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Available by subscription only LATEST TECHNOLOGY LATEST TECHNOLOGY LATEST TECHNOLOGY LATEST Available by subscription only Summer Issue 2017 HOW COLLAGEN PEPTIDES HOLD THE KEY TO QUALITY AGING SLOW AND STEADY WINS THE RACE FOR SUGAR REDUCTION Human milk oligosaccharides A challenge for the future

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LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST

Available by subscription only

LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST

Available by subscription only

Summer Issue 2017

HOW COLLAGEN PEPTIDES HOLD THE KEY TO QUALITY AGING

SLOW AND STEADY WINS THE RACE FOR SUGAR REDUCTION

Human milk oligosaccharides

A challenge for the future

nutraceuticals now 03

Singapore and BeyondAs Asia’s leading food and nutrition hub, Singapore houses many R&D centres and regional offices from leading F&B companies around the world. For Vitafoods Asia, this strategic move will bring in new visitors from other parts of the world while maintaining its reach in Asia Pacific.

As with previous editions, the nutraceutical event for Asia will cover four key industry areas – Ingredients & Raw Materials, Contract Manufacturing & Private Label, Services & Equipment, and Branded Finished Products – offering a more focused and targeted content across all segments. Designed to facilitate business interactions, these areas reflect the diverse nature of the nutraceutical industry and the classification will allow visitors to identify exhibitors of interest with greater ease. This year, attendees can expect to view a wide portfolio of offerings from a record number of over 250 exhibitors from around the world, including major manufacturers and service providers like analyze & realize, AstaReal, Catalent, Gelita, Graminex, Ingredia, KSM, Lesaffre, Sabinsa, Troikaa, and Vidya Herbs.

Returning Event HighlightsVisitors interested in uncovering the latest launches and core products can head over to the Inspiration Showcase, featuring a wide range of products - such as energy drinks, meal replacement bars, and collagen jellies - that address a variety of needs. Those seeking the opportunity to see, touch, and taste the latest functional food and beverages in order to make informed purchasing decisions can head to the Tasting Centre, where visitors are also encouraged to vote for their favourite product in the annual Tasting Centre Awards.

Attendees looking to keep up-to-date with key developments in the industry can pay a visit to the Market & Trend Overview section. There, experts from Innova Market Insights will offer a range of poster and tablet device presentations delving into carefully selected health categories to broaden visitor’s understanding on the pan-Asian market leading ingredients, products, and consumer trends.

The popular Omega-3 Resource Centre also makes a return, bringing new trends and product developments from the market. Industry members can learn all about the Omega-3 supply chain and even access market data on selected topics at the focused knowledge hub.

In addition, attendees can further expand their network

and knowledge at the New Exhibitor Pavilion, where new entrepreneurial businesses and start-ups in the industry will be exhibiting for the very first time.

The coming edition also offers the highest number of International Pavilions. Visitors planning to source from specific countries can narrow their search by zooming in on the 8 pavilions – Australia, Canada, France, Germany, Japan, Poland, Taiwan and USA.

New Education Opportunities

Apart from gaining access to the latest innovations and networking opportunities, attendees can look forward to new educational offerings lined up at Vitafoods Asia. This year, the revamped Vitafoods Asia Conference will be split into two segments: four 1/2-day Masterclasses and a full-day Digestive Health & Microbiome Summit. The conference will feature an impressive panel of global industry experts from countries such as Australia, Germany, Sweden, Thailand, The Netherlands, and USA, across various segments and job functions. Each unique segment will address the key challenges within Asia’s nutraceutical, supplement, and functional food industry.

For those seeking complimentary learning opportunities on the show floor, two brand-new presentation theatres are available. The Innovation Theatre is a two-day programme that is fully dedicated to the future of the Asian nutraceutical and functional nutrition industry. It aims to explore the upcoming developments in the industry, namely in the categories of Open Innovation, Personalised Nutrition, and New Technology. Separately, the Vitafoods Asia Life Stages Theatre is designed to examine on the specific nutrition requirements throughout the human life stages, focusing on three core themes – Infant & Maternal Health, Adult Health, and Healthy Ageing.

Lastly, attendees looking for a successful market access to Asia can also seek regulatory advice at the new Industry Experts Advice Centre, featuring regional and pan-Asian market and regulatory experts. Interested parties can visit Vitafoods Asia website prior to the event to secure a free 1-2-1 consultation.

For more information on Vitafoods Asia, visit www.vitafoodsasia.com.

Vitafoods Asia 2017: New Venue and City, Bigger and Better ExperienceVitafoods Asia – the only event dedicated to the nutraceutical, functional food and beverages, and dietary supplement industries in Asia – will be held in Singapore for the first time ever. Happening at the Sands Expo and Convention Centre in Marina Bay Sands from 5 – 6 September, the seventh edition will be twice as large as before, with over 250 exhibiting companies, and will present more of the best innovations that the industry has to offer.

••• show preview

contents

Nutraceuticals Now is a technical review providing the latest information on functional products and ingredients which are defined as having a disease preventing and/or health promoting benefit in addition to their nutritional value.It is targeted at manufacturers of food and drink, who are producing finished products aimed at the ever increasingly health conscious consumer.Any views and/or opinions expressed in the articles in this magazine are entirely those of the individual authors and do not necessarily express the views of the editorial staff.

ISSN -1478-6605

Editor: Charles FaulknerOperations Manager: Dan PeacockConsultant: Christopher McIntyreAccounts: Steve ClarkDesigner: Al Knight

Published by: Johnson-Johnsen Publishing 6 Victoria Terrace, Inverness, IV2 3QA, Scotland.Tel: +44(0) 1463 718993Fax: +44(0) 1463 229976Email: [email protected]: www.nutraceuticalsnow.com

Printed by: Harrisons

Available by subscription onlyadvertisers02 VitaFoods Asia04 Supply Side West 06 NSF12 Brenntag13 OmniActives19 Natural Products Scandinavia23 Indena28 IFIS28 Fi Asia29 Food Matters Live35 Sabinsa36 LHC

03 Show Preview: Vitafoods Asia 201706 Foreword: Vitafoods Asia 201708-09 How collagen peptides hold the key to quality aging10-13 Brenntag UK & Ireland: Formulating the future together14-15 Capsaicinoids’ new role in weight management16-17 Human milk oligosaccharides - a challenge for the future18 Tate & Lyle extends clean-label portfolio20-21 The food matrix effect, beyond the nutrients22 Prinova aquires Lycored’s UK and China-based premix manufacturing locations 22 Hauts-de-France, a champion in food processing24-25 Nutraceuticals market can rely on highest levels of authenticity via testing and certification26-27 Dietary Polyphenols as nutraceuticals30-31 Slow and steady wins the race for sugar reduction32-33 Heading for the mainstream34 Fruit d’Or cranberry seed oil approved by Health Canada

nutraceuticals now 05

LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST

Spring 2016

Available by subscription only

LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST TECHNOLOGY • LATEST

Spring 2016

Autumn 2016

Available by subscription only

Winter issue

• Adverts become moving animated graphics with further options, menus, links and content• Readers point their device at your advert and watch with amazement as your advert unfolds into a visual multidimensional journey.• The standard advert image acts as a portal, opening up a world of moving images. The app is free to download and available on iphone and android devices at: playstore/appstore

When you see this icon

simply point your device at the advert to experience Augmented Reality contentDOWNLOAD - OPEN - POINT APP - ENJOY!

IntroducIng nutranow app and how It works

Download app – NUTRANOWFor more information contact Anisha Mcdermaid:

[email protected] www.nutraceuticalsnow.com

06 nutraceuticals now nutraceuticals now 07

According to Allied Market Research1, the global nutraceuticals market size is expected to reach $302,306 million by 2022, with a CAGR of 7.04% from 2016 to 2022. Asia Pacific is expected to surpass the global growth average with a CAGR of 7.33%, making noteworthy contributions to the global market.

Increasingly, consumers believe that supplements can help them achieve their nutrition goals, and this signals a wide open market with plentiful opportunities. Based on our interactions with industry players, we expect personalised nutrition and probiotics to feature strongly in this year’s Vitafoods Asia.

Herbalife revealed the results of its Asia Pacific Balanced Nutrition Survey2 earlier this year, and it showed that one in three consumers are keen on personalised nutrition products and nutrigenomics. However, due to a lack of practitioners in the region, such products have generally been too costly for consumers. Separately, probiotics is likely to remain a popular category, given the size of the Asia Pacific market – accounting for an estimated majority share of 38% in 20163 – and the rising awareness of health benefits associated with it.

This year, Vitafoods Asia will be held in Singapore for the first time ever. Twice as large as before, with over 250 exhibiting companies, the seventh edition will present more of the best innovations that the industry has to offer. As Asia’s leading food and nutrition hub, Singapore houses many R&D centres and regional offices from leading F&B companies around the world. For Vitafoods Asia, this strategic move will bring in new visitors from other parts of the world and maintain the show’s reach in Asia Pacific.

As with previous editions, the nutraceutical event for Asia will cover four key industry areas – Ingredients & Raw Materials, Contract Manufacturing & Private Label, Services & Equipment, and Branded Finished Products – offering a more focused and targeted content across all segments.

Returning Event HighlightsVisitors interested in uncovering the latest launches and core products can head over to the Inspiration Showcase, featuring a wide range of products - such as energy drinks, meal replacement bars, and collagen jellies - that address a variety of needs. Those seeking the opportunity to see, touch, and taste the latest functional food and beverages in order to make informed purchasing decisions can head to the Tasting Centre, where visitors are also encouraged to vote for their favourite product in the annual Tasting Centre Awards.

Attendees looking to keep up-to-date with key developments in the industry can pay a visit to the Market & Trend Overview area of the show. There, experts from Innova Market Insights will offer a range of poster and tablet device presentations that delve into carefully selected health categories to broaden visitor’s understanding on the pan-Asian market leading ingredients, products, and consumer trends.

The popular Omega-3 Resource Centre also makes a return, bringing new trends and product developments from the market. Industry members can learn all about the Omega-3

supply chain and even access market data on selected topics at the focused knowledge hub.

In addition, attendees can further expand their network and knowledge at the New Exhibitor Pavilion, where new entrepreneurial businesses and start-ups in the industry will be exhibiting for the very first time. The coming edition also offers the highest number of International Pavilions. Visitors planning to source from specific countries can narrow their search by zooming in on the 8 pavilions – Australia, Canada, France, Germany, Japan, Poland, Taiwan, and USA.

New Education OpportunitiesApart from gaining access to the latest innovations and networking opportunities, attendees can look forward to new educational offerings lined up at Vitafoods Asia. This year, the revamped Vitafoods Asia Conference will be split into two segments: four 1/2-day Masterclasses and a full-day Digestive Health & Microbiome Summit. Those seeking complimentary learning opportunities on the show floor can expect two brand-new presentation theatres. The Innovation Theatre is a two-day programme dedicated to the future of the Asian nutraceutical and functional nutrition industry, and it explores the upcoming industry developments in the categories of Open Innovation, Personalised Nutrition, and New Technology. Separately, the Vitafoods Asia Life Stages Theatre is designed to examine on the specific nutrition requirements throughout the human life stages, focusing on three core themes – Infant & Maternal Health, Adult Health, and Healthy Ageing.

Last, attendees looking for a successful market access to Asia can also seek regulatory advice at the new Industry Experts Advice Centre, featuring regional and pan-Asian market and regulatory experts. Interested parties can visit the Vitafoods Asia website prior to the event to secure a free 1-2-1 consultation.

My team and I look forward to welcoming industry professionals from all over the world at Vitafoods Asia 2017.

References• Allied Market Research, Nutraceuticals Market by Type - Global Opportunity Analysis and Industry Forecast, 2014-2022, Dec 2016 • Herbalife, Asia Pacific Balanced Nutrition Survey Findings, 5 April 2017 • Mordor Intelligence, Asia Pacific Probiotics Market (2017-2022), May 2017

Chris LeeManaging DirectorGlobal Health & Nutrition NetworkInforma Exhibitions

www.vitafoodsasia.com

Vitafoods Asia 2017: Uncover Opportunities to Enter Burgeoning Nutraceuticals Market New Venue and City, Bigger and Better ExperienceCome September, Asia’s nutraceutical, functional food and beverages, and dietary supplement industries will gather in Singapore for Vitafoods Asia, the regions’ only event dedicated to these markets. Despite what crowd sentiment and ‘common sense’ say about the global economy, many of those we’ve spoken to have expressed positivity about the future of their companies.

••• foreword

strength in 60 sarcopenic men aged 65 and older. Overall, the results clearly show that the combination of resistance

exercise and specific collagen peptide supplementation can strengthen muscular power and fight and prevent sarcopenia.

Q: Science has not yet provided a cure for osteoarthritis, another huge age-related health concern. Do you believe that collagen peptides could provide the breakthrough we have been waiting for?A: Well, they are not a drug and they can’t cure osteoarthritis but they can do a lot to reduce or to postpone the condition. The principal reason for joint problems as people age is wear and tear of joint cartilage. In most cases, the symptoms are treated, rather than the cause. At GELITA, we have worked hard to develop a solution that tackles

this problem in a completely different way. We have developed a product called FORTIGEL®. It stimulates the body’s cartilage cells to increase production of both collagen and proteoglycans — the two major components that make up almost 90% of cartilage dry mass. In doing so, these collagen peptides

considerably improve joint mobility, reduce pain and produce lasting quality of life. We have proven the effectiveness of our product in joint cartilage recovery in several clinical and pre-clinical studies.

Q: Bone health is a particular concern for women after the menopause. Is there anything collagen peptides can do to help in this respect?A: Loss of bone density and stability is a significant problem for many postmenopausal women. It can develop into osteoporosis, a bone weakening condition that is actually a major public health threat for many population groups – not just post-menopausal women. In fact, the WHO predicts that the already huge number of men and women with osteoporosis in the EU will rise to 33.9 million in 2025 – that’s a 23% increase from 2010.1 Bone is a mixture of mineral crystals held in an organic collagen matrix. Without this collagen matrix, the crystals are extremely brittle and prone to breakage. Thus, it can be seen that collagen is as vital as calcium for bone health. We have therefore developed a bone health product called FORTIBONE®. It stimulates osteoblast activity to increase the production of the extracellular bone matrix. In addition, it regulates the degenerative processes that affect bones by reducing osteoclast-based protease production. A recent

double-blinded study on post-menopausal women showed that FORTIBONE® administration statistically significantly increased the bone mineral density in the spine and the femoral neck by more than 5% compared to placebo over the period of one year. This study confirms the anabolic effects FORTIBONE® has on the bone metabolism.

Q: Women in particular also worry about the condition of their skin as they grow older. How can collagen peptides be incorporated into skin health products, and what results can consumers expect to see?A: Collagen is what gives the skin its firm structure. However, from the age of 30 onwards collagen synthesis in the dermis is reduced. At the same time, the skin suffers from a progressive loss of moisture, which makes it increasingly dry. Our collagen peptides in VERISOL® stimulate the fibroblasts in the dermis. This substantially increases the synthesis of collagen, elastin and proteoglycans, all of which contribute to the skin’s elasticity. As a result, the epidermis is supported from beneath and skin sagging is prevented. Clinical studies have been published that prove these positive effects on skin elasticity, wrinkle reduction and the appearance of cellulite-affected skin with a daily dose of 2.5 g of VERISOL®.With regards to applications: all GELITA collagen peptides can easily be incorporated into a wide variety of products — from pharmaceutical-like applications such as capsules, film-coated tablets and standard tablets to indulgence products such as chocolate, instant coffee, beauty drinks, shots or even fortified gummies.

Q: When sourcing collagen peptides, what should manufacturers look out for?A: As with many things in life, not all collagen peptides are equal. We would always advise manufacturers to source and use only the products used in the clinical trials. Whatever the intended application, it is essential that the promised functionality is based on sound science and has been proven in high quality clinical studies. GELITA’s philosophy of substantiating all product functionalities on solid science is what I believe makes the company the preferred supplier for healthy aging products.

Reference1 www.iofbonehealth.org/facts-statistics#category-22

About GELITAGELITA is the world’s leading manufacturer and supplier of collagen proteins. Providing functional, health and wellbeing benefits, the company’s extensive range of collagen proteins provides versatile functionalities in functional foods, nutraceuticals and dietary supplements and offers innovative opportunities for a wide variety of product development options. GELITA offers comprehensive service, support and many years of expertise in collagen protein applications. With its strong commitment to science-based innovation, GELITA is continually looking for new solutions for food, as well as for health and nutrition applications. The company provides its customers with tailor-made formulations and a range of products that meet and exceed the requirements of each and every application.

08 nutraceuticals now nutraceuticals now 09

Q: How is the desire to live better for longer manifesting itself in populations around the world?A: Consumers are aware that they are likely to live longer than their predecessors, and the number of people aged 60 and older is growing faster than any other age group. This has led to increased consumer desire to be healthy now and in the future. Across the globe, people are taking an increasingly proactive role in their own health by adopting more nutritious diets and more active lifestyles. At the same time, governments and health organizations are keen to encourage people to adopt healthy lifestyles in order to avoid the potentially huge burdens that illness and infirmity in older people could place on their health and social services.

Q: What kind of opportunities does this open up for manufacturers?A: This shift in attitudes has created exciting new opportunities for food, beverage and nutraceutical producers. Consumer demand for solutions that can tackle age-related conditions and keep people active for longer is growing at an impressive rate. In order to be able to meet this demand, however, manufacturers require scientifically proven ingredients that can be incorporated into a wide variety of everyday items.

Q: Which aspects of their health in later years are consumers most concerned about?A: Limited physical performance, loss of muscle tone and skin vitality, as well as degenerative joint diseases and cartilage problems are some of the main concerns that people associate with aging – and without some form of intervention, these are

very real possibilities for many.

Q: What are the options when it comes to finding solutions to these problems?A: People who want to stay fit and healthy as they grow older have several options, from sports and lifestyle interventions to the use of preventative nutrients. We believe that specific collagen peptides can be a powerful ally for people looking to take the preventative nutrient approach. With their special nutritional properties, high quality proteins are important tools when it comes to effectively improving health and wellbeing. In fact, GELITA’s specific collagen peptides are scientifically proven to be very useful in many serious health issues related to aging.

Q: Can collagen peptides really help to fight serious age-related problems? Aren’t they just good for healthy skin and nails?A: The potential roles for collagen peptides in supporting health as we age go far beyond skin, nails and outward appearance. Specific peptides can be tailored to deliver solutions to age-related problems that could potentially place huge burdens on health budgets as well as personal wellbeing.Age-related muscle wasting, or sarcopenia, for instance, is a problem that poses serious concern. As well as causing a steady loss of lean muscle mass, it is characterized by an increase in fat mass and a loss of strength and mobility. To fight sarcopenia, GELITA has developed specific Bioactive Collagen Peptides® named BODYBALANCE®. A high quality study investigating its effects on body composition and muscle

As people all over the world realize they are likely to live to a ripe old age, the desire to live better for longer is becoming increasingly important. Collagen peptide expert GELITA believes that its multifunctional ingredients are what consumers are looking for, in more ways than one. Nutraceuticals now speaks to Dr Stephan Hausmanns, Vice President BU Health & Nutrition at GELITA, to find out why.

How collagen peptides hold the key to quality aging

Dr Stephan Hausmanns,

Vice President BU Health & Nutrition at GELITA

10 nutraceuticals now nutraceuticals now 11

solutionising plant, offering our customers a range of pre-diluted ingredients. All of our Brenntag UK & Ireland distribution sites have gained certification for the British Retail Consortium (BRC) which demonstrates our commitment to being the custodians of safety for the ingredients supply chain we operate in.

DISCUSSING KEY TRENDS IN THE MARKETSpecific market trends depend on the market application, however we are continuing to see the focus on ranges for health conscious customers across the food and beverage sectors. Demand for “well being” or “good for you” products are increasing. Fat, salt and sugar reduction, “Free From”, clean and clear label continue to be some of the key messages

calling for more diversified product offerings. Consumption is largely driven by external factors that are common across most food categories, such as concerns over healthy eating or “Macro Trend of Health”.

For instance, the bakery market has changed significantly, as shoppers direct their purchasing process through a prism of health trends as well as price. The increasing demand for natural bakery products that contain ingredients such as fibre is expected to fuel the demand for bakery products. We have seen ongoing success of using chicory root fibre in bakery formulations, as it is rapidly becoming the favoured choice with its clean labelling and ability to replace sugar and addition of fibre.

In the beverage market, sugar reduction continues to be one

Brenntag UK & Ireland is part of an organisation that dates back close to 150 years. From its headquarters located in Leeds, Yorkshire, and strategic sites across the UK & Ireland, Brenntag offers its business partners a wide range of products and value added services such as filling, mixing and blending services, extensive formulation, technical and regulatory support within the Life Science, Environmental and Material Science sectors. Today we speak to Alastair Nicoll, Business Manager Food & Nutrition, on what is the key to Brenntag’s continued success in the food and beverage industry

Alastair says:Distribution of specialty ingredients across food and

beverage sectors has been Brenntag’s successful focus for several decades. We offer products for all food and beverage applications, including meat, poultry & fish processing, bakery, dairy and ice cream, beverages, confectionery, convenience foods, fruit and vegetable processing, sports nutrition and many more. Innovations are developed through the introduction of new nutritional and functional ingredients, while new technologies or processing can also provide opportunities for further optimisation of the formulation. Our specialist technical teams work with customers to develop new products and new application advantage, whether it is choosing the right ingredients for their products, or developing solutions that are tailor-made for each customer’s unique and specific needs. My colleagues can advise the right ingredient combinations, interactions and processing conditions to get ingredients to perform to their fullest.

CHOOSING THE RIGHT INGREDIENT Formulation flexibility is one of the key attributes required to react quickly on the raw materials situation and on market

trends. In many cases there is not just one ingredient that can satisfy all the requirements in an alternative formulation. The whole recipe should be reviewed taking into consideration processing conditions and ingredient interaction to arrive to a tailored, customer specific recommendation.

The choice of appropriate ingredients depends on the positioning or the value/ benefit proposition of a product. Finding ingredients that meet a specific criteria and still deliver on texture, taste, flavour, shelf life and safety can be a challenge. The right ingredient, in combination with the correct processing, packaging and storage conditions, helps to ensure product quality. We help our customers to achieve cost optimisation and flexibility with alternative ingredients or develop innovative flavour profiles in a range of areas of food design and technology, health and nutrition, food safety, processing aids.

INNOVATIVE PRODUCT CONCEPTS I am delighted to announce the launch of a new Brenntag Food Application Kitchen. We have always taken pride in our ability to provide extensive technical support to our customers through our network of Food Application Centres across Europe. Our new UK based facility will allow us to undertake even more bespoke projects and formulating trials across the variety of food and beverage applications, featuring formulation, product and stability testing.

Our Food Application Kitchen is located at our food hub site in Widnes, Cheshire, which is also the flagship in our evolving focus on food, feed and pharmaceutical blends in the UK & Ireland. The site now incorporates a facility that manufactures dilutions of acidulants, preservatives and other ingredients at customer-designated strengths as part of our standard portfolio.

Along with Widnes, our Belfast site houses a food

Brenntag UK & Ireland: Formulating the Future Together

10 nutraceuticals now

of the key aspects. Some of the simplest and most cost effective ways to decrease the sugar without affecting flavour is to select an intensive sweetener system. Cellulose gums can help counter the loss of body following the removal of sugar.

Demand for fibre fortified drinks is also on the increase. The ever-growing energy drinks market leads to the need for suppliers to provide bespoke food blending at an increased output level. We have seen increased demand for specific vitamin and mineral blends in beverage to replace those lost when juices are pressed, heat treated and transported. Blending of course is not only limited to powders. From simple blends like a 50% Citric Acid to solution in bulk, to a more bespoke blend of sweeteners or preservatives in an IBC- the highest quality standard such as the BRC accreditation is key.

Dairy products have always been associated with health, and are seen as an essential part of a well-balanced, enjoyable diet. Value, convenience, health, wellness and even indulgence now actively influence buying decisions. The texture, mouthfeel, shelf life and appearance of dairy products such as milk, drinking or spoonable yoghurts, and flavoured milk are all key factors that consumers are looking for, and multiple benefit claims are on the rise. Low fat and Free From (such as allergy and gluten free) claims continue to be popular. We are also seeing digestive/gut health positioning gaining further share of this segment. Again, in case of texture improvement, clean label alternatives, low fat/sugar content for dairy products – correct choice of ingredients can help deliver the right positioning of the product.

A growing consumer trend for healthier foods is now looking at sectors that have not traditionally been considered as healthy - in a confectionery market for instance. Consumers are looking for healthier alternatives that still provide the taste

and comfort of a traditional confectionery product. Ingredients such as Inulin from Sensus allow manufacturers remove part of the sugar but still deliver a pleasant tasting finished product with no changes in the manufacturing process.

In my view, a successful product is one which interacts with a variety of consumer beliefs and shows the benefits of ingredients, and innovation is vital to engage with existing and new potential users. Innovation can be achieved through the introduction of ingredients, new technologies and processing - or all of these aspects for optimal formulation.

For more information please contact [email protected].

nutraceuticals now 13

nutraceuticals now 1514 nutraceuticals now

Getting to know Capsicum The genus Capsicum is native to the Americas. The active ingredient responsible for their spicy kick is called capsaicin and was first isolated in 1846. Its chemical structure was elucidated later in 1919. More recent research found that a whole group of compounds contribute to the hot sensation and are collectively known as capsaicinoids. They fall into a class called alkaloids and include capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin and homodihydrocapsaicin. The first three of these account for 90% or more of the capsaicinoid concentration in the chili and cayenne pepper varieties (See Figure 1). One gram of dried red pepper contains approximately 3 mg of capsaicinoids but the actual amount is highly variable and depends on growing locations and conditions.

Figure 1. Structures of the three most abundant capsaicinoids in chili and cayenne peppers.

The Special Action of Capsaicin in the BodyThe body has a special subset of nerve receptors that perceive stimuli such as heat and acid. When these receptors are activated, the body feels a painful burning or itching sensation. A subset of these receptors, called transient receptor potential vanilloid 1 (aka TRPV1), can be activated by capsaicinoids and their analogs. These receptors are found throughout the body and especially in the gastrointestinal tract, adipose tissue and the brain and play a key role in the physiological effects seen when capsaicinoids are consumed. Over 90 clinical studies have been conducted with capsaicinoids, demonstrating their ability to increase lipolysis (the

breakdown of fat) and energy expenditure and reduce appetite. The culmination of these effects not only promote weight loss but also healthy body composition, which may be a better indicator of overall health and reducing risk associated with chronic diseases.

Body Composition is a Better Indicator of Weight and HealthBody weight by itself only indicates the combined weight of all the tissues of the body and is not nearly as important as composition. Body composition describes the relative amount of fat to fat-free mass (bones, muscles, organs, etc…) and how that fat is distributed throughout the body. So, even a healthy person with seemingly normal weight on the scale may still have an unhealthy body composition. People are generally classified as having body composition that is either android (a.k.a. “apple shaped”) or gynoid (“pear shaped”). Carrying more weight in the waist (“apple shaped”) is associated with increased risk factors of hypertension, diabetes, high cholesterol and cardiovascular disease. The waist-to-hip ratio accounts for body composition by measuring the dimensions of the circumference of the waist to that of the hips. It provides insight into both the amount of weight a person carries, how it is distributed in the body and the risk of associated illness from excess fat. Therefore dietary and supplementation interventions that reduces

Capsaicinoids’ New Role in Weight Management – Promoting Healthy Body Composition

Despite the fact that more and more people are aware of the health implications of weight gain and obesity, they are still a growing problem and projected to significantly increase in the coming decade. Diet and exercise often bring little long-term success, even though many try to lose weight using these methods. Maintaining consistency with a diet plan is challenging and exercise, even when done regularly, may not significantly impact caloric expenditure to make a difference. To help, many turn to dietary supplements. One naturally occurring ingredient comes from red chili pepper (Capsicum) and over the last 40 years, research has shown how it supports key aspects of healthy weight management including lipolysis – the breakdown of fat, metabolism (thermogenesis) and

By Lynda Doyle

body fat and improve body composition provide a more comprehensive approach to weight management and overall health. Several studies have confirmed that Capsimax supports key mechanisms for weight management, including increasing lipolysis (the breakdown of fat) and energy expenditure and reducing appetite. A recent study demonstrates that Capsimax not only supports weight management but also healthy body composition.

The ABC Benefits of CapsimaxOmniActive’s Appetite and Body Composition Study (ABC), published in the journal Appetite and entitled “Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals,” was a 12-week, randomized, double-blind, placebo-controlled study. Seventy-seven healthy subjects (mildly overweight but not obese) were assigned to receive one of three protocols: 100mg Capsimax (containing 2 mg capsaicinoids), 200 mg Capsimax (containing 4 mg capsaicinoids) or placebo. At baseline, 6 weeks and 12 weeks waist: hip ratio, body composition (via dual energy x-ray absorptiometry) self-reported calorie intakes and appetite levels were analyzed. The results show that by 6-weeks of supplementation, waist: hip ratio significantly decreased in the group taking 100 mg Capsimax and by 12-weeks subjects consuming 200 mg Capsimax consumed less calories per day compared to the placebo group. The results suggest that Capsimax supplementation reduces self-reported energy intake after 12-weeks and can significantly reduce the waist-to-hip ratio in healthy individuals.

Capsaicinoids are a potent class of compounds that has been extensively studied for their weight management benefits. Derived from chili peppers, there are few supplements derived from a food commonly consumed throughout the world that can boost metabolism, increase fat breakdown, reduce appetite and, now, support healthy body composition by its ability to improve waist-to-hip ratio. Using OmniActive’s OmniBead™ technology Capsimax provides a concentrated source of highly active capsicum in a controlled-release coating without the oral and gastric burning sensation of unprotected chili peppers. The capsaicinoids found in Capsimax provide a low-dose, convenient and proven solution for weight management and a healthy lifestyle.

References1 Centers for Disease Control and Prevention. http://www.cdc.gov/obesity/data/adult.html, 2017.2 Sassi F, Devaux M. Obesity update 2012. OCED. http://www.oecd.org/health/49716427.pdf3 Szallasi A, Blumberg PM. Lypo. Pharmacol Rev. 1999 Jun;51(2):159-212.Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite. 2012 Oct;59(2):341-8.4 De Lourdes Reyes-Escogido, M, Gonzalez-Mondragon, ED and Vazquez-Tzompantzi E. Chemical and pharmacological aspects of capsaicin. Molecules. 2011;16: 1253-1270.5 Ku Y & Choi S (1990) The composition of foods. In: The Scientific Technology of Kimchi, pp. 33–34 [Korean Institute of Food Development, editors]. Seoul, Korea: Korean Institute of Food Development. 6 Tremblay A, Arguin H, Panahi S. Capsaicinoids: a spicy solution to the management of obesity? Int J Obes (Lond). 2016 Aug;40(8):1198-204.7 Lopez H, Ziegenfuss TN, Hofheins JE, Habowski S, Arent SM, Weir JP, Ferrando AA. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nut. 2013; 10: 1-14.8 Yoshioka M, St-Pierre S, Suzuki M, Tremblay A. Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr. 1998 Dec;80(6):503-10.9 Bloomer RJ, Canale RE, Shastri S, Suvarnapathki S. Effect of oral intake of capsaicinoid beadlets on catecholamine secretion and blood markers of lipolysis in healthy adults: a randomized, placebo controlled, double-blind, cross-over study. Lipids Health Dis. 2010 Jul 15;9:72.10 Galgani JE, Ravussin E. Effect of dihydrocapsiate on resting metabolic rate in humans. Am J Clin Nutr. 2010; 92:1089–1093.11 Ryan ED, Beck TW, Herda TJ, Smith AE, Walter AA, Stout JR, Cramer JT. Acute effects of a thermogenic nutritional supplement on energy expenditure and cardiovascular function at rest, during low-intensity exercise, and recovery from exercise. J Strength Cond Res. 2009 May;23(3):807-17.12 Deng Y, Chen F, Juturu V, Forzani E. Capsaicinoids enhance metabolic rate using a novel metabolic tracker Breezing Device: An open-label study. Adv Nutr. 2017;8:5.13 Matsumoto T, Miyawaki C, Ue H, Yuasa T, Miyatsuji A, Moritani T. Effects of capsaicin-containing yellow curry sauce on sympathetic nervous system activity and diet-induced thermogenesis in lean and obese young women. J Nutr Sci Vitaminol (Tokyo). 2000 Dec;46(6):309-15.14 Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite. 2012 Oct;59(2):341-8.15 Russek M, Vega C, Barrera J, Soto-Mora LM, Lanzagorta A, Racotta R. Anorexia elicited by different catecholamines in rats. Appetite. 1987 Oct;9(2):119-26.16 Urbina SL et al. Capsaicinoids supplementation reduces appetite and body circumferences in healthy men and women a placebo controlled randomized double blind study. Appetite. 2017; 113: 264e273 17 http://www.fda.gov/ucm/groups/fdagov-public/@fdagov-foods-gen/documents/document/ucm269479.pdf18 No authors listed. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int J

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By the early 1900s, eminent pediatricians had already noted the much lower mortality rate of breastfed infants compared to bottle-fed infants, and observed a correlation between breastfeeding and disease resistance, including resistance to infectious diarrhea. Furthermore, they found important differences in the intestinal microbiota, including the predominance of Lactobacillus bifidus (later known as Bifidobacterium bifidum) in the feces of breastfed infants. This was attributed to an unidentified “bifidus factor”. In the 1950s, evidence began to emerge that the bifidus factor was a specific group of carbohydrates in human milk, now known as human milk oligosaccharides. These HMOs support the growth of lactobacilli, which in turn inhibit pathogens by outcompeting them for nutrients and by secreting acids (lactic acid and acetic acid) that make the environment unfavorable for pathogen growth. Nowadays, it is well known that the diet influences the composition of the gut microbiome, not only in infants but also in adults. The gut microbiome of breastfed infants is typically dominated by commensal bacteria of the genera Bifidobacterium and Bacteroides due to their competence to metabolize HMOs. HMOs are not digested by humans, so they lack any nutritional value and enter the colon largely intact, where they act as prebiotics to enrich the beneficial microbial population and suppress the growth of harmful bacteria.

As well as inhibiting pathogens indirectly by supporting the growth of commensals, HMOs prevent many pathogens from binding to cellular receptors, as discussed above for

norovirus. Gastrointestinal pathogens often bind to glycans on the surface of the mucosal epithelium, the innermost cell layer which is in direct contact with the contents of the gut. Soluble HMOs with similar glycan structures act as adhesion-blocking decoys to prevent this critical initial stage of the infection process. The trisaccharide 2’-fucosyllactose prevents the binding of bacteria such as Campylobacter jejuni, one of the most harmful pathogens responsible for bacterial diarrhea (Yu et al., 2016). Other HMOs have been shown to block Escherichia coli, Salmonella fyris and Vibrio cholerae (Coppa et al., 2006). Acidic HMOs similarly block Helicobacter pylori, which promotes the development of gastritis and gastric ulcers (Simon et al., 1997). The effectiveness of fucosylated HMOs is not limited to viruses and bacteria – HMOs also provide passive immunity against the fungus Candida albicans and even the phagocytosis of eukaryotic parasites can be hindered by the same adhesion-blocking mechanism.

Many scientific reports have confirmed the positive effects of breast milk and specific HMOs on infant health and development in vitro and in vivo. HMOs have the potential to modulate systemic immunity by triggering immune factors that influence immune cell population and its functions. HMOs reduce intestinal inflammation, and by promoting the growth of lactobacilli and bifidobacteria, these bacteria themselves also have a positive influence on innate immunity. Acidic HMOs such as sialyllactose may provide the sialic acid required for the biosynthesis of gangliosides and glycoproteins, which are

According to the Centers for Disease Control and Prevention (Atlanta, Georgia, USA), approximately 20% of all global cases of acute gastroenteritis are caused by norovirus infections. Norovirus is responsible for more than 650 million infections worldwide every year, 200,000 of which are fatal. Although norovirus causes diarrheal diseases in all age groups, it is the most common cause of diarrheal death in children up to 5 years of age. There is no vaccine against norovirus and no specific treatment for infections. However, recent studies have shown that human milk oligosaccharides (HMOs), specifically 2’-fucosyllactose and 3- fucosyllactose, may help to prevent norovirus infections by stopping the virus particles from attaching to their receptors on the cell surface. Norovirus infections begin when the virus binds to glycans expressed on the surface of mucosal epithelial cells in the digestive tract – the so-called histo-blood group antigens (HBGA). Fucosylated HMOs such as 2’-fucosyllactose, 3-fucosyllactose and more complex HMOs containing an alpha 1,2-fucose epitope are structurally similar to these HBGA receptors. This resemblance is sufficient for the HMOs to act as decoys – thus norovirus particles bind to HBGAs and HMOs in vitro in a similar manner (Weichert et al., 2016, Shang et al., 2013). More importantly, the reduced frequency of diarrhea caused by microbial infections correlates with the content of fucosylated HMOs in breast milk (Morrow et al., 2004, Yu et al., 2016).

Human milk oligosaccharides. . . a challenge for the future

in turn essential for brain development. Approximately 200 structurally diverse HMOs have been

identified thus far, comprising various monosaccharide building blocks such as glucose, galactose, L-fucose, N-acetylneuraminic acid and N-acetylglucosamine. HMOs are the third most abundant component of human breast milk after lactose and lipids, with a concentration of 5–10 g/L. However, the quantity and composition of HMOs depends on the individual and changes during the period of lactation. At the beginning of lactation, when the infant is most vulnerable to infections, the concentration of HMOs can reach 24 g/L in the early milk known as colostrum. Remarkably, both the concentration and diversity of carbohydrates appears unique to human breast milk. For

example, the concentration of oligosaccharides in bovine colostrum is only about 1 g/L, and this declines rapidly during lactation. The oligosaccharides in bovine milk and the milk of other domestic ruminants are not only less abundant but also less diverse, and in some cases, they differ structurally from the oligosaccharides in human breast milk. Accordingly, oligosaccharides from the milk of domestic ruminants are not ideal as food additives, particularly for infant formulae. Theoretically, authentic HMOs could be produced by total chemical or enzymatic synthesis, but this is laborious and expensive and synthetic HMO supplements are therefore economically unfeasible. What is needed, is an alternative source of HMOs based on a safe and cost-effective production

process. In 2016, 2’-fucosyllactose was produced for the first time

as a food-grade quality product on a scale sufficient to meet the demands of the US infant formula market. This 2’-fucosyllactose product is manufactured by Jennewein Biotechnologie GmbH, a German company founded in 2005 and located in Rheinbreitbach, near the former German capital of Bonn. Jennewein Biotechnologie is the leading company in the production of rare oligosaccharides and monosaccharides for nutritional, pharmaceutical and medical applications, and the technology to achieve this was developed in house by its own research and development department. The Jennewein Biotechnologie 2’-fucosyllactose production process is based

on bacterial fermentation, and allows the ton-scale synthesis of safe, high-quality HMOs fulfilling all US legal requirements for use as a supplement in infant formulae. Jennewein Biotechnologie 2’-fucosyllactose has been granted “generally regarded as safe” (GRAS) status for general nutrition, medical nutrition and use as a dietary supplement, and is also compliant with the requirements for classification as kosher and halal food. As well as its use in infant formulae, Jennewein Biotechnologie 2’-fucosyllactose is approved as an additive for US medical food products, which benefit patients suffering from digestive disorders such as malabsorption. The anti-inflammatory and prebiotic properties of 2’-fucosyllactose may also help to alleviate the symptoms of irritable bowel disease, by improving the integrity of the mucosal barrier. In Europe, and other markets such as China and Korea, a Novel Food Application for Jennewein Biotechnologie 2’-fucosyllactose is currently pending, whereas the product has already been approved as a novel food in Israel and Canada.

What is next for Jennewein Biotechnologie? Nature is the paradigm, and the HMO story will now move beyond 2’-fucosyllactose to focus on the development of production processes for other HMOs, such as neutral HMOs like 3-fucosyllactose, or lacto-N-tetraose and lacto-N-fucopentaose I, and acidic HMOs like sialyllactoses. Combinations of different HMOs will make infant formula increasingly similar to breast milk, with its highly diverse and complex mixture of functional carbohydrates. Jennewein Biotechnologie will investigate

the health benefits of HMOs as pure products and mixtures, collaborating with leading academic institutes such as the German Cancer Research Center and the Mannheim University Hospital. Ultimately, the company seeks Novel Food status and GRAS approval for other HMOs, for general and medical use, and for use in infant formulae.

References• Weichert, Stefan, et al. “Structural basis for norovirus inhibition by human milk oligosaccharides.” Journal of Virology 90.9 (2016): 4843–4848.• Shang, Jing, et al. “Identifying human milk glycans that inhibit norovirus binding using surface plasmon resonance.” Glycobiology 23.12 (2013): 1491–1498.• Morrow, Ardythe L., et al. “Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants.” The Journal of pediatrics 145.3 (2004): 297–303.• Yu, Zhuo-Teng, Nanthakumar, N. Nanda, and Newburg, David S.. “The human milk oligosaccharide

2′-fucosyllactose quenches Campylobacter jejuni–induced inflammation in human epithelial cells HEp-2 and HT-29 and in mouse intestinal mucosa.” The Journal of Nutrition 146.10 (2016): 1980–1990.• Simon, Paul. M., et al. “Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid-containing oligosaccharides.” Infection and Immunity 65.2 (1997): 750–757.• Coppa, Giovanni V., et al. “Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris.” Pediatric Research 59.3 (2006): 377–382.

By Dr. Katja ParschatDeputy Head of Research & Development, Jennewein Biotechnologie GmbH

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Extension to the line will enable manufacturers to formulate products with cleaner labels in line with consumer demand, while maintaining excellent taste, texture, colour and performance.

Tate & Lyle Extends Clean-Label Portfolio with the launch of CLARIA® Bliss Tapioca-Based Starch in Europe, Middle East & Africa

Tate & Lyle PLC (“Tate & Lyle”), a leading global provider of speciality food ingredients and solutions, has announced the introduction of its tapioca-based CLARIA® Bliss starch to the Europe, Middle East & Africa (EMEA) region, responding to growing demand from consumers for cleaner label products.

An extension to the line of CLARIA® Functional Clean-Label Starches, the launch of CLARIA® Bliss in EMEA follows its debut at the Institute of Food Technologists Food Expo in Chicago last year.

CLARIA® Bliss has functionalities like modified tapioca starches and can help manufacturers develop high quality and great tasting products. With tolerance to shear, heat and acid, even under extreme conditions like ultra-high temperatures (UHT) and homogenisation, CLARIA® Bliss makes it easier than ever for food manufacturers to develop products with cleaner labels and differentiated texture.

Its launch follows market research from Innova that shows the number of food products defined as clean-label sharply increased in Europe in categories such as chilled desserts (+54%) or ready meals (+39%) between 2014 and 2016 .

Yves Maltête, VP Global Product Management, Texturants at Tate & Lyle, said: “At a time when 86% of European consumers regard food and beverages as processed if they contain ingredients they don’t recognise , CLARIA® Bliss can help manufacturers maintain great taste in their products. It will also allow them to simplify their ingredient list in a variety of applications, including delicate dairy desserts, clear sauces, chilled ready meals or filling of fresh baked goods.”

CLARIA® Bliss delivers on the growing tapioca-based starch trend, which has seen launches of products including tapioca ingredients increasing on average by 25% each year since 2010. Tapioca is popular among manufacturers and consumers for its clean flavour and colour, soft gel texture and non-GMO and gluten free attributes. CLARIA® Bliss thickens and sets to form a soft, translucent gel that is especially desirable in applications like a dairy custard or in speciality sauces.

Yves Maltête continued: “There is an enormous opportunity for our customers around the world to simplify ingredient lists and take advantage of demand for cleaner labelled products. We want to partner with our customers to help them meet these challenges, and retain their competitive edge locally and globally. With our expanded CLARIA® line now including CLARIA® Bliss, it’s easier than ever to make that a reality.”

For more information on CLARIA® Bliss, please visit www.clariastarch.com/clariar-bliss.

20 nutraceuticals now

THE FOOD MATRIX EFFECT, BEYOND THE NUTRIENTS

On 14 june 2017 was organized a scientific symposium by the Nutrition Department of Institut Pasteur de Lille on “The food matrix effect” during the Nutrevent in Lille (North of France).

Classically nutrition science examines the nutrients intakes and their effects on biological and clinical markers. For instance everyone knows the relationship between saturated fatty acid intakes and the blood LDL-cholesterol; or between the fat intake and the energy balance. However when you look at the link between dairy milk saturated fatty acid and the LDL-cholesterol concentration it is quite lesser than expected probably due to the interaction between saturated fatty acids and calcium in the small intestine. Similarly it has been shown that the fat balance is not so high when you eat almonds or nuts due to the interaction between their lipid content and the food matrix of such plant foods.

The role of the food matrix is quite important in nutrition because we do not eat nutrients, nor a sum of nutrients, but foods. The food matrix effect is related to the interaction between nutrients, their bioavailability, the food complexity and particularly the non-nutrients components, and the food structure. It implies physical and chemicals factors related to the native composition of foods but also alterations related to the food process. For instance the size of the lipid droplets of the fat phase in milk or butter interacts with the fatty acid digestion, absorption, and energy use. The size of the lipid droplets depends on the type of fat (sauce or emulsion).

The food matrix effect is observed for any foods : plant foods and animal products (meat, dairy products).Epidemiological issuesThe consequences of that effect are major for epidemiological considerations.

Recently the Multi Ethnic Study of Atherosclerosis (MESA) including 5209 female of 45-84 years with a 10 years follow-up (1) has shown that with the same intake of saturated fatty acids the dairy fat consumption is associated to a decrease of the incidence of cardiovascular disease and that the meat fat consumption is associated to an increase of the incidence of cardiovascular disease. Probably because other nutrients or components than saturated fatty acids interact and explain opposite effects.

Another study has shown that the association between dietary saturated fatty acids and ischemic heart disease

depends on the source: the EPIC-Netherlands (2) cohort has included 35 597 subjects with a follow-up of 12 years and has observed that there is an inverse association between cheese, milk and dairy products and the risk of ischemic heart disease but no effect of saturated fatty acids from meat.

Finally the Malmö Diet and Cancer Cohort (3) on 2693 subjects with a follow-up of 14 years has shown that the subjects having the highest consumption of whole fat dairy products have a decrease of the risk of type 2 diabetes ; however that risk is increased for the consumption of lean or fat meat.Dairy pruductsThe impact of the structure of whole dairy matrix on digestion, absorption and on health effects has been largely studied (4). The kinetics of digestion and the gastric emptying of dairy products with identical protein composition depends on the matrix structure which depends on the heating process. So the bioactive peptides released during digestion differ from one matrix to another. For instance more bioactive peptides are identified during digestion of acid gel than rennet gel because the kinetics of release are different although the nature of peptides is identical (5).

Other studies have compared the protein of human milk, bovine milk and infant formula (6): the size of human casein micelle is smaller than that of bovine milk. Similarly the homogenization of infant formula induces smaller particles size than raw formula: so the lipolysis of homogenized formula is increased due to increase in specific surface of the interface. This may have consequences on the growth and health of infants or neonates.Fat foodsThe different lipid structure of foods may explain the fat metabolism. We can distinguish three kinds of structure: continuous lipid phase, continuous aqueous phase, complex solid structure. Emulsion droplet size can modify lipid absorption in human: a fine emulsion stimulates more digestive lipolysis and absorption than a coarse one; moreover emulsion gastric stability and droplet size modulate gastric emptying time; oil emulsification enhances lipid absorption in humans comparing to oil. And finally fat emulsion modify post-prandial lipid metabolism, provokes an early enhancement of chylomicronemia and increases the βoxidation of ingested fatty acids and probably less storage: that support the new concept of slow vs fast fat (7). So the fat-foods structure plays a great role in metabolism beyond the nutrients.

In addition emulsification modulates also endotoxin (LPS) transport by chylomicrons; and the type of emulsifiers (dietary

By Lecerf Jean-Michel, Medical Doctor, Head of the Nutrition Department, Institut Pasteur de Lille

polar lipid, synthetic emulsifiers) modulates these phenomena (8).Meat productsSome process may have an impact on digestibility. In usual conditions the impact of cooking on meat protein digestibility is low, but even small differences in digestion rate are sufficient to affect protein digestion rate (which is better at 90°C, 30 min than at 55°C, 5 min); and affects post-prandial assimilation of proteins.

In elderly, studies have demonstrated than bad chewing efficiency slows down protein meat digestion rate and that mincing comparing to cut meat increases protein digestion and improves post-prandial assimilation of meat proteins (9).

Moreover there is an interaction with other meat components. For instance when extracted from their matrix polyphenol extracts largely decrease the apparent meat protein digestibility. Finally processing has an impact on peptide generation: 20% of identified peptides are reproducibly observed in intestinal digesta, but none was already present in the ingested meat (10).Fruit and vegetablesA lot of factors are able to affect the lipid-micronutrients bioaccessibility and bioavailability. The lower the physiologically bioavailability, the higher the effect of food matrix. The difference in location and form strongly affects lipid-micronutrients bioavailability (11). For example carotenoids from thylakoids (in green plant foods) or from crystalloid chloroplast containing lipid-dissolved or liquid-crystalline carotenoids (orange fruits and veggies) have good bioavailability (like carotenoids from animal foods). It is well known that the presence of fat in an high amount increase also carotenoid bioavailability, since fibers may decrease carotenoid absorption, and phytosterols impairs carotenoids, mainly beta-carotene blood concentration by inhibiting their absorption (12). Finally lutein from spinach is more bio accessible than pure lutein, but lutein form eggs is quite more bioavailable than lutein form spinach.Cereals, grains, seeds, nuts and legumesThe differences for the biological effect of these foods are coming from the type of carbohydrate and protein-containing cells. This can be explained by the structure of the cells and the food matrix which seems more important than the fiber content (13). The fiber content has few effects on insulin or glucose concentration, but the particle size play a major role on area under the glucose curve and on the area under the satiety curve. The bread volume and the bread density is related to the glycemic index, more than the fiber content. Mechanical treatments such as grinding, roasting, chewing determine the free-fatty acids release from almonds (14).

Cooking, oven cooking and fermentative treatments modify the solubility of arabinoxylane and protein, and influence glycemia and insulinemia response (15).Biological and clinical issuesFor the same amount of saturated fatty acids it is well established than cheese induced a lesser increase of LDL-cholesterol than butter because of the formation of soaps in the small intestine coming from calcium and free saturated fatty acids released from the position 1 or 3 on the glycerol on triacylglycerol (16)(17).

Fibers are good for health but the source is important: in the Iowa Women’s Health Study (18) those who consume 6 g of cereal fibers (for 2 000 Kcal) from whole grains have a lesser total mortality and non-cancer, non-cardiovascular mortality than those who consume 6 g of cereal fibers and refined cereals.

In an animal study with a drug-induced prostate cancer the mortality is lower when tomato powder is given to the animal than lycopene (19).

It has been shown that dairy products consumption is associated to a neutral effect or an improvement of cardiovascular risk, but that calcium supplements higher than 500 mg/d are associated to a significant increase of

cardiovascular risk (20).Finally interventional studies with reduction of saturated

fatty acids and high increase of linoleic acid have no effect or impairment on secondary cardiovascular prevention : however Mediterranean diet intervention (Predimed study) is beneficial (21).ConclusionThe food matrix effect is the new revolution in nutrition science (22). It proves the role of the complexity of foods, the role of process and structure on interaction, bioavailability, biological effects who finally have clinical and epidemiological impact. So we propose a new dietary pyramid (figure 1).

More must be still demonstrated but actually it appears that food matrix may explain lot of differences between the sum of single nutrients and whole foods. Food science and food technology must be combined to nutrition in order to improve our knowledges and our recommendations.References1. de Oliveira Otto MC, Mozaffarian D, Kromhout D, Bertoni AG, Sibley CT, Jacobs DR, et al. Dietary intake of saturated fat by food source and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2012 Aug 1;96(2):397–404. 2. Praagman J, Beulens JW, Alssema M, Zock PL, Wanders AJ, Sluijs I, et al. The association between dietary saturated fatty acids and ischemic heart disease depends on the type and source of fatty acid in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort. Am J Clin Nutr. 2016 Feb 1;103(2):356–65. 3. Ericson U, Hellstrand S, Brunkwall L, Schulz C-A, Sonestedt E, Wallström P, et al. Food sources of fat may clarify the inconsistent role of dietary fat intake for incidence of type 2 diabetes. Am J Clin Nutr. 2015 May;101(5):1065–80. 4. Thorning TK, Bertram HC, Bonjour J-P, de Groot L, Dupont D, Feeney E, et al. Whole dairy matrix or single nutrients in assessment of health effects: current evidence and knowledge gaps. Am J Clin Nutr. 2017 May;105(5):1033–45. 5. Barbé F, Ménard O, Le Gouar Y, Buffière C, Famelart M-H, Laroche B, et al. Acid and rennet gels exhibit strong differences in the kinetics of milk protein digestion and amino acid bioavailability. Food Chem. 2014 Jan 15;143:1–8. 6. Menard O, Chever S, Deglaire A, Bourlieu C, Bonhomme C, Le Ruyet P et al. Infant formula and human milk: Is their digestion identical? Cah Nutr Diet. 2014;49:67–73. 7. Vors C, Pineau G, Gabert L, Drai J, Louche-Pélissier C, Defoort C, et al. Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial. Am J Clin Nutr. 2013 Jan 1;97(1):23–36. 8. Michalski MC, Genot C, Gayet C, Lopez C, Fine F, Joffre F, et al. Multiscale structures of lipids in foods as parameters affecting fatty acid bioavailability and lipid metabolism. Prog Lipid Res. 2013 Oct;52(4):354–73. 9. Rémond D, Machebeuf M, Yven C, Buffière C, Mioche L, Mosoni L, et al. Postprandial whole-body protein metabolism after a meat meal is influenced by chewing efficiency in elderly subjects. Am J Clin Nutr. 2007 May;85(5):1286–92. 10. Barbé F, Le Feunteun S, Rémond D, Ménard O, Jardin J, Henry G, et al. Tracking the in vivo release of bioactive peptides in the gut during digestion: Mass spectrometry peptidomic characterization of effluents collected in the gut of dairy matrix fed mini-pigs. Food Res Int. 2014 Sep;63:147–56. 11. Reboul E. Lipid intestinal absorption and fat-soluble vitamins: Interactions during the digestion process and the transport through enterocyte membranes. Cah Nutr Diététique. 2014 Nov;49(5):218–24. 12. Parada J, Aguilera JM. Food microstructure affects the bioavailability of several nutrients. J Food Sci. 2007 Mar;72(2):R21-32. 13. Grundy MM-L, Edwards CH, Mackie AR, Gidley MJ, Butterworth PJ, Ellis PR. Re-evaluation of the mechanisms of dietary fibre and implications for macronutrient bioaccessibility, digestion and postprandial metabolism. Br J Nutr. 2016 Sep 7;116(5):816–33. 14. Grundy MM-L, Lapsley K, Ellis PR. A review of the impact of processing on nutrient bioaccessibility and digestion of almonds. Int J food Sci Technol. 2016 Sep;51(9):1937–46. 15. Lappi J, Selinheimo E, Schwab U, Katina K, Lehtinen P, Mykkänen H, et al. Sourdough fermentation of wholemeal wheat bread increases solubility of arabinoxylan and protein and decreases postprandial glucose and insulin responses. J Cereal Sci. 2010 Jan;51(1):152–8. 16. Lorenzen JK, Nielsen S, Holst JJ, Tetens I, Rehfeld JF, Astrup A. Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake. Am J Clin Nutr. 2007 Mar;85(3):678–87. 17. Nestel PJ, Chronopulos A, Cehun M. Dairy fat in cheese raises LDL cholesterol less than that in butter in mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 2005 Sep 29;59(9):1059–63. 18. Jacobs DR, Pereira MA, Meyer KA, Kushi LH. Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: the Iowa women’s health study. J Am Coll Nutr. 2000 Jun;19(3 Suppl):326S–330S. 19. Stacewicz-Sapuntzakis M, Bowen PE. Role of lycopene and tomato products in prostate health. Biochim Biophys Acta. 2005 May 30;1740(2):202–5. 20. Bolland MJ, Leung W, Tai V, Bastin S, Gamble GD, Grey A, et al. Calcium intake and risk of fracture: systematic review. BMJ. 2015 Sep 29;351:h4580. 21. Estruch R, Ros E, Salas-Salvadó J, Covas M-I, Corella D, Arós F, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med. 2013 Apr 4;368(14):1279–90. 22. Lecerf J-M, Legrand P. Are the nutrients effects depending from the foods which contain them? The matrix effect. Cah Nutr Diététique. 2015 Jun;50(3):158–64.

nutraceuticals now 21

NEW DIETARY PYRAMID

Figure 1 THE NEW DIETARY PYRAMID

NUTRIENTS

REFINED OR SKIMMED FOODS

WHOLE FOODS

FOOD GROUPS

COMPLEX MEAL

DIETARY PATTERNS

LIFE STYLE

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company news . . . company news . . . company news

Prinova Acquires Lycored’s United Kingdom and China-based Premix Manufacturing Locations

June 26, 2017—Carol Stream, Ill.-based Prinova today announced it has reached an agreement to acquire Israeli-based Lycored’s China and United Kingdom Premix operations.

Prinova is a global supplier of ingredients, flavors, blending and contract manufacturing solutions for the food, beverage and nutrition industries. Prinova holds strategic stocks in numerous distribution centers around the world to ensure continuity of supply and is the leading global supplier of Vitamin C, B and food grade Amino Acids.

“Prinova has made substantial investments in our North American premix operations and supplies a wide variety of dry and liquid nutrient and flavor premix blends in the U.S. and internationally,” said Don Thorp, President, Prinova. “The addition of these premix capabilities gives Prinova the ability to extend these offerings on a global basis, customized to the needs of the regional markets,” he said.

The Lycored facilities in China and the United Kingdom have been supplying leading international food companies with premixes to fortify their products with vitamins, minerals and other nutrients. These premixes address the cereal, beverage, dairy, infant formulation, and other premix categories, reflecting the ability to deliver product solutions to the entire range of premix markets.

“This acquisition gives Prinova a global footprint with six manufacturing sites around the world located on three different continents”, Thorp said.

David York, CFO, Prinova stated “Prinova is incredibly excited about this acquisition. We now feel very confident we can

supply our customers worldwide.” York said that as part of the agreement, Prinova will retain all Lycored’s employees in China and the United Kingdom.

About PrinovaSince 1978, Prinova has been a leader in providing high-quality ingredients, flavors and value-added nutrient fortification products to the global food, feed and wellness industries. Prinova holds strategic stocks in numerous distribution centers around the world to ensure continuity of supply and is the leading global supplier of Vitamin C, B and food grade Amino Acids. The company also has a team of application and technical specialists and certified flavorists to help customers develop, improve, and enhance the taste and function of their products. Prinova’s facilities are BRC certified. The company’s main corporate office is in Carol Stream, Illinois with the European head office in the United Kingdom. Additional regional offices are located throughout the United States as well as global sales associates in Mexico, Spain, Germany, Belgium, France, Turkey and China.For more information, visit www.prinovausa.com. About LycoredCommitted to ‘Cultivating Wellness’, Lycored, part of Adama Group, is an international company at the forefront of unearthing and combining nature’s nutrition potential with cutting edge science to develop natural ingredients and products. Established in 1995 in Israel, Lycored is the global leader in natural carotenoids for food, beverage and dietary supplement products.

For more information, visit www.lycored.com.

Hauts-de-France, a champion in food processing

Nutraceuticals Now attended a press trip in Hauts-de-France region in the North of France for two days in June, organized by Nord France Invest, the investment promotion agency for Hauts-de-France.

The Hauts-de-France region lies at the heart of a 78-million-consumer market in a 300-km radius, served by a first-rate infrastructure network (highway, railway, ports, airports).

Northern France is the first-ranked food cluster in France, and leading businesses in the industry have chosen the region as their springboard for European growth. Easy access to leading consumer markets, abundant resources, and a highly-trained labor pool are the keys to the success.KEY FIGURES• 1,300 businesses• 53,000 jobs• Over €10 billion turnover• No. 1 export region in France

Hauts-de-France region is the birthplace of worldwide giants in food processing: Bonduelle, Lesaffre, Roquette, Leroux, Paul (Holder group), Ingredia … all these groups were born in the region and have become national leaders or international leaders in their fields.

The region is also very attractive for international food companies : Coca-Cola, Barilla, Häagen Dazs, Tate&Lyle, Mc Cain, Vandemoortele, Marine Harvest, Moy Park, Ajinomoto,

Cargill, Kerry have major operations in Northern France, mainly in manufacturing and distribution, but also in R&D and innovation.

With more than 30 private and 20 public research units (Lille Pasteur Institute, National Institute for Agronomics Research…) and engineering schools, Hauts-de-France is at the forefront of the french R&D for the food industry.THE PRESS TRIPThe highlight of the press trip was Nutr’Event. Every two years, the Region holds the leading European business convention Nutr’Event. Organized by Eurasanté (health cluster), this convention is dedicated to innovation in food, nutrition and health. This year, the topic was about how to make customers’ needs evolve with the latest innovations in functional and active ingredients, market regulatory changes, traceability enhancement and food safety improvement.More information about food industry in Hauts-de-France:http://www.nordfranceinvest.com/business-sectors/food-and-health/food-industry.html

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Nutraceuticals market can rely on highest levels of authenticity via testing and certification. Indena is at the forefront of this trend.

There has been a great deal of focus on transparency, both in finished products and raw materials at worldwide level. This debate followed the New York Attorney General’s activity in which an agency investigation that found that four of five tested herbal products did not contain any of the herbs promised in their labels, and consequently required producers to conduct advanced genetic testing to ensure the herbal products actually contain the ingredients promised on the label.[2] From that

point on, manufacturers expected increasingly greater transparency and compliance from their suppliers, in a market characterised by more stringent legal and regulatory frameworks and an increasing number of certification requirements, above all for quality controls.

With the aim of being compliant, and also

acting as a frontrunner in achieving the excellent levels of safety and quality, Indena is moving forward. Approaching DNA-based technologiesThe fundamentals in quality control of botanical preparations ensure the accurate identification of the plants to be used. Most plants can be correctly identified by a macroscopic and microscopic analysis. Yet some cases resort to DNA-based methodologies. The main difficulty in applying DNA identification techniques in the herbal basin is the lack of a universal DNA barcode for plants to be used for such a purpose as occurs in the animal kingdom. Unlike animals, the main pitfall of botanical DNA identification is that there is no check for origin in the DNA genomic data at public databases such as Genbank, thus raising questions about potential attribution errors of DNA sequences to the correct species or variety proven by existing misidentifications and missing data

of medicinal plant species emerged in recent years. Successful development of DNA-based authentication

tools for plants and botanicals of unknown or unassignable origin would require the creation of “reference” DNA profiles that would be shared and validated by the whole scientific community. These “reference” DNA profiles should derive from the analysis of plant samples of known, certified origin (herbarium, taxonomically identified samples).

Based on the above assumptions, it is of paramount importance to have “certified” pure samples in order to derive reference DNA sequences for use in analyzing DNA data. The botanical extracts industry is demanding such an assurance and it is crucial, now more than ever, to utilize the appropriate tools and methodology to authenticate botanicals for purity, absence of adulterants, and tissue of origin. Indena is able to recover samples to authenticate the identification of plants on a rigorous scientific basis through botanical in-depth analysis.

This unique and extensive wide knowledge enables Indena to go even further.DNA sequencing-based tests are emerging as highly reliable and powerful tools to authenticate botanicals, identify medicinal plant species and varieties in herbal products and in the future on dietary supplements.

The recent focus on the authenticity of herbal-based dietary supplements puts the spotlight on a concern that many operators in the industry had about how to guarantee the safety, purity, and identity of dietary supplement products. By anticipating the need for both an appropriate answer to this issue and for the safeguard and protection of supply chains all the way back to the plant’s harvest, Indena has not only developed a proprietary genomic technology for botanical ID testing based on the NGS approach, but it also gave birth to its own “DNA Tested” certification. The company owns a proprietary herbarium from which Indena derives reference DNA profiles via analysis of plant samples of known certified origin in a directly managed and monitored environment.

Indena is injecting robust investments in working to validate proper DNA-based technologies to include these

According to a recent report [1], the global dietary supplements market is valued at USD 132.8 billion in 2016 and is expected to reach USD 220.3 billion in 2022; it is anticipated to grow at a CAGR of 8.8% between 2017 and 2022. But, as consumer awareness of these health conditions increases, negative publicity and fake product claims may have negative consequences on the overall growth of the market. In recent years, in fact, the topic of potentially mislabelled botanical products has raised questions about the overall quality and safety of products made available to manufacturers, with regards to raw materials, and to consumers, with regards to finished products.

tests on the final extracts. Next-generation DNA sequencing for authentication of species in both raw materials and extracts is a unique and key aspect of Indena’s business that will continue to grow rapidly.The Next Generation Sequencing (NGS) approach The NGS approach is the only analytical tool now enabling the precise identification of the composition of multi-ingredients products, which is often the case in the nutraceutical market. The precision and application of the NGS technology relies on the presence of DNA, even if only in traces, and on the use of four universal barcodes representing both chloroplast and nuclear genomes. The utilisation of multiple barcodes aims to guarantee that the identification of the ingredients, fillers and adulterants is always possible at the species level.Pioneering complete AuthenticityAs Indena is always in search of reliable and science-conscious partners, it has recently formed a joint partnership with UK biotechnology company Hyris Ltd. Hyris’s portable bCUBE technology, which weighs only 1.5 kg, allows users to analyse nucleic acids and run both temperature cycles and isothermal analysis. Hyris’s platform is able to perform a full genetic analysis of biological samples in any setting, and includes all the testing software, hardware, and reagents necessary to do so. The points of strengths are its portability, speed, and accuracy, and, since the system is portable, results are available much more quickly than by using traditional methods. In addition, the bCUBE device can be controlled by bAPP, a mobile app that allows users to download required test protocol, check the reaction as it is happening, and receive immediate diagnostic information on the sample being examined. Therefore, this technology enables instant ID testing on the plant starting material. Results are available in approximately one hour, versus the higher amount of time required by traditional lab equipment. In addition to the shorter timeline, this innovative technology is even complimentary to other tests. Moreover, results are available anywhere in real time thanks to data transferring to the cloud.“Indena DNA tested”, a label that combines decades of knowledge, testing, controls and transparency with the latest innovations in technologyYet Indena, which is already approaching customers about this new powerful tool, continues to pursue the highest levels of reliability. In fact, Indena has recently launched the new “Indena DNA tested” seal, a certification that brings a declaration of authenticity as well as an evidence of solid scientific background. Indena’s consolidated expertise in dietary supplements and long-term presence on the market is generated by the company’s constant aim at the highest

standards of quality, integrity, and safety of their products as well as at the consumers’ maximum confidence. DNA-based identification technologies are contributing decisively to the authentication of botanicals, but they are not the reference methods: they complement the botanical, chemotaxonomic and metabolomic analytical methods well. Accordingly, they must be part of a complete quality texting toolbox, which constitutes a reliable authentication platform. Throughout its history of almost one hundred years, Indena has been mapping the genetic identity of the raw materials used for its botanical extracts. As no universal Genomic ID method is available, this knowledge has allowed Indena to develop species-specific DNA identification analytical tools. As part of its Quality System, Indena is able to apply the appropriate technology to each case.

Sophisticated DNA sequencing-based tests are powerful technologies but they are just one piece of the puzzle. What really counts is gaining knowledge in plant genetic diversity.

When consumers consume a nutraceutical product, they should be able to do so with peace of mind, confident that the plant on the label is the plant in the supplement, and that every reasonable precaution has been taken to guarantee the product’s authenticity. Consumers can have such confidence if the companies along the supply chain have employed the best and most reliable testing measures for counteracting fraud and displacing allergens and other pathogens.

With its innovative methodology, Indena is not only increasing transparency and improving controls, always keeping in mind the final users in order to protect them at the highest levels possible. Indena also encourages and urges the rest of the industry to follow this path, considering that the interpretation of results should involve an interdisciplinary approach, and take into account the processes involved in production of herbal supplements, as well as biocomplexity of plants.

References:[1] – Zion Market Research, “Dietary Supplements Market by Ingredients (Botanicals, Vitamins, Minerals, Amino Acids, Enzymes) for Additional Supplements, Medicinal Supplements, and Sports Nutrition Applications - Global Industry Perspective, Comprehensive Analysis and Forecast, 2016 – 2022”.[2] - The New York Times, What’s in Your Herbal Pills? Firm Promises DNA Testing for Proof, Sept 28, 2016. Available at: https://www.nytimes.com/2016/09/28/well/eat/nbty-promises-genetic-testing-of-its-herbal-supplements.html Last access on 07/11/2017.

Polyphenols are natural compounds widely distributed in several fruits and vegetables. The term phenolics encompasses approximately 8000 naturally occurring compounds, all of which possess one common structural feature, an aromatic ring having at least one hydroxyl substituent. Most phenolics have two or more hydroxyl groups and are biologically active substances occurring widely in food plants that are eaten regularly by substantial numbers of people. Phenolic acids, flavonoids, stilbenes and lignans are the most abundantly occurring polyphenols in plants, of which flavonoids and phenolic acids account for 60 and 30% of total dietary polyphenols, respectively. Health benefits of polyphenols (depicted in figure-1) have been extensively studied scientifically for the several decades with perceived health benefits including antioxidative, chemopreventive properties. Most widely studied polyphenols for human health include resveratrol from red wine, curcumin from turmeric, cocoa polyphenols, quercetin from different sources of fruits and vegetable. Polyphenols are tough antioxidants in order that complement to the functions of antioxidant vitamins and enzymes as a good defence counter to oxidative stress induced by surplus reactive oxygen species (ROS). Though antioxidant property contribute for most of the observed biological activity, increasing evidence indicates that polyphenols may act in ways beyond the antioxidant functions activity (Tsao, 2010). The greater interest in polyphenols observed in recent years is due to several factors including recognition of the antioxidant properties of polyphenols, their great abundance in our diet, and their probable role in the prevention of various diseases associated with oxidative stress, such as cancer and cardiovascular and neurodegenerative diseases. The health effects of dietary polyphenols depend on the amount consumed and their bioavailability. Bioavailability seems to diverge between several polyphenols, and the most ample polyphenols in our diet are not necessarily those leading to the highest concentrations of active metabolites in target tissues. Therefore, mere presence of polyphenolic compound in diet is not sufficient to exploit the full beneficial potential of that particular polyphenol until it reaches the systemic circulation/ site of action in sufficient quantities. Types of Dietary PolyphenolsDietary polyphenols exhibit a group of secondary metabolites which are extensively present in vegetables, fruits, whole grains, wine, tea, chocolate and other cocoa products. They are mainly derivatives, and/or isomers of flavones, isoflavones, flavonols, catechins, and phenolic acids. Dietary polyphenols are secondary metabolites of plants and are subdivided into sub groups such as phenolic acids (gallic acid, caffeic, ferulic, and coumaric acid), flavonoid (including flavonols, flavones, isoflavones, flavanones, anthocyanidins, and flavanols), the stilbenes and the tannins.Phenolic acidsPhenolic acids are secondary metabolites extensively spread throughout the plant kingdom. The term phenolic acid, in general, describes phenols that possess one functional group, carboxylic acid. However, when describing plant metabolites, it refers to a distinct group of organic acids. Phenolic acid compounds and functions have been the subject of a great number of agricultural,

biological, chemical and medical research. These compounds form a diverse group that includes the widely distributed hydroxybenzoic and hydroxycinnamic acids often as simple esters with glucose or other hydroxy carboxylic acids. Plant phenolic compounds are diverse in molecular structure, and are characterized by hydroxylated aromatic rings (Mandal et al., 2010).FlavonoidsFlavonoids are the most abundant polyphenols in human diets. Dietary flavonoids are naturally occurring in fruit, vegetables, chocolate, and beverages like wine and tea. Chemically, flavonoids are based upon a fifteen-carbon skeleton (C6-C3-C6) consisting of two benzene rings (A and B) linked via a heterocyclic pyrone ring ©. Flavonoids may be subcategorized as anthocyanidins, flavan-3-ols, flavonols, flavanones, flavones, and isoflavones, flavonols are the most widespread in the human diet (Han et al, 2007). TanninsTannins are a group of water-soluble polyphenols bearing molecular weights from 500 to 3,000. Tannins have been reported to be responsible for decreases in feed intake, growth rate, feed efficiency, net metabolizable energy, and protein digestibility in experimental animals. Therefore, foods rich in tannins are considered to be of low nutritional value (Chung et al., 1998). Tannins naturally occur in black tea and their characteristics emerge when the tea is brewed a few minutes longer than recommended. Tannins result in the precipitation of proteins when come in contact with proteins.StilbenesStilbenes are structurally characterized by the presence of a 1,2-diphenylethylene nucleus with hydroxyls substituted on the aromatic rings. Resveratrol is well known compound belonging to this class which is found in grape skins, red wine, peanuts, blueberries and cranberries (Reinisalo et al., 2015). Resveratrol is considered as bioactive principle of red wines that were shown to reduce heart diseases.Biological ActivitiesDietary polyphenols possess diverse biological properties such as anti-inflammatory, anti-mutagenic, anti-apoptosis, anti-aging, anti-atherosclerosis, cardiovascular protection, improvement of the endothelial function, as well as inhibition of angiogenesis and cell proliferation activity. Many of observed biological actions of dietary polyphenols are associated to their anti-oxidant potential.

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Antioxidant ActivityAntioxidant property of polyphenols has been recognized since decades. A number of in vitro studies have demonstrated the beneficial effect of polyphenols as anti-oxidant or free radical scavengers. Phenolics antioxidants function as terminators of free radicals and as chelating agent for metal ions that are capable of catalyzing lipid peroxidation, thereby exerting protection against cardiovascular pathogenesis. Polyphenols repress the generation of free radicals and thereby reducing the rate of oxidation by inhibiting the formation of or deactivating the active species and precursors of free radicals. Usually, they act as direct radical scavengers of the lipid peroxidation chain reactions. Further, polyphenols also act as chelating agent for metals such as iron. Chelation of transition metals such as Fe2+ can directly reduce the rate of Fenton reaction, hence preventing oxidation caused by highly reactive hydroxyl radicals (Tsao, 2010).Anti-inflammatoryReactive oxygen species play a critical role in enhancing the inflammation through the activation of NF-kappaB and AP-1 transcription factors, and nuclear histone acetylation and deacetylation in various inflammatory diseases. Analogous undesired effects of oxidative stress are controlled by the antioxidant and/or anti-inflammatory effects of dietary polyphenols such as curcumin and resveratrol. A number of flavonoids such as hesperidin, apigenin, luteolin, and quercetin are reported to possess anti-inflammatory and analgesic effects. Several studies have confirmed the anti-inflammation potential of phenolics. Recently, Chanput et al., 2016 suggested to use ABTS assay as a marker for anti-inflammatory activity of flavonoids.Anti-atherosclerosis and cardioprotectionA large number of studies have suggested that dietary polyphenols are helpful in the prevention of atherosclerosis and cardiovascular diseases. Biological potential of phenolics, particularly flavonoids indicates the possibility of their use in primary and secondary prevention of atherosclerosis and its clinical consequences. Citrus flavonoids, including naringenin, hesperidin, nobiletin and tangeretin, have emerged as promising therapeutic agents for the treatment of metabolic dysregulation. Abundant literature has shown that polyphenols can inhibit oxidation of LDL in vitro. LDL oxidation is considered to be a key mechanism in atherosclerosis. These antioxidant effects result in the decreased oxidation of LDL lipids and of α-tocopherol. Polyphenols can improve endothelial dysfunction. Dietary flavonoids and tea consumption have been described to improve endothelial function and NO-dependent flow-mediated dilation (FMD). Cocoa and cocoa flavonoids may positively affect the pathophysiological mechanisms involved in insulin resistance and endothelial dysfunction with possible benefits in the prevention of cardiometabolic diseases (Grassi et al., 2015). A clinical study showed dietary cocoa flavanol ingestion mitigates acute hemodialysis -induced and chronic endothelial dysfunction in patients with ESRD and thus, improves vascular function in this high-risk population (Rassaf et al., 2016). Neurodegenerative diseasesAlzheimer’s disease (AD) is a devastating disorder that strikes 1 in 10 Americans over the age of 65, and almost half of all Americans over 85 years old. The odds of an individual developing AD double every five years after the age of 65. Dietary polyphenols from green tea, quercetin, resveratrol and catechin have been shown, in various cell culture and animal models, to protect neuronal cells by attenuating oxidative stress and damage and may be helpful in neurodegenerative diseases. A nutritional approach to prevent, slow, or halt the progression of Alzheimer’s disease is a promising strategy that has been widely investigated. Recently, EGCG ((-)-epigallocatechin-3-gallate) has been found effective in cognitive deterioration in AD model in mice (Chang et al., 2015). Flavan-3-ols (or flavanols), which are present in cocoa extracts, may beneficially influence cognitive deterioration, such as in AD (Dubner et al., 2015). Several studies have demonstrated the efficacy of various dietary polyphenols in AD and Parkinson’s disease. EGCG, gallic acid, and curcumin were identified as multifunctional compounds,

however their poor brain uptake might limit their therapeutic effects.Anti-carcinogenic propertiesNumerous studies have suggested that polyphenols such as green tea catechins, curcumin, resveratrol and genistein, found in green tea, cocoa, red wine and fruit juices, influence carcinogenesis. Polyphenols, when given to rats or mice before and/or after the administration of a carcinogenic agent or the implantation of a human cancer cell line, are most often protective and induce a reduction of the number of tumors or tumor growth. These effects have been observed at various sites, including mouth, stomach, duodenum, colon, liver, lung, mammary, or skin. Polyphenols, such as quercetin, catechins, isoflavones, lignans, flavanones, ellagic acid, red wine polyphenols, resveratrol, or curcumin, were tested; all of them showed protective effects in some models (Scalbert et al., 2005). Despite promising results from experimental studies, only a limited number of these compounds have been tested in clinical trials and have shown variable results (Kotecha et al., 2016). Therefore, clinical evaluation is warranted on promising agents like curcumin, resveratrol, lycopene, folates and tea polyphenols.Anti-diabeticNumerous studies have reported the antidiabetic property of polyphenols. Polyphenols such as catechins, epicatechins, epigallocatechins from tea, isoflavones from soybean, tannic acid, glycyrrhizin from licorice root, chlorogenic acid, and saponins decrease the intestinal transport of glucose. Polyphenolic compounds can also prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy (Bahadoran et al., 2013). ConclusionPhenolic compounds are ubiquitous in plant foods, and therefore, a significant quantity is consumed through dietary sources. Polyphenols may have vital role in the prevention and treatment of highly prevalent human diseases, such as cardiovascular diseases, cancer, and metabolic disorders. Dietary polyphenols are effective in such diseases due to their gross antioxidant potential as well as associated beneficial effects in health and disease conditions.

National Center for Natural Products Research does not endorse any products or biological activities. The views expressed in this article are from the scientific literature and do not necessarily reflect the views or policies of the NCNPR.

References• Bahadoran Z, Mirmiran P, Azizi F (2013). Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. Journal of diabetes and metabolic disorders 12(1): 43.• Chang X, Rong C, Chen Y, Yang C, Hu Q, Mo Y, et al. (2015). (-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer’s disease model mice by upregulating neprilysin expression. Experimental cell research 334(1): 136-145.• Chanput W, Krueyos N, Ritthiruangdej P (2016). Anti-oxidative assays as markers for anti-inflammatory activity of flavonoids. Int Immunopharmacol 40: 170-175.• Chung KT, Wong TY, Wei CI, Huang YW, Lin Y (1998). Tannins and human health: a review. Critical reviews in food science and nutrition 38(6): 421-464.• Grassi D, Desideri G, Mai F, Martella L, De Feo M, Soddu D, et al. (2015). Cocoa, glucose tolerance, and insulin signaling: cardiometabolic protection. J Agric Food Chem 63(45): 9919-9926.• Han X, Shen T, Lou H. Dietary Polyphenols and Their Biological Significance. International Journal of Molecular Sciences. 2007; 8(9):950-988.• Kotecha R, Takami A, Espinoza JL (2016). Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence. Oncotarget.• Mandal SM, Chakraborty D, Dey S (2010). Phenolic acids act as signaling molecules in plant-microbe symbioses. Plant signaling & behavior 5(4): 359-368.• Rassaf T, Rammos C, Hendgen-Cotta UB, Heiss C, Kleophas W, Dellanna F, et al. (2016). Vasculoprotective Effects of Dietary Cocoa Flavanols in Patients on Hemodialysis: A Double-Blind, Randomized, Placebo-Controlled Trial. Clinical journal of the American Society of Nephrology : CJASN 11(1): 108-118.• Reinisalo M, Karlund A, Koskela A, Kaarniranta K, Karjalainen RO (2015). Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases. Oxid Med Cell Longev 2015: 340520.• Scalbert A, Manach C, Morand C, Rémésy C, Jiménez L (2005). Dietary Polyphenols and the Prevention of Diseases. Critical reviews in food science and nutrition 45(4): 287-306.• Tsao R (2010). Chemistry and Biochemistry of Dietary Polyphenols. Nutrients 2(12): 1231-1246.

Dietary Polyphenols as NutraceuticalsBy Vikas Kumar, Amar Chittiboyina, Ikhlas KhanNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677

Figure-1: Health benefits of dietary polyphenols.

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Slow and Steady Wins the Race for Sugar Reduction A desire for sugar reduction has been expressed worldwide.

In the UK, the Department of Health is showing strong support for the government’s target of 20% sugar reduction in products by 2020, although manufacturers are beginning to push back on this goal. Chile and Mexico are also putting similar regulations in place. Recent nutritional guidelines have hit the headlines in the US for “no added sugars” on product labels and many countries across Asia and the Pacific region, including India, are implementing strategies, such as improved dietary guidelines, sugar taxes and regulation alterations, to forcibly encourage change.

Many food and beverage manufacturers, as well as retailers (a recent example being Lidl in Germany and Albert Heijn in BeNeLux), are committed to reducing sugar, as well as fat and salt in their products. Companies such as Nestlé have hit the headlines with commitments to cut 10% of sugar in their confectionery ranges by 2018. However, as Dr Joerg Spieldenner, head of Nestlé’s Public Health Nutrition department has said , when it comes to reducing the sugar content in products: “…it’s very difficult from a technological point of view and from an education and consumer information point of view”. Consumer perception of ‘sugar reduced’More and more consumers understand the need to reduce daily sugar consumption; a recent survey in Germany shows that 48% of consumers are now actively cutting down or avoiding sugary foods. However, consumers are not prepared to sacrifice the taste and texture of their favourite products for sugar reduction and they are not keen on anything artificial in their food and drink either. Being ‘not artificial’ is seen as critical for consumers and globally more than half of those surveyed rated this as important, or very important, on pack and were also willing to pay more for foods and beverages made with no artificial sweeteners. Stealth sugar reductionIt is no surprise therefore that many food and drink manufacturers that are implementing sugar reduction

programmes across their product portfolios, are adopting a ‘slow and steady’ approach. ‘Stealth sugar reduction’ can vary between 10% and 20% per re-formulation, however, the majority of companies seem to be aiming for 10% as a target at present. This paced reduction allows consumers’ palates to adjust and get used to mild and natural sweet tastes more gradually, this in turn minimises the potential for negative reactions.

Stealth is also being used by many manufacturers with regard to the communication of these sugar reductions. Many are opting not to promote the reductions on pack, assuming that consumers will see ‘sugar reduced’, or ‘light’ and be concerned over the product’s taste and whether artificial sweeteners were used to boost sweetness.Sugar reduction in practiceWhether a manufacturer is adopting a stealth approach to sugar reduction or not, the non-negotiable factor from consumers is that the product’s taste and texture must stay the same. There are many challenges to overcome when reducing sugar, because it has various functionalities in food products. Sugar doesn’t just deliver sweetness and taste but also provides important bulk, texture and mouthfeel qualities as well. This means that great expertise is required to know how to reduce sugar, whilst obtaining similar taste and texture, with no alteration to the production process.

Dairy, baked goods and cereal products all create a wide range of sugar reduction challenges, as an indulgent, creamy dairy taste, easy dough handling or a chewy textured bite all need to be maintained. Functional ingredients experts such as BENEO have been working hard for years, creating recipe formulations that overcome these challenges and deliver in terms of taste and texture when managing sugar reduction. BENEO’s part in sugar reductionBENEO’s functional carbohydrates and fibres offer manufacturers many ways to replace more commonly used high glycaemic sugars in food and drink products, whilst maintaining the desired taste and texture. In addition,

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There has been a vast amount of coverage in the media over recent years concerning sugar, government sugar taxes and the need for consumers to reduce consumption levels to curb increasing obesity and diabetes levels. As the responsibility for this has been turned onto manufacturers and food reformulation has been put under the spotlight, more companies are choosing to adopt the path of ‘stealth’ sugar reduction. Rudy Wouters, Vice President of the BENEO-Technology Center explains why this ‘slow and steady’ approach is being taken to re-educate a generation of sweet-toothed consumers.

BENEO’s ingredients offer consumers a range of other EFSA approved benefits such as blood sugar management and improved digestive health.

BENEO’s chicory root fibres Orafti® inulin and oligofructose are ideal solutions for sugar reduction, as they have texturising properties, a mild sweetness, well-balanced, round flavour and less calories than sugar (max. 2 kcal/g). Having no effect on the blood glucose level, they help to lower the blood glucose response of final food products. As clean label, soluble prebiotic fibres they can be easily integrated into various applications, while supporting excellent taste and texture and improving digestive health. Putting it into practiceSpecialists at the BENEO-Technology Center conduct regular recipe trials that also undergo stringent sensorial evaluation, to ensure that they will be able to deliver in terms of taste and texture, whether the sugar reduction is 10% or 20%.

In recent trials, Orafti® inulin was used in the coating of breakfast cereals. The results clearly show that it is possible to achieve 20% sugar reduction with no sensorial difference in terms of texture, crispiness, sweetness or taste intensity compared to the full sugar equivalent. BENEO’s Orafti® oligofructose also performed well in recent yoghurt trials, helping to reduce total sugars by 20% and added sugars by 35% with no negative impact on taste or texture.Slow release carbohydrate benefitsWhilst less sugar is important, the physiological diversity of some sugars and their beneficial role in blood sugar and weight management is also something that consumers are gradually becoming more aware of. BENEO’s Palatinose™ is an example of an alternative, “slow release” sugar that is derived from sugar beet. It is clean label and has a mild, natural sweet taste. As a slowly yet fully digestible, low glycaemic carbohydrate, it can be used to replace high glycaemic sugars. It provides balanced and sustained energy, reflected by a low and steady blood glucose response

curve. As a result, products such as muffins, donuts or cereal bars that contain Palatinose™ help consumers get through a busy day without feelings of tiredness or cravings shortly after eating.

Sugar reduction is now a key mindset for consumers across the globe, yet most want to cut their sugar intake levels without it affecting the type of foods and drink they choose to consume. To enable consumers to do this, reformulation is the key to success. The goal, however, remains to deliver premium taste in a healthier way to demanding consumers.

Whether manufacturers are looking to adopt a stealth sugar reduction policy of 10 to 20%, or reduce by significantly more, the technical challenges remain the same. Sugar replacement is not a straightforward process and requires the close collaboration of manufacturers and functional ingredients experts, such as BENEO, to ensure that the end product tastes as good as usual, but is healthier than ever before.

20% sugar reduced (SR) coated cereals with Orafti® inulin – generic recipe

Heading for the Mainstream. . . how Lycored is changing the way consumers perceive ingestible skincare

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Ingestible skincare – once seen as a niche category – is rapidly heading for the mainstream. Consumers, particularly those under the age of 35, are increasingly recognising the benefits of supplementation for healthy, resilient skin.

How do we know? Because we asked them. Earlier this year, Lycored surveyed 480 British and French consumers. Two thirds (66%) agreed with the statement “The idea of taking a supplement for skin health or beauty is normal.” Only 14% said the idea was “not normal.”

Over four in ten (43%) consumers in the millennial age group (18-35) said they had used an oral product to benefit their skin health at some point. This compared with 39% of 36-49 year olds, 23% of those aged between 50 and 69, and 14% of those aged 70 or over.

We also explored barriers to the category. Among respondents who had never taken a pill or supplement for skincare, 46% said the main reason was that “It seems to make more sense to apply a product to my skin.” The second most commonly cited reason was “I wasn’t aware I could achieve the same skincare benefits by taking a pill or capsule.” (32%). These barriers were least likely to be cited by the millennials who were surveyed, suggesting that awareness of the potential of ingestible skincare is highest among younger

consumers. At Lycored, we believe this is only the beginning. We’re on

a mission to disrupt traditional consumer thinking about both skincare and beauty itself, thereby changing conventional trade thinking. By doing so we hope to create new opportunities for our whole industry.

We’re frequently told to “love the skin we’re in,” but how often do we really practice that? Over the years, Lycored has come to realize that maintaining skin health and wellness is a lifelong journey that begins on the inside, the home of our “inner glow.” We created our proprietary carotenoid blend Lycoderm™ with that in mind. It’s been formulated with whole tomato fruit extract with carnosic acid derived from rosemary leaf to foster overall skin wellness.

Proven safe and effective in several clinical trials, Lycoderm™ works to foster overall skin wellness from the inside out to protect skin from the primary causes of ageing and damage while promoting healthy, resilient skin, supporting tone and texture.

Lycoderm™ offers consumers a range of health benefits. It has been shown to protect against UV damage and reduce the redness associated with sunburn. It also helps prevent skin ageing caused by UV exposure and limits the induction of markers for inflammation and skin ageing. And it offers benefits for skin texture: after twelve weeks of supplementation in one trial, participants’ epidermis showed an increase in density as well as a decrease in roughness and scaling. Moreover, ageing is an increasingly important trend in the nutraceutical market, and there is growing consumer demand for non-invasive treatments.

But despite these apparent drivers, and its many clinically demonstrated benefits, Lycoderm™ is constrained by the same barriers as other ingestible skincare products. The category has to date been seen as “a bit niche”, with consumers either not aware of the benefits that supplements can offer for their skin, or intuitively believing that a skincare product can only work if it is applied topically.A Strategy of DisruptionSkin health starts on the inside and when we feel beautiful it shows. This is why we believe everyone should have the chance to define beauty for themselves and why we’re using our foray into the skincare industry to do more than simply introduce the world to our portfolio of products that enhance skin health and appearance. Rather than just building a campaign, we want to rethink what it means to be beautiful and to challenge our perceptions about wellness, starting with some very promising results from our on-going clinical studies for Lycoderm™. This is why we’re on a mission to #rethinkbeautiful and want you to join us.

Our #rethinkbeautiful movement is built around one idea – beauty goes beyond skin deep. We’re seeking to change the perception of “beautiful,” and start a conversation about what beauty actually is. By doing so, the campaign aims to free beauty from its proverbial box and create an emotional connection to ingestible skincare. By shedding light on the concept of beauty as something greater than physical appearance we aim to educate the public on how the same can be said for the role of ingestible skincare. The campaign messaging deliberately relates the idea of ‘Beauty From Within’ to health and wellbeing – both physical and emotional. Its foundation is that what we feel on the inside shows through on the outside. Social Media PhaseThe campaign began with an extensive social media programme. Along with a dedicated landing page on Lycored’s website, we created a film called ‘Beauty is What You Make It’, which highlights various individuals, male and female, sharing what beauty means to them.

To spread the word, we created two hashtags. The first was #rethinkbeautiful. The second was #Ifeelbeautifulwhen, which was used to engage influencers and Lycored’s existing Brand

Ambassadors. This was also deployed to invite people to share personal stories with the world. Engaging Hollywood – Letters of LoveAt the start of 2017, Lycored embarked on a new partnership with the ‘Playing for Change’ Foundation, a not-for-profit organization which aims to create positive change through music and arts education.

Working with them, we sponsored two letter-writing stations at the Sundance Film Festival in Utah. The aim of this ‘Letters of Love’ initiative was to encourage people to write letters containing positive affirmations to themselves, echoing the message of self-love that originated with the #rethinkbeautiful campaign.

The letters were sent back to the writer when they least expected it in an effort to remind future them of the positive feelings they had at the time. We were honored to know we would be sending their personalized notes back to them. The station was visited by a string of Hollywood stars, including Charlize Theron. In addition to writing personal letters, they had the option to sign an enlarged replica of the postcard to share thoughts about what makes them feel beautiful. Those who signed included Tim Robbins, Armie Hammer and Jack Black, who wrote: “Beauty is the realization that life is an insane miracle.” Love is Beautiful VideoMost of us celebrate Valentine’s Day by showing the people in our lives just how much we care. It’s a wonderful impulse; however, this year we invited everyone do the same for themselves via a very special short film titled “Love is Beautiful.” It featured women, children and men being asked a simple question: “What do you love about yourself?” Much to their surprise they weren’t able to answer the question. In contrast, when asked to describe people closest to them, they immediately listed what they cherished most in them. The idea was to encourage people to understand that seeing themselves the way others see them can be difficult, but is a good step in helping them love themselves for the skin they’re in and get a truly lit-from-within glow. To promote the film, we replaced 200 outdoor advertisements in the London market with 200 bright and inspiring posters bearing the message “Your Heart Has No Limits”. This was then distributed as a direct mailing to 8,000 dermatologists, educating them about ingestible skincare to bring the campaign full-circle. Conclusion The campaign has achieved some remarkable results. The first video was viewed over 400,000 times, liked 2,600 times, and shared over 2,300 times.

The first day of the “Letters of Love” initiative resulted in vast numbers of letters being sent by Sundance attendees. After the Valentine’s Day takeover, the brand saw 288% growth in “Letters of Love” digital love letters compared to the previous month. There was a 688% increase in “Love is Beautiful” video views over a week.

The campaign has also generated media coverage in consumer beauty and celebrity outlets including Popsugar, Entertainment Tonight and Hollywood Life. At each stage we have tried to create an opening to communicate the benefits of LycodermTM. We are currently undertaking more consumer research to build a detailed picture of where people are on the concept of ‘Beauty from Within’, and the messages that are most likely to shift their perceptions while we keep on trucking by hitting the road at upcoming “Letters of Love” events, including the Wanderlust Festival in Squaw Valley, California and Art Basel in Miami Beach, Florida.

Feedback we are seeing so far suggests that those who like what we are doing want to engage with our movement in a deeper way, and that our message of disruption is resonating powerfully.

At the very least, we’ve started a conversation with consumers, and that’s always a good step in bringing about change.

By Zev Ziegler, Head of Global Brand & Marketing, Health at Lycored

company news . . . company news . . . company news

Fruit d’Or cranberry seed oil approved by Health Canada for maintenance of good health

. . . Cranberry seed oil is a foodceutical, cosmeceutical and nutraceutical ingredient

Fruit d’Or Nutraceuticals has received Natural Product Number (NPN #80079040) from Health Canada’s Natural and Non-prescription Health Products Directorate (NNHPD), for both Cran Naturelle and Cran d’Or cranberry seed oil. Fruit d’Or Cranberry Seed Oil is registered with an NPN claim as a, “source of omega-3 and omega-6 fatty acids for the maintenance of good health. Source of antioxidants. Source of oleic acid.” Each tablespoon (15 ml) contains 34.8% ALA, 36.6% LA and 19.9% Oleic acid.

“This is a major breakthrough for culinary applications. Fruit d’Or is the first to extract the oil from the cranberry seed and earn this health claim of taking one tablespoon daily, or as directed by a healthcare practitioner, for the maintenance of good health. And because Health Canada has recognized that our cranberry seed oil is safe for consumption, it does not have to be GRAS-approved,” says Stephen Lukawski, director of global sales and product development, Fruit d’Or Nutraceuticals.

“No other fruit oil has this combination of omega 3, 6 and 9 in these high amounts,” Lukawski continues. “This news is a home run for the food industry around the world to use Fruit d’Or cranberry seed oil as a functional artisanal oil.” The rich, golden oil is flavor neutral with no aftertaste.

He adds, “No chemicals are used in our cold-pressed extraction method, which was developed to preserve the cranberry seed oil’s phospholipid content and its abundant natural antioxidants.” Fruit d’Or cranberry seed oil is a rich source of vitamin E tocopherols and tocotrienols, as well as sterols.

Cranberry seed oil is also creating exciting new cosmeceutical opportunitiesDemand for Fruit d’Or cranberry seed oil is also increasing for its skin care and anti-aging benefits. Cranberry seed oil is one of the most unsaturated oils available, making it an ideal moisturizing ingredient. With a composition of more than 95 percent fatty acids, cranberry seed oil may protect and reestablish the protective lipid barrier of the skin. It has excellent oxidative stability, a pleasant odor and texture, and the ideal 1:1 ratio of omega 3 to omega 6. “Essential fatty acids are nourishing, protective, aid in the formation and maintenance of cellular membranes and are essential to the formation of prostaglandins to reduce inflammation,” confirms Lukawski.

Due to its stability and the protective characteristics of its high vitamin E content, cranberry seed oil is an excellent ingredient for products requiring stabilizing, emulsifying and penetrating actions to enhance the fatty acids and other components within its health product composition.

“By using a cold-pressed extraction method with no excipients, the multitude of beneficial compounds and

biological activities housed within Fruit d’Or cranberry seed oil are retained,” explains Lukawski. “The bioavailability of these ingredients in skin care applications may enhance the regeneration, healing, protection and ultimately the beautification of the skin.”

Formulators are excited by cranberry seed oil’s versatilityLukawski confirms that Fruit d’Or is already working with nutraceutical and cosmetic companies to combine its cranberry seed oil with vitamins, chia and other trending ingredients. “We are welcoming all researchers and formulators to embrace cranberry seed oil by putting this superstar ingredient into their dietary supplements, blending it with vitamin D and other fatty oils such as CoQ10, selling it on its own, using it for skincare products or to complement other dietary oils such as those found in fish oil,” he says.

In keeping with Fruit d’Or Nutraceutical’s commitment to ongoing research, Lukawski says the company is excited to further investigate the benefits of the beta sitosterol found in cranberry seed oil, which has been linked to prostate health.

He also reconfirms the company’s farm-to-table advantages. “Fruit d’Or produces its own cranberries and cranberry concentrate so they can control the quality from farm to factory, seed to table. Having a one-stop shop prevents the possibility of adulteration and degradation while protecting the health and safety of consumers. Vertical integration by Fruit d’Or allows for control of the supply chain and maintains a standardized quality that delivers on promise,” states Lukawski.

Those interested in learning more about the advantages of Fruit d’Or cranberry seed oil, and of working with Fruit d’Or Nutraceuticals, should visit www.bestcranberry.com

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