciurba F, Weinmann G, Mohsenifar Z, DeCamp M, Fishman AP, Celli BR for the NETT Research Group. Longitudinal change in BODE index predicts mortality in severe emphysema. Am J Respir Crit Care Med 178: 491-499, 2008. PMID: 18535255. PMCID: PMC2542428.

59. Osterholzer JJ, Curtis JL, Polak T, Ames T, Chen G-H, McDonald R, Huffnagle GB, Toews GB. CCR2 mediates myeloid dendritic cell recruitment and the formation of bronchovascul-ar mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans infection. J Immunol 181:610-622, 2008. PMID: 18566428. PMCID: PMC2735104.

60. Todt JC, Hu B, Curtis JL. The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. J Leukocyt Biol 84: 510-518, 2008. PMID: 18511575. PMCID: PMC2718803.

61. Zhao L, Sheldon K, Chen M, Yin MS, Hayman JA, Kalemkerian G, Arenberg DA, Lyons S, Curtis JL, Davis M, Cease K, Brenner D, Anscher MS, Lawrence TS, Kong F-M. The predictive role of plasma TGF-beta1 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer. Lung Cancer 59: 232-239, 2008. PMID: 17905467.

62. Curtis JL, Todt JC, Hu B, Osterholzer JJ, Freeman CM. Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake. Front Biosci 14:2631-2646, 2009. PMID: 19273223. PMCID: PMC4191832.

63. Han M-LK, Barthomai B, Liu LX, Murray S, Curtis JL, Sciurba FC, Kazerooni EA, Thompson B, Frederick M, Li D, Schwarz J, Limper A, Freeman C, Landreneau RJ, Wise R, Martinez FJ. Clinical significance of radiological correlation in COPD. COPD 6:459-67, 2009. PMID: 19938970.

64. Osterholzer JJ, Suran R, Milam JE, Montano GT, Chen GH, Sonstein J, Curtis JL, Huffnagle GB, Toews GB, Olszewski MA. Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung. Am J Pathol 174:932-943, 2009. PMID: 19218345. PMCID: PMC2665753.

65. Sajjan US, Ganesan S, Comstock AT, Shim J, Wang Q, Nagarkar DR, Zhao Y, Goldsmith AM, Sonstein J, Linn MJ, Curtis JL, Hershenson MB. Elastase- and LPS-exposed mice display altered responses to Rhinovirus infection. Am J Physiol: Lung Cell Mol Physiol 297:L931-L944, 2009. PMID: 19748999. PMCID: PMC2777490.

66. Freeman CM, Martinez FJ, Han M-LK, Ames TM, Chensue SW, Todt JC, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Lung dendritic cell expression of maturation molecules increases with worsening COPD. Am J Respir Crit Care Med 180: 1179-1188, 2009. PMID: 19729666. PMCID: PMC2796731.

67. Osterholzer JJ, Chen GHW, Olszewski MA, Curtis JL, Huffnagel GB, Toews GB. Accumulation of CD11b+ lung dendritic cells in response to fungal pneumonia results from the CCR2-mediated recruitment and differentiation of Ly6Chigh monocytes. J Immunol 183:8044-8053, 2009. PMID: 19933856.


68. Wang L, Correa CR, Hayman JA, Zhao L, Cease K, Brenner D, Arenberg D, Curtis J, Kalemkerian GP, Kong FM. Time to treatment in patients with stage III non-small cell lung cancer. Int J Radiat Oncol Biol Phys 74:790-5, 2009. PMID: 19231108. PMCID: PMC3381995.

69. Phipps JC, Aronoff DM, Curtis JL, Goel D, Mancuso P. Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae. Infect Immun 78:1214-20, 2010. PMID: 20008540. PMCID: PMC2825918.

70. Han MK, Wise R Mumford J, Sciurba F, Criner GJ, Curtis JL, Murray S, Sternberg A, Weinman G, Kazerooni E, Fishman AP, Make B, Hoffman EA, Mosenifar Z, Martinez FJ, for the NETT Research Group. Prevalence and clinical correlates of bronchoreversibility in patients with severe emphysema. Eur Respir J 35:1048-53, 2010. PMID: 19926748.

71. Giardino N, Curtis JL, Liberzon I, King A, Martinez FJ, Pamp B, Abelson J. The impact of panic disorder on interoception and dyspnea reports in chronic obstructive pulmonary disease. Biol Psychol 84:142-146, 2010. doi: 10.1016/j.biopsycho.2010.02.007. PMID: 20176074.

72. Giardino ND, Curtis JL, Andrei A-C, Fan VS, Benditt JO, Lyubkin M, Naunheim K, Criner G, Make B, Wise R, Murray S, Fishman AP, Sciurba FC, Liberzon I, Martinez FJ for the NETT Research Group. Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study. Respir Res 11:29, 2010. doi: 10.1186/1465-9921-11-29. PMID: 20214820. PMCID: PMC2848143.

73. Schneider D, Ganesan S, Comstock AT, Meldrum CA, Mahidhara R, Goldsmith AM, Curtis JL, Martinez FJ, Hershenson MB, Sajjan U. Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 182; 332-40, 2010. PMID: 20395558. PMCID: PMC2921598.

74. Freeman CM, Han M-LK, Martinez FJ, Murray S, Liu LX, Chensue SW, Polak T, Sonstein J, Todt JC, Ames TM, Arenberg DA, Meldrum CA, Getty C, McCloskey L, Curtis JL. Cytotoxic potential of lung CD8+ T cells in COPD is increased with disease severity and by in vitro stimulation with IL-18 and IL-15. J Immunol 184:6504-13, 2010. PMID: 20427767. PMCID: PMC4098931.

75. Thelen T, Hao Y, Medeiros AI, Curtis JL, Serezani CH, Kobzik L, Harris LH, Aronoff DM. The class A scavenger receptor, Macrophage Receptor with Collagenous Structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macro-phages. J Immunol 85; 4328-35, 2010. PMID: 20810988.

76. Ganesan S, Faris AN, Comstock AT, Chattoraj SS, Chattoraj A, Burgess JR, Curtis JL, Martinez FJ, Zick S, Hershenson MB, Sajjan US. Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression. Respir Res 11:131, 2010. doi: 10.1186/1465-9921-11-131. PMID: 20920189. PMCID: PMC2954923.

77. Albert RA, Connett J, Bailey WC, Casaburi R, Cooper JAD, Jr., Criner GJ, Curtis JL, Dransfield MT, Han ML, Lazarus SC, Make B, Marchetti N, Martinez FJ, Mattinger N, McEvoy C, Niewoehner DE, Porsasz J, Price CS, Reilly J, Scanlon PD, Sciurba FC, Scharf SM, Washko GR, Woodruff PG, Anthonisen NR, for the COPD Clinical Research Network. Azithromycin for prevention of COPD exacerbations. N Engl J Med 365; 689-698, 2011. PMID: 21864166. PMCID: PMC3220999.

78. Yuan ST, Frey KA, Gross MD, Hayman JA, Arenberg D, Curtis JL, Cai XW, Ramnath N, Kalemkerian GP, Ten Haken RK, Eisbruch A, Kong FM. Semiquantification and classificat-ion of local pulmonary function by V/Q single photon emission computed tomography in


patients with non-small cell lung cancer: potential indication for radiotherapy planning. J Thorac Oncol 6: 71-78, 2011. PMID: 21119546. PMCID: PMC3351273.

79. Osterholzer JJ, Chen GH, Olsziewski MA, Zhang, Y-M, Curtis JL, Huffnagel GB, Toews GB. Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection. Am J Pathol 178:198-211, 2011. PMID: 21224057. PMCID: PMC3069860.

80. Mendez M, Monroy Y, Du M, Preston A, Tolle L, Lin Y, Van Dussen K, Samuelson L, Standiford T, Curtis JL, Beck JM, Christensen PJ, Paine R III. Overexpression of sICAM-1 in the alveolar epithelial apace results in an exaggerated inflammatory response and early death in Gram negative pneumonia. Respir Res 12:12, 2011. PMID: 21247482. PMCID: PMC3034680.

81. Woodruff PG, Criner GJ, Kim V, Dransfield MT, Bailey WC, Cooper JA Jr , Scharf SM, Casaburi R, Martinez FJ, Han MK, Curtis JL, Sciurba FC, Niewoehner DE, McEvoy CE, Scanlon PD, Rice K, Albert RK, Washko GR, Reilly JR, Harnden SM, Connett JE, Lazarus SC, for the COPD Clinical Research Network. Randomized controlled trial of Zileuton for treatment of COPD exacerbations requiring hospitalization. COPD 8:21-29, 2011. PMID: 21299475. PMCID: PMC3774706.

82. Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB. Analysis of the lung microbiome in the “healthy” smoker and in COPD. PLoS One; 6:e16384, 2011. PMID: 21364979. PMCID: PMC3043049.

83. Han MK, Martinez FJ, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, Anzueto AR, Make B, Hokanson JE, Crapo J, Silverman EK, Lynch DA, Washko GR for the COPDGene® Investigators. Radiologic predictors of COPD exacerbations in COPDGene®. Radiology 261; 274-282, 2011. PMID: 21788524. PMCID: PMC3184233.

84. Ganesan S, Faris AN, Comstock AT, Sonstein J, Curtis JL, Sajjan US. Elastase/LPS-exposed mice show impaired innate immune responses to bacterial challenge: Role of scavenger receptor A. Am J Pathol 180:61-72, 2012. PMID: 22079429. PMCID: PMC3338352.

85. Schneider D, Popova AP, Bowman ER, Linn MJ, McLean AM, Zhao Y, Sonstein J, Bentley K, Weinberg JB, Lukacs NW, Curtis JL, Sajjan US, Hershenson MB. Neonatal rhinovirus infection induces persistent mucous metaplasia and airways hyperresponsiveness. J Immunol 188:2894-904, 2012. PMID 22331068. PMCID: PMC3294163.

86. Casaburi R, Porszasz J, Hecht A, Tiep B, Albert RK, Anthonisen NR, Bailey WC, Connett JE, Cooper JA Jr, Criner GJ, Curtis J, Dransfield M, Lazarus SC, Make B, Martinez FJ, McEvoy C, Niewoehner DE, Reilly JJ, Scanlon P, Scharf SM, Frank C. Sciurba FC, Woodruff P, for the COPD Clinical Research Network. Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy. COPD 9:3–11, 2012. PMID: 22292592.

87. Barr CC, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, Macnee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD, Jr., Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, Beek EJ, Washington L, Washko GR, Westney G, Wood SA,

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294163/?tool=nihms


Woodruff PG. A combined pulmonary-radiology workshop for visual evaluation of COPD: Study design, chest CT findings and concordance with quantitative evaluation. COPD 9:151-159, 2012. PMID: 22429093. PMCID: PMC3752926.

88. Martinez CH, Chen YH, Westgate PM, Liu LX, Murray S, Curtis JL, Make BJ, Kazerooni EA, Lynch DA, Marchetti N, Washko GR, Martinez FJ, Han MK. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax 67:399-406, 2012. PMID: 22514236. PMCID: PMC3719874.

89. McCubbrey AL, Sonstein J, Ames TM, Freeman CM, Curtis JL. Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα. J Immunol 189:112-9, 2012. (Featured “In This Issue”). PMID: 22615206. PMCID: PMC3381851.

90. Dransfield MT, Harnden S, Burton RL, Albert RK, Bailey WC, Casaburi R, Connett J, Cooper JA, Criner GJ, Curtis JL, Han MK, Make B, Marchetti N, Martinez FJ, McEvoy C, Nahm MH, Niewoehner DE, Porszasz J, Reilly J, Scanlon PD, Scharf SM, Sciurba FC, Washko GR, Woodruff PG, Lazarus SC. Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease. Clin Infect Dis 55:e35-e44, 2012. PMID: 22652582. PMCID: PMC3491850.

91. Wells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, Regan E, Bailey WC, Martinez FJ, Westfall E, Beaty TH, Curran-Everett D, Curtis JL, Hokanson JE, Lynch DA, Make BJ, Crapo JD, Silverman EK, Bowler RP, Dransfield MT. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med 367:913-21, 2012. PMID: 22938715. PMCID: PMC3690810.

92. Albert RK, Connett J, Curtis JL, Martinez FJ, Han M, Lazarus SC, Woodruff PG. Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease. Internat J COPD 7:1-11, 2012. PMID: 23226013. PMCID: PMC3514010.

93. Martinez CH, Raparla S, Plauschinat CA, Giardino ND, Rogers B, Beresford J, Bentkover JD, Schatner-Appel A, Curtis JL, Martinez FJ, Han MK. Gender differences in symptoms and care delivery for chronic obstructive pulmonary disease. J Women’s Health 21: 1267-1274, 2012. doi: 10.1089/jwh.2012.3650. PMID 23210491. PMCID: PMC3518541.

94. Erb-Downward JR, Sadighi Akha AA, Wang J, Shen N, He B, Martinez FJ, Gyetko MR, Curtis JL, Huffnagle GB. Use of direct gradient analysis to uncover biological hypotheses in 16S survey data and beyond. Sci Rep 2:774, 2012. doi: 10.1038/srep00774. PMID: 23336065. PMCID: PMC3540687.

95. Freeman CM, Martinez FJ, Han MK, Washko GR Jr., McCubbrey AL, Chensue SW, Arenberg DA, Meldrum CA, Thompson DL, McCloskey L, Curtis JL. Lung CD8+ T cells in COPD have increased expression of bacterial TLRs. Respir Res 14:13, 2013. doi: 10.1186/1465-9921-14-13. PMID: 23374856. PMCID: PMC3583694.

96. Todt JC, Freeman CM, Brown JP, Sonstein J, Ames TM, McCloskey L, McCubbrey AL, Martinez FJ, Chensue SW, Beck JM, Curtis JL. Smoking decreases the human lung macrophage response to double-stranded RNA by reducing TLR3 expression. Respir Res 14:33, 2013. doi: 10.1186/1465-9921-14-33. PMID: 23497334. PMCID: PMC3599854.

97. Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP. Widespread colonization of the lung by Tropheryma whipplei in HIV


infection. Am J Respir Crit Care Med 187:1110–1117, 2013. PMID: 23392441. PMCID: PMC3734615.

98. Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM. Comparison of the respiratory microbiome in healthy non-smokers and smokers. Am J Respir Crit Care Med 187; 1067–1075, 2013. PMID: 23491408. PMCID: PMC3734620.

99. Qiu Y, Dayrit JK, Davis MJ, Carolan JF, Osterholzer JJ, Curtis JL, Olszewski MA. Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection. J Immunol 191: 238–248, 2013. PMID: 23733871. PMCID PMC4007509.

100. O'Neal WK, Anderson W, Basta PV, Carretta EE, Doerschuk CM, Barr RG, Bleecker ER, Christenson SA, Curtis JL, Han MK, Hansel NN, Kanner RE, Kleerup EC, Martinez FJ, Miller BE, Peters SP, Rennard SI, Scholand MB, Tal-Singer R, Woodruff PG, Couper DJ, Davis SM. Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med 12:9, 2014. PMID: 24397870. PMCID: PMC3928911.

101. Stolberg VR, Martin B, Mancuso P, Olszewski MA, Freeman CM, Curtis JL, Chensue SW. Role of C-C chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure. Am J Pathol 184:454-63, 2014. PMID: 24333113. PMCID: PMC3906485.

102. Martinez CH, Kim V, Chen YH, Kazerooni EA, Murray S, Gerard J. Criner GJ, Curtis JL, Regan EA, Wan E, Hersh CP, Silverman EK, Crapo JD, Martinez FJ, Han MK, and the COPDGene Investigators. The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med 108:491-9, 2014. PMID: 24280543. PMCID: PMC3943716.

103. Woodruff PG, Chatila W, Connett JE, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Marchetti N, Rogers TJ, Scanlon PD, Sin DD, Voelker H, Wendt C, Albert RK. Tumour necrosis factor receptor 75 and risk for COPD exacerbation in the azithro-mycin trial. Eur Respir J 43:295-8, 2014. PMID: 24136332. PMCID: PMC4326242

104. Freeman CM, McCubbrey AL, Crudgington S, Nelson J, Martinez FJ, Han ML, Washko GR, Jr, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Basal gene expression by lung CD4+ T cells in chronic obstructive pulmonary disease identifies independent molecular correlates of airflow obstruction and emphysema extent. PLoS One 9; e96421, 2014. doi:10.1371/journal.pone.0096421. PMID: 24805101. PMCID: PMC4013040.

105. Dickson RP, Erb-Downward JR, Freeman CM, Walker N, Scales BS, Beck JM, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB. Changes in the lung microbiome following lung transplantation include the emergence of two distinct Pseudomonas species with distinct clinical associations. PLoS One 9:e97214, 2014. PMID: 24831685. PMCID: PMC4022512.

106. Martinez CH, Okajima Y, Murray S, Washko GR, Martinez FJ, Silverman EK, Lee JH, Regan EA, Crapo JD, Curtis JL, Hatabu H, Han MK. Impact of self-reported gastro-esophageal reflux disease in subjects from COPDGene Cohort. Respir Res 15:62, 2014. PMID: 24894541. PMCID: PMC4049804.

107. Criner GJ, Connett JE, Aaron SD, Albert RK, Bailey WC, Casaburi R, Cooper JAD, Jr., Curtis JL, Dransfield MT , Han MK, Make B, Marchetti N, Martinez FJ, Niewoehner DE, Scanlon PD, Sciurba FC, Scharf SM, Sin DD, Voelker H, Washko GR, Jr., Woodruff PG,


Stephen C. Lazarus SC, for the NHLBI COPD Clinical Research Network and the Canadian Institute of Health Research. Simvastatin for the prevention of exacerbations in moderate to severe COPD. N Engl J Med 370:2201-2210, 2014. PMID: 24836125. PMCID: PMC4375247.

108. Wan ES, Castaldi PJ, Cho MH, Hokanson JE, Regan EA, Make BJ, Beaty TH, Han MK, Curtis JL, Curran-Everett D, Lynch DA, DeMeo DL, Crapo JD, Silverman EK. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res 15:89, 2014. PMID: 25096860. PMCID: PMC4256936.

109. Freeman CM, Stolberg VR, Crudgington S, Martinez FJ, Han MK, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Curtis JL. Human CD56+ cytotoxic lung lymphocytes kill autologous lung cells in chronic obstructive pulmonary disease. PLoS One 9:e103840, 2014. PMID: 25078269. PMCID: PMC4117545.

110. Dickson RP, Erb-Downward JR, Prescott HC, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB. Cell-associated bacteria in the human lung microbiome. Microbiome 2:28, 2014. PMID: 25206976. PMCID: PMC4158729.

111. Dickson RP, Erb-Downward JR, Prescott HC, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB. Analysis of culture-dependent vs. culture-independent techniques for the identification of bacteria in clinically-obtained bronchoalveolar lavage fluid. J Clin Microbiol 52:3605-13, 2014. PMID: 25078910. PMCID: PMC4187760.

112. Murdock BJ, Teitz-Tennenbaum S, Chen GH, Dils AJ, Malachowski AN, Curtis JL, Olszewski MA, Osterholzer JJ. Early or late IL-10 blockade enhances Th1 and th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection. J Immunol 193:4107-16, 2014. PMID: 25225664. PMCID: PMC4193595.

113. Putcha N, Han MK, Martinez CH, Foreman MG, Anzueto AR, Casaburi R, Cho MH, Hanania NA, Hersh CP, Kinney GL, Make BJ, Steiner RM, Lutz SM, Thomashow BM, Williams AA, Bhatt SP, Beaty TH, Bowler RP, Ramsdell JW, Curtis JL, Everett D, Hokanson JE, Lynch DA, Sutherland ER, Silverman EK, Crapo JD, Wise RA, Regan EA, Hansel NN. Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans. Chronic Obstr Pulm Dis (Miami) 1:105-14, 2014. PMID: 25695106. PMCID: PMC4329763.

114. Domingo-Gonzalez R, Wilke CA, Huang SK, Laouar Y, Brown JP, Freeman CM, Curtis JL, Yanik GA, Moore BB. Transforming growth factor-β induces microRNA-29b to pro-mote murine alveolar macrophage dysfunction post-bone marrow transplantation. Am J Physiol Lung Cell Mol Physiol 308: L86–L95, 2015. PMID: 25361568. PMCID: PMC4281703.

115. Venkataraman A, Bassis CM, Beck JM, Young VB, Curtis JL, Huffnagle GB, Schmidt TM. Application of ecological theory suggests that dispersal outweighs selection in structuring the composition of the healthy human lung microbiome. mBio 6:e02284-14, 2015. PMID: 25604788. PMCID: PMC4324308.

116. Freeman CM, Crudgington S, Stolberg VR, Brown JP, Sonstein J, Alexis NE, Doerschuk CM, Basta PV, Carretta EE, Couper DJ, Hastie AT, Kaner RJ, O’Neal WK, Paine R, III, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL. Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). J Translation Med 2015; 13:19. doi: 10.1186/s12967-014-0374-z. PMID: 25622723. PMCID: PMC4314767.


117. Davis MJ, Yafeng Qiu Y, Eastman A, Osterholzer JJ, Huffnagle GB, Curtis JL, Swanson JA, Olszewski MA. Lysosome damage is a critical mechanism of virulence of Cryptococ-cus neoformans in vitro and in vivo. J Immunol 194:2219-31, 2015. PMID: 25637026.

118. Bassis CM, Erb-Downward JR, Dickson RP, Freeman CM, Schmidt TM, Young VB, Beck JM, Curtis JL, Huffnagle GB. Analysis of the upper respiratory tract microbiome as the source of the lower respiratory tract and gastric microbiomes in healthy individuals. mBio 2015; 6:e00037-15. PMID: 25736890. PMCID: PMC4358017.

119. Bourdonnay E, Zasłona Z, Kumar-Penke LR, Przybranowski S, Swanson JA, Mancuso P, Freeman CM, Curtis JL, Peters-Golden M. Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. J Exp Med 212:729-742, 2015. PMID: 25847945. PMCID: PMC4419346.

120. Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Beck JM, Huffnagle GB, Curtis JL Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography. Ann Am Thorac Soc 12:821-830, 2015. PMID: 25803243.

121. Stolberg VR, McCubbrey AL, Freeman CM, Brown JP, Crudgington SW, Taitano SH, Saxton BL, Mancuso P, Curtis JL. Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function. J Immunol 195:174-84, 2015. PMID: 25987742. PMCID: PMC4475455.

122. Martinez CH Mannino D, Curtis JL, Han MK, Diaz A. Socioeconomic characteristics are major contributors to ethnic differences in health status in obstructive lung disease: an analysis of NHANES 2007-2010. Chest 148:151-8, 2015. PMID: 25633478.

123. Dickson RP, Erb-Downward JR, Prescott HC, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB. Intraalveolar catecholamines and the human lung microbiome. Am J Respir Crit Care Med 192:257-259, 2015. PMID: 26177175.

124. Freeman DM, Martinez CH, Todt JC, Martinez FJ, Han MK, Thompson DL, McCloskey L, Curtis JL. Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood. Respir Res 16:94, 2015. DOI: 10.1186/s12931-015-0251-1. PMID: 26243260. PMCID: PMC4531816.

125. Regan EA, Lynch DA, Curran-Everett D, Curtis JL, Austin JH, Grenier PA, Kauczor HU, Bailey WC, DeMeo DL, Casaburi RH, Friedman P, Van Beek EJ, Hokanson JE, Bowler RP, Beaty TH, Washko GR, Han MK, Kim V, Kim SS, Yagihashi K, Washington L, McEvoy CE, Tanner C, Mannino DM, Make BJ, Silverman EK, Crapo JD. Clinical and radiologic disease in smokers with normal spirometry. JAMA Intern Med 175:1539-49, 2015. PMID: 26098755.

Multicenter Clinical Trials (“Corporate Authorship”) 1. Niewoehner DE, Erbland ML, Deupree RH, Collins D, Gross NJ, Light RW, Anderson P,

Morgan NA and the Department of Veterans Affairs Cooperative Study Group (Curtis JL). Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. N Engl J Med 340:1941-1947, 1999. PMID: 10379017.

2. Nelson S, Heyder AM, Stone J, Bergeron M, Daugherty S, Peterson G, Fotheringham N, Welch W, Milwee S, Root R for the Multilobar Pneumonia Study Group (Curtis JL). A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia. J Infect Dis 182:970-973, 2000. PMID: 10950800.


3. Dransfield MT, Nahm MH, Han MK, Harnden S, Criner GJ, Martinez FJ, Scanlon PD, Woodruff PG, Washko GR, Connett JE, Anthonisen NR, Bailey WC for the COPD Clinical Research Network (Curtis JL). Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 180:499-505, 2009. PMID: 19556517.

4. Hecht A, Ma S, Porszasz J, Casaburi R for the COPD Clinical Research Network (Curtis JL). Methodology for using long-term accelerometry monitoring to describe daily activity patterns in COPD. COPD 6:121-9, 2009. PMID: 19378225. PMCID: PMC2862250.

5. Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, Curran-Everett D, Silverman EK, Crapo JD, COPDGene Investigators (Curtis JL). Genetic epidemiology of COPD (COPDGene) study design. COPD 2010; 7:32-43. PMID: 20214461.

6. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estepar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, COPDGene Investigators (Curtis J). Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med; 364:897-906, 2011. PMID: 21388308.

7. Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK, COPDGene Investigators (Curtis J). The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol 45:1147-53, 2011. PMID: 21659657. PMC3262664: PMC3262664.

8. Kim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK, COPDGene Investigators (Curtis J). Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res 12:9, 2011. PMID: 21310839.

9. Hersh CP, Hokanson JE, Lynch DA, Washko GR, Make BJ, Crapo JD, Silverman EK, COPDGene Investigators (Curtis J). Family history is a risk factor for chronic obstructive pulmonary disease. CHEST 140:343-50, 2011. PMID: 21310839.

10. Kunisaki KM, Niewoehner DE, Connett JE for the COPDGene Investigators (Curtis JL) Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. Am J Respir Crit Care Med 185:286-90, 2012. PMID: 22077070. PMCID: PMC3297108.

11. Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK, COPDGene Investigators (Curtis JL). The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol 45:1147-53, 2011. PMID: 21659657. PMCID: PMC3262664.

12. Foreman MG, Zhang L, Murphy J, Hansel NN, Make B, Hokanson JE, Washko G, Regan EA, Crapo JD, Silverman EK, DeMeo DL, COPDGene Investigators (Curtis JL). Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med 184:414-20, 2011. PMID: 21562134. PMCID: PMC3175544.

13. Han MK, Curran-Everett D, Dransfield MT, Criner GJ, Zhang L, Murphy JR, Hansel NN, DeMeo DL, Hanania NA, Regan EA, Make BJ, Martinez FJ, Westney GE, Foreman MG, COPDGene Investigators (Curtis JL). Racial differences in quality of life in patients with COPD. CHEST 140:1169-76, 2011. PMID: 21636665. PMCID: PMC3184233.

14. Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP, COPDGene Investigators (Curtis JL). The clinical features of the overlap between COPD and asthma. Respir Res 12:127, 2011. PMID: 21951550. PMCID: PMC3204243.

http://www.ncbi.nlm.nih.gov/pubmed/19556517

http://www.ncbi.nlm.nih.gov/pubmed/19556517


15. Kim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK, COPDGene Investigators (Curtis JL). Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res 12:9 2011. PMID: 21232152. PMCID: PMC3033825.

16. Kim V, Han MK, Vance GB, Make BJ, Newell JD, Hokanson JE, Hersh CP, Stinson D, Silverman EK, Criner GJ, COPDGene Investigators (Curtis JL). The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. CHEST 140:626-33, 2011. PMID: 21474571.

17. Kim YI, Schroeder J, Lynch D, Newell J, Make B, Friedlander A, Estepar RS, Hanania NA, Washko G, Murphy JR, Wilson C, Hokanson JE, Zach J, Butterfield K, Bowler RP, COPDGene Investigators (Curtis JL). Gender differences of airway dimensions in anatomically matched sites on CT in smokers. COPD 8:285-92, 2011. PMID: 21756032.

18. Siedlinski M, Cho MH, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Silverman EK, COPDGene Investigators (Curtis J). Genome-wide association study of smoking behaviours in patients with COPD. Thorax 2011; 66:894-902. PMID: 21685187. PMCID: PMC3302576.

19. Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL. COPDGene Investigators (Curtis JL). Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 45:304-10, 2011. PMID: 21037115.

20. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estepar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, COPDGene Investigators (Curtis JL). Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 364:897-906, 2011. PMID: 21388308. PMCID: PMC3074462.

21. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK, COPDGene Investigators (Curtis JL). A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet 21:947-57, 2012. PMID: 22080838. PMCID: PMC3298111.

22. Diaz AA, Come CE, Ross JC, San Jose Estepar R, Han MK, Loring SH, Silverman EK, Washko GR, COPDGene Investigators (Curtis JL). Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. CHEST 2012; 141:736-44. PMID: 21940776.

23. Doyle TJ, Washko GR, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Divo MJ, Celli BR, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, Hunninghake GM, COPDGene Investigators (Curtis JL). Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med 2012; 185:756-62. PMID: 22268134.

24. Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R, COPDGene Investigators (Curtis J). Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. CHEST 141:867-75, 2012. PMID: 21960696. PMCID: PMC3318949.

25. Swift I, Satti A, Kim V, Make BJ, Newell J, Steiner RM, Wilson C, Murphy JR, Silverman EK, Criner GJ, COPDGene Investigators (Curtis JL). Demographic, physiologic and


radiographic characteristics of COPD patients taking chronic systemic corticosteroids. COPD 9:29-35, 2012. PMID: 22292596.

26. Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estepar RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM, COPDGene Investigators (Curtis JL). Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med 185:547-56, 2012. PMID: 22246178.

27. Zach JA, Newell JD, Jr., Schroeder J, Murphy JR, Curran-Everett D, Hoffman EA, Westgate PM, Han MK, Silverman EK, Crapo JD, Lynch DA, COPDGene Investigators (Curtis JL). Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol 47:596-602, 2012. PMID: 22836310.

28. San Jose Estepar R, Kinney GL, Black-Shinn JL, Bowler RP, Kindlmann GL, Ross JC, Kikinis R, Han MK, Come CE, Diaz A, Cho MH, Hersh CP, Schroeder JD, Reilly JJ, Lynch DA, Crapo JD, Wells JM, Dransfield MT, Hokanson JE, Washko GR, for the COPDGene Investigators (Curtis JL). Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. Am J Respir Crit Care Med 2013; PMID: 23656466.

29. Hersh CP, Washko GR, Estepar RS, Lutz S, Friedman PJ, Han MK, Hokanson JE, Judy PF, Lynch DA, Make BJ, Marchetti N, Newell JD, Jr., Sciurba FC, Crapo JD, Silverman EK, COPDGene Investigators (Curtis JL). Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res 2013; 14:42. PMID: 23566024.

30. Bhatt SP, Sieren JC, Dransfield MT, Washko GR, Newell JD, Jr., Stinson DA, Zamba GK, Hoffman EA, Hersh CP, Washko GR, Estepar RS, Lutz S, Friedman PJ, Han MK, Hokanson JE, Judy PF, Lynch DA, Make BJ, Marchetti N, Newell JD, Jr., Sciurba FC, Crapo JD, Silverman EK COPDGene Investigators (Curtis JL). Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res 2013; 14:42. PMID: 23566024.

31. Bhatt SP, Sieren JC, Dransfield MT, Washko GR, Newell JD, Jr., Stinson DA, Zamba GK, Hoffman EA, COPDGene Investigators (Curtis JL). Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax 2013; PMID: 23525095.

32. Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK, COPDGene Investigators (Curtis J). Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet 132:431-41, 2013. PMID: 23299987. PMCID: PMC3600068.

33. Hansel NN, Washko GR, Foreman MG, Han MK, Hoffman EA, DeMeo DL, Barr RG, Van Beek EJ, Kazerooni EA, Wise RA, Brown RH, Black-Shinn J, Hokanson JE, Hanania NA, Make B, Silverman EK, Crapo JD, Dransfield MT Bhatt SP, Sieren JC, Dransfield MT, Washko GR, Newell JD, Jr., Stinson DA, Zamba GK, Hoffman EA, COPDGene Investigators (Curtis J). Racial differences in CT phenotypes in COPD. COPD 2013; 10:20-7. PMID: 23413893.

34. Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK, Hersh CP, Washko GR, Estepar RS, Lutz S, Friedman PJ, Han MK, Hokanson JE, Judy PF, Lynch DA, Make BJ, Marchetti N, Newell JD, Jr., Sciurba FC, Crapo JD, Silverman EK, COPDGene Investigators (Curtis JL). Paired inspiratory-


expiratory chest CT scans to assess for small airways disease in COPD. Respir Res 2013; 14:42. PMID: 23566024.

35. Kim SS, Seo JB, Lee HY, Nevrekar DV, Forssen AV, Crapo JD, Schroeder JD, Lynch DA, COPDGene Investigators (Curtis JL). Chronic obstructive pulmonary disease: lobe-based visual assessment of volumetric CT by using standard images--comparison with quantitative CT and pulmonary function test in the COPDGene study. Radiology 2013; 266:626-35. PMID: 23220894.

36. Couper D, Lavange LM, Han M, Barr RG, Bleecker E, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Rennard S, SPIROMICS Research Group (Curtis J). Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax 69:491-494, 2014. PMID: 24029743.

37. Bowler RP, Kim V, Regan E, Williams AA, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner GJ, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells JM, Hersh CP, MacIntyre N, Martinez F, Nath HP, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, van Beek EJ, Wilson C, Wendt C, Wise RA, COPDGene Investigators (Curtis J). Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest 146:941-50, 2014. PMID: 24945159. PMCID: PMC4188150.

38. Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek EJ, Silverman EK, Crapo JD, COPDGene Investigators (Curtis JL). Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med 14:164, 2014. PMID: 25341556. PMCID: PMC4216374.

39. Hobbs BD, Foreman MG, Bowler R, Jacobson F, Make BJ, Castaldi PJ, San Jose Estepar R, Silverman EK, Hersh CP, COPDGene Investigators (Curtis J). Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc 11:1387-94, 2014. PMID: 25295410. PMC4298989: PMC4298989.

40. Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med 2:214-25, 2014. PMID: 24621683. PMCID: PMC4176924.

41. Albert RK, Schuller JL, COPD Clinical Research Network Investigators (Curtis JL). Macrolide antibiotics and the risk of cardiac arrhythmias. Am J Respir Crit Care Med 189:1173-80, 2014. PMID: 24707986. PMCID: PMC4061901.

42. Lee JH, McDonald ML, Cho MH, Wan ES, Castaldi PJ, Hunninghake GM, Marchetti N, Lynch DA, Crapo JD, Lomas DA, Coxson HO, Bakke PS, Silverman EK, Hersh CP, COPDGene Investigators (Curtis JL). DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res 15:97, 2014. PMID: 25134640. PMCID: PMC4169636.

43. McDonald ML, Cho MH, Sorheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP, COPDGene Investigators (Curtis JL). Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 51:678-87, 2014. PMID: 24825563. PMCID: PMC4224086.


44. Kim V, Desai P, Newell JD, Make BJ, Washko GR, Silverman EK, Crapo JD, Bhatt SP, Criner GJ, COPDGene Investigators (Curtis JL). Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. Respir Res 15:84, 2014. PMID: 25248436. PMCID: PMC4198908.

45. Jaramillo JD, Wilson C, Stinson DJ, Lynch DA, Bowler RP, Lutz S, Bon JM, Arnold B, McDonald ML, Washko GR, Wan ES, DeMeo DL, Foreman MG, Soler X, Lindsay SE, Lane NE, Genant HK, Silverman EK, Hokanson JE, Make BJ, Crapo JD, Regan EA, COPDGene Investigators (Curtis J). Reduced bone density and vertebral fractures in smokers. Men and COPD patients at increased risk. Ann Am Thorac Soc 12:648-56, 2015. PMID: 25719895. PMC4418341: PMC4418341.

46. Lee JH, Cho MH, Hersh CP, McDonald ML, Wells JM, Dransfield MT, Bowler RP, Lynch DA, Lomas DA, Crapo JD, Silverman EK, COPDGene Investigators (Curtis J). IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 52:365-76, 2015. PMID: 25101718. PMC4370263: PMC4370263.

47. Kim V, Crapo J, Zhao H, Jones PW, Silverman EK, Comellas A, Make BJ, Criner GJ, COPDGene Investigators (Curtis JL). Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc 12:332-339, 2015. PMID: 25575351.

Peer-reviewed Articles Accepted for Publication 1. Beck JM, Schloss PD, Venkataraman A, Twigg H, III, Jablonski KA, Bushman FD,

Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, Huang L, Lynch SV, Morris A, Palmer BE, Schmidt TM, Sodergren E, Weinstock GM, Young VB, for the Lung HIV Microbiome Project. Multi-center comparison of lung and oral microbiomes of HIV-infected and HIV-uninfected individuals. Am J Respir Crit Care Med (in press). PMID: 26247840.

2. Hardin M, Foreman M, Dransfield MT, Hansel N, Han MK, Cho MH, Bhatt SP, Ramsdell J, Lynch D, Curtis JL, Silverman EK, Washko G, DeMeo D, For the COPDGene Investigators. Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J (in press). PMID: 26541532.

3. Martinez CH, Mannino DM, Jaimes FA, Curtis JL, Han MK, Hansel NN, Diaz AA. Undiagnosed obstructive lung disease in the U.S.: Associated factors, and long-term mortality. Ann Am Thorac Soc (in press). PMID: 26524488.

4. Curtis JL. At the checkpoint: lung CD8+ T cells, respiratory viruses and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (in press).

5. Martinez CH, Curtis JL. Implications of the GOLD COPD classification and guidelines, Fed Pract (in press).

6. McCubbrey AL, Nelson JD, Stolberg VR, Blakely PK, McCloskey L, Janssen WJ, Freeman CM, Curtis JL. miR-34a negatively regulates efferocytosis by tissue macrophages in part via SIRT1. J Immunol (in press).

Invited Review Articles 1. Curtis JL Punturieri A. Enhancing anti-tumor immunity peri-operatively: a matter of

timing, cooperation, and specificity. Am J Respir Cell Mol Biol 28: 541-545, 2003. PMID: 12707008. PMCID: PMC2640487.

2. Curtis JL. Cell-mediated adaptive immune defense of the lungs. Proc Am Thorac Soc 2: 412-416, 2005. PMID: 16322591. PMCID: PMC2259246.


3. Martinez FJ, Curtis JL. COPD update for the primary care physician. Prim Care Quarterly 1; 59-68, 2006.

4. Martinez FJ, Han M-LK, Flaherty K, Curtis JL. Role of infection and antimicrobial therapy in acute exacerbations of chronic obstructive pulmonary disease. Expert Rev Anti Infect Ther 4:101-124, 2006. PMID: 16441213.

5. Martinez FJ, Curtis JL. Acute exacerbations of COPD - I: definition and etiology. J COPD Management 1:4-10, 2006.

6. Martinez FJ, Curtis JL. Acute exacerbations of COPD - II: pathogenesis and treatment. J COPD Management 1:10-17, 2006.

7. Curtis JL, Freeman CM, Hogg JC. The immunopathogenesis of COPD: insights from recent research. Proc Am Thorac Soc 4:512-21, 2007. (Cover Article). PMID: 17878463. PMCID: PMC2365762.

8. Han M-LK, Postma D, Mannino D, Giardino ND, Buist S, Curtis JL, Martinez FJ. Gender and COPD: why it matters. Am J Respir Crit Care Med 176; 1179-1184, 2007. PMID: 17673696. PMCID: PMC2720110.

9. Martinez FJ, Curtis JL, Albert R. Role of macrolide therapy in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 3: 331-350, 2008. PMID: 18990961. PMCID: PMC2629987.

10. Han MLK, Agusti A. Calverley PM, Celli BR, Criner G, Curtis JL, Goldin JG, Jones P, MacNee W, Make BJ, Rabe K, Rennard SI, Sciurba FC, Silverman EK, Vestbo J, Washko GR, Wouters EFM, Martinez FJ. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med 182; 598-604, 2010. PMID: 20522794.

11. Han MK, Huang YJ, LiPuma JJ, Boushey H, Boucher R, Cookson WO, Curtis JL, Erb-Downward J, Lynch S, Sethi S, Toews GB, Young V, Wolfgang M, Huffnagle GB, Martinez FJ. Significance of the microbiome in obstructive lung disease. Thorax 67:456-63, 2012. PMID: 22318161. PMCID: PMC3578398.

12. McCubbrey AL, Curtis JL. Efferocytosis and lung disease. CHEST 143:1750-7, 2013. PMID: 23732585. PMCID: PMC3673667.

13. Twigg HL III, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G on behalf of the Lung HIV Microbiome Project. Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. Lancet Respir Med 2013; 1:354-6. PMID: 24429191.

14. Curtis JL, Martinez CH. Preventing COPD exacerbations: new options for a crucial and growing problem. Fed Pract 31:18S-24S, 2014. PMID: 25750508. PMC4350387: PMC4350387.

Editorials 1. Martinez FJ, Curtis JL. Procalcitonin-guided antibiotic therapy in COPD exacerbations:

closer but not quite there. CHEST 131: 1, 2007. PMID: 17218546. 2. Curtis JL, Freeman CM. Why do we need a non-human primate model of smoking-induced

COPD? Am J Pathol 185:610-613, 2015. PMID: 25576784. PMCID: PMC4348463.


3. Curtis JL. Queens beat One-Eyed Jacks, but nobody’s played the Ace yet: Adipokines as chronic obstructive pulmonary disease biomarkers. Ann Am Thorac Soc 12:971-973, 2015. PMID: 10925298. PMCID: PMC4513940.

4. Curtis JL, Freeman CM, Huffnagle GB. “B” for Bad, Beneficial, or Both? Lung lymphoid neogenesis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 192:648-51, 2015. PMID: 26371807. PMCID: PMC4595684.

Letters to the Editor 1. Pierce NF, Millan JC, Bender BS, Curtis JL. Disseminated Curvularia infection. Arch

Pathol Lab Med 110:871, 1986. PMID: 3767608 2. Curtis JL, Lampe GH, Stulbarg MS. Mediastinal mass and tracheal obstruction during

general anesthesia (comment). Mayo Clin Proc 64:475-476, 1989. PMID: 2716361. Non Peer-Reviewed Publications 1. Curtis JL, Warnock ML. New concepts in the pathogenesis of immune lung injury. Semin

Respir Med 12:158-176, 1991. 2. Curtis JL. Regulation of lung lymphocyte numbers by recruitment and apoptosis. in Talwar

GP, Indira N, Ganguly NK, Rao KVS eds. The 10th International Congress of Immunology; Monduzzi Editore, Bologna; 521-526, 1998.

Book Chapters 1. Curtis JL, Schuyler MR. Immunologically mediated lung disease. In: Baum GL, Wolinsky

E. (eds). Textbook of Pulmonary Medicine; fifth edition; 1993; Little Brown & Company, Boston p 689-744.

2. Curtis JL, Langmore S. Respiratory function in its relation to deglutition. In: Perlman A, Schultze-Delrieu K. (eds). Deglutition and its disorders: anatomy, physiology, clinical diagnosis and management; first edition; 1997; Singular Publishing Group, Inc. San Diego, CA p 99-123.

3. Curtis JL, Schuyler MR. Immunologically mediated lung disease. In: Baum GL, Crapo JD, Celli BR, Karlinsky JB (eds). Textbook of Pulmonary Diseases; sixth edition 1998; Little Brown & Company, Boston p 367-406.

4. Curtis JL, Toews GB. Rationale and experimental support for cytokine therapy of fungal pneumonias. In: Nelson S, Martin T (eds). Cytokines in Pulmonary Infectious Diseases: Infection and Inflammation; first edition 2000; Lung Biology in Health and Disease, Lenfant C. (series Ed); Marcel Dekker, Inc., New York p 253-292.

5. Curtis JL. Interleukin 4. In: Laurent GJ, Shapiro SD ed. Encyclopedia of Respiratory Medicine; first edition 2006; Elsevier Limited: Oxford, UK p 354-359.

6. Christensen PJ, Fields WB, Freeman CM, Curtis JL. Animal models of COPD - Current status of an evolving field. In: Wedzicha JA, Martinez FJ, eds. Chronic Obstructive Pulmonary Disease Exacerbations. Lung biology in health and disease, vol. 228 (Lenfant C, series editor). New York, NY. Informa Healthcare. 2009, pp. 169-189.

7. Martinez FJ, Han MK, Curtis JL. Design of trials for COPD exacerbations. In: Wedzicha JA, Martinez FJ, eds. Chronic Obstructive Pulmonary Disease Exacerbations. Lung biology in health and disease, vol. 228 (Lenfant C, series editor). New York, NY. Informa Health-care. 2009, pp. 387-405.

8. Martinez FJ, Curtis JL. Prevention of acute exacerbations of COPD. In: Cazzola M, Sethi S, Francesco Blasi F, Anzueto A, eds. Therapeutic Strategies: Acute Exacerbations in COPD. Oxford, UK. Clinical Publishing. 2009, pp. 179-205.


Books none Other Media 1. Curtis JL. Pulmonary complications of oral-pharyngeal motility disorders. In: Goyal and

Shaker’s GI Motility Online; Edited by Goyal, R K and Shaker, R. Nature Publishing Group: New York, 2006. doi:10.1038/gimo 33; http://www.nature.com/gimo/contents/pt1/full/gimo33.html

Abstracts 1. Curtis JL, Gross R. Medical consultation: preoperative assessment and postoperative

management of medical problems in elderly hip fracture patients. Presented to the Maryland chapter of the American College of Physicians, Baltimore, MD; October 6, 1979.

2. Curtis JL, Buchholz MA, Nordin AA. Mechanism of lipopolysaccharide enhancement of in vitro primary antibody response to DAGG-Ficoll. Fed Proc 1983; 42:415. Presented to the American Association of Immunologists/ FASEB, Chicago IL; April 11, 1983.

3. Curtis JL, Chrest FJ, Briefel GB, Krause ES, Adler WH. Natural killer cell number and function in ambulatory uremic humans. Clinical Res 3:341A, 1983.

4. Curtis JL, Byrd PK, Kaltreider HB. Kinetics of appearance of specific antibody-forming cells in lungs after intratracheal challenge of systemically sensitized and adoptively transferred mice. Am Rev Respir Dis 1984; 129:A6. Presented to the American Thoracic Society, Miami, FL; May 22, 1984.

5. Bender BS, Curtis JL, Chrest FJ, Krause ES, Briefel GB, Adler WH. Blood transfusions in hemodialyzed adults: effects on lymphocyte subpopulations defined by monoclonal antibodies. Presented to the IXth International Congress of Nephrology, Los Angeles, CA; June 12, 1984.

6. Bigby TD, Margolskee D, Curtis JL, Michael PF, Sheppard D, Hadley KL, Hopewell PC. The clinical utility of induced sputum in the diagnosis of pneumonia caused by Pneumocystis carinii in patients with the acquired immunodeficiency syndrome. Am Rev Respir Dis 1985; 131:A222. Presented to the American Thoracic Society, Anaheim, CA; May 14, 1985.

7. Bender BS, Curtis JL, Nagel JE, Briefel GB, Krause ES, Pyle RS, Adler WH. Serological evidence for chronic herpes virus infections in patients undergoing chronic hemodialysis. Clinical Res 1985; 33:769A. Presented to the Eastern Section of the American Federation for Clinical Research, Baltimore, MD; September 26, 1985.

8. Gross R, Curtis JL, Brooker A. Effects of coexisting medical illness on mortality of hip fracture repair. Clinical Res 1986; 34:819A. Presented to the American College of Physicians, Baltimore, MD; April 30, 1986.

9. Curtis JL, Arraj SM, Byrd PK, Kaltreider HB. Characterization of bronchoalveolar cells during a specific antibody-forming cell response to sheep erythrocytes in pulmonary parenchyma of inbred mice. Am Rev Respir Dis 1986; 113:A97. Presented to the American Thoracic Society, Kansas City, MO; May 12, 1986.

10. Curtis JL, Goodman P, Hopewell PC. Noninvasive testing in the diagnostic evaluation for P. carinii pneumonia in patients with or suspected of having the acquired immuno-deficiency syndrome. Am Rev Respir Dis 1986; 113:A182. Presented to the American Thoracic Society, Kansas City, MO; May 13, 1986. Presented to the Second International Conference on AIDS, Paris, France; June 24, 1986.

http://www.nature.com/gimo/contents/pt1/full/gimo33.html


11. Curtis JL, Michael FP, Byrd PK, Kaltreider HB. Upregulation of murine alveolar macrophage Ia expression during a pulmonary immune response in vivo. Am Rev Respir Dis 1987; 135: A103. Presented to the Western Society for Clinical Investigation, Carmel, CA May 12, 1987.

12. Curtis JL, Kaltreider HB. Bronchoalveolar and mediastinal lymphocyte subpopulations analyzed by flow cytometry during a pulmonary immune response in mice. Clinical Res 1987; 35:531A. Presented to the American Federation for Clinical Research, San Diego, CA; May 2, 1987.

13. Fuchs HJ, Curtis JL, McDowell J, Michael PF, Byrd PK, Shellito JE, Kaltreider HB. Use of allophycocyanin permits detection by flow cytometry of surface antigens present on few alveolar macrophages. Clinical Res 1988; 36:173A. Presented to the Western Society for Clinical Investigation, Carmel CA; February 17, 1988. Presented to the American Thoracic Society, Las Vegas, NV; May 9, 1988.

14. Geoffrey JS, Yednock TA, Curtis JL, Rosen SD. Evidence for a distinct lymphocyte homing specificity involved in lymphocyte migration to lung-associated lymph nodes. FASEB J 1988; 2:A667. Presented to the American Association of Immunologists, Las Vegas, NV; May 2, 1988.

15. Curtis JL, Geoffroy JS, Yednock TA, Arraj SM, Kaltreider HB, Rosen SD. Lymphocytes bind to high endothelial venules induced in mouse lungs during a specific pulmonary immune response. FASEB J 1988; 2:A1260. Presented to the American Association of Immunologists, Las Vegas, NV; May 4, 1988.

16. Geoffroy JS, Yednock, TA, Curtis JL, Rosen SD. Further evidence for a distinct lung-associated lymphocyte homing specificity. J Cell Biol 1988; 107:552A. Presented to the American Association of Cell Biology, San Francisco, CA; February 1, 1989.

17. Curtis JL, Warnock ML, Arraj SM, Kaltreider HB. Pulmonary arteriovenous changes during an immune response in the lungs of mice. FASEB J 1989; 3:A1228. Presented to the American Association of Pathologists, New Orleans, LA; March 23, 1989.

18. Curtis JL, Byrd PK, Warnock ML, Kaltreider HB. Requirement for CD4+ T cells for inflammatory cell recruitment in response to intratracheal antigen in mice. Clinical Res 1990; 38: 438A. Presented to the American Federation for Clinical Research, Washington, D.C.; May 6, 1990.

19. Beck JL, Sniezek MJ, Arraj-Peffer SM, Curtis JL, Shellito JE. Cellular responses to Pneumocystis carinii pneumonia in a murine model. Am Rev Respir Dis 1990; 141:A530. Presented to the World Congress on Lung Health, Boston, MA; May 22, 1990.

20. Curtis JL, Byrd PK, Warnock ML, Beck JM, Kaltreider HB. Depletion of CD8+ T cells in mice does not impair cellular recruitment to the lungs in response to intratracheal antigen, but prolongs pulmonary arterial injury. Clinical Res 1991; 39:217A. Presented to the American Federation for Clinical Research, Seattle, WA; May 4, 1991.

21. Chen G-H, Gyetko MR, Curtis JL, Christensen PJ, Armstrong LR, Toews GB. Recombinant macrophage colony-stimulating factor activates rat alveolar macrophages to inhibit Cryptococcus neoformans in vitro. Clinical Res 1991; 39:704A. Presented to the Central Society for Clinical Research, Chicago, IL; November 6, 1991.

22. Chen G-H, Christensen PJ, Armstrong LR, Gyetko MR, Curtis JL, Toews GB. Characterization of Cryptococcus neoformans-specific MHC-restricted T cell lines. Clinical Res 1991; 39: 751A. Presented to the Central Society for Clinical Research, Chicago, IL; November 8, 1991.

23. Gyetko M, Curtis J, Chen G-H, Wilkinson CC, Toews GB. Pulmonary cryptococcal infection: a role for gamma-delta T cells. Clinical Res 1992; 40:327A. Presented to the American Federation for Clinical Research, Baltimore, MD; May 3, 1992.


24. Curtis JL, Chen G-H, Warnock ML, McDonald RA, Kim S, Gyetko MR, Toews GB. Experimental pulmonary cryptococcosis: differences in pulmonary inflammation and lymphocyte recruitment induced by two strains of C. neoformans. Am Rev Respir Dis 145:A547, 1992. Presented to the American Thoracic Society, Miami, FL; May 19, 1992.

25. Kim S, Scott PJ, Doyle PD, Curtis JL. Preferential accumulation of murine memory CD4+ T cells in alveoli and of virgin CD4+ T cells in paratracheal nodes in response to intratracheal sheep red blood cells. Am Rev Respir Dis 145:A487, 1992. Presented to the American Thoracic Society, Miami, FL; May 19, 1992.

26. Kim S, Scott PJ, Curtis JL. CD4+ T cell subsets in pulmonary lymphocyte recruitment. CHEST 1993; 103:94S. Presented to the 35th Annual Thomas Petty Lung Conference, Aspen, CO, June 4, 1992.

27. Kim S, Scott PJ, Curtis JL. Analysis of the role of CD4+ T cell subsets in pulmonary lymphocyte recruitment by use of adoptive transfer to athymic mice. Clinical Res 1992;40:743A. Presented to the Central Society for Clinical Research, Chicago, IL; November 6, 1992.

28. Kim S, Scott PJ, Curtis JL. Development of an adoptive transfer model to define the role of CD4+ T cell subsets in pulmonary lymphocyte recruitment. Am Rev Respir Dis 147: A12, 1993. Presented to the American Thoracic Society, San Francisco, CA; May 16, 1993.

29. Raslan MH, Kim S, Fields KL, Stoolman LM, Curtis JL. Expression of endothelial cell adhesion molecules in the lungs during a murine pulmonary immune response. Clinical Res 1993; 41:774A. Presented to the Southern Society for Clinical Investigation, New Orleans, LA; February 5, 1994.

30. Seitzman GD, Scott PJ, Milik AM, Kim S, Curtis JL. Mouse lung lymphocytes proliferate minimally during the pulmonary response to sheep erythrocytes. Clinical Res 1993; 41:774A. Presented to the Southern Society for Clinical Investigation, New Orleans, LA; February 5, 1994.

31. Kim S, Huffnagle GB, Toews GB, McDonald RA, Curtis JL. Experimental pulmonary cryptococcosis: activated CD4+ T cell predominate in both protective and non-protective pulmonary immune responses. Clinical Res 1993; 41:774A. Presented to the Southern Society for Clinical Investigation, New Orleans, LA; February 5, 1994. Presented to the American Thoracic Society, Boston, MA; May 22, 1994.

32. Curtis JL, Seitzman GD, Milik AM, Kim S, Beals TF, Scott PJ. Recruitment and apoptosis, not local proliferation, determine lung lymphocyte numbers in the murine response to sheep erythrocytes. J Cell Biochem 1994: supplement 18D: 414. Presented at the Keystone Conference on Cellular and Molecular Immunology, Keystone, CO; April 14, 1994.

33. Kim S, Raslan MH, Fields KL, Stoolman LM, Curtis JL. Expression of endothelial cell adhesion molecules in the lungs during a murine pulmonary immune response. Am J Respir Crit Care Med 149: A12. Presented to the American Thoracic Society, Boston, MA; May 22,1994.

34. Milik AM, Kim S, Sonstein J, Curtis JL. Determination of lung T cell cytokine levels by polymerase chain reaction during the murine response to intratracheal sheep erythrocytes. Clinical Res 1994; 42 397A. Presented to the Central Society for Clinical Research, Chicago, IL; September 17, 1994. Am J Respir Crit Care Med 1995; 151:A451. Presented at the Annual Scientific Session of the American Thoracic Society, Seattle, WA; May 23, 1995.

35. Buechner-Maxwell VA, Milik AM, Sonstein J, Seitzman GD, Beals TF, Curtis JL. Apoptosis contributes to lung lymphocyte elimination in the murine response to sheep


erythrocytes. Am J Respir Crit Care Med 1995; 151:A232. Presented at the Annual Scientific Session of the American Thoracic Society, Seattle, WA; May 23, 1995. Presented to the Ninth International Congress on Immunology, San Francisco, CA; July 1995.

36. Wolber FM, Curtis JL, Kim S, Sonstein J, Fields KL, Stoolman LM. Kinetics and distribution of pulmonary endothelial cell adhesion molecule expression during the murine immune response to intratracheal sheep erythrocytes. Presented to the Ninth International Congress on Immunology, San Francisco, CA; July 27, 1995.

37. Greenberger MJ, Kazerooni R, Gross B, Hampton J, Spizarny D, Popovich J, Hyzy R, Major M, Curtis J, Flint A, Whyte R, Toews GB, Lynch J III, Martinez FJ. High resolution CT (HRCT) correlates with pathologic scoring system in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1996; 153:A449. Presented at the Annual Scientific Session of the American Thoracic Society, New Orleans, LA; May 12, 1996.

38. Gay SE, Christensen P, Curtis JL, Paine R, Bria W, Watts C, Kazerooni E, Whyte R, Martinez FJ. Functional improvement after lung volume reduction surgery (LVRS) is independent of spirometric changes. Am J Respir Crit Care Med 1996; 153:A150; Presented at the Annual Scientific Session of the American Thoracic Society, New Orleans, LA; May 13, 1996.

39. Wolber FM, Milik AM, Curtis JL, Lowe J, Smith P, Stoolman LM. P- and E-selectin mediate lymphocyte recruitment in murine pulmonary inflammation. J Invest Med 1996; 44: A380. Presented to the American Association of Immunology/Experimental Biology Meeting, New Orleans, LA; June 5, 1996.

40. Wolber FM, Stoolman LM, Curtis JL. Alpha4 integrin partially mediates CD8+ T cell recruitment to the lungs in response to particulate antigen. Presented to the Central Society for Clinical Investigation, Chicago, IL; September 20, 1996.

41. Martinez FJ, Whyte RI, Gay SE, Christensen PJ, Paine R, Curtis JL, Mulligan M, Weg JG, Ojo TC, Bria WF, Watts CF, Kazerooni EA. Bilateral lung volume reduction surgery (LVRS): mechanisms of improvement in dyspnea. Presented to the American College of Chest Physicians, San Francisco, CA; September 1996.

42. Bailey TM, Gay SE, Lownebergh N, Lewis P, Ojo TC, Christensen PJ, Curtis JL, Paine R, Bria WF, Weg JG, Watts CF, Quint LE, Kazerooni EA, Whyte RI, Martinez FJ. Lung volume reduction surgery (LVRS): implications on cost of care for severe chronic airflow obstruction (CAO). Presented to the American College of Chest Physicians, San Francisco, CA; September 1996.

43. Ojo TC, Gay SE, Martinez FJ, Lownebergh N, Lewis P, Christensen PJ, Curtis JL, Paine R, Bria WF, Weg JG, Watts CF, Quint LE, Kazerooni EA, Whyte RI. Management of solitary pulmonary nodules incidentally discovered during evaluation for lung volume reduction surgery (LVRS). Presented to the American College of Chest Physicians, San Francisco, CA; September 1996.

44. Curtis JL, Sonstein J, Milik AM, Wolber FM, Polak TJ, Seitzman GD. IL-10 down-regulates murine lung inflammation to intratracheal particulate antigen by decreasing T cell recruitment and cytokine production. Presented to the American Thoracic Society, San Francisco, CA; May 1997.

45. Gay S, Christensen P, Paine R, Weg J, Watts C, Bria W, True M, Foss K, Lewis P, Curtis J, Christensen P, Roth D, Curtis J, Paine R, Weg J, Watts C, Bria W, Kazerooni E, Gay S, Clark-Ojo T, Whyte R, Martinez F. Weight gain after LVRS is not correlated with improvements in pulmonary mechanics. Am J Respir Crit Care Med 1997;155: A604. Presented to the American Thoracic Society, San Francisco, CA; May 1997.


46. Martinez F, Gay S, Christensen P, Paine R, Weg J, Watts C, Bria W, Kazerooni E, True M, Foss K, Lewis P, Curtis J. Determination of dyspnea during exercise in severe chronic airflow obstruction (CAO). Presented to the American Thoracic Society, San Francisco, CA; May 1997.

47. Martinez F, Whyte R, Gay S, Christensen P, Paine R, Weg J, Watts C, Bria W, Kazerooni E, True M, Foss K, Lewis P, Curtis J. Dyspnea relief after bilateral lung volume reduction surgery (LVRS) correlates best with improved exertional hyperinflation and expiratory pleural pressure. Am J Respir Crit Care Med 1997;155: A604. Presented to the American Thoracic Society, San Francisco, CA; May 1997.

48. Bailey TM, Martinez FJ, Lowenbergh N, Lewis P, Christensen P, Curtis J, Paine R, Bria W, Weg J, Watts C, Kazerooni E, Whyte R. Lung volume reduction surgery (LVRS): short and long term cost effectiveness of patients with chronic airflow obstruction (CAO). Am J Respir Crit Care Med 1997;155: A604. Presented to the American Thoracic Society, San Francisco, CA; May 1997.

49. Martinez F, Whyte R, Gay S, Christensen P, Paine R, Weg J, Watts C, Bria W, Kazerooni E, True M, Foss K, Lewis P, Curtis J. Expiratory limitation during exercise persists after lung volume reduction (LVRS). Am J Respir Crit Care Med 1997;155: A911. Presented to the American Thoracic Society, San Francisco, CA; May 1997.

50. Kazerooni EA, Christensen PJ, Martinez FJ, Paine R III, Curtis JL, Iannettoni MD. Optimum quantitative helical CT attenuation threshold for emphysema. Radiology 1997; 205: 353-353 Suppl. S. Presented to the Radiological Society of North American, Chicago, IL; April 1997.

51. Martinez F, Bach D, Curtis JL, Christensen P, Lewis P, Iannettoni M, Whyte R, Bria W, Ojo-Clark T, Weg J. Preoperative dobutamine echocardiography in patients evaluated for LVRS. Presented to the American Thoracic Society, Chicago, IL; April 1998.

52. Zisman D, Curtis J, Kazerooni E, Christensen P, Iannettoni M, Whyte R, Bria W, Ojo-Clark T, Weg J, Martinez F. Emphysema heterogeneity and hyperinflation predict improvement after bilateral lung volume reduction surgery. Presented to the American Thoracic Society, Chicago, IL; April 1998.

53. Kazerooni EA, Curtis JL, Paine R III, Iannettoni, MD, Lewis P, Martinez FJ. Long-term outcome after bilateral apical lung volume reduction surgery (LVRS) via median sternotomy: predictive value of quantitative helical CT analysis (QCT) and physiologic severity of hyperinflation. Presented to the Radiology Society of North America Chicago, IL; April 1998.

54. Todt J, Sonstein J, Polak T, Hu B, Seitzman GD, Curtis JL. Changes in cytokine mRNA levels in lungs of mice exposed to repeated intratracheal antigen challenge. Presented to American Thoracic Society, San Diego, CA; April 1999.

55. Hu B, Sonstein J, Curtis JL. Murine alveolar & peritoneal macrophages differ in phagocytosis of apoptotic lymphocytes. Presented to the Midwest Autumn Immunology Meeting, Chicago, IL; November 20, 1999.

56. Flaherty K, Kazerooni E, Christensen P, Paine R, Curtis J, Bria W, Iannettoni M, Martinez F. Failure of quantitative emphysema define by HRCT to correlate with bronchorevers-ibility. CHEST 1999; 116:276S. Presented to the American College of Chest Physicians.

57. Curtis JL, Sonstein J, Craig RA, Todt J, Knibbs RN, Polak T, Stoolman LM. Altered lung lymphocyte accumulation in mice lacking endothelial selectins. Presented to the Midwest Autumn Immunology Meeting, Chicago, IL; November 20, 1999.

58. Hu B, Sonstein J, Curtis JL. Deficient phagocytosis of apoptotic T cells by murine alveolar macrophages. Presented to the American Thoracic Society, Toronto, Ottawa; May 10, 2000.


59. Beck JM, Preston AM, Siu BB, Curtis JL. Cytotoxic CD8+ T cells in host defense against Pneumocystis carinii. Am J Respir Crit Care Med 161:A510, 2000. Presented to the American Thoracic Society, Toronto, Ottawa; May 10, 2000.

60. Curtis JL, Sonstein J, Craig RA, Todt J, Knibbs RN, Polak T, Stoolman LM. Altered lung lymphocyte recruitment in mice lacking endothelial selectins is subset specific. Presented to the American Association of Immunologists, Seattle, WA; May 15, 2000.

61. Martinez FJ, Flaherty KR, Kazerooni EA, Curtis JL, Paine R III, Iannettoni MD. Four year follow-up after bilateral lung volume reduction surgery. Presented to the World Congress on Lung Health and the 10th annual congress of the European Respiratory Society, Florence, Italy; August 2000.

62. Hu B, Punturieri A, Todt J, Sonstein J, Polak T, Curtis JL. Multi-step signal transduction during phagocytosis of apoptotic T cells by resident murine macrophages. Am J Respir Crit Care Med 161: A246, 2001. Presented at the Autumn Immunology Meeting, Chicago, IL; November 19, 2000. Presented to the American Thoracic Society, San Francisco, CA; May 20, 2001.

63. Hu B, Sonstein J, Polak T, Curtis JL. Adhesion of apoptotic T cells to murine alveolar and peritoneal macrophages. Am J Respir Crit Care Med 161: A187, 2001. Presented at the Autumn Immunology Meeting, Chicago, IL; November 19, 2000. Presented to the American Thoracic Society, San Francisco, CA; May 20, 2001.

64. Punturieri A, Clift R, Curtis JL. Cloning and characterization of a new chitinase selectively expressed by murine resident alveolar macrophages. Presented to the American Thoracic Society, San Francisco, CA; May 21, 2001.

65. Gyetko MR, Sud S, Sonstein J, Curtis JL. Antigen-driven T-cell recruitment to the lung is diminished in the absence of uPA receptor but is independent of uPA. Presented to the American Thoracic Society, San Francisco, CA; May 22, 2001.

66. Hu B, Todt JC, Sonstein J, Polak T, Curtis JL. Mer mediates recognition but not adhesion of apoptotic cells by resident murine tissue macrophages. Presented to the American Association of Immunologists at Experimental Biology 2002, New Orleans, LA; April 2002.

67. Todt JC, Curtis JL. Role of PKC bII in the phagocytosis of apoptotic thymocytes by mouse macrophages. Presented at the Autumn Immunology meeting, Chicago, IL; November 2001; and to the International Scientific Conference of the American Thoracic Society, Atlanta, GA; May 2002.

68. Punturieri A, Polak T, Sonstein J, Curtis JL. The response of murine alveolar macrophages to bacterial products relies primarily on TLR2 stimulation. Presented at the Autumn Immunology meeting, Chicago, IL; November 2001; and to the International Scientific Conference of the American Thoracic Society, Atlanta, GA; May 2002.

69. Jennings JH, Hu B, Sonstein J, Polak T, Curtis JL. Resident human alveolar macrophages bind and ingest apoptotic cell poorly relative to other phagocytic targets. Am J Respir Crit Care Med 2002; 165: A658. Presented to the International Scientific Conference of the American Thoracic Society, Atlanta, GA; May 2002.

70. Todt JC, Hu B, Curtis JL. Role of PLC gamma2 in the phagocytosis of apoptotic cells by mouse macrophages. Presented to the Autumn Immunology meeting, Chicago, IL, November 25, 2002; and at the Keystone Conference “Regulatory & effector functions of macrophages”, Taos, NM, February 2, 2003.

71. Punturieri A, Polak T, Sonstein J, Curtis JL. Resident murine alveolar macrophages are activated to produce TNF-alpha by Gram-negative bacterial lipoprotein and soluble CD14 enhances their response. Am J Respir Crit Care Med 2003; 167:A479. Presented to the Autumn Immunology meeting, Chicago, IL, November 24, 2002. Presented at the


International Scientific Conference of the American Thoracic Society; Seattle, WA, May 19, 2003.

72. Christensen PJ, Punturieri A, Sonstein J, Polak T, Du M, Ling A, Curtis JL. Character-ization of pulmonary inflammation in mice in response to cigarette smoke exposure. Am J Respir Crit Care Med 2003; 167:A25. Presented at the International Scientific Conference of the American Thoracic Society; Seattle, WA, May 18, 2003.

73. Jennings JH, Hu B, Sonstein J, Curtis JL. Murine monocytes recruited to the lungs during antigen-induced inflammation play a minor role in apoptotic cell clearance. Am J Respir Crit Care Med 2003; 167:A491. Presented at the International Scientific Conference of the American Thoracic Society; Seattle, WA, May 19, 2003.

74. Todt JC, Hu B, Curtis JL. Phospholipase C gamma2 occupies a central signaling role during phagocytosis of apoptotic cells by mouse macrophages. Am J Respir Crit Care Med 2003; 167:A299. Presented at the International Scientific Conference of the American Thoracic Society; Seattle, WA, May 19, 2003.

75. Osterholzer JJ, Sonstein J, Curtis JL. Immature murine dendritic cells are recruited from the blood during the response to particulate antigen-induced lung inflammation. Am J Respir Crit Care Med 2003; 167:A592. Presented at the International Scientific Conference of the American Thoracic Society; Seattle, WA, May 20, 2003.

76. Canetti CA, Hu B, Curtis JL, Peters-Golden M. Macrophage activation of Syk is a leukotriene B4-regulated target in Fc gamma receptor- but not phosphatidylserine receptor-mediated phagocytosis. Am J Respir Crit Care Med 2003; 167:A644. Presented at the International Scientific Conference of the American Thoracic Society; Seattle, WA, May 20, 2003.

77. Christensen PJ, Du M, Sonstein J, Curtis JL. Physiologic changes in response to cigarette smoke exposure in mice. Am J Respir Crit Care Med 2003; 167:A486. Presented at the International Scientific Conference of the American Thoracic Society; Seattle, WA, May 20, 2003.

78. Hu B, Jennings JH, Todt JC, Sonstein J, Polak T, Punturieri A, Curtis JL. The receptor tyrosine kinases MerTK and Axl both contribute to apoptotic cell ingestion by resident murine alveolar macrophages. Presented at the Experimental Biology 2004; Washington, D.C; April 2004.

79. Punturieri A, Alviani RS, Polak R, Copper P, Curtis JL. Murine alveolar macrophages do not phosphorylate STAT-1 in response to viral or bacterial molecular patterns. Am J Respir Crit Care Med 2004; 169:A75. Presented at the International Scientific Conference of the American Thoracic Society; Orlando FL; May 23, 2004.

80. Linderman, DJ, Sonstein J, Polak T, Curtis JL. Leukocyte integrins and endothelial selectins in recruitment of murine CD8 T cells to the lungs. Am J Respir Crit Care Med 2004; 169:A83. Presented at the International Scientific Conference of the American Thoracic Society; Orlando FL; May 23. 2004.

81. Punturieri A, Christensen PJ, Ling A, Allen T, Alviani RS, Hu B, Curtis JL. Chronic tobacco-smoke exposure impairs innate immune responses of murine alveolar macrophages. Am J Respir Crit Care Med 2004; 169:273. Presented at the International Scientific Conference of the American Thoracic Society; Orlando FL; May 24. 2004.

82. Jennings JH, Linderman DJ, Hu B, Curtis JL. Monocytes recruited to the alveoli during immune inflammation in mice lack MerTK and ingest apoptotic cells poorly. Am J Respir Crit Care Med 2004; 169:A502. Presented at the International Scientific Conference of the American Thoracic Society; Orlando FL; May 25. 2004.

83. Gay SE, Kazerooni EA, Cheng D, Flaherty KR, Mumford JA, Murray S, Curtis JL, Lama VN, Christensen PJ, Martinez FJ. The predictive value of exercise induced desaturation


on mortality in patients with severe COPD. Am J Respir Crit Care Med 2004;169:A773. Presented at the International Scientific Conference of the American Thoracic Society; Orlando FL; May 26, 2004.

84. Hu B, Polak T, Todt JC, Curtis JL. Activation of the apoptotic cell receptor MerTK does not impair macrophage signaling distal to TLR4. Proc Am Thorac Soc 2005;2:A903. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 25, 2005.

85. Punturieri A, Cooper P, Polak T, Sonstein J, Curtis JL. IFN-b & non-typeable Haemophilus-derived TLR2 agonists increase TNF-alpha production by macrophages by a novel STAT1-dependent mechanism. Proc Am Thor Soc 2006; 3: A623. Presented at the Keystone Symposium on Innate Immunity; Banff, Alberta, CA; February 11, 2006; and at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 23, 2006.

86. Freeman CM, Curtis JL, Chensue SW. CCR5 and CXCR6 expression on lung T cells correlates with COPD severity. Presented at the American Society for Investigative Pathology Meeting; San Francisco, Ca; April 2006.

87. Martinez FJ, Andrei A, Beniditt J, Naunheim K, Criner G, Make B, Murray S, Fishman A, Gay S, Flaherty K, Curtis J, Sciurba F, Celli B and the NETT Research Group. Change in modified BODE (mBODE) in severe emphysema patients treated medically or with lung volume reduction surgery (LVRS). Proc Am Thorac Soc 2006; 3: A119. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 21, 2006.

88. Osterholzer JJ, Curtis JL, Huffnagle GB, Toews GB. CCR2 mediates the accumulation of murine myeloid and plasmacytoid dendritic cells in response to pulmonary infection with Cryptococcus neoformans. Proc Am Thor Soc 2006; 3:A346. Presented at the Inter-national Scientific Conference of the American Thoracic Society; San Diego, CA; May 22, 2006.

89. Olszewski MA, Montano GT, Surana R, Osterholzer JJ, Sonstein J, Curtis JL, Huffnagle GB, Toews GB. Altered dendritic cell maturation and shift to a non-protective T2 immune response is a mechanism for C. neoformans virulence in the lungs. Proc Am Thor Soc 2006; 3:A468. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 22, 2006.

90. Olszewski MA, McNamar DA, Montano GT, Djergovic D, Tsai WC, Hansen EJ, Brock TG, Curtis JL, Toews GB. The effect of tobacco smoke-exposure on nontypeable Haemophilus influenzae challenge in a murine COPD model. Proc Am Thor Soc 2006; 3:A621. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 23, 2006.

91. Phipps J, Curtis JL, Christensen PJ, Aronoff D, Mancuso P. Regular and low-tar cigarette smoke exposure attenuates murine pulmonary host defense against Streptococcus pneumoniae. Proc Am Thor Soc 2006; 3:A806. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 24, 2006.

92. Han MK, Flaherty K, Curtis J, Saint S, Gay S, Martinez FJ. Systematic review of antibiotic therapy and Haemophilus influenzae eradication in acute exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006; 3: A841. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 24, 2006.

93. Martinez FJ, Mumford J, Murray S, Weinmann G, Curtis J, Hoffman E, Criner G, Robinswood B, Mohsenifar Z, Giardino N, Ries A, Kaplan R, Make B, Sciurba F and the NETT Research Group. Severe emphysema is associated with greater depression in


women than men at a younger age. Proc Am Thorac Soc 2006; 3: A846. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA; May 24, 2006.

94. Martinez FJ, Andrei A, Gay S, Curtis JL, Benditt J, Naunheim K, Criner G, Make B, Wise R, Murray S, Fishman A, Flaherty K, Sciurba F, Celli B. Short term change in modified BODE (mBODE) in severe emphysema patients predicts mortality after lung volume reduction surgery (LVRS). Presented at the European Respiratory Society Meeting; Munich, Germany; September 2006.

95. Giardino N, Curtis JL, Andrei A, Gay S, Benditt J, Naunheim K, Criner G, Make B, Wise R, Murray S, Fishman A, Flaherty K, Sciurba F, Celli B, Martinez FJ. Baseline anxiety independently predicts functional limitation and reduced health status in severe emphysema. Presented at the European Respiratory Society Meeting; Munich, Germany; September 2006.

96. Curtis JL, Linderman DJ, Sonstein J, Polak T, Hu B, Todt JC, Stolberg VR, Chensue SW. CCR6 is required for optimal recruitment of B lymphoblasts to the murine lung in response to particulate intratracheal antigen. Presented at the European Respiratory Society Meeting; Munich, Germany; September 2006.

97. Giardino ND, Abelson J, Liberzon I, Curtis JL, Benditt J, Criner G, Make B, Wise R, Fishman A, Sciurba F, Martinez FJ. Cognitive mediators of the association between anxiety and impaired exercise performance in COPD. Paper presentation, Psychiatric Research Society annual meeting, Park City, UT. February 2007.

98. Todt JC, Curtis JL. Scavenger Receptor A signals via the receptor tyrosine kinase MerTK in murine macrophages exposed to apoptotic thymocytes. Proc Am Thorac Soc 2007; 4:A182. Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.

99. Fields WB, Preston A, Pitzer J, Du M, Beck JM, Curtis JL, Weinberg JB, Christensen PJ. The effects of cigarette-smoke exposure in a murine model of Adenoviral infection. Proc Am Thorac Soc 2007; 4: . Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.

100. Giardino ND, Curtis JL, Fan V, Naunheim K, G Criner G, Make B, Wise R, Fishman A, Gay G, Weinmann G, Reilly J, Washko G, Sciurba F, Scharf S, Martinez FJ for NETT Research Group. Maladaptive beliefs mediate of the association between anxiety and impaired exercise performance in severe COPD. Proc Am Thorac Soc 2007; 4:A548. Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.

101. Freeman CM, Curtis JL, Chensue SW. CCR5, CXCR3, and CXCR6 expression on lung CD8+ T cells and corresponding chemokine production by dendritic cells correlates with COPD severity. Proc Am Thorac Soc 2007; 4:A646. Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.

102. Martinez FJ, Andrei A, Curtis JL, Benditt J, Naunheim K, G Criner G, Make B, Wise R, Murray S, Fishman A, Gay G, Weinmann G, Reilly J, Sciurba F, Celli B for NETT Research Group. The BODE as a potential outcome marker in therapeutic trials in COPD. Proc Am Thorac Soc 2007; 4:A617. Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.

103. Martinez FJ, Andrei A, Curtis JL, Benditt J, Naunheim K, G Criner G, Make B, Wise R, Murray S, Fishman A, Gay G, Weinmann G, Reilly J, Sciurba F, Celli B for NETT Research Group. The BODE predicts quality of life in severe emphysema patients. Proc Am Thorac Soc 2007; 4:A617. Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.


104. Olszewski MA, Surana R, Choe MY, Sonstein J, Curtis JL, Huffnagle GB, Toews GB. Cryptococcal urease induces a non-protective type 2 murine immune response via changes in lymphoid DC but not plasmacytoid DC. Proc Am Thorac Soc 2007; 4:A923. Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.

105. Choe MY, Montano GT, McNamara DA, Sonstein J, Curtis JL, and Olszewski MA. Alveolar macrophages in a murine model of S. aureus bronchopneumonia: resident or recruited cells? Proc Am Thorac Soc 2007; 4:A675. Presented at the International Scientific Conference of the American Thoracic Society; San Francisco, CA; May, 2007.

106. Giardino ND, Chan L, Borson S, Curtis JL, Martinez FJ, Liberzon I. Dyspnea-related anxiety versus dyspnea intensity during exercise in patients with COPD. Poster discussion presentation, European Respiratory Society Annual Congress; Stockholm, Sweden; September 2007.

107. Giardino N.D, Chan L, Borson S, Curtis JL, Martinez FJ, Liberzon I. Factors associated with seeking care for COPD: a qualitative analysis. Poster discussion presentation, European Respiratory Society Annual Congress; Stockholm, Sweden; September 2007.

108. Giardino ND, Curtis JL, Martinez FJ. Heart rate variability biofeedback for panic disorder with COPD: preliminary data. Paper presentation, International Society for the Advancement of Respiratory Psychophysiology annual meeting, Bristol, UK; October 2007.

109. Osterholzer JJ, Curtis JL, Huffnagel GB, Toews GB. CCR2-mediated recruitment of inflammatory lung dendritic cells promotes in situ T1 immune responses. Am J Respir Crit Care Med 2008; 177:A84. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 19, 2008.

110. Todt JC, Freeman CM, Ames T, Christensen PJ, Martinez FJ, Curtis JL. Human alveolar macrophages produce IL-23p19 in response to stimulation of several Toll-like receptors. Am J Respir Crit Care Med 2008; 177:A357. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 19, 2008.

111. Han MK, Bartholmai B, Curtis JL, Limper A, Sciurba FC, Bon JM, Robb RA, Karwoski RA, Frederick M, Thompson B, Li D, Flaherty KR, Schwarz MI, Martinez FJ. Emphysema percent predicts quality of life and symptoms in COPD: An analysis of Lung Tissue Research Consortium patients. Am J Respir Crit Care Med 2008; 177:A520. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 20, 2008.

112. Bartholmai BJ, Han M-LK, Curtis JL, Robb RA, Karwoski RA, Sciurba FC, Frederick M, Thompson BW, Li, Limper AH, Martinez, FJ. Correlation of visual and quantitative CT measures of disease with physiologic parameters in the Lung Tissue Research Consortium (LTRC) Database of COPD subjects. Am J Respir Crit Care Med 2008; 177:A661. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 20, 2008.

113. Bartholmai BJ, Martinez, FJ, Han M-LK, Curtis JL, Robb RA, Karwoski RA, Sciurba FC, Frederick M, Thompson BW, Li, Limper AH. Correlation of radiologist visual assessment of COPD features with quantitative measures of disease on volumetric high-resolution CT of the chest. A Lung Tissue Research Consortium (LTRC) Study. Am J Respir Crit Care Med 2008; 177:A751. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 20, 2008.

114. Han MK, Curtis JL, Gay SE, Flaherty KR, Kazerooni EA, Martinez FJ. Desaturation area predicts pulmonary artery systolic pressure in patients with emphysema. Am J Respir


Crit Care Med 2008; 177:A780. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 20. 2008.

115. Fields WB, Du M, Preston AM, Todd B, Beck KM, Curtis JL, Weinberg JB, Christensen PJ. Cigarette smoke exposure in a murine model of Adenoviral infection. Am J Respir Crit Care Med 2008; 177:A865. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 21, 2008.

116. Freeman CM, Martinez FJ, Chensue SW, Murphy HS, Arenberg DA, Sonstein J, Meldrum C, Thompson DL, Curtis JL. Lung CD8+ T cell expression of IL-18R and CD69 increases with COPD severity. Am J Respir Crit Care Med 2008; 177:A878. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 21, 2008.

117. Freeman CM, Martinez FJ, Chensue SW, Murphy SW, Arenberg DA, Sonstein J, Meldrum C, Thompson DL, Curtis JL. COPD severity correlates with an increased percentage of dendritic cells expressing CD80 and CD83. Am J Respir Crit Care Med 2008; 177:A960. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 21. 2008.

118. Freeman CM, Martinez FJ, Arenberg DA, Chensue SW, Murphy HS, Meldrum C, Han M-LK Flaherty K, Frederick M, Thompson B, Curtis JL. Lung IL-15 production in COPD correlates with measures of disease severity: a study using LTRC resources. Am J Respir Crit Care Med 2008; 177:A961. Presented at the International Scientific Conference of the American Thoracic Society; Toronto, ON, May 21. 2008.

119. Osterholzer JJ, Chen G-H, Curtis JL, Olszewski MA, Huffnagle GB, Toews GB. CCR2-mediated recruitment of inflammatory lung dendritic cells is associated with protective T1 immune responses against Cryptococcus neoformans. Presented at the 7th International Conference on Cryptococcus and Cryptococcosis, Nagasaki, Japan, September 11-14, 2008.

120. Han MK, Bartholmai B, Murray S, Curtis JL, Limper A, Sciurba F, Robb R, Karowski R, Frederick M, Thompson B, Li D, Flaherty KR, Schwarz MI, Martinez FJ. Quantified radiographic measures predict cough and self-reported acute exacerbation frequency in COPD. Am J Respir Crit Care Med 2009; 179: A6213

121. Freeman CM, Martinez FJ, Polak T, Han MK, Chensue SW, Murphy HS, Arenberg DA, Meldrum C, Getty C, Curtis JL. Engagement of TLR3 on CD8+ T Cells from COPD Patients Increases In Vitro Production of IFNγ, TNFα, and Perforin. Am J Respir Crit Care Med 2009; 179: A3950.

122. Todt JC, Punturieri A, Ames T, Polak T, Freeman CM, Curtis JL. IFN-beta Enhances the Response of Human Alveolar Macrophages to the TLR4 Agonist Lipopolysaccharide (LPS) Via TLR4 Up-Regulation and PKR-Dependent Chemokine Induction. Am J Respir Crit Care Med 2009; 179: A5738.

123. Osterholzer JJ, Chen G, Batchelor N, Olszewski M, Curtis JL. Accumulation of Inflammatory Lung Dendritic Cells Results from the CCR2-Mediated Recruitment of Ly6C-high/CD11b+ Monocytes Am J Respir Crit Care Med 2009; 179: A6079.

124. McCubbrey AL, Freeman CM, Martinez FJ, Ames T, Han M-LK, Chensue CW, Arenberg DA, Meldrum CA, Getty C, Thompson D, McCloseky L, Curtis JL. Decreased cytokine production by lung CD4+ T cells in advanced chronic obstructive pulmonary disease. Presented at the Keystone Symposium, Lymphocyte Activation; Breckenridge, CO; 3/1/10.

125. Sweerus KA, Freeman CM, Martinez FJ, Han MK, Chensue SW, Arenberg DA, Meldrum CA, Getty C, Thompson DL, McCloskey L, Curtis JL. COPD severity correlates with increased numbers of lung CD27+ B cells and increased expression of TNF-alpha and


CD80. Presented at the International Scientific Conference of the American Thoracic Society; New Orleans, LA, May, 2010.

126. Freeman CM, McCubbrey AL, Martinez FJ, Han MK, Polak T, Chensue SW, Arenberg DA, Meldrum CA , Getty C, McCloskey L, Thompson DL, Curtis JL. Resident lung CD4+ T cells are unresponsive in severe COPD. Presented at the International Scientific Conference of the American Thoracic Society; New Orleans, LA, May, 2010.

127. Freeman CM, Martinez FJ, Han M-LK, Ames TM, McCubbrey AL, Chensue SW, Arenberg DA, Meldrum CA , Getty C, McCloskey L, Thompson DL , Curtis JL. COPD spirometric severity correlates with an increased percentage of myeloid dendritic cells expressing CCR7 and CD103. Am J Respir Crit Care Med 2010; 181: A3839. Presented at the International Scientific Conference of the American Thoracic Society; New Orleans, LA, May, 2010.

128. Osterholzer JJ, Chen G, Olsewski MA, Curtis JL, Toews GB. Classically-activated CD11c+ CD11b+ exudate macrophages are derived from recruited Ly6C-high CD11b+ monocytes in the lungs of mice with fungal pneumonia. Presented at the International Scientific Conference of the American Thoracic Society; New Orleans, LA, May, 2010.

129. Erb-Downward JR, Thompson D, Han M-LK, Freeman CM, Chensue SW, Arenberg DA, Meldrum C, Getty C, McCloskey L, Young VB, Toews GB, Curtis JL, Martinez FJ, Huffnagle GB. Analysis of the microbiome of the normal and COPD lung. Am J Respir Crit Care Med 2010; 181:A5628. Presented at the International Scientific Conference of the American Thoracic Society; New Orleans, LA, May, 2010.

130. Todt JC, Sonstein J, Ames T, Polak T, Freeman CM, Han M-LK, Martinez FJ, Curtis JL. Downregulation of TLR3 in alveolar macrophages of human smokers leads to reduced CXCL10 (IP-10) in response to viral double stranded RNA (dsRNA) analogue polyinosinic –polycytidylic acid (Poly I:C). Am J Respir Crit Care Med 2010; 181:A1278. Presented at the International Scientific Conference of the American Thoracic Society; New Orleans, LA, May, 2010.

131. Freeman CM, Martinez FJ, Han M-LK, Chensue SW, Arenberg DA, Meldrum CA, Getty C , McCloskey L, Thompson DL, Curtis JL. Stimulation of TLR2/1 on Lung CD8+ T cells from COPD patients increases cytotoxic effector molecule expression. Presented at the International Scientific Conference of the American Thoracic Society; New Orleans, LA, May, 2010.

132. Todt, JC, Ames T, Sonstein J, Polak T, Han ML, Martinez FJ, Curtis JL. Fluticasone increases efferocytosis by human alveolar macrophages. Presented at the 18th Annual Congress of the European Respiratory Society; Barcelona, Spain, September 19, 2010.

133. Freeman CM, Martinez FJ, Han MK, Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Thompson DL, Curtis JL. Lung CD8+ T cells induce apoptosis of autologous lung target cells in COPD. Presented at the 9th Lung Science Conference of the European Respiratory Society, Estoril, Portugal, April 2011.

134. Martinez CH, Freeman CM, Todt JC, Ames T, Martinez FJ, Han MK, Murray S, Thompson DL, McCloskey L, Curtis JL. Expression of CD8+ T cell-attracting chemokines is limited to the airway compartment during early acute exacerbation of chronic obstructive pulmonary disease. Presented at t the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

135. Freeman CM, Martinez FJ, Han MK, S.W. Chensue SW, Arenberg DA, Meldrum CA, McCloskey L, Thompson DL, Curtis JL. Recognition of stressed epithelial cells by NKG2D on human lung CD8+ T cells may contribute to emphysema pathogenesis. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.


136. Osterholzer JJ, Chen G, Curtis JL, Toews GB. Dendritic cell accumulation in mice with persistent fungal pneumonia is critically dependent on the GM-CSF induced differentiation of Ly-6c(high) monocytes within the lung. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

137. Martinez CH, Martinez FJ, Okajima Y, Murray S, Reagan EA, Kazerooni EA, Curtis JL Han MK, for the COPDGene® Investigators. Chronic Obstructive Pulmonary Disease and Gastroesophageal Reflux Disease in COPDGene®. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

138. Todt JC, Sonstein, J, Ames T, Woniewski W, McCloskey L. Todd B, Freeman CM, Preston A, Beck JM, Curtis JL. Downregulation of Class A scavenger receptor I (SRA I) in bronchoalveolar lavage macrophages of human smokers. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

139. Freeman CM, Attawala P, Todt JC, Martinez CH, Martinez FJ, Han MK, McCloskey L, Thompson DL, Curtis JL. Heterogeneity of blood monocyte subsets in chronic obstructive pulmonary disease; a sub-study of COPDGene®. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

140. Albert RK, Bailey WC, Casaburi R, Connett JR, Cooper A, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Make BJ, Marchetti N, Martinez FJ, Mattinger N, McEvoy C, Niewoehner DE, Porszasz J, Price C, Riley J, Scanlon P, Sciurba FC, Scharf S, Washko GR, Woodruff P, Anthonisen N. Chronic azithromycin decreases the frequency of chronic obstructive pulmonary disease exacerbations. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

141. Ganesan S, Faris AN, Comstock AT, Curtis JL, Martinez FJ, Hershenson MB, Sajjan U. Nuclear localization of FOX03A is decreased in COPD airway epithelial cells. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

142. Ganesan S, Faris AN, Comstock AT, Curtis JL, Martinez FJ, Hershenson MB, Sajjan U. Quercetin improves lung function in rhinovirus-infected mice with a COPD phenotype. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011

143. Beck JM, Preston AM, Todd B, Du M, Curtis JL, Christensen PJ. Intermittent depletion of CD4+ T cells alters lung inflammatory responses to Pneumocystis infection and cigarette smoke exposure in mice: a model of HIV-related emphysema. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

144. Giardino ND, Curtis JL, Liberzon I, Pamp B, Abelson J The impact of trauma reminders on dyspnea in combat Veterans with PTSD. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CA, May, 2011.

145. McCubbrey A, Curtis JL. Corticosteroids increase murine alveolar macrophage efferocytosis with innate immune consequences. Presented at the Gordon Research Conference on “Apoptotic Cell Recognition & Clearance” at Bates College (Lewiston, ME; July 17-23, 2011).

146. Martinez CH, Giardino ND, Curtis JL, Martinez FJ , Connett J , Han MK for the CCRN. COPD comorbidities are related to baseline and one-year quality-of-life metrics. An analysis of the placebo arm of the CCRN Macrolide clinical trial. Presented at the International Scientific Conference of the American Thoracic Society; Philadelphia, PA, May 2013.

147. Freeman CM, Erb-Downward JR, Brown SR, Nelson JD, McCubbrey AL, McCloskey L, Geal T, HeY, Mancuso P , Olszewski MA, Chensue SW, Huffnagle GB, Curtis JL.


Human lung microbiome community structures correlate with the responsiveness of alveolar macrophages to stimulated cytokine production. Presented at the International Scientific Conference of the American Thoracic Society; Philadelphia, PA, May 2013.

148. Freeman CM, Crudgington SW, Erb-Downward JR, Alexis NE, Doerschuk CM, Hoidlal JR, Paine R, III, Rennard SI, Woodruff PW, Zeidler M, Curtis JL. Multi-center cell staining with centralized flow analysis of sputum, BAL and blood leukocytes in the SPIROMICS Immunophenotyping sub-study. Presented at the International Scientific Conference of the American Thoracic Society; Philadelphia, PA, May 2013.

149. McCubbrey A, Curtis JL. miR-34a is a suppressor of efferocytosis that is activated by the alveolar environment, restraining apoptotic cell uptake by alveolar macrophages. Presented at the Gordon Research Conference on “Apoptotic Cell Recognition & Clearance” at Bates University of New England (Biddeford, ME; June 23-28, 2013).

150. Dickson RP, Erb-Downward JR, Freeman CM, Beck JM, Martinez FJ, Huffnagle GB, Curtis JL. Analysis of Spatial Variation in the Microbiota of the Healthy Respiratory Tract by Illumina-based Sequencing. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA, May 2014.

151. Brown JP, Nelson JD, McCloskey L, Freeman CM, Curtis JL. Type I IFN enhances poly(I:C)-induced Type III IFN production by human alveolar macrophages. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA, May 2014.

152. Mancuso P, Hasty A, Curtis JL, Freeman CM, Ward L, Peters-Golden M, Myers, MG Jr. Defective pulmonary host defense against pneumococcal pneumonia in lean mice that lack the leptin receptor in myeloid cells. Presented at the International Scientific Conference of the American Thoracic Society; San Diego, CA, May 2014.

153. Freeman SM, Crudgington S, Stolberg VR, Brown JP, L. McCloskey L, Chensue SW, Curtis JL. Inhaled corticosteroid usage blocks nontypeable Haemophilus influenzae (NTHI)-mediated increase in cytotoxicity of lung CD56+ cells and reduces NKp46 expression. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

154. Freeman SM, Stolberg VR, Crudgington S, Ferguson J, Briend E, McCloskey L, Ward L, Mancuso P, Finch DK, Curtis JL. Lung cytotoxic CD56+ natural killer cells drive increased cytotoxicity in both COPD subjects and short-term smoke-exposed mice. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

155. Freeman SM, Crudgington S, McCubbrey AL, Todt JC, Brown JP, McCloskey L, Curtis JL. Glucocorticoid-augmented efferocytosis impairs host defense by alveolar macrophages of human smokers by reducing specific microRNAs. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

156. Freeman SM, McCubbrey AL, Stolberg VR, Crudgington S, Brown JP, Chensue SW, Taitano SH, Saxton BL, Mancuso P, Curtis JL. Glucocorticoid-augmented efferocytosis inhibits pulmonary pneumococcal clearance in mice by reducing alveolar macrophage bactericidal function. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

157. Brown JP, Scales BS, Freeman SM, Dickson RP, Crudgington S, Erb-Downward JR, Stolberg VR, Sonstein J, Huffnagle GB, Curtis JL. Human alveolar macrophages recognize heat-killed Pseudomonas fluorescens by up-regulating the innate receptors TLR2 and Mertk and producing IL-6. Presented at the International Scientific Conference of the


American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

158. Keene J, Curtis JL, Doerschuk CM, Foreman M, Kinney, G, Black-shinn J, Han MK, Jacobson S, Kechris K, Prescott Woodruff PG, O’Neal W, Rennard SI, Barr G, Bleecker E, Kleerup E, Kanner R, Hansel N, Martinez FJ, Bowler R. Blood biomarkers of exacerbations in the SPIROMICS and COPDGene cohorts. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

159. Clausen E, Qin S, Freeman CM, Curtis JL, Morris A. Presence of Tropheryma whipplei in the lung and gastrum. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191: A4723.

160. Kim V, Anzueto A, Martinez CH, Dass C, Comellas A, Ramsdell JW , Sharafkhaneh A, Yen A, Crapo J, Make BJ, Silverman EK, Curtis JL and the COPDGene Investigators. Newly developed chronic bronchitis is associated with worse outcomes and symptoms in smokers with and without chronic obstructive pulmonary disease. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

161. Brown JP, Freeman SM, Crudgington S, Stolberg VR, Sonstein J, Alexis NE, Basta P, Carretta EE, Couper DJ, Doerschuk CM, Hastie AT, Kaner RJ, O’Neil WK, Paine R III, Rennard SI, Shimbo D, Woodruff PG, Zeidler M, Curtis JL. Monocytoid macrophages comprise an increased percentage of both mononuclear phagocytes and all leukocytes in bronchoalveolar lavages of smokers: SPIROMICS Immunophenotyping Sub-study. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

162. Anderson W, Basta P, Carretta EE, Cui G, Davis S, Doerschuk CM, Barr RG, Bleecker G, Bowler R, Curtis JL, Drummond B, Han MK, Hansel N, Kanner R, Kleerup E, Martinez FJ, Peters S, Woodruff PG, Rennard SI, Couper D, O’Neal WK, for the SPIROMICS Investigators. Technical and biological reliability of multiplex-based blood biomarkers as measured in SPIROMICS. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

163. Kinney GL, Darabian S, Jacobs M, Lambert A, Black-Shinn J, Anzuet A, Bon J, Boriek A, Bowler R, Dass C, DeMeo D, Foreman M, Hoffman E, Kim V, Li D, Parulekar A, Van Beek E, Yen A, Wise B, Curtis J, Newell J, Hokanson J, Make B, Washko G, Rossiter H, Casaburi R, Rennard S, McDonald ML. Determinant of change in BMI in heavy smokers. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

164. Martinez CH, Diaz AA, Parulekar AD, Rennard SI, Kanner RE, Hansel NH, Couper D, Holm KE, Hoth KF, Curtis JL, Martinez FJ, Hanania NA, Regan EA, Paine R III, Cigolle CT, Han MK and the SPIROMICS and COPDGene Investigators. Age-related differences in quality of life in COPD: An analysis of the SPIROMICS and COPDGene cohorts. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

165. Martinez CH, Giardino ND, Curtis JL, Rennard SI, Kanner RE, Hansel NH, Martinez FJ, Han MK and the SPIROMICS Investigators. Reporting SGRQ subscales provides information on non-physical aspects of Quality-of-Life in COPD that is not revealed by CAT or SGRQ total scores. Presented at the International Scientific Conference of the




American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

166. Martinez CH, Mannino DM, Jaimes FA, Divo MJ, Curtis JL, Han MK Diaz AA. Factors associated with under-diagnosis of obstructive lung disease in American adults. Findings from NHANES III and NHANES 2007-2010. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

167. AT Hastie, Curtis JL, CM Doerschuk, NE Alexis, NN Hansel, SP Peters, G Barr, D Couper, ML Han, R Kanner, E Kleerup, FJ Martinez, S Rennard, PG Woodruff, DA Meyers, ER Bleecker. Analyses of COPD severity phenotypes and emphysema in SPIROMICS subjects stratified by sputum granulocytes. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

168. Young KA, Kinney GL, Castaldi PJ, Cho MH, Regan EA, Make BJ, Beaty TH, Han MK, Curtis JL, DeMeo DL, Crapo JD, Silverman EK, Budoff M, Hokanson JE, Wan ES; COPDGene Investigators. PRISm (preserved ratio, impaired spirometry) subjects have more sub-clinical atherosclerosis than smokers with normal spirometry. The COPDGene Study. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

169. Kechris K, Jacobson S, Sun W, Yang J, Chen TH, Barr RG, Basta P, Bleecker ER, Couper D, Curtis JL, Doerschuk CM, Drummond MB, Han MK, Hansel N, Hawkins GA, Hoffman E, Kanner RE, Kleerup E, Martinez FJ, Meyer DA, Peters S, Rennard S, Woodruff PG, O’Neal WK, Bowler RP, SPIROMICS and COPDGene Investigators. Blood biomarker quantitative trait loci in chronic obstructive pulmonary disease (COPD). Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

170. Kim V, Zhao H, Comellas A, Han MK, Martinez FJ, Barr RG, Bleecker E, Couper D, Hoffman EA, Kanner R, Kleerup E, Postow P, Woodruff P, Hansel N, Bowler R, Curtis JL, Drummond B, Peters S, Doerschuk C, O'Neal W, Cooper C, Rennard S, Criner GJ, and the SPIROMICS Investigators. Plasma Biomarkers Associated with Chronic Bronchitis in COPD in SPIROMICS. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

171. Voelker H, Albert RK, Bailey WC, Casaburi R, Cooper JAD, Curtis JL, Dransfield MT, Han MK, Criner GJ, Washko PG. Cardiac events and relationship to rates Of acute Exacerbation in COPD. Am J Respir Crit Care Med 2015; 191:A6368. Presented at the International Scientific Conference of the American Thoracic Society; Denver, CO, May 2015. Am J Respir Crit Care Med 2015; 191:

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