18 THERAPY

Isradapine - fulfilling its promise

• The antihypertensive efficacy of isradipine was maintained over 2 years in 102 evaluable patients with mild to moderate hypertension who elected to continue isradipine treatment following a short term study. Isradipine was well tolerated with the incidence of adverse events diminishing over time.

D'Hont G, et aI. Long-tenn (2-year) isradipine data in the treatment of mild-Io-moderate hypertension. Journal of Cardiovascular Pharmacology 19 (Suppl. 3): 46-48,1992 MOOI44(J77

• Once-daily isradipine Smg (n = 160) achieved antihypertensive efficacy equivalent to that of the currently available formulation of isradipine 2.5mg given twice-daily (154) after 6 weeks' treatment. The incidences of headache and flushing were notably lower in recipients of the new extended release formulation. Holmc~ D. et al. Clinical cyuivaienct:' of once-daily adll1ini~tration of a modified-relea:-.e fomwiatillll of i:-.radipine and t\\ icc-dail~ aJmini~tration of the standard formulation. Juurnal of Cardio\ a\cular Pharmacoiog! 1 L)

(SUppl. .o): 61·65.1992 ""14",'1

• The good tolerability of isradipine was shown in a general practice surveillance study which involved 5526 patients with mild to moderate hypertension who received isradipine for 12 weeks at therapeutic dosages (1.25-2.5mg bid). No newly occurring adverse events occurred with an incidence of> 1/1000 patients. Only oedema and flushing occurred significantly more frequently than during the placebo phase. 4.6% of patients withdrew because of adverse events. Hennans L. el al. Tolerabilily of isradipine in the lrealmel1l11f mild-tn-moderate hypel1c-n-.ilm in general practil:e: a iarge-"caie ..,ufveillance

qudy, 10umal of Cardiovascular Pharmacolog~ 1<) I Suppl. .11: .1X-~5. 1<)<)2

• Isradipine effective in Filipino patients with hypertension, In a nationwide surveillance study conducted in the Philippines, isradipine 2.Smg bid produced a statistically and clinically significant decrease in the mean standing and sitting systolic and diastolic BPs of 2016 patients. BP normalised in 85% of patients, decreased inadequately in 9% of patients and did not change in 2%. Porciuncula CI. el aL Nalionwide evalualion of isradipine IDynacirc) in Filipino patienls wilh essential hypeI1en,ion. To" ard, The Ralional and

Ideal Trealment of Blood Pressure Elevation (TRIBE) Study. Philippine

lournal of Intemal Medicine 30: 109-115. Mar·Apr 1992 ""'';'".

25 Jul1992 INPHARMA"" ISSN 0156-2703/92/0725-0018/$1,00'" Adls International Ltd