heme-mediated spi-c induction promotes monocyte differentiation into iron-recycling macrophages...

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Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh KC, Xiaodi Wu, Carlos G. Briseño, Ansuman T. Satpathy, Nicole M. Kretzer, Hisashi Arase, Namakkal S. Rajasekaran, Li Wang, Takeshi Egawa, Kazuhiko Igarashi, David Baltimore, Theresa L. Murphy, Kenneth M. Murphy Cell Volume 156, Issue 6, Pages 1223-1234 (March 2014) DOI: 10.1016/j.cell.2014.01.069 Copyright © 2014 Elsevier Inc. Terms and Conditions

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Page 1: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages 

Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh KC, Xiaodi Wu, Carlos G. Briseño, Ansuman T. Satpathy, Nicole M. Kretzer, Hisashi Arase, Namakkal S. Rajasekaran, Li Wang, Takeshi Egawa, Kazuhiko Igarashi, David Baltimore, Theresa L. Murphy,

Kenneth M. Murphy 

Cell Volume 156, Issue 6, Pages 1223-1234 (March 2014)

DOI: 10.1016/j.cell.2014.01.069

Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 2: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure 1

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 3: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure 2

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 4: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure 3

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 5: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure 4

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 6: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure 5

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 7: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure 6

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 8: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure 7

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 9: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure S1

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 10: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure S2

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 11: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure S3

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 12: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure S4

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 13: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure S5

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 14: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure S6

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 15: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Figure S7

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 16: Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages Malay Haldar, Masako Kohyama, Alex Yick-Lun So, Wumesh

Cell 2014 156, 1223-1234DOI: (10.1016/j.cell.2014.01.069) Copyright © 2014 Elsevier Inc. Terms and Conditions