Inhaled corticosteroids in acute asthma: A systematic review of the literature

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  • RESEARCH FORUM ABSTRACTS

    initial pH class. A 2-way analysis of variance was done with each parameter as the dependent variable and pH class and disposition as independent variables. InterQual criteria for ICU admission were used to assess likely disposition from a routine ED visit. The difference in disposition was the basis for cost analysis.

    Results: Fifteen of 61 patients were admitted to the ICU after initial high-severity ED management including all 7 with serum pH less than or equal to 7.00, 5 of 10 with pH less than or equal to 7.10, 2 of 17 with pH less than or equal to 7.20, and 1 of 27 with pH greater than or equal to 7.21. Factors that had a statistically significant effect on disposition were initial pH and HCO-3; glucose levels did not. There was no significant difference in ED stay between ICU and floor admission. One patient with pH less than 7.00 died of sepsis in the ICU. All others were discharged from the hos- pital. Mean stay in ICU was 2 days. Fifty-six of the 61 patients met InterQual criteria for ICU admission; 41 of these were diverted to a regular floor after aggressive man- agement in the ED without adverse effect on outcome.

    Conclusion: We estimate a reduction in charges of $65,600 for care of these 61 patients.

    328 Evaluation of Physical Examination in Determining the Outcomes of Ultrasound for Deep Vein Thrombosis

    Chan L, Reilly KM/Albany Medical College, Albany, NY

    Study objective: To evaluate the ability of physical examination to determine the results of ultrasound (US) for deep vein thrombosis (DVT).

    Methods: Our tertiary care emergency department has an annual census of 59,000 with a diverse racial and socioeconomic population. This was a retrospec- tive chart review of ED patients who underwent US to diagnose DVT. Charts were identified by the radiology computer system. Age, sex, and the presence or absence of the following physical examination findings were recorded: extremity edema, vein distention, extremity tenderness to palpation, extremity erythema, extremity warmth, calf pain on passive dorsiflexion of the toe, and palpable cord. The out- comes of the US study were recorded as well. Charts were excluded if the US results could not differentiate between chronic and acute DVT. The physical exami- nation was considered positive if any one or more of the physical signs were pres- ent. The sensitivity and specificity of physical examination for DVT by US diagnosis were calculated. Positive and negative predictive values of physical examination to predict the results of US for DVT were also calculated. The odds ratio was deter- mined as well.

    Results: The charts of 186 patients were reviewed. Thirteen charts were excluded because of US inability to determine between acute and chronic DVT. One hundred seventy-three charts (67 males and 106 females) were evaluated. The mean age was 55.0_+18.9 years. Ultrasound diagnosed 43 cases of acute DVT and ruled out 130 cases of DVT. Physical examination had a sensitivity of 95% (95% confidence interval [CI] 92% to 98%); specificity of 31% (95% CI 24% to 38%); positive predictive value of 31% (95% CI 24% to 38%); and negative predictive value of 95% (95% CI 92% to 98%). The odds ratio was 9.11.

    Conclusion: A negative physical examination was reliable and predictive of a nega- tive US result for DVT. Presence of physical examination findings was not reliable or predictive of US results for DVT.

    329 Patient Preferences Regarding Pain Medication in the Emergency Department

    Beel TL, Mitchiner JC, Fraderiksen S. McCormick J/St. Joseph Mercy Hospital, Ann Arbor, MI

    Previous studies have shown that pain control in the emergency department is inadequate.

    Study objectives: To determine the proportion of ED patients with acute frac- tures who want pain medication, the level of pain present on ED admission and desired at ED discharge, and the manner in which these patients want pain medi- cation given.

    Methods: A convenience sample of 107 adults with acute long-bone fractures seen in a community hospital ED completed a brief 8-item pain questionnaire. Patients with head injury, multiple trauma, fractures more than 6 hours old, questionable fractures, prehospital pain control, evidence of intoxication, or inability to answer questions were excluded. The questionnaire asked patients to score their pain level on ED admission and the level of pain desired at discharge on a 10O-mm visual analog scale, and to answer 6 questions.

    Results: Eighty-eight percent of the patients wanted pain medication given in the ED, and 77% actually received it. Sixty-nine percent were comfortable with a nurse administering pain medication before being seen by a physician. Preferred routes were as follows: intravenous 40% orally 34%, intramuscular 20%. Seventy percent wanted pain control without being sedated, and 25% wanted complete pain relief even if seda- tion was necessary to achieve it. Sixty percent of patients were either slightly con- cerned or not concerned about potential medication side effects.

    Conclusion: More than 8 of L0 patients with acute fractures want pain medication given while in the ED, and 7 of 10 would accept pain medication administered by a nurse before physician evaluation.

    330 What Does "Risk of Mr" Mean to the Emergency Physician? Results of an Observational Study

    Feldman J, Wallace E, Betty C, Mitchell P, Fish S/Boston Medical Center, Boston University School of Medicine, Boston, MA

    Previous research has demonstrated that non-emergency physicians' estimates of risk varied widely and that the estimates of risk correlated positively with testing decisions.

    Study objective: To determine the emergency physician variability in the quantifica- tion of 4 categories of estimated probability of myocardial infarction (MI), and to determine the relationship between estimated probability of MI and disposition decisions.

    Methods: We performed an observational study using a questionnaire given to all emergency medicine faculty at an urban Level I trauma center with an established emergency medicine residency program. The instrument required study subjects to define a range of probability of MI for a 4-group risk classification (very low, low, medium, high) and to determine the appropriate ED disposition based on the esti- mated probability of MI (home, telemetry/chest pain unit [CPUI, coronary care unit [CCU]). We recorded gender and years of emergency medicine experience for all sub- jects. Years of experience were dichotomized as less than or equal to 5 years (junior) and more than 5 years (senior). Means and SDs were calculated for the cut points between each risk category. We evaluated the effect of gender and experience on risk cut points and triage cut points with a t test (2-sided, ~=.05). The very low risk cut point was compared with estimated MI risk for discharge home.

    Results: All 24 physicians responded. Of these, 5 (21%) were female; 12 (50%) were seniors in terms of experience. Each cut point for risk classification demonstrated substantial variability: very low to low 3.5%_+2.7%; low to medium 12.1%_+7.9%; medium to high 48.9%_+23.5%. The mean estimated probability of MI that would sup- port direct ED discharge to home was 2.3%_+3.0%; to CCU 45.2%_+28.7%. We found that female gender was associated with higher risk cut points (very low to low mean 6.2% versus 2.8%, P=.009; low to medium mean 17.2% versus 10.8% P=.ll) and MI estimate for discharge to home (4.5% versus 1.9%, P=.08), whereas years of experience was not associated with lower risk probability cut points (/:'>.07 for all cut points). Fourteen physicians indicated a lower threshold for home discharge than their very low to low cut point, whereas 3 indicated a higher acceptable MI risk for home discharge.

    Conclusion: Emergency physicians demonstrate great variability when assigning absolute numerical values to commonly used risk categories of estimated probability of MI. Women tended to have higher cut points for very low and low risk of MI cate- gories and higher estimated MI risk for discharge to home. Further research is required to determine the effect of physician risk estimates on testing and triage for patients with possible acute cardiac ischemia.

    31 Inhaled Corticosteroids in Acute Asthma: A Systematic Review of the Literature

    Edmonds ML, Camargo CA Jr, Pollack CA Jr, Rowe BH/University of Nberta, Edmonton, Alberta, Canada; Massachusetts 6eneral Hospital, Boston, MA; Maricopa Medical Center, Phoenix, AZ

    Study objectives: The use of inhaled corticosteroids in asthma is increasing; how- ever, their benefit in the acute setting is unclear. This systematic review was designed to determine the benefit of inhaled corticosteroids for acute asthma in the emergency department.

    Methods: Randomized controlled trials (RCTs) were identified using the Cochrane Collaboration's Airways Review Group database, hand searching, bibliographies, phar- maceutical company, and author contact. Studies in which an inhaled corticosteroid was compared with placebo or any corticosteroid were considered. Relevance, inclu- sion, and study quality were assessed independently by 2 reviewers.

    Results: From 396 identified references, 7 were included. Six of the trials were

    S 84 ANNALS OF EMERGENCY MEDICINE 34:4 OCTOBER 1999, PART 2

  • RESEARCH FORUM ABSTRACTS

    published after 1994; overall, study quality was high but trials were not large (maxi- mum 111 patients). Four trials included only adults; 3 trials included only children. Three studies compared inhaled corticosteroids with corticosteroids; 2 studies com- pared inhaled corticosreroids plus corticosteroids with corticosteroids, and 2 studies compared inhaled corticosteroids alone versus placebo. Various outcome measures were used, including pulmonary function tests, clinical scores, admission rates, and incidence of adverse side effects. Despite the marked differences in study characteris- tics, results suggest a homogeneous decrease in admissions with inhaled corticosteroid treatment (odds ratio 0.46, 95% confidence interval 0.27, 0.79).

    Conclusion: Recent interest in the use of inhaled corticosteroids in the ED has led to a number of small studies with disparate study characteristics. Individually, studies have not demonstrated a clear benefit with addition of inhaled eorticosteroids to stan- dard therapy; however, pooled analyses suggest a beneficial effect of inhaled cortico- steroids. To clarify this issue, a large RCT of inhaled corticosteroid use in the ED is needed

    32 Intravenous Magnesium Sulfate in the Treatment of Severe Asthma: A Systematic Review of the Evidence

    Rowe BH, Michaud J, Bourdon C, Bota GW. Camargo CA Jr/University of Alberta. Edmonton, Alberta, Canada; Sudbury Regional Hospital. Sudbury, Ontario. Canada; Massachusetts General Hospital, Boston, MA

    Study objectives: To determine the effect of intravenous magnesium sulfate (Mg) for treatment of patients with acute asthma managed in the emergency department.

    Methods: Computerized, hand, and bibliographic searches identified randomized controlled mals (Mg versus placebo); the author contact produced additional studies. Outcomes included pulmonary function tests, admissions, and adverse effects. Selection, data extraction, and quality assessments were conducted independently by 2 reviewers. Studies were pooled using weighted mean differences (WMDs) or odds ratios (ORs) with 95% confidence intervals (95% CIs).

    Results: From 91 references, 7 trials were included (5 adult, 2 pediatric): a total of 665 patients have been studied (337 Mg; 328 placebo). Overall, patients recei'.'mg Mg demonstrated nonsignificant improvements in peak expiratory llow rate (PEFR) (WMD=29.4; 95% C1-3.4 to 62) and % predicted FEV t (WMD=4.3; 95% C1-2.3 to 10.9). For patients with severe asthma, Mg improved both PEFR (WMD 52.3; 95% CI 27 to 77.5) and % predicted FEV t (9.8; 95% C1 38 to 15.8). Likewise, Mg did not significantly reduce admissions overall (OR=0.31; 95% C1 0.09 to 1.02) but did reduce admissmns among severe patients (OR=0.10; 95% C[ 0.04 to 0.27). Mg was generally very well tolerated.

    Conclusion: Current evidence does not support the routine use of intravenous Mg in all patients presenting to the ED with acute asthma. However, Mg appears beneficial in patients who present to the ED with severe asthma, and its use should be incorpo- rated into practice guidelines.

    33 Edentulism Worsens Obstructive Sleep Apnea Pivetti S. Navone F, Urbino R, Bonetto C, Colagrande P, Arienti A, Preti G, Carossa S, 6ai V/Medicina d'Urgenza, A 0 San Giovanni Battista, Torino, Italy

    Obstructive sleep apnea (OSA) has a prevalence of 2% to 4% in the general popula- tion, but it is estimated that 61% of subjects older than 50 years meet the minimum criteria for OSA (apnea/hypopnea index [AHI] >5), with potentially life-threatening consequences. OSA correlates with diurnal systemic hypertension, bradycardic and tachycardic arrhythmias, sudden death, pulmonary hypertension, and chronic respi- ratory failure Although craniomandibular abnormalities have been recognized as risk factors for OSA, the role of edentulism has never been systematically investi- gated.

    Study objectives: We investigated whether edentulism is associated with increased risk for OSA.

    Methods: We examined 20 edentulous patients wearing complete mobile dentures. 11 with OSA (7 men and 4 women) and 9 without OSA (3 men and 6 women). The 2 groups had similar age (mean age 64 years) and body mass index. All patients under- went 2 full nights of polysomnography (continuous recording of dectroencephalogra- phy, elecrromyography, electrooculography. ECG. nasal airflow, body position. thoracic and abdominal respirator)" efforts, and ox3,hemoglobin level ISao2]) on 2 con- secutive nights, one with and one without dentures, in randomized order. OSA was

    defined as more than 5 episodes of apnea or hypopnea per hour of sleep (AHI >5) The anteropostenor phaD'ngeal wall distance (A-PphwD) with and without dentures was assessed by cephalometry.

    Results As shown in the Table, in OSA patients, sleeping without dentures was associated with a significant increase in the AHI (9.4 versus 16.2.12; P