individual drug info fall 2014. similar properties across drugs withdrawal (physical dependence)...
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Individual Drug InfoIndividual Drug InfoFall 2014
Similar Properties Across Similar Properties Across DrugsDrugsWithdrawal (physical
dependence)Psychological dependenceTolerance
DifferencesDifferences
FormsAvailabilityDEA ScheduleEffects
◦Acute◦Chronic◦Overdose
Photo, originally taken by Thoric, available to use in the public domain
Cannabis - marijuanaCannabis - marijuana
How does marijuana affect anxiety and depression?Does marijuana affect respiratory function? Especially during exercise?Is marijuana more destructive to your brain than alcohol?
CannabisCannabis Cannabis sativa
◦ Different subspecies/varietals used for clothing vs drug use
Active ingredient: THC THC is a cannabinoid
◦ Interacts with cannabinoid receptors in brain
◦ Many other cannabinoids exist, but not thought to cause psychoactive reactions
DEA: Schedule I Despite state
regulations, marijuana still federally illegal
Medical cannabis Medical cannabis (10/30/14), source: (10/30/14), source: procon.org)
Alaska (98) Maine (99) New Jersey (10)
Arizona (10) Maryland (14) New Mexico (07)
California (96) Massachusetts (12)
New York (14)
Colorado (00) Michigan (08) Oregon (98)
Connecticut (12)
Minnesota (14) Rhode Island (06)
Delaware (11) Montana (04) Vermont (04)
Hawaii (00) Nevada (00) Washington (98)
Illinois (13) New Hampshire (13)
Washington, DC (10)
Recreational CannabisRecreational CannabisWashington (2013)Colorado (2013)Washington, DC (2014)Alaska (2014)
CannabisCannabisAcute effectsTHC acts on cannabinoid receptors, increases dopamine, serotoninIncreases appetiteASAP Science: Your Brain on Marijuana (via YouTube)Overdose generally doesn’t occur
◦ Large amount required◦ Smoking a lot may induce sleepiness◦ Eating too much may trigger nausea, vomiting◦ Q13 News story, Michigan
Mixing any chemical substances can potentially cause a problem
Alcohol vs CannabisAlcohol vs CannabisMore research on alcoholAge dependentAmount of alcohol/amount of
cannabisMixing substancesAlcohol interferes with neurogenesis
of brain cells (Gary L. Wenk, Psychology Today, 2010)
Cannabis: 2014 study showing regular use impacted decision-making and judgment (Published online before print November 10, 2014, doi:
10.1073/pnas.1415297111. PNAS November 10, 2014)
Depression and AnxietyDepression and AnxietyMany use marijuana to ease moodRegular use may trigger, or worsen, either
condition, especially in younger people2013 Imperial College study showed lower
dopamine levels in regular users, which may lead to more anxiety
Marijuana, conversely, may help those with Post-Traumatic Stress Disorder◦ Memory inhibition
CannabisCannabisChronic effectsRespiratory distressMood swingsImpaired memory (potential hippocampus damage)Earlier research2011 NIMH/NIDA study
◦Daily use may reduce brain receptor number
◦Receptors regenerated with cessation◦ Society of Nuclear Medicine. "Chronic marijuana smoking affects brain chemistry,
molecular imaging shows." ScienceDaily. ScienceDaily, 13 June 2011. <www.sciencedaily.com/releases/2011/06/110606131705.htm>.
Marijuana & Respiratory Marijuana & Respiratory Function During ExerciseFunction During Exercise
Acute effect: any smoke can interfere with oxygen binding to red blood cells
Acute: marijuana can disrupt coordination, balance, reaction time
Acute: increase heart rate and blood pressure
Acute: stored THC in fat could be released into bloodstream during exercise
Chronic: depends on how frequently one smokes, type of exercise
Dimethyltryptamine Dimethyltryptamine (DMT)(DMT)
What is DMT?How does DMT work as a psychoactive drug?
DimethyltryptamineDimethyltryptamine
Chemical structureHallucinogenic
ingredientPresent in a variety of
plantsOccurs naturally in the
bodySchedule I substance
Image source: Wikimedia Commons
DimethyltryptamineDimethyltryptamine
Often consumed via beverage: ayahuasca tea◦ Requires MAO-I
(specific vine)◦ Ceremonial purposes◦ Ashland, OR Brazilian
church lawsuitCan be injected,
inhaled, smoked
Dimethyltryptamine Dimethyltryptamine EffectsEffectsHallucinogenic visualizationsMood changeTime distortionDissociationMuscle twitching, coordination difficultiesNausea, vomitingShorter-lasting effects than other
hallucinogens◦ “businessman’s trip” per DEA◦ 30-60 minutes
Video Clip - The Spirit Molecule, Part 1 (YouTube)
Video Clip – London Real (34:00+ = trip described)
Source: Arch Gen Pesychiatry. 1994 Feb;51(2):98-108.
LSDLSD
Learn the effects of acidAre there different types?
LSDLSD• Albert Hoffman: “Last Friday,
April 16,1943, I was forced to interrupt my work in the laboratory in the middle of the afternoon and proceed home, being affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicated-like condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.”
LSDLSD• Schedule I hallucinogen synthesized in
1930s• Manufacturing secretive: Nick Sand
(National Geographic, 3:39)• “Types”
• Same basic chemical structure
• Illegal, so cannot guarantee contents, care of product
• Light and air may degrade drug
• Dosage measured in micrograms (very small)
LSD FormsLSD Forms Crystal can be crushed,
mixed with other materials into tablets: microdots
Gelatin squares Converted to liquid paper
◦ Dosed onto sugar cubes◦ Placed on candy (gummy
bears - Lake Tahoe, 2011, e.g.)
Usually taken orally◦ Can be inhaled, injected,
applied transdermally
LSD Acute EffectsLSD Acute Effects• Duration of “trip” = several hours in length• Visual hallucinations (images, color, light)• Altered perception of senses
• “Seeing sounds, hearing colors”• Color, size of objects
• Altered perception of time, depth• Potential anxiety/panic• Experiences can vary widely• Serotonin receptors may be excited or inhibited• LSD experimentation on British soldiers
(YouTube.com)• Overdose thought to be rare, but some individuals
may not respond well, or may experience problems if drug is different than LSD
LSDLSDChronic effects may involve
flashbacks◦Sudden onset of abnormal
perceptions◦Hallucinogen Persisting Perception
Disorder Visual images remain longer than in
consciousness Dr. Henry Abraham (Tufts University)
blog
LSD ResearchLSD ResearchUS Food and Drug Administration
allowed LSD researchRecent study sponsored by
Multidisciplinary Association for Psychedelic Studies, carried out by Swiss physician Peter Gasser◦ Information published 2014◦ 12 patients with terminal illness, end-of-life
anxiety◦ Took two doses of LSD with talk therapy, across
eight weeks◦ Those with larger dose reported improvement
Which Drugs are Most Which Drugs are Most Dangerous?Dangerous?Largely depends on availability
◦Most emergency department (ED) visits: alcohol (DAWN, 2011)
◦Half + of 2.5 million ED visits: illicit substances
Which Drugs are Most Which Drugs are Most Dangerous?Dangerous?
Cocaine – 505,224 Combinations – 10,388
Marijuana – 455,668 Inhalants – 10,032
Heroin – 258,482 Unclassified hallucinogens – 8,043
Amphetamine/meth. – 159,840 LSD – 4,819
PCP – 75,538 GHB – 2,406
Synthetic cannabinoids – 28,531
Ketamine – 1,550
MDMA – 22,498
MDMAMDMA3,4-methylenedioxy-N-methylamphetamine3,4-methylenedioxy-N-methylamphetamine
How does Ecstasy prove to help people with PTSD?What exactly is Molly & why does it kill people?How do you overdose Ecstasy? Molly?
MDMAMDMA
• Molly, Ecstasy, Thizz
• Synthetic drug• Stimulant and
hallucinogenic properties
MDMAMDMA Acute effects on the brain
◦ Increased serotonin release◦ Increased dopamine release◦ Increased norepinephrine release◦ Effects will vary since formula is not standardized or
regulated◦ Effects will vary based on the synthetic nature of
substance◦ MDMA-assisted therapy (Multidisciplinary
Association for Psychedelic Studies, video; 0-2:00; 14 subjects, per website)
◦ More on MDMA therapy for PTSD (The Verge via YouTube, MAPS research through 7:00)
MDMAMDMA Chronic effects are controversial, per Carl Hart,
Columbia University (YouTube)◦ Well-circulated animal studies showing neuron
damage
Emergency Department Emergency Department VisitsVisits
Synthetics are currently Synthetics are currently popularpopular 2C-I, MDMA, bath salts, synthetic cannabis Lower price (think about economy’s influence) Drug popularity changes with time (synthetics were
popular in 1970s) Health-related issues will subsequently ebb and flow
as drugs move in and out of favor That acknowledged, some can be devastating:
Krokodil (CBS, 2013)
Which drugs are the most popular? Which drugs are the most popular? (by country (by country here)
MushroomsMushrooms
mushroomsmushrooms Psilocybin/psilocin are
two active psyhoacticve substances found in “magic mushrooms”
Couple dozen species Taken orally Recognized for centuriesProbably used in religious rites Hallucinogen Schedule I
mushroomsmushrooms Acute effects:
◦ Relaxation◦ Altered perception of reality◦ Altered perception of time◦ Sense of connection to others/universe◦ Visual hallucinations (images, color, light)◦ Potential for anxiety and subsequent panic, heart
rate & blood pressure increase Chronic effects:
◦ A “bad trip” may trigger fear◦ Hallucinogens may exacerbate mental illness
Being investigated as treatment for OCD, depression, smoking cessation◦ Johns Hopkins Psilocybin Cancer Project (via
YouTube, 0:30-4:03)
Dextroamphetamine Dextroamphetamine (Adderall)(Adderall)
About AdderallAbout AdderallStimulantWorks on dopamine
and norepinephrineUsed as prescription
for ADHD, narcolepsySome abuse Adderall
for its performance-related effects
60 Minutes program, April 2010
Schedule II
Adderall AvailabilityAdderall AvailabilityReadily available across U.S.$5-10 per pill
Adderall Prescriptions, by Adderall Prescriptions, by Year Year (U.S. Department of Justice)(U.S. Department of Justice)
Adderall EffectsAdderall Effects Increased alertnessEuphoriaSelf-assuredness Increased heart rate, blood pressureEmotional changesWeight lossStomach discomfort (nausea, cramps)Long-term effects are not yet known
Adderall FormsAdderall Forms
Tablet (5-30mg)Time release
capsule (10-25mg)
Adderall OverdoseAdderall OverdoseAccording to Dailymed (National Library
of Medicine), traditional symptoms can develop: anxiety, confusion, restlessness
2C-I2C-I4-iodo-2,5-dimethoxyphenethylamine
2C-I2C-I• “Smiles”• Synthetic
substance• Usually inhaled or
taken orally; may also be taken via blotter paper
• Stimulant & hallucinogenic properties
• Schedule I
2C-I2C-I• Impacts dopamine &
serotonin• Onset of effects may
not be immediate, triggering overdose
• Little information on brain impact
• Additives, chemical changes make drug unpredictable, similar to bath salts
MethamphetamineMethamphetamine
MethamphetamineMethamphetamine Famous/notorious for laboratory production, short-
term dopamine effects & long-term effects Stimulant (blood pressure, heart rate, alertness) DEA: Schedule II substance (Desoxyn: ADD,
narcolepsy, weight control)
Methamphetamine acute Methamphetamine acute effectseffects Intense high/euphoria
◦ May last up to 12 hours (longer than cocaine)◦ Meth Inside and Out video describing effects
Energetic, talkative, excitable Insomnia Increased heart rate, blood pressure Sweating Dry mouth Jaw clenching Nausea, vomiting Comparison: meth vs cocaine,Brookhaven
National Laboratory, 2008
Methamphetamine chronic Methamphetamine chronic effectseffects Chronic users may experience hallucinations, rage,
paranoia, heart “meth mouth;” damage to dopamine-, serotonin-containing nerve cells◦ Crank Bugs (Meth Project)◦ Meth Mouth (Meth Project)◦ Ashley’s Story (Meth Project)◦ Research supports both brain damage as well as lack of
brain damage
Methamphetamine Methamphetamine Chronic EffectsChronic Effects
Before & After Photos
Before and After Photos
3 Years and 5 months after starting methMeth Awareness Prevention Project: http://www.mappsd.org/Faces%20of%20Meth.htm
Before and After
17 months after starting methMeth Awareness Prevention Project: http://www.mappsd.org/Faces%20of%20Meth.htm
Before and After
3 months laterMeth Awareness Prevention Project: http://www.mappsd.org/Faces%20of%20Meth.htm
HeroinHeroin
HeroinHeroinNarcoticSynthesized from morphine in late
1800’s◦ Morphine synthesized from opium poppy◦ Heroin 10x more powerful than morphine◦ Was thought to be less addictive◦ After many people became addicted,
heroin was outlawed in 1920’s◦ Drug Ads (wings.buffalo.edu)
Schedule I