imidapril as effective as candesartan cilexetil for hypertension

Inpharma 1592 - 16 Jun 2007 Imidapril as effective as candesartan cilexetil for hypertension Imidapril is at least as effective as candesartan cilexetil in patients with mild to moderate essential hypertension, report researchers from Spain and Portugal. In their double-blind, randomised, multicentre trial, * 112 evaluable patients received either imidapril 5mg (n = 55) or candesartan cilexetil 4mg, for 12 weeks; doses could be titrated up to imidapril 10mg or 20mg and candesartan cilexetil 8mg or 16mg, at 4-week intervals to achieve systolic BP (SBP) and diastolic BP (DBP) readings of < 140mm Hg and < 90mm Hg, respectively. Significant reductions in mean SBP and DBP from baseline to study end were seen with both imidapril treatment (156.6 vs 138.9mm Hg and 96.8 vs 86.8mm Hg, respectively) and candesartan cilexetil treatment (159.2 vs 140.1mm Hg and 98.6 vs 88.5mm Hg, respectively); between-treatment differences were comparable. Overall, 24-hour ambulatory BP monitoring (ABPM) measurements showed effective BP control throughout the 24-hour dosing interval in both treatment groups. Moreover, all ABPM parameters were similar in the two treatment groups, although there was a trend towards lower awake and sleeping HR values in the imidapril group. The imidapril arm demonstrated greater reductions from baseline than the candesartan cilexetil arm in both BP load ** (DBP load, 44.6% vs 34.5%; SBP load, 38.0% vs 32.9%) and 24-hour average deviation load index (41.0% vs 33.6%). * supported by Bial ** the percentage of ABPM readings > 140/90mm Hg during the awake period and > 120/90mm Hg in the sleep period Palma-Gamiz JL, et al. A multicentre, 12-week study of imidapril and candesartan cilexetil in patients with mild to moderate hypertension using ambulatory blood pressure monitoring. Clinical Drug Investigation 27: 407-418, No. 6, 2007 801055215 1 Inpharma 16 Jun 2007 No. 1592 1173-8324/10/1592-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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Inpharma 1592 - 16 Jun 2007

Imidapril as effective ascandesartan cilexetil for

hypertensionImidapril is at least as effective as candesartan cilexetil

in patients with mild to moderate essentialhypertension, report researchers from Spain andPortugal.

In their double-blind, randomised, multicentre trial,*112 evaluable patients received either imidapril 5mg(n = 55) or candesartan cilexetil 4mg, for 12 weeks;doses could be titrated up to imidapril 10mg or 20mgand candesartan cilexetil 8mg or 16mg, at 4-weekintervals to achieve systolic BP (SBP) and diastolic BP(DBP) readings of < 140mm Hg and < 90mm Hg,respectively.

Significant reductions in mean SBP and DBP frombaseline to study end were seen with both imidapriltreatment (156.6 vs 138.9mm Hg and 96.8 vs86.8mm Hg, respectively) and candesartan cilexetiltreatment (159.2 vs 140.1mm Hg and 98.6 vs88.5mm Hg, respectively); between-treatmentdifferences were comparable.

Overall, 24-hour ambulatory BP monitoring (ABPM)measurements showed effective BP control throughoutthe 24-hour dosing interval in both treatment groups.Moreover, all ABPM parameters were similar in the twotreatment groups, although there was a trend towardslower awake and sleeping HR values in the imidaprilgroup.

The imidapril arm demonstrated greater reductionsfrom baseline than the candesartan cilexetil arm in bothBP load** (DBP load, 44.6% vs 34.5%; SBP load, 38.0%vs 32.9%) and 24-hour average deviation load index(41.0% vs 33.6%).* supported by Bial** the percentage of ABPM readings > 140/90mm Hg during theawake period and > 120/90mm Hg in the sleep period

Palma-Gamiz JL, et al. A multicentre, 12-week study of imidapril and candesartancilexetil in patients with mild to moderate hypertension using ambulatory bloodpressure monitoring. Clinical Drug Investigation 27: 407-418, No. 6,2007 801055215

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