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  • Hematopoietic Stem Cell Transplantation

  • Cancer Treatment and Research Steven T. Rosen, M.D., Series Editor

    Bishop, M.R. (ed): Hematopoietic Stem Cell Transplantation. 2009. ISBN 978-0-387-78579-0.

    Blake, M., Kalra, M. (eds): Imaging in Oncology. 2008. ISBN 978-0-387-75586-1.

    Gradishar, W.J., Wood, W.C. (eds): Advances in Breast Care Management, Second Edition. 2008.

    978-0-387-73160-5.

    Ansell, S. (ed): Rare Hematological Malignancies. 2008. ISBN 978-0-387-73743-0.

    Angelos, P. (ed): Ethical Issues in Cancer Patient Care, Second Edition. 2008.

    ISBN 978-0-387-73638-9.

    Woodruff, T., Snyder, K.A. (eds): Oncofertility. 2007. ISBN 978-0-387-72292-4.

    Raizer, J., Abrey, L.E. (eds): Brain Metastases. 2007. ISBN 978-0-387-69221-0.

    Leong, S.P.L. (ed): Cancer Metastasis and the Lymphovascular System: Basis for rational therapy.

    2007. ISBN 978-0-387-69218-0.

    Ceelen, W.P. (ed): Peritoneal Carcinomatosis: A Multidisciplinary Approach. 2007.

    ISBN 978-0-387-48991-9.

    Meyers, C. (ed): Aids-Associated Viral Oncogenesis. 2007. ISBN 978-0-387-46804-4.

    Leong, S.P.L. (ed): Cancer Clinical Trials: Proactive Strategies. 2006. ISBN 0-387-33224-3.

    Leonard, J.P., Coleman, M. (eds): Hodgkin’s and Non-Hodgkin’s Lymphoma. 2006.

    ISBN 0-387-29345.

    Haefner, B., Dalgleish, A. (eds): The Link Between Inflammation and Cancer. 2006.

    ISBN 0-387-26282-2.

    Small, Jr. W., Woloschak, G. (eds): Radiation Toxicity: A Practical Guide. 2005.

    ISBN 1-4020-8053-0.

    Leong, S.P.L., Kitagawa, Y., Kitajima, M. (eds): Selective Sentinel Lymphadenectomy for Human

    Solid Cancer. 2005. ISBN 0-387-23603-1.

    Platanias, L.C. (ed.): Cytokines and Cancer. 2005. ISBN 0-387-24360-7.

    Abrey, L.E., Chamberlain, M.C., Engelhard, H.H. (eds): Leptomeningeal Metastases. 2005.

    ISBN 0-387-24198-1

    Balducci, L., Extermann, M. (eds): Biological Basis of Geriatric Oncology. 2004. ISBN

    Khleif, S. (ed.): Tumor Immunology and Cancer Vaccines. 2004. ISBN 1-4020-8119-7.

    Farid, N. (ed.): Molecular Basis of Thyroid Cancer. 2004. ISBN 1-4020-8106-5.

    Finn, W.G., Peterson, L.C. (eds.): Hematopathology in Oncology. 2004. ISBN 1-4020-7919-2.

    Verweij, J., Pinedo, H.M. (eds): Targeting Treatment of Soft Tissue Sarcomas. 2004.

    ISBN 1-4020-7808-0.

    Kumar, R. (ed.): Molecular Targeting and Signal Transduction. 2004. ISBN 1-4020-7822-6.

    Keller, E.T., Chung, L.W.K. (eds): The Biology of Skeletal Metastases. 2004. ISBN 1-4020-7749-1.

    For further volumes:

    http://www.springer.com/5808

  • Michael R. Bishop Editor

    Hematopoietic Stem Cell Transplantation

    1 3

  • Editor

    Michael R. Bishop National Cancer Institute Bethesda, MD, USA mbishop@mail.nih.gov

    ISSN: 0927-3042 ISBN: 978-0-387-78579-0 e-ISBN: 978-0-387-78580-6 DOI 10.1007/978-0-387-78580-6

    Library of Congress Control Number: 2008921984

    # Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This workmay not be translated or copied in whole or in part without the written permission of the publisher (Springer ScienceþBusinessMedia, LLC, 233 Spring Street, NewYork, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein.

    Printed on acid-free paper

    springer.com

  • Contents

    1 Principles and Overview of Allogeneic Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Sergio Giralt and Michael R. Bishop

    2 The Principles and Overview of Autologous Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 William Vaughan, Tara Seshadri, Mark Bridges, and Armand Keating

    3 Natural Killer Cell Activity and Killer Immunoglobulin-Like Receptors in Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . 47 Loredana Ruggeri, Shuhong Zhang, and Sherif S. Farag

    4 Advancement and Clinical Implications of HLA Typing in Allogeneic Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . 71 Lee Ann Baxter-Lowe and Carolyn Katovich Hurley

    5 Immunogenomics and Proteomics in Hematopoietic Stem Cell Transplantation: Predicting Post-Hematopoietic Stem Cell Transplant Complications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Eva M. Weissinger and Anne M. Dickinson

    6 Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . 131 Karl S. Peggs, Aviva C. Krauss and Crystal L. Mackall

    7 Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells. . . . . . . . . . . . . . . . . 155 Daniel Fowler, Petra Hoffmann, and Matthias Edinger

    8 Understanding and Enhancing the Graft-Versus-Leukemia Effect After Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . 187 Jeffrey Molldrem and Stanley Riddell

    v

  • 9 Reduced-Intensity and Nonmyeloablative Conditioning Regimens . . . 209 Francine Foss and Koen van Besien

    10 Umbilical Cord Blood Transplantation. . . . . . . . . . . . . . . . . . . . . . . . 233 John E. Wagner, Claudio Brunstein, William Tse, and Mary Laughlin

    11 Biology and Management of Acute Graft-Versus-Host Disease . . . . . 257 Robert Korngold and Joseph H. Antin

    12 Biology and Management of Chronic Graft-Versus-Host Disease . . . 277 Paul J. Martin and Steven Z. Pavletic

    13 Radioimmunoconjugates in Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Ajay K. Gopal and Jane N. Winter

    14 Evolving Indications for Hematopoietic Stem Cell Transplantation in Multiple Myeloma and Other Plasma Cell Disorders. . . . . . . . . . . 317 Guido Tricot, Maurizio Zangari, Roberto Sorasio, and Benedetto Bruno

    15 Role of Hematopoietic Stem Cell Transplantation in the Treatment of Non-Hodgkin’s Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357 Philip J. Bierman and Gordon L. Phillips

    16 The Role of Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 399 Craig Moskowitz and John Sweetenham

    17 Role of Hematopoietic Stem Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndrome . . . . . . . . . . 415 Martin S. Tallman, Vikram Mathews, and John F. DiPersio

    18 Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 441 Daniel Weisdorf and Stephen Forman

    19 Hematopoietic Stem Cell Transplantation in Children and Adolescents with Malignant Disease . . . . . . . . . . . . . . . . . . . . . . 455 Mitchell S. Cairo and Thomas G. Gross

    20 Cellular Adoptive Immunotherapy After Autologous and Allogeneic Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . 497 David L. Porter, Elizabeth O. Hexner, Sarah Cooley, and Jeffrey S. Miller

    vi Contents

  • 21 Improvements in the Prevention and Management of Infectious Complications After Hematopoietic Stem Cell Transplantation . . . . . 539 Juan C. Gea-Banacloche and James C. Wade

    Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 575

    Contents vii

  • Introduction

    The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew.

    Abraham Lincoln, 1862

    When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research.

    It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hemat

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