eyelash growth pg analogs bauman ishrs09 finalforshare

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Alan J. Bauman, M.D. Diplomate, American Board of Hair Restoration Surgery ISHRS Annual Meeting / Amsterdam 2009 FDA-Approval of Bimatoprost for Eyelash Growth

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In December of 2008, the FDA approved the first medication for eyelash growth, called Latisse (Allergan) containing Bimatoprost a prostaglandin F2a analog. This presentation discusses the basics of the research which led to the approval including side effects and off-label uses (like scalp hair growth). Presented by Alan J. Bauman MD at the International Society of Hair Restoration Surgery's Annual Scientific Meeting, Amsterdam, The Netherlands, July 2009.

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Page 1: Eyelash Growth Pg Analogs Bauman Ishrs09 Finalforshare

Alan J. Bauman, M.D.Diplomate, American Board of Hair Restoration

SurgeryISHRS Annual Meeting / Amsterdam 2009

FDA-Approval of Bimatoprost forFDA-Approval of Bimatoprost for

Eyelash GrowthEyelash Growth

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Disclosures / COI The following potential conflict of

interest relationships are germane to my presentation: NONE

FDA-approved & non-FDA approved indications will be discussed

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Overview Eyelashes & Eyelash

Hypotrichosis Prostaglandin Analogs Latisse™ (bimatoprost 0.03%) Clinical Studies Photographic Results Side Effects Off-Label Use

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Prostaglandin Analogs Travoprost (Travatan) Latanoprost (Xalatan) Bimatoprost (Lumigan / Latisse)

Intraocular Pressure-lowering Agents No systemic side effects Increase in length, thickness, pigmentation, number of

lashes Eyelid skin darkening Eye irritation

bimatoprost

latanoprost travoprost4

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(Bimatoprost 0.03%)

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1.

2.

3.

4.

5.

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RESULTS: Primary Efficacy Endpoint

WeekLATISSE™(n=137)

N (%)

Vehicle(n=141)

N (%)

1 7 (5%) 3 (2%)

4 20 (15%) 11 (8%)

8 69 (50%) 21 (15%)

12 95 (69%) 28 (20%)

16 107 (78%) 26 (18%)

20 103 (79%) 27 (21%)

Number (%) of subjects with ≥ 1-grade increase from baseline in Global Eyelash Assessment

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RESULTS:

‘BEFORE’&

‘AFTER’

16 WKS

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Side Effects

• Itching sensation in the eye ~4%• Eye redness• Hair growth outside of target area• Eyelid skin darkening• Eye irritation• Potential for iris darkening*• Intraocular pressure effects

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16 wks x PG Analog + Tint + Perm:

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Off-Label Bimatoprost Use: Scalp

BEFORE AFTER: 8wks10

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References1. International Society of Hair Restoration Surgery. 2007 Practice Census Survey; Available at: http://www.ishrs.org/PDF/ISHRS_Practice_Census_Survey_Report_2007.pdf.

2. Website: www.ishrs.org/mediacenter/media-statistics.htm. Accessed January 2009.

3. American Society of Plastic Surgeons. 2000/2004/2005 National plastic surgery statistics. Cosmetic Hair Transplantation and reconstructive procedure trends. http://www.plasticsurgery.org/media/statistics/loader.cfm?url=/commonspot/security/getfile.cfm&;PageID=17870. Accessed January 31, 2007.

4. Breeling J, Gandelman M. ‘‘Eyelash transplantation: who, why and how.’’ January 2007. International Society of Hair Restoration Surgery. http://www.ishrs.org/articles/eyelashtransplantation.htm. Accessed April 2007.

5. Krusius FF. Ueber die Einplflanzung Lebender Haare zur Wimpernbildung. Dtch Med Wochenschr. 1914; 19:958.

6. Knapp P. Klin Mbl Augenheilk. 1917; 59:447.

7. Sasagawa M. Hair transplantation. Jpn J Dermatol. 1930; 30:493.

8. Fujita K. Reconstruction of eyebrows. La Lepro 1953; 22:364.

9. Marritt, E. Transplantation of single hairs from the scalp as eyelashes. Review of the literature and a case report. J Dermatol Surg Oncol. 1980; 6(4):271–273.

10. Flowers RS. ‘‘Pluck and Sew’’ individual hair follicle placement. American Society of Aesthetic Plastic Surgery, Orlando FL, April 1980. Caputy GG, Flowers RS. The ‘‘pluck and sew’’ technique of individual hair follicle placement. Plast Reconstr Surg. 1994; 93(3): 615–620.

11. Gandelman, M. Hair Transplantation, 2nd Ed, Walter Unger, MD (ed.).

12. Herna´ndez-Zendejas G., Guerrerosantos J. Eyelash reconstruction and aesthetic augmentation with strip composite sideburn graft. Plast Reconstr Surg. 1998 Jun; 101(7):1978–1980.

13. Gandelman M. Single follicles harvested from donor area and inserted through a curved 18g needle placed into the lid. ISHRS Regional Live SurgeryWorkshop on Eyelash Transplantation, Los Angeles CA, October 23, 2006.

14. Choi YC, Kim JC. ‘‘Single hair transplantation using the Choi hair transplanter. ’’ J Dermatol Surg Oncol. 1992; 18:945–948.

15. Gandelman M. ‘‘Reverse follicular extraction’’ Hair Transplant Forum Intl. November/December 2004; 14(6):197, 203.

16. Martinick J. ISHRS Regional Live Surgery Workshop on Eyelash Transplantation, Los Angeles CA, October 23, 2006.

17. Martinick J. Direct placement of grafts into overlapping coronal slits in the eyelid; ISHRS Regional Live Surgery Workshop on Eyelash Transplantation, Los Angeles CA, October 23, 2006.

18. Lee EW, Tucker NA. Pain associated with local anesthetic injection in eyelid procedures: comparison of microprocessor controlled versus traditional techniques. Ophthal Plast Reconstr Surg. 2007; January– February; 23(1):37–38.

19. Johnstone M. Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in the region of the ipsilateral eyelids of patients treated with unilateral topical latanoprost. Am J Ophthalmol. 1997; 124:544–547.

20. Stober B, Potash S, Grossman M. Eyelash hypertrichosis in a patient treated with topical latanoprost. Cutis 2001; 67:109–110.

21. Hollo G. The side effects of the prostaglandin analogues. Expert Opin Drug Saf. 2007; 6(1):45–52.

22. Wand M. Latanaprost and hyperpigmentation of eyelashes. Arch Ophthalmol. 1997; 115:1206–1208.

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Thank You!

[email protected]

www.baumanmedical.com

http://www.twitter.com/DrAlanBauman

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