hematopoietic stem cell transplantation 1 principles and overview of allogeneic hematopoietic stem...

Hematopoietic Stem Cell Transplantation

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Bishop, M.R. (ed): Hematopoietic Stem Cell Transplantation. 2009. ISBN 978-0-387-78579-0.

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Michael R. Bishop Editor

Hematopoietic Stem Cell Transplantation

1 3

Editor

Michael R. Bishop National Cancer Institute Bethesda, MD, USA mbishop@mail.nih.gov

ISSN: 0927-3042 ISBN: 978-0-387-78579-0 e-ISBN: 978-0-387-78580-6 DOI 10.1007/978-0-387-78580-6

Library of Congress Control Number: 2008921984

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Contents

1 Principles and Overview of Allogeneic Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Sergio Giralt and Michael R. Bishop

2 The Principles and Overview of Autologous Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 William Vaughan, Tara Seshadri, Mark Bridges, and Armand Keating

3 Natural Killer Cell Activity and Killer Immunoglobulin-Like Receptors in Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . 47 Loredana Ruggeri, Shuhong Zhang, and Sherif S. Farag

4 Advancement and Clinical Implications of HLA Typing in Allogeneic Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . 71 Lee Ann Baxter-Lowe and Carolyn Katovich Hurley

5 Immunogenomics and Proteomics in Hematopoietic Stem Cell Transplantation: Predicting Post-Hematopoietic Stem Cell Transplant Complications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Eva M. Weissinger and Anne M. Dickinson

6 Clinical Implications of Immune Reconstitution Following Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . 131 Karl S. Peggs, Aviva C. Krauss and Crystal L. Mackall

7 Functionally Defined T Cell Subsets in Transplantation Biology and Therapy: Regulatory T Cells and Th2 Cells. . . . . . . . . . . . . . . . . 155 Daniel Fowler, Petra Hoffmann, and Matthias Edinger

8 Understanding and Enhancing the Graft-Versus-Leukemia Effect After Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . 187 Jeffrey Molldrem and Stanley Riddell

v

9 Reduced-Intensity and Nonmyeloablative Conditioning Regimens . . . 209 Francine Foss and Koen van Besien

10 Umbilical Cord Blood Transplantation. . . . . . . . . . . . . . . . . . . . . . . . 233 John E. Wagner, Claudio Brunstein, William Tse, and Mary Laughlin

11 Biology and Management of Acute Graft-Versus-Host Disease . . . . . 257 Robert Korngold and Joseph H. Antin

12 Biology and Management of Chronic Graft-Versus-Host Disease . . . 277 Paul J. Martin and Steven Z. Pavletic

13 Radioimmunoconjugates in Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299 Ajay K. Gopal and Jane N. Winter

14 Evolving Indications for Hematopoietic Stem Cell Transplantation in Multiple Myeloma and Other Plasma Cell Disorders. . . . . . . . . . . 317 Guido Tricot, Maurizio Zangari, Roberto Sorasio, and Benedetto Bruno

15 Role of Hematopoietic Stem Cell Transplantation in the Treatment of Non-Hodgkin’s Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 357 Philip J. Bierman and Gordon L. Phillips

16 The Role of Hematopoietic Stem Cell Transplantation in Hodgkin Lymphoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 399 Craig Moskowitz and John Sweetenham

17 Role of Hematopoietic Stem Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndrome . . . . . . . . . . 415 Martin S. Tallman, Vikram Mathews, and John F. DiPersio

18 Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 441 Daniel Weisdorf and Stephen Forman

19 Hematopoietic Stem Cell Transplantation in Children and Adolescents with Malignant Disease . . . . . . . . . . . . . . . . . . . . . . 455 Mitchell S. Cairo and Thomas G. Gross

20 Cellular Adoptive Immunotherapy After Autologous and Allogeneic Hematopoietic Stem Cell Transplantation . . . . . . . . . . . . . . . . . . . . . 497 David L. Porter, Elizabeth O. Hexner, Sarah Cooley, and Jeffrey S. Miller

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21 Improvements in the Prevention and Management of Infectious Complications After Hematopoietic Stem Cell Transplantation . . . . . 539 Juan C. Gea-Banacloche and James C. Wade

Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 575

Contents vii

Introduction

The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew.

Abraham Lincoln, 1862

When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research.

It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hemat