gc-msd - agilent · 3 7890a/5975c gc/msd: the most popular gc/ms in the world over 20,000 . 5975...

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GC-MSD Introducing the new 7890B/5977A

January 8, 2013 Agilent Confidential

Badr Astiphan GCMS Product Sales Specialist 1-866-524-7936 302-290-5631 cell [email protected]


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We are First in GC Continuously innovating

5970 MSD Fused Silica Capillary Column

Microprocessor Control

5840 GC

5880 GC

5890 GC

Hyperbolic Gold Quad

Inert MS Ion Source

6890 GC

7200 GC QTOF 7000 GC

Triple Quad

Capillary Flow Technology

AutoInjection

Electronic Pneumatic Control

Retention Time Locking

2nd Gen Linear Electron Capture

Detector

Low Thermal Mass Technology

Units Installed >250,000 GC >60,000 MS

Multi-Mode Inlet


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7890A/5975C GC/MSD: The Most Popular GC/MS in the World

Over 20,000 5975 systems since 2005

The industry standard GCMS

Agilent 5977 MSD


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Proven Technologies Improving the Industry Standards for GC/SQ

Gold Quartz Quad Triple Axis Detector

High Temperature Inert Source Unique Entrance

Lens Design

All of 5975’s features also built in 5977, such as “Gold Quad”, SIM/Scan, Gain tuning, Triple-Axis Detector, Trace Ion Detection, Auto CI, etc..


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230°C

275°C

300°C

325°C

350°C


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High Temperature Ion Source Solid inert material – not a coating

– Not damaged by multiple cleanings Programmable to 350ºC Improved response for many compounds

– More robust operation for “dirty” samples – Better response for “sticky” compounds – Sharper peaks for high boilers (late eluters)

… more performance for a wide range of applications

Polyaromatic Hydrocarbon (PAH)


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Unique Entrance Lens Eliminates Pre-filter

New, improved lens


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Fringe fields

Unique Entrance Lens Eliminates Pre-filter


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Quartz – Gold – Hyperbolic and Beautiful!

Why quartz?

– Low coefficient of linear expansion

(expansivity; α)

• dL = α L0 dt [t = ºC; dL = change in

length (m); L0 = length at 0 ºC]

Why gold?

– Inert material with excellent electrical

properties for high voltage

Why hyperbolic?

– Ideal electrical field is generated by

hyperbolic surfaces (NOT ROUND)

Much more than just a beautiful piece of glass

Round Quad


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Triple-Axis Detector

ion beam X

Y

Offset Z

With a combination of three axes and appropriate shielding, noise from secondary particles can be reduced to a minimum


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Triple Channel EM

Triple channels improve signal amplification

– Lower initial EM voltage required Triple channels increase life

– Lower cost of operation

Exit of the triple channels

Collector removed to show exit passages

Collector

Expanded Capabilities: 7890B/5977A Improving the Industry Standards for GC/SQ

Higher Ion Count • Extractor EI source

• Increased ion count • S/N > 1500:1 • IDL < 10 fg (industry first) • Improved thermal profile

Save Time & Energy •Sequence Scheduler

• “Standby” post run • “Ready to run” from standby • “Bake Mode” as needed

• Factory backflush option • Fast Vent capability • DS42i rough pump“standby” power reduction

Safety/Protection • Vacuum failure Shut off gas (He or H2)

Better Vacuum by Agilent Pump • New Agilent V304 Turbo • TwisTorr

• Molecular Drag technology • Improved pumping light gases

• H2 (220 L/s); He (255 L/s) • Agilent Floating Suspension

• Longer life • Quiet operation

Faster Scanning • 20,000 u/s

• But never equal to the 7200 Q-TOF speed or ‘scan’ sensitivity

7890B GC “Direct Communications Features • EMF, calculator, etc.


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New Extractor Ion Source for 5977

Agilent Confidential

Why the Extractor EI Source? Increase in ion count True increase in sensitivity

Better trace level precision Lower IDL and MDL

Proven sensitivity increase demonstrated with over 1500 7000 Series GC/TQ!

January 8, 2013

Comparison of Inert and Extractor Ion Source


Repeller (Push)

Drawout Plate

Ion Focus Lens

Entrance Lens

Ionization area

Ions

Inert Ion Source

Extractor Lens (Pull)

Extractor Source More ions to Mass Filter

Mass Filter

January 8, 2013

Extractor Source “Etune” Sensitivity Increase


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Blue – Extractor 40ppb solution (SVOC) Red – Standard 40ppb solution (SVOC)

More improvements on 5977’s Extractor Ion Source: Improved Thermal Profile

Why is this important? Better performance of high boilers i.e. PAH even at lower concentration!

10 Injections 80 min analysis

Good repeatability of PAH even at the trace level (5ppb)!!

Improvement for better Mass Spectrometer of Gas Chromatograph

January 15, 2013

Comparing repeatability of 80min Method

Phthalates analysis with 5977 GC/MSD

Oct 2012

1x10

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+ TIC SIM PAHs-12.D

Counts (%) vs. Acquisition Time (min)

37 37.1 37.2 37.3 37.4 37.5 37.6 37.7 37.8 37.9 38 38.1 38.2 38.3 38.4 38.5 38.6 38.7 38.8 38.9

5977 result

5975 result Two years ago

1x10

-0

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+ TIC SIM pah_etune_300_long_R9.D Smooth

Counts (%) vs. Acquisition Time (min)

35.2 35.4 35.6 35.8 36 36.2 36.4 36.6 36.8 37 37.2 37.4 37.6 37.8 38 38.2 38.4 38.6 38.8 39 39.2 39.4 39.6 39.8 40

5977 result

200ppb PAH 5ppb PAH

Key features of “Direct Communication” between 7890B and 5977A


Sleep/Wake mode • Sleep mode saves power (320W 190W) Lower lab operating cost

Safety Control • If 5977A MSD pump fail, 7890B will shut off the gas supply

Cool Down MSD Faster (FastVent) • When MSD Vent Cycle started, GC will cool down MSD analyzer at the

optimum gas flow to MSD.

Helium carrier gas : gas waste is eliminated Hydrogen carrier gas: risk of explosion is reduced

40% faster when cooling down from 280C to 100C (< 25 min)

January 8, 2013

Saving Energy and Time

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050

100150200250300350400

NormalOp

Standby

Power Consumption - 5977

0

50

100

150

200

250

0 4 6 7 15 20 23 30 35 40

Vent FastVent

Power saved

Time saved

Pow

er( V

A)

Sour

ce T

emp

Time(min)

Time saved using Fast Vent

Better HW Features: Agilent Turbo Pump (V304)


Agilent Quality Standard

TwisTorr 304 FS

Innovation for: •Higher pumping performance

• especially for He and H2 •High reliability

• lower cost of operation

January 8, 2013

Press release : http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html

http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html




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TwisTorr 304 FS: Vacuum Design

8 EDM turbo stages (rotor) designed to optimize pumping speed for light gases 8 Turbo stators

made by pressed SST sheet technology

3 TwisTorr drag stages (spiral channels) designed for high compression ratio performances

Agilent’s new patent-pending Floating Suspension for robust, low noise operation

Better HW Features: Agilent Rough Pumps


New DS42i New IDP-3c

High performance Energy saving design “Inverter” not compatible with diff pump

High performance Oil-free scroll pump NH3 CI compatible

with Agilent Quality Standards

January 8, 2013


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Agilent Inert Flow Path … From Injection to Detection

Ultimetal – TCD, FPD, NPD/FID Jets

Ultimetal Capillary Flow Technology Devices, Ultimate Union

Ultimetal Inlet Weldment, Shell and Transfer Lines

Ultra Inert GC Column

Ultra Inert Gold Seal

Ultra Inert Inlet Liner

New

…now from a single supplier

Programmable Helium Conservation Module

Works with Gas Saver function of 7890 based GC Standby Method can be programmed after the sequence ends Analytical methods are unchanged since Helium is still the carrier during the run

5977A GC/MSD IDL Specification IDL is a statistically derived value from the precision (%RSD) of 8 consecutive, splitless injections of 100fg OFN at 99 % confidence level. The more precise instruments (lower %RSD) will generate lower IDLs.

The Agilent 7890B/5977A with an ALS or CTC autosampler has the following specifications:

January 15, 2013 25

Ion Source type High Vacuum pump type IDL of OFN by 8 replicates of ALS*

Extractor Source Turbo Pump 10fg

Inert Source Turbo Pump 24fg

Diffusion Pump 30fg

*Systems without an Autosampler will have only S/N specification.

These are installation specification, performed on customer site, immediately after installation and carry a lot more value than a reference specs.

Why IDL specification is useful for the 5977 in SIM? Influence of Noise in S/N specs • In SIM (or MS/MS) when the Noise is too low, such as during acquisition of

an OFN standard, S/N results may not give the best characterization

• If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant

Value of IDL • IDL is derived from reproducibility/precision results, the same metrics most

users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance

• IDL characterizes the whole system – AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions

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The Influence of the low Noise on S/N values Same Data File, RMS, 5 Second Noise Region

Noise region: 5.66min - 5.74 min S/N: 3335

Noise region: 5.65min - 5.73 min S/N: 10785

A 0.01 min. shift in the noise region resulted a 6000 higher S/N value. When the noise is insignificant (low), the derived S/N value is also insignificant!

Noise region: 5.65min-5.73 min

Noise region: 5.66min-5.74 min

S/N S/N

January 15, 2013 27


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Market Leading Performance Premium Value: The Best Just Got Better

Detector Performance MSD Scan 1500:1 S/N; SIM 10 fg IDL – Best in Class with IDL

tested at installation when ALS or Combi available (with Extractor Source)

FID <1.4 pg C/sec ECD <4.4 fg/sec FPD <2.5 pg S/sec; <45 fg P/sec SCD <0.5 pg S/sec NPD Best for P, 0.08 pg/sec N beat only by Thermo 0.05 pg/sec–

but only using OUR Blos bead! TCD 400 pg/mL

No one can now offer a better specification package than Agilent


Market’s Best S/N (SNR) > 1500:1 Market’s Best Scan Rate = 20,000 u/s

Market’s ONLY IDL < 10 fg Better from Agilent Statistical confirmation of entire system’s performance

January 8, 2013


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Mass Hunter GC/MSD Software MassHunter Qual

MassHunter Quant MH

CS

MassHunter GC/MS Acquisition And Use Either MassHunter Data Analysis OR MSD ChemStation Data Analysis MSD ChemStation DA

G1701FA


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MSD ChemStation DA

QEdit

Reports

MSD ChemStation Standard interface

Quantitation

Macros

Library Searching


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MassHunter WorkStation Qualitative Analysis Data Navigator

Method Explorer

Chromatogram Results

Method Editor

Spectrum Results


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Mass Hunter Quantitative Analysis

Compound Information

Results Information

Batch Information (i.e., Calibration Curve)

Results Information for the batch can be displayed. Visual guides highlight specific data that fall outside specific, predefined conditions.

Batch Information provides easy visualization and customization of relevant desired data.

The Quant Batch screen looks like this.

Compound Information displays graphical representation of the peak, qualifier information, spectral information, and the ISTD. Visual guides help identify associated data problems.


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Unknowns Analysis


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MassHunter Excel Reporting

•Excel Based (Excel 2010 supported)

•MassHunter application exports data in XML and graphics files

•Templates define report formatting

•Over 100 shipping report templates

•Reports can be altered for desired information & appearance

•Customization using Excel features (function, formatting, code)

•Computer Based Training for report customization by users

•Some customization available through Agilent


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Application Notes

Flexibility: Performance and Budget

Lowest Price Performance Meets Method Requirement

5977E Turbo MS 5977E Diff MS

7820A Stainless source

Highest GC Performance & MS Performance

5977A EI 5977A EI/CI

7890B GC Extractor source DS42i

Balance of Price, GC performance, & MS performance

5977A Turbo MS 5977A Diff MS

7890B GC Inert source


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Maintenance and Support Issues


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Q&A Discussion

gc-msd - agilent · 3 7890a/5975c gc/msd: the most popular gc/ms in the world over 20,000 . 5975...

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