Reactions 1084 - 14 Jan 2006

■ Concomitant fluvoxamine increases plasmacaffeine concentrations in healthy volunteers withoutenhancing caffeine’s pharmacodynamic effects,according to US-based researchers. In a randomised,four-way crossover trial, seven healthy subjectsreceived four doses of fluvoxamine 100mg over 2 days(or placebo) plus single-dose caffeine 250mg (orplacebo). Each treatment course was separated by atleast 7 days. Caffeine Cmax, t1/2 and total AUC were allsignificantly increased, and apparent oral caffeine CLwas significantly reduced, by coadministration offluvoxamine. However, tests for mood, sedation,psychomotor performance and EEG were not affectedsignificantly by the increased caffeine availability.Despite these findings, the researchers suggest thatsustained caffeine consumption with concomitantfluvoxamine may still have the potential to causeclinically significant pharmacodynamic effects.Culm-Merdek KE, et al. Fluvoxamine impairs single-dose caffeine clearancewithout altering caffeine pharmacodynamics. British Journal of ClinicalPharmacology 60: 486-493, No. 5, Nov 2005 801030370

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Reactions 14 Jan 2006 No. 10840114-9954/10/1084-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved