Jeopardy

for the Psychiatry ClerkshipJeopardyis proudto present

And Now Here Is The Host . . .

Insert Name HereThe categories for todays Jeopardy will be:Typical AntipsychoticsAtypical AntipsychoticsSide EffectsMechanism of Action1,8This antipsychotic can also be used to treat intractable hiccupsWhat is chlorpromazine (Thorazine)?

2,7This atypical is FDA approved for adjunct treatment of major depression What is aripiprazole (Abilify)?

5,5This atypical has a significant risk of causing hyperprolactinemia, is the active metabolite of risperidone (Risperdal), and needs to be taken with foodWhat is paliperidone (Invega)?

5,8Young or ElderlyMales or Females

This demographic is at the greatest risk for dystonia from antipsychoticsWhat is young males?

Row 1, Col 1Not only was this drug the first antipsychotic, it was the first psychotropic medication of any kind

What is chlorpromazine (Thorazine)?

1,7While prochlorperazine (Compazine) is a D2 blocker it is more commonly used for this than its antipsychotic propertiesWhat is antiemetic properties?

2,5What is ziprasidone (Geodon)?

Of all the atypicals, this medication has the highest risk of causing QTc prolongation3,7

The antipsychotic side effect seen in this patient is this What is oculogyric crisis?

3,4The picture showsa pt experiencing this EPS sideeffect

What is dystonia?

3,8The picture shows apatient with this D2 blocking medication side effectWhat is gynecomasitia?(From hyperprolactinemia)

4,3Excess blockade of this dopamine tract may cause infertility, galactorrhea, & osteopenia.What is the Tubuloinfundibular Pathway?

1,6This type of typical antipsychotic is anti-cholinergic, anti-histaminic, & an 1 adrenergic antagonistWhat is low potency antipsychotic?Chlorpromazine (thorazine)

5,1Prochlorperazine (Compazine) Metoclopramide (Reglan)Droperidol (Inapsine) Promethazine (Phenergan)

This antiemetic medication(s) is/are a D2 blocker(s) and may cause EPS or TDWhat is all 4 of them?

1,4Three medications commonly used to counter EPS side effects are trihexyphenidyl (artane), benztropine (cogentin), &this medication What is diphenhydramine (Benadryl)?

1,9This typical antipsychotic has the greatest risk of any antipsychotic for dose dependent QTc prolongation, torsades de pointes, and cardiotoxicityWhat is thioridazine (Mellaril)?

2,9Lurasidone (latuda), asenapine (saphris) & these two atypicals are the most metabolically neutralWhat are ziprasidone (geodone) & aripiprazole (abilify)?

3,9This atypical may cause dry mouth due to its anticholinergic properties, but ironically it may also cause excess salivation What is clozapine (Clozaril)?

5,9While muscular rigidity, hyperthermia, & autonomic stability are all common symptoms of NMS, this symptom appears first in the great majority of presentationsWhat is mental status changes?

4,5The percentage of D2 occupancy necessary for the antipsychotic effect is thisWhat is 60%?

4,8Hypoactivity of this dopamine tract is associated with the development of negative symptoms

What is the mesocortical pathway?

4,1Atypical antipsychotics work primary by blocking these 2 receptorsWhat are the D2 & 5HT2A receptor?

4,9The atypical antipsychotic with the unique mechanism of action of partial dopamine antagonism is thisWhat is aripiprazole (Abilify)?

1,5When used in their long acting decanoate form, these 2 typical antipsychotics are given IM every 2-4 weeks to treat patients with chronic schizophrenicsWhat are haloperidol (Haldol) & fluphenazine (Prolixin)?

1,2Typical antipsychotics are divided into these two categories which also correlates to their D2 receptorsbinding affinityWhat are high potency & low potency?

2,3These 2 atypicals areavailable in a long acting injectable form & has the highest risk among atypicals of causing prolactin elevationWhat is risperidone (Risperdal) & paliperidone (Invega)

2,4These two atypicals are most likely to cause side effects of significant sedation and/or the metabolic syndromeWhat is olanzapine (Zyprexa) and clozapine (Clozaril)?

2,6This atypical is a partial dopamine agonist & commonly has the side effect akathisiaWhat is aripiprazole (Abilify)?

2,8Due to the risk of seizure induction, slow dose titration must be done for this atypicalWhat is clozapine (Clozaril?)?

3,2Gradual taper Abrupt stop

For a patient taking Clozapine (Clozaril) this is done when the WBC is