erythropoietin laboratory - birminghamquality.org.uk · erythropoietin distribution : 117 date :...

9
Date : DD-MMM-YYYY Feedback Page 1 Erythropoietin Distribution : 117 Laboratory : Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK To contact us, email [email protected] or phone us on +44 (0)121 414 7300 © The data in this UK NEQAS report are confidential. For this Scheme, the Organiser is Dr. Malcolm Hamilton. www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016 Quality Manager Pathology Laboratory Biochemistry Department Town County Postcode Country This Scheme is essentially web-based. We can alert you to information regarding the Scheme via email. The e-mail address (or addresses) we are currently using to contact your laboratory is shown below in red . If no e-mail address is displayed or the information shown is incorrect, please email us with an appropriate contact e-mail address as soon as possible, using the word 'feedback' in the title line. Based on the date information you have provided, the transit time from specimen dispatch [ ] to receipt [ ] was day(s), and the subsequent time to analysis [ ] in your laboratory was day(s). (Missing values indicate dates not provided. "0 days" represents same day). Any comments you made to us are shown below and have been acted upon where necessary Any specific comments applicable only to laboratory are shown below Any general comments applicable to all laboratories are shown below *****Birmingham Quality Participant Survey***** We are currently undertaking our annual participant survey and would very much welcome your feedback. Your comments are very important to us and will help us to improve the service we provide to you. The survey relates only to the EQA services provided from the Birmingham Quality [UK NEQAS] centre. A copy of the questionnaire is attached to the back of this report. It is very simple and asks only two questions: 1) What do we do well? and 2) What could we do better? We are very happy for you to submit your comments anonymously but please do provide your contact details on the form ONLY if you would like to receive a response. Please e-mail the completed survey to [email protected] or FAX to +44 (0) 121 414 1179 Many thanks The Birmingham Quality Team Report authorised on Tuesday 30 June 2015 by: Jane French (Consultant EQA Scientist), Birmingham Quality Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. Please see http://www.ukas.com for full details of the accreditation status of our services Birmingham Quality is proud to offer EQA services that adhere to the Code of Practice and have the badge of quality of UK NEQAS of 9

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Date : DD-MMM-YYYY

Feedback

Page 1

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

Quality ManagerPathology LaboratoryBiochemistry DepartmentTownCountyPostcodeCountry

This Scheme is essentially web-based. We can alert you to information regarding the Scheme via email. The e-mail address (or addresses) we are currently using to contact your laboratory is shown below in red . If no e-mail address is displayed or the information shown is incorrect, please email us with an appropriate contact e-mail address as soon as possible, using the word 'feedback' in the title line.

Based on the date information you have provided, the transit time from specimen dispatch [ ] to receipt [ ] was day(s), and the subsequent time to analysis [ ] in your laboratory was day(s). (Missing values indicate dates not provided. "0 days" represents same day).

Any comments you made to us are shown below and have been acted upon where necessary

Any specific comments applicable only to laboratory are shown below

Any general comments applicable to all laboratories are shown below

*****Birmingham Quality Participant Survey*****

We are currently undertaking our annual participant survey and would very much welcome your feedback. Your comments are very important to us and will help us to improve the service we provide to you. The survey relates only to the EQA services provided from the Birmingham Quality [UK NEQAS] centre.

A copy of the questionnaire is attached to the back of this report. It is very simple and asks only two questions:

1) What do we do well? and2) What could we do better?

We are very happy for you to submit your comments anonymously but please do provide your contact details on the form ONLY if you would like to receive a response.

Please e-mail the completed survey to [email protected] or FAX to +44 (0) 121 414 1179

Many thanks

The Birmingham Quality Team

Report authorised on Tuesday 30 June 2015 by:

Jane French (Consultant EQA Scientist), Birmingham Quality

Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. Please see http://www.ukas.com for full details of the accreditation status of our services

Birmingham Quality is proud to offer EQA services that adhere to the Code of Practice and have the badge of quality of UK NEQAS

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Erythropoietin

Distribution : 117 Date : DD-MMM-YYYY

Performance Summary Icons (click graph for details)

Page 2

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

B s

core

C score

Serum Erythropoietin

P-ABCPENR (DASH1)

0 5 10 15 20 25 30

-20

-15

-10

-5

0

5

10

15

20

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Date : DD-MMM-YYYY

Participation summary

Page 3

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

All our time periods are 'rolling' to give you current information. You may wish to keep you own log of Calendar Year or Financial Year time points if you require 'year-end' statements for your own internal use. Any analytes with out of consensus performance will be highlighted in red and can be clicked for further details.

You have no performance data for:

You have in consensus performance for:

You have out of consensus performance for:

Serum Erythropoietin

Analytical Performance over the last 6 months (rolling time window of 6 distributions)

None

None

This scheme cycle is notionally every four weeks. Analytically, we assess you over a six month time window (6 Distributions). For return rates, late and amended results we assess you over a twelve month period (12 distributions).

Participation 12 distributions out of a possible 12

Satisfactory

0 distributions from the last 12Late Returns

Amendments 0 distributions accepted from the last 12

Satisfactory

Satisfactory

Distributions

Participation and Return Rates

Rating

You can judge, in association with your IQC and other QA measures, if your current performance is a blip or part of a trend.

You have no specimen data for:

In consensus for all specimens for: Serum Erythropoietin

Out of consensus for at least one specimen for:

You are not registered for:

None

Analytical Performance for specimens from distribution 117 only

None

None

The new Participation Summary page is an exciting new feature which we hope you will like. It is currently in prototype mode but will ultimately expand into having the Interpretative analytes as well as the existing ‘numerical’ analytes listed and will contain turnaround graphs etc., too.

For the moment it would be helpful if you could check the accuracy of the data presented, particularly the return-rate elements.

Many thanks, Finlay

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Date : DD-MMM-YYYY

Distribution Summary

Page 4

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

%biasBResult A score C scorePool CB scoreTargetSpecimen A ¸˛Specimen

504.0

+0.971.4(IU/L)

502.4

Serum Erythropoietin-2.2+0.3

69.912.29117A -3.6

223117B 220

50219 3.9

117C

12.4

If your laboratory is outside of the acceptable limits of performance for any its rolling time-window scores (A, B or C scores), this will be indicated by a red traffic light symbol. It is the responsibility of the laboratory to undertake an internal investigation to establish the underlying cause and put in place corrective and preventive action. Please do not wait to receive a formal notification of performance from the Scheme Organiser or the National Quality Assurance Advisory Panel (NQAAP) before logging the non-conformity and, where necessary, acting upon the data contained in your report. A green traffic light merely reflects that your laboratory is performing as well as the state-of-the-art allows; it does not necessarily mean that your assay / laboratory performance is good enough clinically.

The A scores for Erythropoietin are all based on concentration- dependent degree of difficulty factors and, as such, are in the same ‘currency’ as the A scores in other Schemes. Please see the online 'Explanation of the ABC of EQA' which may be found under the 'Centre' button on the UK NEQAS Results & Reports page. You will need your user-name and password to access this information.

All samples issued have been tested negative by standard methods for HIV, TPHA, Hepatitis B and C.

Gentamycin, penicillin and fluconazole have been added to all specimens.

Please note that any 'spiked' specimens distributed through the scheme will be clearly marked as such. Unless stated otherwise, they will contain non-endogenous Epoetin beta which may not be recovered by the kit assays in the same way as patients’ erythropoietin.

Specimens for Distribution 118 will be dispatched on Monday 6 July 2015, results are due back by Sunday 26 July 2015.

If we have entered your results as 'XPL' , it is because you did not report a result for that analyte, but you did provide an explanation as to why a result was not reported.

You can enter any Late results or Non-analytical errors for Distribution 117 on the web under the usual Results button. Please ensure you select the correct Distribution number from the dropdown. You should include your name and a valid reason. Amending results is at the discretion of the Programme Organiser and is not an automatic entitlement. You have until the close of the Distribution 118 to make requests for any such amendments.

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Date : DD-MMM-YYYY

Analyte : Serum Erythropoietin (IU/L)

Page 5

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

Pooled human serum donations

223

Pool description / Treatments / Additions

117B Pool 219 + 60 IU/L Epoetin BetaPool 219 + 480 IU/L Epoetin Beta

Pool

220

Spec.

117A

117C

219 3.9

The B limit is +/-

Your B score is

The A limit is15.0

50

20.0

Your A score is-3.6

The C limit is

200

Your C score is

Based on the information you have provided, your reagent lot number is [] and your calibrator lot number is []. (Missing values indicate data not provided).

All methods Siemens Imm 2000/XPi [DC11]

Specimen : 117A

8.0 10.1 12.2 14.3 16.4Serum Erythropoietin (IU/L)

0

5

10

15

20

no. o

f lab

orat

orie

s

6.00.77

Not stated, please specify

12.29

10.81

7

Meann

10.94

46

Beckman DXi [SF5]

1.237 11.4

3.60.16

R and D systems [RN1]12.81

4

Beckman Access [SF6]

1

10.84

13.50

Siemens Imm 2000/XPi [DC11]

73

13.65

SD

10.2

8 1.5

1.25

CV(%)

Siemens Immulite 1 [DC7]

0.39

All methods [ALTM](ALTM)

transformed bias

12.4Your result

+11

Method mean

+0.9Your specimen:

12.29

(Siemens Imm 2000/XPi [DC11])

Standard Uncertainty

%bias

11

12.81

0.19

Accuracy Index

Target value

Specimen : 117B

50 61 72 83 94Serum Erythropoietin (IU/L)

0

5

10

15

20

no. o

f lab

orat

orie

s

5.44.0

Not stated, please specify

71.4

61.1

7

Meann

65.0

46

Beckman DXi [SF5]

8.47 13.7

7.51.4

R and D systems [RN1]74.6

4

Beckman Access [SF6]

1

64.0

72.0

Siemens Imm 2000/XPi [DC11]

73

77.3

SD

9.6

8 2.1

6.9

CV(%)

Siemens Immulite 1 [DC7]

4.9

All methods [ALTM](ALTM)

transformed bias

69.9Your result

-27

Method mean

-2.2Your specimen:

(Siemens Imm 2000/XPi [DC11])

71.4

Standard Uncertainty

27

%bias

74.6

Accuracy Index

1.07

Target value

Specimen : 117C

376 439 502 565 628Serum Erythropoietin (IU/L)

0

5

10

15

20

25

30

no. o

f lab

orat

orie

s

4.422.7

Not stated, please specify

502.4

465.5

7

Meann

456.0

46

Beckman DXi [SF5]

80.56 17.3

3.016.7

R and D systems [RN1]517.6

4

Beckman Access [SF6]

1

456.8

440.0

Siemens Imm 2000/XPi [DC11]

72

561.5

SD

8.3

8 3.7

41.8

CV(%)

Siemens Immulite 1 [DC7]

13.9

All methods [ALTM](ALTM)

transformed bias

504.0Your result

+4

Method mean

+0.3Your specimen:

(Siemens Imm 2000/XPi [DC11])

502.4

Standard Uncertainty

4

%bias

517.6

Accuracy Index

6.53

Target value

B s

core

Serum Erythropoietin Median and IQRs of B scores

P-BWABCBR

SF

6

SF

5

RN

1

DC

11

-20

-15

-10

-5

0

5

10

15

20

All

Met

hod

C s

core

Serum Erythropoietin Median and IQRs of C scores

P-BWABCCR

SF

6

SF

5

RN

1

DC

11

0

5

10

15

20

25

30

All

Met

hod

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Pool

(exclusion)

[Type]

Distribution 112

25-Jan-2015

result target %bias

Distribution 113

22-Feb-2015

result target %bias

Distribution 114

22-Mar-2015

result target %bias

Distribution 115

26-Apr-2015

result target %bias

Distribution 116

31-May-2015

result target %bias

Distribution 117

28-Jun-2015

result target %bias

Distribution

result target %bias

5.2 5.31 -2.0211 7.5 7.17 +4.6208 6.9 7.62 -9.4 7.5 7.74 -3.1216 8.4 8.43 -0.4210

9.4 10.13 -7.2212 10.0 10.56 -5.3204

12.4 12.29 +0.9219 13.3 13.60 -2.2224

14.7 17.10 -14.0213 18.7 19.10 -2.1205 41.2 45.1 -8.6206

69.9 71.4 -2.2220 118.0 122.8 -3.9217

118.0 125.6 -6.0225 231.0 239.4 -3.5218

233.0 244.0 -4.5226 504.0 502.4 +0.3223

MethodmeanA scoreB scoreC score

DC11-5.3

96-7.56.9

DC11-1.7

79-5.16.6

DC11-7.7

69-4.46.1

DC11-3.5

56-3.45.1

DC11-4.2

54-3.74.0

DC11-0.3

50-3.63.9

Date : DD-MMM-YYYY

Analyte : Serum Erythropoietin (IU/L)

Page 6

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

A s

core

Serum Erythropoietin Median and IQRs of A scores

P-BWABCAT

SF

6

SF

5

RN

1

DC

11

0

50

100

150

200

250

300

All

Met

hod

B s

core

Serum Erythropoietin Median and IQRs of B scores

P-BWABCBR

SF

6

SF

5

RN

1

DC

11

-20

-15

-10

-5

0

5

10

15

20

All

Met

hod

B s

core

C score

Serum Erythropoietin B score is -3.6 and C score is 3.9 Siemens Imm 2000/XPi [DC11]

P-ABCPENR

0 5 10 15 20 25 30-20

-15

-10

-5

0

5

10

15

20Your labYour methodOverall (n=72)Your method (n=44)

C s

core

Serum Erythropoietin Median and IQRs of C scores

P-BWABCCR

SF

6

SF

5

RN

1

DC

11

0

5

10

15

20

25

30

All

Met

hod

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Date : DD-MMM-YYYY

Serum Erythropoietin IU/L

Page 7

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

Spe

cim

en A

ccur

acy

Inde

x

Distribution

Specimen Accuracy Indexfor each specimen in time-window

P-ABCATS (ABC1)

112 113 114 115 116 1170

50

100

150

200

250

300

A s

core

Distribution

A score by distributionYour current A score is 50

P-ABCAT (ABC1)

106 107 108 109 110 111 112 113 114 115 116 1170

50

100

150

200

250

300

All

Met

hod

Spe

cim

en %

bias

Distribution

Specimen %biasfor each specimen in time-window

P-ABCBRS (ABC1)

112 113 114 115 116 117-20

-15

-10

-5

0

5

10

15

20

B s

core

Distribution

B score by distributionYour current B score is -3.6

P-ABCBR (ABC1)

106 107 108 109 110 111 112 113 114 115 116 117-20

-15

-10

-5

0

5

10

15

20

All

Met

hod

Diff

eren

ce (

IU/L

)

Concentration (IU/L)

Difference (result - target)for each specimen in time-window

P-BA1FS1A (ABC1)

0 50 100 150 200 250-20

-15

-10

-5

0

5

10

15

20

C s

core

Distribution

C score by distributionYour current C score is 3.9

P-ABCCR (ABC1)

106 107 108 109 110 111 112 113 114 115 116 1170

10

20

30

All

Met

hod

Spe

cim

en %

bias

Concentration (IU/L)

Specimen %biasfor each specimen in time-window

P-BA1FS1P (ABC1)

0 50 100 150 200 250-20

-15

-10

-5

0

5

10

15

20

B s

core

C score

Serum Erythropoietin B score is -3.6 and C score is 3.9 Siemens Imm 2000/XPi [DC11]

P-ABCPENR (ABC1)

0 5 10 15 20 25 30-20

-15

-10

-5

0

5

10

15

20Your labYour methodOverall (n=72)Your method (n=44)

Spe

cim

en A

ccur

acy

Inde

x

Concentration (IU/L)

Specimen Accuracy Indexfor each specimen in time-window

P-YSTMOD (ABC1)

0 50 100 150 200 2500

50

100

150

200

250

300 ALTMMLTM

CV

%

Concentration (IU/L)

Between-laboratory agreementSiemens Imm 2000/XPi [DC11]

P-PROFILE (ABC1)

0 50 100 150 200 2500

5

10

15

20

25

30

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Birmingham Quality Participants’ Questionnaire

This is a very brief questionnaire specifically about the EQA services provided by the Birmingham Quality

[UK NEQAS] Centre. Your feedback is very important to us and will help us to improve our service to you

so please be as specific as possible when answering the questions below. A brief ‘memory jogger’ has

been provided overleaf but please do comment on any aspect of our service.

Please provide your contact details overleaf ONLY if you would like us to respond to your comments.

We are always happy to receive anonymous feedback.

What do we do well?

What could we do better?

Please use this space to suggest improvements or make recommendations

Please complete and return to Birmingham Quality by e-mail: [email protected] or

FAX +44 (0) 121 414 1179

Date : DD-MMM-YYYY Page 8

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

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Memory Jogger

Our interaction with participants

• Joining / signing-up to EQA programmes

• E-mail notifications of specimen dispatch / reportpublication

• Information on the Birmingham Quality website(www.BirminghamQuality.org.uk)

• Entering your results online

• Viewing your reports online

• Updating your information (methods, contact e-mailaddresses etc)

• Responses to telephone enquiries

• Should we use other forms of social media tocommunicate with participants? E.g. Twitter,Facebook, Instagram etc

• Meetings / training days

• Invoicing

• Payment

EQA programmes

• Are there any additional programmes / analytes thatyou would like us to provide EQA services for?

• What could we do to improve / enhance any of ourexisting EQA programmes?

• Interpretative EQA programmes e.g. UK NEQAS forInterpretative Comments

• Fees

EQA specimens

• Number of specimens per distribution

• Frequency of distributions

• Type of material provided

• Volume of material provided (scheme-specific)

• Sample tubes

• Packaging

• Mechanism of delivery (postal service etc)

• Information on results documents

• Booking-in process

EQA reports

• Information contained in the report e.g. tables,statistics (mean, SD, CV%, median, IQR) etc

• Information about your performance e.g. ParticipationSummary page, numerical scores (ABC of EQA), trafficlights, colour-coded symbols, etc

• Graphs (e.g. histograms, pie charts, penalty box plotsetc)

• Network reports

Problem solving

• Notification of (poor) performance

• Availability / usefulness of help and advice fromBirmingham Quality

Your contact details*

Your UK NEQAS laboratory number (if known):

Title: Job title:

First name:

Surname:

Organisation:

Address 1:

Address 2:

Postcode: Country:

E-mail address:

Mobile tel no: Work tel no:

*Your details will only be used for the purposes of responding to your comments and will not be shared with any third parties.

Date : DD-MMM-YYYY Page 9

Erythropoietin

Distribution : 117

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust

and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK

To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© The data in this UK NEQAS report are confidential.

For this Scheme, the Organiser is Dr. Malcolm Hamilton.

www.birminghamquality.org.uk Published at 14:34 on Friday 11 March 2016

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