healthy mind, healthy sight

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Healthy Mind, Healthy Sight.

Dr. Guy Eakin, BrightFocus Foundation

Dr. Elia Duh, Johns Hopkins University Dr. Seth Margolis, Johns Hopkins University

Healthy Mind, Healthy Sight.

BrightFocus Foundation A Non-Profit Organization

Based in Clarksburg, Maryland

Supporting Research and Education to Save Mind and Sight

One in 16 Americans, age 40 and above, has Alzheimers disease, macular degeneration, or glaucoma.

The Need for Cures is Great

Support Innovative, Cutting-Edge Research

BrightFocus has awarded more than 1,000 grants totaling $130 million. More than $26 million awarded in last four years.

Our Research Mission

Providing the Public with Information: Risk Factors Early Detection /Diagnosis Current Treatments Coping Strategies for Patients and Caregivers

Public Education

Glaucoma and Age-Related Macular DegenerationElia Duh, M.D.Wilmer Eye InstituteJohns Hopkins School of MedicineOctober 30, 2013

7Glaucoma and Age-related Macular Degeneration (AMD)Two of the most common causes of blindness in the United States

Risk factors:AGE: especially over the age of 60Family historyRace

Glaucoma Glaucoma: Fluid builds up in the eye, so that the eye pressure rises

This higher eye pressure can damage the optic nerve over time

Symptoms

Treatment

Research to improve treatments

Glaucoma Age-Related Macular Degeneration (AMD)AMD: Eye condition among people age 50 or olderIt gradually damages (and even destroys) the macula

Dry form of AMD

Wet form of AMD

Age-Related Macular Degeneration (AMD)Symptoms

Treatments

Research to improve treatments for AMD

Alzheimers DiseaseDr. Seth MargolisJohns Hopkins UniversityDepartment of Biological Chemistry Johns Hopkins School of MedicineOctober 30, 2013

13

NeuronsSynapsesMoleculesBehaviorCircuits1414

040608010020(Years)Genetic mutation andRisk factorsMisfolding and aggregation of Ab and tau followed by plaques and tanglesInflammatoryCell damagePreventativeModifyingSymptomaticCell deathClinical diagnosisAbnormalNormalAmyloidNeuronInjuryMemoryDementiaMild

Daniel Colon-Ramos

Karl Deisseroth16Spine Abnormalities are a Hallmark of Cognitive DisordersReviewed in Ramakers et al. 2002, TINS UnaffectedAffectedNon-syndromic MRDowns SyndromeRett SyndromeFragile X syndromePhenylketonuriaAngelman SyndromeAlzheimers disease

17Spine densityAge

Wenbiao GanDendritic Spine Density Changes with Development

anti-N-E5anti-EphB2Braak334556Embryonic8682931028988Genetic Cross Between Alzheimer Mice Models and Ephexin5 Knockout MiceXFemaleMaleElectrophysiological properties:Dendritic spine morphology: Learning and memory:Alzheimer MiceEphexin5-/Ephexin5-Ephexin5-/Ephexin5+Alzheimers20If You Have QuestionsVisit our website:www.BrightFocus.org

Send us an email:info@BrightFocus.org Give us a call:1-800-437-2423