A GLIMPSE ON MCQ OF PHARMACEUTICAL SCIENCES

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TEST NO: 11

(PHARMACEUTICS)

Q1. Identity the false statement for cyclodextrins

a. The interior of cavity have –CH grps while – OH grps are at exterior 2

b. They are macrocyclic host composed of a 1,4 linkage of glucopyranose c. Partial meth ylation of OH grp in CD decrease the aqueous solubility d. Glucopyranose units form a intramolecular cavity of truncated cone which dissolves hydrophobic

compounds

Q2. Identify the wrong statement for pyrogens

a. Pyrogen test is not necessary for the ophthalmic preparations b. They are water soluble components which are metabolic products of growing bacteria c. Pyrogens are lipopolysaccrides compounds which are produced by gram –ve bacteria d. LAL or BET (bacterial endotoxin test) represents gelling property of pyrogen s with RBCs is common test

pyrogen

Q3. Identify the false statement for micelles

a. They are colloidal aggregates above cmc and exhibit tyndall effect b. Micelles are more soluble in water than monomers c. Micelles have no effect on surface or interfacial tension of the system after above cmc d. At low con centration they are colloidal e. Micelles are amphiphiles in heads are polar and tails are nonpolar

Q4. Identify the false statement for lyophobic colloid

a. Unstable even in small concentration of electrolyte b. Colloidal particals are unsolvated c. lyophobic colloid Increase the viscosity of the dispersion medium d. They posses high charge on their surface and are prepared by special dispersion and condensation methods e. Stability can be enhanced by addition of opposite charge Lyophilic colloid in excess

Q5. Which of the following is solublizing agent for gelatin?

a. Lecith in b. PEG c. HCHO d. Fumaric acid

Q6. Perfect wetting of hydrophobic compound with solvent occurs if contact angle is

a . 90

b. 45

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c. 0 d 180

Q7. Match the following various preformulation studies 1

1. Differential scanning calorimetry a. Solubility analysis 2

2. Wood’s apparatus b. Thermal gravimetric analysis 3

3. Potentiometry c. Polymo rphism 4

4. Hydrates / water of crystallization d. Partical size and shape 5

5. Scanning Electron Microscopy (SEM) e. pKa determination

Q8. Match the following equipments 1

1. Accogel a. For manufacturing of SGC 2

2. Roto sort b. Filling equipment for HGC 3

3. Lilly/Park dav is c. To sort out unfilled joined capsules, loose caps 4

4. Rotary die process d. Filling of solid s to SGC

Q9. Match the following HLB scale of nonionic surfactants 1

1. 3-6 a. W/O emulsions 2

2. 7-9 b. O/W emulsions 3

3. 8-16 c. Solublizing ag ents / hydrotrope 4

4. 16-18 d. Wetting agents

Q10. For content of uniformity, (USP) out of 10 tablets, 9 tablets may contain

I. May contain not less than 75% and not more than 125 % of lab eled drug content

II. May contain not less than 85% and not more than 115 % of lab eled drug content

III. May contain not less than 65% and not more than 135 % of lab eled drug content

IV. May contain not less than 95% and not more than 105 % of lab eled drug content

Q11. Hardness of gelatin shell is ratio of dry weight of plasticizer / dry weight of gelatin is 0.8 then gelatin shell will be

a. Soft b. Moderate c. Hard d. Very soft

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Q12. Liposomes are

a. Nonionic surfactant meant for targeted drug delivery systems

b. Branched anionic polymers meant for DNA transfer

c. Phospho lipids bilayer v esicles meant for targeted drug delivery systems

d. Biodegradable polymers meant for sustained release of drugs

Q13. Which of the Non-Newtonian fluid does not exhibit thixotrophy?

a. Plastic b. Pseudo plastic c. Dilatants /rheopexy d. Both a and b

Q14. The Isoelectric point of Type II gelatin is

a. 9 b. 4.7 c. 8.5 d. 7.5

Q15. Base absorption in SGC is mainly calculated for

a. Emulsions b. Susp ensions c. Aqueous solutions d. powders

Q16. Moisture content in the gelatin shell is

a. < 2 % b. 5 % c. 10-15 % d. 15-20 %

Q17. Wetting agent used for SGC is

a. Sorbito l b. Lecithin c. HCHO d. Fumaric acid

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Q18. Which of the following treatment can retard the solubility/dissolution of gelatin shell?

a. PEG b. SO treatment

2c. HCHO d. Fumaric acid

Q19. Antithixotropy is exhibited by

a. Deflocculated suspensions b. Flocculated suspensions c. Polymers d. Clay suspension

Q20. Iron content in gelatin shell should not be more ………….. as it can cause color reaction

a. 1 ppm b. 5 ppm c. 10 ppm d. 15 ppm

Q21. The maximum volume in ml that can be filled in gelatin shell is

a. 0.5 ml b. 1 ml c. 0.75 ml d. 2 ml

Q22. Which of the following polymer can be used for enteric coating?

a. Gelatin b. Methyl cellulose c. Sodium cmc d. Shellac

Q23. Which of the polymer is water soluble?

a. Ethyl cellulose b. Polyamide c. Methyl cellulose d. Cellulo se nitrate

Q24. Viscosity of 6.66% gelatin solution in water at 60 C is ranges from 0

a. 1-1.5 centipoises b. 2.5-4.5 centipoises c. 4.5-6.5 centipoises d. 6.5-8.5 centipoises

Q25. Capping in tablets can be due to

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a. Low concentration of fines b. High concentration of fines c. Rapid removal of water from core of tablet d. Low concentration of plasticizer

Q26. Which of the diluent is also used as binder and disintegrating agent?

a. Mannitol b. DCP c. Lactose d. Starch

Q27. Lozenges have disintegration time

1. 15min 2. 30 min. 3. 10 min. 4. None

Q28. Which diluent cannot be used if API is tetracycline?

1. Lactose 2. Mannitol 3. DCP 4. Avicel-101

Q29. La rgest ca psule size is

a. 000 b. 0 c. 5 d. 1

Q30. Coacervation phase for microencapsulation is achieved in

a. 2 steps b. 3 steps c. 4 steps d. 5 steps

Q31. Bloom strength which measures cohesive strength/ internal cross linking varies from

a. 50-100 gm b. 100-150 gm c. 150-250 gm d. 300-400 gm

Q32. Brookfield viscometer is

a. Cup and bob type b. Cone and plate type c. Falling sphere type d. Capillary typ e

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Q33. Ultrafilteraion have membrane filter size

a. 0.1-1µm b. 0.01 – 0.1µm c. 0.001 – 0.01 µm d. 0.0001 – 0.001 µm

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Q34. Kraft point represents

a. pH b. Concentration c. Temperature d. Time

Q35. Kraft point is related to

a. Anionic surfactant b. Cationic surfactant c. Nonionic surfactant d. Both a and b

Q36. Which of the following is called as shear thinning systems?

a. Plastic b. Pseudo plastic c. Dilatants d. Newtonians

Q37. Yield value is characteristic of

a. Plastic flow b. Pseudo plastic c. Dilatants d. Newtonian

Q38. Identify the false statement

a. Flocculated suspensions exhibit plastic flo w b. Deflocculated suspensions with high solid content exhibit dilatent flow c. Magnesia exhibit Antithixotropy d. Polymers exhibit pseudo plastic flow

e. Equilibrium state in dilatants fluid is sol state f. Equilibrium state in Antithixotrop y fluid is sol state

Q39. Condensation and dispersion methods are employed for preparation of

a. Lyophilic colloid b. Lyophobic colloid c. Association colloid d. Both a and b

Q40. Coacervation which represents the separation of colloidal system into two phases is

a. When opposite charge Lyophilic colloid are mixed together b. Wh en opposite charge lyophobic collo id mixed together

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c. Wh en oppo site charge Lyophilic colloid is mixed with lyophobic colloid d. When same charge Lyophilic colloid is mixed with lyophobic colloid

Q41. Which of the following have lowest gold number?

a. Albumin b. Acacia c. Gelatin d. Casein

Q42. Hardy schule rule is for

a. Lyophilic colloid b. Lyophobic colloid c. Association colloid d. Both band c

Q43. Which of the following act as Co-solvent in parenterals preparations?

a. Benzyl alcohol b. Isopropyl myristate c. Dioxolanes d. Ethyl oleate

Q44. Which of the following drug undergo racemization in water?

a. Barbiturates b. Epinephrin e

c. Atropine d. Both a & b

Q45. ß-cyclodextrins have how many glucopyranose units?

a. 6 b. 7 c. 8 d. 9

Q46. Which of the cyclodextrins have largest intramolecular cavity?

a. a b. ß c. d. All have same cavity size

Q47. Which of the following is used as chelator in iron poising?

a. Dimercaprole

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b. D-Penicillamine c. Deferoxamine d. EDTA

Q48. Different polymorphic forms can be obtained by

a. Varying storage temperature b. Varying recrystalization solven t c. Varying cooling rates d. All

Q49. Polymorphism can not be studied by

a. X-ray diffraction b. Solubility analysis c. DSC and SEM d. Karl fisher titration

Q50. Solubility analysis can be done by

a. HPLC b. UV spectrometry

c. Gas chromatography d. Fluorescence spectroscopy e. All

Q51. Which polymorphic form of Chloramphenicol is more soluble?

a. A b. B c. C d. D

Q52. Moisture level in drug ca n be monitored by

a. Karl fisher titration b. Gas chromatography c. Thermogravemetric analysis d. All

Q53. Sequestration is

a. Chelate and metal ion form lipid soluble complex b. Chelate and metal ion form water soluble complex c. Chelate and metal ion form partially water soluble complex d. Chelate and metal ion form partially lipid soluble complex

Q54. Which of the following antineoplastic agents exhibit their action by complex formation with DNA base pair?

a. Topotecan b. Actinomycin D c. Hydroxy urea d. Procarbazine

Q55. Which of the following agent can cause incompatibility due to complex formation with phenols and

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carbo xy lic acids grp in the ingredients?

a. Lecith in b. Polysorbates c. PEG d. Both b and c

Q56. Units for rate constant (K) for second order kinetics

a. S -1b. Moles /liter. S c. Moles .liter. S -1 -1d. Moles. Liter . S -1 -1

Q57. Match the following

1. Mannitol a. Millard’s reaction 2. Lactose b. Incompatibility with Tetracyclines 3. DCP c. Sugar based diluent 4. NUTAB d. Negative heat of solvation

1 2 3 4

Q58. Which of the following is not a binder?

a. Glucose b. Gelatin c. PVP d. Microcrystalline cellulose

Q59. Which of the diluents can alter the GIT transit time of the drugs absorbed from GIT?

a. Sorbito l b. Avicel c. Lactose d. Starch

Q60. Which diluent is not suitable for water sensitive drugs?

a. Lactose b. Starch c. Mannitol d. DCP

Q61. Which diluent acts as a binder, disintegratant, glidant?

a. Sorbito l

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b. Avicelc. Lactose d. Starch

Q62. Which of the sweetening agent is sensitive towards moisture?

a. Saccharin b. Aspartame c. Cyclamate d. Mannitol

Q63. Match the following binder concentration generally used in tablet granulation

1. Gelatin a. 5-20 % 2. Starch mucilage b. 5- 10% 3. Glucose c. 50 % 4. PVP d. 2- 10 %

Q64. A translucent Starch paste is prepared by dispersing the starch into water which on heating gives

a. Dextrins b. Glucose c. Amylose and amylopectin d. Glucose and dextrins

Q65. Which of the binder can be in both aqueous and alcoholic solutions?

a. Ethyl cellulose b. Methyl cellulose c. PVP d. Starch

Q66. Which of the binder can retard the dissolution and disintegration time of drugs when employed in wet granulation?

a. Ethyl cellulose b. PVP c. Methyl cellulose d. Glucose

Q67. Match the following excipients used in tablets 1. Primogel and explotab a. Microcrystalline cellulose

2. Ac-Di-SOL b. Internally cross linked sodium carboxymethylcellulose 3. Avicel c. Sugar based diluent 4. Dipac d. Low substitu ted carbox ymethyl starches

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Q68. Which of the following is water soluble lubricant and does not alter the dissolution time of drugs?

a. Talc b. Sodium benzoate c. Stearates d. Silicon oils

Q69. Which of the following lubricant generally not used when Drugs breakdown is catalyzed by the iron

a. Talc b. Sodium benzoate c. Stearates a. Silicon oils

Q70. Which of the diluent is mostly used in direct compressible tablets?

a. Sorbito l b. Avicel c. Lactose d. Starch

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Q71. Hauser‘s ratio is tapped density/ bulk density, when the factor is <1.25 then the flow of the powder will be

a. Good flow b. Moderate c. Poor d. Very po or

Q72. Carr index is or percentage of compressibility is

a. Tapped density – bulk density × 100

Tapped density

b. Bulk density – Tapped density × 100

Tapped density

c. Tapped density – bulk density × 100

Bulk density

d. Bulk density – Tapped density × 100

Bulk density

Q73. Match the following film defects with their possible cause

1. Cracking a. Inadequate spreading of coating solution

2. Hazing b. Shrinkage of film from sharp corners during drying 3. Blistering c. loss of gloom due to high processing temperature 4. Orange peel effect d. Rapid evaporation of solvent from core due to high temperatu re.

5. Bridging e. Internal stress in film exceeds the tensile strength of the film

Q74. Identify the false statement in sugar coating?

a. Increase up to 50-52% weight of tablet and desired thickness is obtained by using binder solution in sub coating step

b. Shellac and zein are used in seal or water proof coating c. Shellac can lengthen the dissolution and d isintegration time due to po lymerization (aging) d. Zein is alcohol soluble protein obtained from corn have no effect on dissolution and disintegration time e. Syrup coating make tablets as convex with thin round edges and overcome the imperfection caused by sub

coating f. Colorants are added in sub coating step

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Q75. Which of the following is equipment for wet granulation?

a. Chilsonator b. Hutt’s compactor c. Roller compactor d. Fitzp atrick communiting mill

Q76. Which of the hardness tester uses hydraulic pressure to determine hardness of tablet?

a. Monsanto b. Strong cobb c. Pfizer d. Schleuniger

Q77. If tablet hardness is 4 kg than tablet is

a. Soft b. Hard c. Good d. Very hard

Q78. For a tablet of 324 mg the weight variation permitted (USP) is

a. ± 10 % b. ± 7.5 % c. ± 5% d. ± 2.5 %

Q79. Permitted weight loss (USP) of compressed tablet in Roche’s friabilator (revolves at 25 rpm and 100 revolution are given) is

a. 0.5 – 1% b. 1 – 1.5 % c. 1.5 – 2% d. 2 – 2.5 %

Q80. What is the maximum concentration of fines that can be added to improve the flow is?

a. 10% b. 15% c. 5% d. 20%

Q81. Which of the following is mostly responsible for chemical degradation?

a. Oxidation b. Reduction c. Racemization d. Hydrolysis

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Q82. Enteric coated tablets are initially tested for disintegration in?

a. Simulated intestin al fluid b. Simulated gastric fluid c. Phosph ate buffer d. Purified water

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Q83. Polymorphism is most important in formulation of

a. Solutions b. Ointments c. Capsules d. Suspensions

Q84. Identify the Protective colloid is

a. When opposite charge Lyophilic colloid are mixed together b. Wh en opposite charge lyophobic collo id mixed together c. Wh en oppo site charge Lyophilic colloid is mixed with lyophobic colloid d. When same charge Lyophilic colloid is mixed with lyophobic colloid

Q85. Partical size reduction will not enhance the absorption of

a. Hydrophobic drugs b. Hydrophilic drugs c. Weak bases d. Weak acids

Q87. An isotonic solution is one which

a. Has freezing point less than plasma b. Has same salt composition of plasma c. Does not cause crenulations d. Does not cause hemolysis

Q88. Hyaluronidase has used an adjunct to

a. Prevent oxidation of drug s b. Increase absorption of injected drugs c. Prevent fluid loss d. Speed detoxication of enzyme induction

Q89. Contact angle measures

a. coefficient of friction in powders b. spreadability in ointments c. moisture content of granules d. disintegration of tablets e. Both a and b

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Q90. One of the vehicle for parenterals also have antioxidant property

a. olive o il b. sesame oil c. cotton seed oil d. ethanol

Q91. Griffin defined HLB value

a. % mol of hydrophilic grp / 5 b. % mol of lipophilic grp / 5 c. % mol of lipophilic grp / 5 + % mol of hydro ph ilic grp / 5 d. % mol of hydrophilic grp × 5

Q92. HLB value for wetting agents is

a. 3-6

b. 7-9

c. 8-16

d. 13-15

Q96. Identify the True / False statement-

1. Stroke law holds good for deflocculated suspensions rather then flocculated suspensions

2. Noyes Whitney equation is related to the rate of diffusion of drugs

3. Adipic acid in parenterals act as buffering agent

4. Aspartame is carcinogenic in nature

5. Benzyl alcohol in parenterals is commonly used as local anesthetic

6. Salol treatment to gelatin shell increases its water solubility

7. Nephlometry is appropriate for measurement of optical density for concentrated solutions

8. Bancroft’s rule, the phase in which emulsifier is more soluble constitutes internal / disperse phase

9. For intramu scular injections, generally solutions are hypotonic

10. Spans and Tweens are Polyoxyalkene derivatives of lauryl and sorbitain ester respectively

11. Lakes are colorants mostly used in wet granulations

12. Mannitol have good flow property

13. Pyrogen testing is not required for ophthalmic preparations

14. Spans will produce W / O emulsions

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15. Drug which is weakly acidic absorbs from intestine

16. Anhydrous lactose can give Millard’s reaction

17. Oily suspensions are generally given by intravenous route

18. Adjusting isotonicity is not officially recommended for intramuscular and subcutaneous routes

19. Diethyl acetamide in parenterals act as co solvent.

20. Sterile water for injection is supplied as multi dose container

21. Hofmeister rule is for coagulation of lyophobic collo ids

22. Colloidal dispersion have partical size 0.5µ – 1 nm

23. Mostly preservatives added in gelatin shell are methyl and propyl parabens

24. For calcu lation of b ase absorption for susp ensions 2-3% lecithin is added

25. Base absorption is ratio of weight of base (ml) / weight of solid (g)

26. Type B gelatin obtained from alkali treated bones and an imal skin have Isoelectric po int 9

27. Conductivity of water for injection should not b e more than 1micro mho

28. Drave’s test and Ostwald ripening are related to wetting agents and crystal g rowth

29. Enteric coated tablets should not dissolve in acid simulated fluid up to 30 mins

30. Noisomes are phospholipids vesicles meant for target drug delivery system

Q98. Cyclic oligomers of glucose that form water soluble inclusion complexes, which are biocompatible and improve the bioavailability o f drugs

a. Chlorophyll b. Polyethylene glycol c. Cross povidone d. Cyclodextrin

Q99. Some of the organic reactions are catalysed by a product obtained from starch on treatment with

amylase from Bacillus macerans. It is

a. Amylopectin b. Amylose c. Cellulose d. Cyclodextrin

Q100. If the Carr’s index of a power is 10% then the type of powder flow is

(A) Poor (B) Excellent (C) Very poor (D) good

Q101. Match the following Physical form of substances Rheological Properties

1. Castor oil a. Plastic flow 2. Concentrated flocculated suspension b. Pseudo plastic flow

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3. Liquid dispersion of methyl cellulose c. Dilatant flow 4. Pates of small deflocculated particles d. Newtonian flo w

Q102. Match the following

1. Crystal growth a. Griffin 2. pH b. Sorensen 3. HLB scale c. DLVO theory 4. Interparticular force d. Ostwald ripening

Q103. Which of the following is used as viscosity builder agent in dispersed system which is insoluble in hot water but soluble in cold water

a. Ethyl cellulose

b. Methyl cellulose c. Sodium carboxymethyl cellulose d. Bentonite

Q104. During the compression of moisture critical granules a hygroscopic substance used to maintain the proper moisture level is

a. Sorbito l b. Talc c. Acacia d. Tragacanth

Q105. In the formulation of suspensions for soft gelatin capsules encapsulation base adsorption of the solid to be suspended is expressed as

a. The no. of grams of liquid base required to produce capsulatable mixture when mixed with 1 gm of solid b. The no. of ml of liquid base required to produce capsulatable mixture when mixed with 1 gm of solid

c. The no. of grams of solid base required to produce capsulatable mixture when mixed with 1 gm of solid d. The no. of milligrams of liquid base required to produce capsulatable mixture when mixed with 10 gm of

solid

Q106. Match the following 1. Hydrophilic suppository base a. Nitrocellulose

2. Polymorphism b. Titanium dioxide 3. Film former used in nail lacquer c. Cocoa butter 4. Opaquant extender d. Polyethylene glycol

Q107. According to I.P sparingly soluble solute is soluble in how many parts of solvent means

a. Less than 1 part b. 1-10 part

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c. 30-100 part

d. 100-1000 part

Q108. The conductance is measured in

a. Ohms b. Amperes c. Mhos d. Milli volts

Q109. The loading dose of a drug usually based on

a. Total body clearance of a drug b. % of drug b oun d to plasma

c. Fraction of drug excreted unchanged in to urine d. Apparent volume od distribution and desired drug concentration in plasma

Q110. Which form of cocao butter is more stable

a. a b. ß c. d. ß 1

Q111. In the tablet coating process, inadequate spreading of the coating solution before drying causes

(A) Orange peel effect (B) Sticking effect (C) Blistering effect (D) Picking effect

Q112. The half-life for a zero order reaction is calculated using

(A) t = 0.693/k (B) t = 2.303/k (C) t = 1/ak (D) t = a/2k 1/ 2 1/ 2 1/ 2 1/ 2

Q113. In the preparation of small pox vaccine, the drying process used is

(A) Spray drying (B) Vacuum drying (C) Drum drying (D) Freeze drying

Q114. The ratio of the void volume to the bulk volume of the packing of the powder is called as

(A) Porosity (B) True density (C) Granular density (D) Bulk density

Q115. A co-solvent used in the preparation of parenteral products is:

(A) Benzyl alcohol (B) Methyl alcohol (C) Dimethyl acetamide (D) Phenol

Q116. A plasticizer and a high boiling point solvent used in the preparation of nail lacquers are

(P) Butyl stearate (Q) Ethyl lactate (R) Ethyl alcohol (S) Acetone

(A) P, Q (B) Q, S (C) R, S (D) Q, R Q117. The measure of cohesive strength of the cross linking that occurs between gelatin molecules and is

proportional to the molecular weight of gelatin is called

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(A) Bloom strength (B) Viscosity (C) Surface tension (D) Partition coefficien t

Q118. A water soluble substance used as coating material in microencapsulation process is:

A. Polyethylene (B) Silicone (C) Hydroxy ethyl cellulo se (D) Paraffin

Q119. One of the following is used as a pH dependent controlled release excipient

(A) Carnauba wax (B) Hydroxy propyl methyl cellulose phthalate (C) Methyl cellulose (D) Glyceryl monostearate

Q120. A drug solution has a half life of 21 days. Assuming that the drug undergoes first order kinetics, how

long will it take for the potency to drop to 90% of the initial potency?

(A) 3.2 days (B) 9.6 days (C) 16 days (D) 6.4 days

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Q121. An amphoteric surfactant used in pharmaceutical disperse system is:

(A) Bile salts (B) Lecithin (C) Sorbitan monolaurate (D) Sorbitan monostearate

Q122. An electrochemical method that enhances the transport of some solute molecules by creating a

potential gradient through the skin tissue with an applied electrical current or voltage is called

(A) Electrophoresis (B) lontophoresis (C) Osmosis (D) Implants

Q123. The identification of propellants in pharmaceutical aerosols is carried out by

(P) Gas-chro mato graphy (Q) Tag-open cup apparatus (R) Pyknometer (S) IR Spectrophotometer

(A) P, Q (B) P, S (C) Q, R (D) R, S

Q124. Liposomes are used as carriers for drugs and macromolecules in pharmaceutical formulations. They are

a. Phospho lipids dispersed g ently in aqueous medium to obtain multilamellar vesicles b. Hydrophilic or lipophilic polymer matrix with a drug reservoir c. A shallow compartment moulded from a drug impermeable system and rate controlling polymeric

membrane d. Microporous membrane made from ethylene / vinyl acetate polymer

Q129. Match the following

Group I Group II Equipment To determine P. Cascade Impactor 1. Flash point Q. Tag Open Cup apparatus 2. Sedimentation rate R. Pycnometer 3. Particle size S. Rheometer 4. Density of liquid (A) P-3,Q-1,R-4,S-2 (B) P-1,Q-3,R-2,S-4 (C) P-4,Q-2,R-3,S-1 (D) P-2,Q-3,R-1,S-4

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Q130. Group I Group II Equipment To determine

a. P. Cascade Impactor 1. Flash point b. Q. Tag Open Cup apparatus 2. Sedimentation rate c. R. Pycnometer 3. Particle size d. S. Rheometer 4. Density of liquid

(A) P-3,Q-1,R-4,S-2 (B) P-1,Q-3,R-2,S-4 (C) P-4,Q-2,R-3,S-1 (D) P-2,Q-3,R-1,S-4 Q131.

Group I Group II

Classification Penetration enhancer

P. Ionic surfactant 1. Terpenes Q. Nonionic surfactant 2. Polyoxyethylene-20-cetyl ether R. Non surfactant 3. Polyethylene-9-lauryl ether S. Chelating agent 4. Citric acid (A) P-3,Q-2,R-1,S-4 (B) P-2,Q-3,R-1,S-4 (C) P-3,Q-4,R-1,S-2 (D) P-4,Q-2,R-3,S-1 Q132. Group I Group II Drugs Source (P) Kaolin (1) natural diatomaceous earth consisting of siliceous skeletons of fossils (Q) Kieselguhr (2) purified native hydrated aluminium silicate free from gritty particles (R) Calamine (3) hydrated magnesium silicate (S) Talc (4) an ore contains zinc oxide with a small amount of ferric oxide (A) P -1 Q - 4 R - 3 S - 2 (B) P - 2 Q - 4 R - 1 S - 3 (C) P - 2 Q - 1 R - 4 S - 3 (D) P - 3 Q - 2 R - 1 S - 4

Q133. Group I Group II Industrial dryers Pharmaceutical materials dried (P) Drum dryer (1) Antibiotic solution (Q) Fluidized bed dryer (2) Tablet granules (R) Spray dryer (3) Gelatin (S) Freeze dryer (4) Suspension of kaolin (A) P - 1 Q - 3 R - 4 S - 2 (B) P - 4 Q - 2 R - 3 S - 1 (C) P - 4 Q - 2 R -1 S - 3 (D) P - 3 Q - 2 R - 4 S – 1 Q134. Group I Terms Group II Explanation (P) Saturated air (1) Pounds of water vapor carried by one pound of dry air under any given set of conditions (Q) Dew point (2) The water vapor is in equilibrium with liquid water at the given conditions of temperature and pressure

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(R) Humid volume (3) The volume in cubic feet occupied by one pound dry of air and its accompanying water vapor (S) Humidity (4) Temperature to which a mixture of air and water vapor must be cooled in order to become saturated.

(A) P-2Q-4R-1S-3 (B) P-4Q-1R-3S-2 (C) P-3Q-2R-45-1 (D) P-3Q-1R-25-4

Q135. Group Group Tablet defects Explanation (P) Picking (1) A term used to describe the surface material from a tablet that is sticking

to and being removed from the tablet’s surface by a punch. (Q) Sticking (2) Term refers to tablet material adhering to the die wall. (R) Mottling (3) Term refers to an unequal distribution of colour on a tablet. (S) Lamination (4) Term refers to separation of a tablet into two or more distinct layers. (A) P - (C) P - (B) P - 3 Q - 4 R - 1 S - 2

(D) P - 4 Q - 1 R - 2 S - 3

Q194. Data based on the statement/problem. Choose the correct answer for each question from among the options A, B, C and D. Data for questions In a formulation development laboratory a tablet is to be formulated. The care tablet has a bad taste and requires physical and chemical protection of the drug from moisture. The tablet should also deliver the drug for local action in the intestine . I. Suggest a suitable method . (A) Sugar coating (B) Film coating (C) Enteric coating (D)Sub coating II. Choose the correct coating material to be used. (A) Sugar (B) Acacia (C) Ethyl cellulose (D) Cellulose acetate phthalate III. Choose the correct solvent for the coating material. (A) Acetone (B) Water (C) Propylene glycol (D) Glycerin

Q195. Da ta for questions: A drug, which is unstable to light, susceptible to oxygen and gets degraded in presence of metallic ions, has to be formulated in the form of a solution for injection . I. Choose a suitable additive to improve the stability of the injection. (A) Preservative (B) Chelating agent (C) Buffer (D) Tonicity contributor

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II. Select the appropriate filling and packing method for the above product . (A) Filling in an amber colored ampou le with an addition of antioxidant, replacing the inside air with nitrogen and sealing. (B) Filling with an antioxidant dissolved in the solution and sealing the ampoule. (C) Filling in an amber colored ampoule with a preservative and sealing. (D) Filling in an ampoule, sealing and giving directions to store it in dark.

Q195. Da ta for questions: A drug, which is unstable to light, susceptible to oxygen and gets degraded in presence of metallic ions, has to be formulated in the form of a solution for injection . I. Choose a suitable additive to improve the stability of the injection. (A) Preservative (B) Chelating agent (C) Buffer (D) Tonicity contributor II. Select the appropriate filling and packing method for the above product . (A) Filling in an amber colored ampou le with an addition of antioxidant, replacing the inside air with nitrogen and sealing. (B) Filling with an antioxidant dissolved in the solution and sealing the ampoule. (C) Filling in an amber colored ampoule with a preservative and sealing. (D) Filling in an ampoule, sealing and giving directions to store it in dark.

Q196. When stiochiometric amount of CaCl is added to an emulsion stabilized with sodium alginate, it will

2a. Creak immediately

b. Change the nature from w/o to o/w c. Change the nature from o/w to w/o d. Accelerate the phenomena of Ostwald ripening

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Q197. In the preparation of suppositories, macrogols used are a. Water soluble base b. Hydrocarbon base c. Absorption base d. Butylated hydroxy toluene

Q198. Antioxidant most commonly used in the formulation of non-aqueous parenteral preparation is

a. Thioglycollic acid b. Ascorbic acid c. Sodium metabisulphite d. BHT

Q199. Phosphatidic acid and its derivatives form Liposomes because

a. In fully hydrated condition s, they are conical in shape b. In fully hydrated condition they are cylindrical in shape c. They contain only non-polar moieties in their structures d. Their saponification values are usually low.

Q200. With the regards of the sterile water for injection, I.P the residue on evaporation limit is

a. Higher than water for injection b. Lower than water for injection c. Same as that of water for injection d. No such standard in the monograph.

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