introducing systemic enzyme therapy · what are enzymes? enzymes are protein molecules, composed of...

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IntroducingSystemic Enzyme Therapy

What Are Enzymes?Enzymes are protein molecules, composed of long chains of amino acids. Enzymes are the

biocatalysts necessary for the chemical reactions associated with breathing, growth, reproducing,

digestion, and all other metabolic functions.

For most people under the age of 25, enzymes are efficiently produced by the body to maintain

optimal health. As we age, our body’s production of enzymes decreases. This reduction of enzyme

levels may reduce the efficiency of our normal body functions. These enzymes are needed to

maintain a healthy immune system, healthy joints, good circulation, and an overall balanced

reaction to injury.

The older we get, our need for enzyme production increases, while the amount of usable enzymes

in our body is gradually depleted. Enzyme deficiency can lead to a wide variety of health problems.

What Are Digestive Enzymes?

Digestive enzymes work in the digestive tract where they help break down

fats, carbohydrates, and proteins for improved digestive function and nutrient

absorption.

What Are Systemic Enzymes?Systemic enzymes are those that operate throughout the body in every system

and organ. Following their resorption from the gastrointestinal tract, enzymes travel

to their “site of action” in the body via the bloodstream, where they ultimately

become effective. This is known as the “systemic effect”. The term “systemic”

indicates that the agent (in this case the enzymes) is distributed throughout the

entire body.

Supplementation with systemic enzymes may help the body to more efficiently

regulate the metabolism, thereby reducing the physiological effects of aging.

Physicians in Europe and Asia have long prescribed enzyme supplements to

restore enzyme levels and promote natural healing.

Systemic enzymes are formulated to resist the acidic environment of the stomach

so that they can be absorbed into the bloodstream from the small intestine. Once in

the bloodstream, the enzymes are able to be used throughout the entire body.

Serrapeptase Overview

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or

prevent any disease.

Serrapeptase is a key ingredient to consider when choosing the right enzyme. To ensure maximum

absorbency without activity loss, an enteric coated delivery system is essential.

Serrapeptase is a naturally occurring, physiological agent with no inhibitory effects on

prostaglandins and is devoid of gastrointestinal side effects. It is a proteolytic enzyme isolated

from the micro-organism Serratia E15. This enzyme is naturally processed commercially today

through fermentation.

Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation

in all forms. The late German physician, Dr. Hans Nieper, used Serrapeptase to treat arterial

blockage in his coronary patients. Serrapeptase protects against stroke and is reportedly more

effective and quicker than EDTA Chelation treatments in removing arterial plaque. He also

reports that Serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish.

Serrapeptase & Inflammation



Enzyme Fights Inflammation

Our bodies have a love-hate relationship with inflammation. On the one hand, inflammation is a

natural response, necessary to protect the body from invading organisms. On the other hand,

inflammation can limit joint function, and destroy bone, cartilage and other articular structures.

An elusive goal of scientists and physicians has been to find a side-effect-free substance to reduce

the pain and inflammation associated with fibrocystic breast disease, rheumatoid arthritis, idiopathic

edema, carpal tunnel syndrome and post-operative swelling. It appears that the search may be

nearing an end, thanks to an enzyme Serrapeptase produced by the larval form of the silk moth.

Serrapeptase is proving to be a superior alternative to the non-steroidal anti-inflammatory agents

(NSAIDs) traditionally used to treat rheumatoid arthritis and osteoarthritis. Its uses have also been

extended to the treatment of chronic sinusitis and postoperative inflammation, and some researchers

believe the substance can play an important role in arterial plaque prevention and removal.

Harmful Effects of NSAIDs



NSAIDs, which include aspirin, ibuprofen, salicylates, and naproxen, are

among the most commonly prescribed medications for inflammation resulting

from rheumatoid arthritis, joint conditions, osteoarthritis, gouty arthritis, joint

and muscle discomfort associated with systemic lupus erythematous, and

other musculoskeletal disorders.(1) In some cases, this overreliance on

NSAIDs has proved deadly. Annually, 76,000 people are hospitalized from

NSAID-induced gastrointestinal complications. The American Medical

Association estimates that from 50-80 percent of those hospitalized for

gastrointestinal bleeding are taking some form of NSAIDs.

5 Functions of a Systemic Enzyme



Natural Anti-inflammatory

Refers to the property of a Systemic Enzyme formula to reduce inflammation which is a reaction by the

immune system to an irritation that causes redness, swelling, pain, tenderness, heat, and disturbed function

to an area of the body.

Anti-Fibrosis

Refers to the property of a Systemic Enzyme formula to reduce the development of excess fibrin (a fibrous

connective tissue or scar tissue) in an organ in the body.

Blood Cleansing

Refers to the property of a Systemic Enzyme formula to clean excess fibrin and waste materials from the

blood.

Immune System Modulating

Refers to the property of a Systemic Enzyme formula to assist the body to balance the immune system and

to maintain an optimal stable, constant condition.

Virus Fighting

Re Refers to the property of a Systemic Enzyme formula to disrupt, eat away, virus protein cell walls to

inhibit the virus from replicating itself and to render individual viruses inert.

* Source for the Five Functions: ENZYMES: The Fountain of Life, by D.A. Lopez, M.D.

Enzyme Effectiveness

How is enzyme effectiveness determined?

It is by the amount of activity level in the bloodstream after the enzyme has been absorbed from the

small intestine. Enzymes lose activity in low pH (1.0 - 3.0) of the stomach. Studies show that

unprotected enzymes can lose up to 100% of their activity in 30 minutes or less. Enteric coating is

the only reliable method to ensure that 100% of the enzymes are not destroyed, and is by far the

most effective delivery method to prevent release of the enzymes before they reach the small

intestine.

What happens to uncoated capsules and tablets?

Stomach acid breaks down tablets and capsules and prematurely releases active enzymes

(enzymes). The highly acidic environment of the stomach destroys the majority of the enzymes’

activities. If the tablet is of poor quality (contains binders and fillers) the product may pass through

both the stomach and intestine with no absorption.

Delivery Systems

The real differentiator among Systemic Enzymes is in the method of delivery to the stomach

and ultimately to the small intestine. The only method to protect and effectively deliver a

systemic enzyme is a 100% enteric-coated product.

“Protein molecules are normally destroyed (denatured) by the hydrochloric acid of the stomach and

broken down into individual components by the special, acid-proof enzymes of the gastric tract

(pepsin) and the enzymes of the pancreas. For this reason, tablets, capsules, or granules are used

that are enteric-coated or covered with an acid-proof layer. In this way, the enzymes are held safely

until that section of the intestines is reached where their resorption is possible.

The acidity of the gastric juices in this region has long been neutralized. The digestive enzymes

found here have, for the most part, already performed their activities and are primarily inactive. Only

then does the covering of the tablets dissolve. The active enzymes are subsequently released and

can be resorbed into the system through the intestinal wall by way of special transport mechanisms.”

“Enzymes – A Drug of the Future” by Prof. Dr. med., rer. nat. Heinrich Wrba; Dr. med. Otto Pecher

Oral Delivery Systems

1. Powder Filled Capsule

2. Tablet

3. Enteric-Coated Liquid Gel Capsule

Powder Filled Capsule

Powder-filled Capsule Digestion

Vegetarian or Gelatin Capsule. Powder filled capsule technology

is suitable for contents that are not susceptible to the acidity of the

stomach. The capsule and its enzymes are dissolved prematurely

in the stomach, resulting in up to 100% destruction of the

enzymes within 30 minutes in the extremely low pH environment.

Tablet

Tablet Digestion

Enteric-Coated Tablet. Enteric-coated tablets are able to withstand

stomach acids, however, they must be introduced into a high pH

environment for extended periods before dissolving. Since individual

pH levels vary, the tablet may dissolve very late in the small intestine

or bypass it completely. Many users also complain of the synthetic

coating.

Liquid Filled Gel Capsule

Gel Capsule Digestion

Enteric Coated Liquid-Filled Gel Capsule. The all-natural protective

coating prevents the enzymes from being destroyed by the stomach

acids. The pancreatic juices break down the coating in the duodenum.

This makes 100% of the enzyme contents available for absorption

into the bloodstream.

Enteric Coating

Enteric Coating is the best and most effective oral delivery

system today for systemic enzymes. The technology of

enteric coated liquid-filled capsules is superior to that of

powdered enzymes because it uses low heat production,

provides more uniform dose distribution, and prolongs

enzyme activity.

Low Heat Production

Low Heat Production– Powder enzyme blends are available today that use an

enteric coating, but they are in tablet form. The disadvantage of these blends is

the amount of heat created with compressing the ingredients into a tablet.

Enzymes are susceptible to high temperatures and may begin to degrade during

the manufacturing process. Solubilized Liquid-Filled Gel Capsules allow for an

enteric-coated enzyme without activity loss from heat. Temperature ranges during

the production of the Solubilized Liquid-Filled Gel Capsules and the enteric

coating process are strictly controlled to ensure that there is no enzyme activity

loss due to heat that sometimes occurs during the production of enteric coated

tablets.

Optimal Dose Distribution

Optimal Dose Distribution– Liquid enzyme blends provide a more uniform dose

consistency, because the mixing of liquids allows for optimal particle distribution.

In powder formulations, each particle of a different enzyme is different in size,

causing greater friction between particles during mixing.

Excipients are introduced to powder formulations to increase the mix ability, but

liquids still provide far more even distribution of ingredients, allowing for more

consistent dosages in each capsule.

Prolonged Enzyme Activity

Enzymes always retain some amount of moisture when they are produced.

Enzymes as proteins are more susceptible to denaturation at higher moisture

content. Enzyme powders typically have lower (5-10%) moisture content. However,

even with lower moisture content, enzyme powders will lose some of their activity

over time, resulting in a loss of up to 20% of activity over a 12-month period.

Liquid-Filled Gel Capsules contain enzymes with a higher degree of purity and less

moisture that when combined with Medium-Chain Triglycerides (MCT), then

decompressed during the manufacturing process, removes the moisture completely.

As a result, loss of enzyme activity over time due to moisture will not occur.

Systemic Enzyme Therapy

A well balanced Systemic Enzyme supplement should have a unique blend of

enzymes, flavonoids, and antioxidants.

Other Key Features:

Advanced Delivery System - Enteric Coated Liquid Filled Gel Capsule

Solubilized Liquid Filled Gel Capsule

Low Heat Production

Optimal Distribution

Prolonged Enzyme Activity



100% Absorption into the Small Intestine

All Natural, Vegetarian Formula

Higher Potency & Purity

Greater Patient Compliance

Minimal Dosage Required for Maximum Benefit

Systemic Enzymes Exclusively for Healthcare

Practitioners Like You

There are thousands of enzymes available on the market today through retail stores and online resellers but choose an unique blend of vegetarian enzymes, flavonoids and antioxidants with 100% absorption and pharmaceutical strength available exclusively through healthcare practitioners like you.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure

or prevent any disease.

No need to compete with the internet after educating your patients on the importance of enzyme therapy.

Pharmaceutical strength systemic enzymes that are enteric coated and liquid filled offer more potency and less dosage meaning better patient compliance.

Serrapeptase -

Is one of the most popular enzymes available.

Protease -

Any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process

known as proteolysis. *

Bromelain -

Found in pineapples and breaks down other proteins, such as collagen.*

Papain -

A proteolytic enzyme obtained from un-ripe papaya.*

Amylase -

Digests carbohydrates and helps convert starch to sugar. *

Lipase -

Digests fat. It is secreted in the digestive tract that catalyzes the breakdown of fats into individual fatty acids that can

be absorbed into the bloodstream. *

Amla -

Is a great source of Vitamin C.

Rutin –

One of the many existing flavonoids and supports health by supporting capillaries and other

connective tissue.*



Ingredients in a Well Balance

Systemic Enzyme

Disintegration and Activity Tests;

What Do They Mean?

The disintegration test consists of two conditions to

see if a capsule will dissolve correctly.

Test 2: Simulates Intestinal Conditions – disintegration in this test will enable enzyme release for absorption in the small intestine. Disintegration=Pass

Test 1: Simulates Stomach Conditions – disintegration in this test will expose enzymes to acidic conditions. Disintegration=Failure



Test #1 shows that when a capsule not enteric coated was exposed to an acidic environment resembling the stomach, the enzyme activity was prematurely released with no activity remaining to pass through to the small intestine.

Test #2 shows that when a capsule remains intact because of enteric coating and it reaches the small intestine, it then breaks down completely and is absorbed at the right time.

The activity test consists

of two differing conditions:

Test 1:

Simulates Intestinal Conditions – activity level of product in ideal conditions.

Test 2:

Simulates Stomach Conditions– activity level if exposed to harshacidic environment (i.e. stomach)

Test #1 looks at the enzyme activity of a capsule when exposed to the small intestine where it should breakdown for maximum benefit.

Test #2 looks at enzyme activity when a capsule is exposed to an acidic condition similar to the stomach and shows that if not enteric coated or protected, it will break down prematurely.



What Does an Activity Test Show?

Disintegration & Activity Test Results Mean...?

Using the certificates of analysis together; can determine if a product will have its maximum activity level intact

when/if a capsule dissolves in the intestinal tract.

So, if a capsule failed the disintegration test, it will have much lower activity levels due to it being exposed to acidic conditions.



Important Features –

Choosing the Right Systemic Enzyme

FULLY ENTERIC COATED CAPSULE -

Capsules that have a full USP (pharmaceutical grade) enteric coating for ease of swallowing and to ensure a

more complete delivery of the product and more assured release. You can expect to receive 100% absolute

consistency with every capsule.*

LIQUID FILLED GEL CAPSULE -

Better consistency, higher potency, more concentrated, greater purity, and unparalleled absorption.*

SMALLER CAPSULES -

Better compliancy.*

SMALLER DOSES – FEWER DOSES -

The combination of the items listed above bring with them just one thing – POTENCY. Fewer capsules really

can bring more benefit.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure

or prevent any disease.

Systemic Enzyme SupplementsClinical studies are important and are a critical component when designing and developing a

supplement. However, clinical studies are generally limited to the ingredients used in a formula.

When choosing the right enzyme supplement, look for one that only uses ingredients that have

solid clinical evidence supporting their efficacy and safety. It is important to examine these

ingredients at a molecular level to determine their compatibility and synergy with other ingredients

in the formula. This is important because when you mix ingredients they can interact with each

other to form a different compound. If ingredients are combined scientifically their individual

effectiveness can be increased exponentially.

Virtually no manufacturer conducts clinical studies on their finished products. This is because of

the cost which can run into millions of dollars and unlike a synthetic pharmaceutical product which

can enjoy patent protection there is no such protection with natural products. Another reason is

science is moving very fast in the area of supplementation.

The understanding of nutrition both internally and externally continues to increase and new active

ingredients are continually developed to improve the efficacy of products. So, even if it was

practical to conduct a clinical study on a supplements it is likely it would be out of date before the

final report was completed.



A Preliminary Trial of Serrapeptase

in Patients with Carpal Tunnel Syndrome*Panagariya A, Sharma AK

Dept. of Neurology, SMS Medical College and Hospital, Jaipur.

J Assoc Physicians India 1999 Dec;47(12):1170-2

OBJECTIVES: This study was planned to assess the response of Serrapeptase in patients with carpal tunnel syndrome

(CTS).

METHODS: Twenty patients with CTS were evaluated clinically. After baseline electrophysiological studies, these

patients were given serrapeptase 10 mg twice daily with initial short course of nimesulide. Clinical and

electrophysiological reassessment was done after 6 weeks.

RESULTS: Mean age was 43.9 years with male to female ratio of 1:2.33. Sixty five percent cases showed significant

clinical improvement which was supported by significant improvement in electrophysiological parameters. Recurrence

was reported in four cases. No significant side effect was observed.

CONCLUSIONS: Serrapeptase therapy may prove to be a useful alternative mode of conservative treatment. Larger

study may be further helpful to establish the role of Serrapeptase in CTS.



Take Heed...

Systemic enzymes may help rid the body of toxins. Some users will experience a detoxification reaction to the enzymes, including short-term fatigue, nausea, fogginess or headache. Though uncomfortable, detoxification is beneficial to the body. Increased water intake can assist in the process, or a reduction in the enzyme dosage will slow the rate of detoxification. If symptoms persist, a patient should contact his or her healthcare professional.



Thank You for Learning About

Systemic Enzyme Therapy

Please contact World Nutrition, Inc. at

(800) 548-2710 if you have any questions.

www.WorldNutrition.net

http://www.worldnutrition.net/

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introducing systemic enzyme therapy · what are enzymes? enzymes are protein molecules, composed of...

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