enzymatic potentiators for agro-chemicals (epacs)

CONFIDENTIAL DOCUMENTFor Internal Use Only

IBEX BIONOMICSwww.IBEXBionomics.com

Correo: [email protected]

Enzymatic Potentiators for Agro-Chemicals


www.ibexbionomics.com Email: [email protected]

Phone: +1-305-669-3211

EPACS

mailto:[email protected]

http://ibexbionomics.com


Disclaimer IBEX Bionomics has prepared this Presentation and Executive Summary that includes certain statements, estimates and projections with respect to anticipated future performance. Such statements, estimates and projections reflect various assumptions, which may or may not prove to be correct. Actual results may vary materially from the projected results contained herein. No representations or warranties are made as to the accuracy or completeness of such statements, estimates or projections, or the probability of achieving such estimates or projections, and IBEX does not have the obligation to update any such information. IBEX does not assume any liability or responsibility for actions or decisions that the recipient might base on this Presentation and Executive Summary or any related information, and this Presentation and Executive Summary is not intended to have any legal effect.

IBEX Bionomics is a US company with manufacturing operations in Colombia, specializing in the development of bionomic products for Agriculture, Environmental Remediation, Bio-Industry, and Human Health.

We integrate natural life processes to obtain innovative, sustainable environmentally friendly solutions, applied to bio-economic systems

Since 2010, our highly experienced research and development (R&D) team has been developing a group of products known as Enzymatic Potentiators for Agro-Chemicals or EPACs. These are commercially viable, 100% organic products with the potential to revolutionize the agrochemical industry by greatly reducing the amounts of agrochemicals used, while maintaining or improving efficacy

Our goal is to develop products that support more sustainable, environmentally friendly agricultural practices to significantly increase environmental and economic benefits for all.


EPACS EPACs are 100% organic adjuvant potentiators obtained from natural metabolites that

▪ Significantly reduce the impact of ingredients in pesticides for agricultural applications

▪ Maintain or, in some cases, increase the efficiency levels of agro-chemicals (AC) ▪ Reduce costs for growers and consumers, while increasing margins for manufacturers

Laboratory and field tests with eight of the most commonly used ACs have shown the following reductions in active ingredient while maintaining or increasing efficacy:

Glyphosate (Herbicide) = 50% Metamidophos (Insecticide) = 50%

Bispyribac (Herbicide) = 50% Azoxystrobin (Fungicide) = 75%

Paraquat (Herbicide) = 50% Atrazine (Herbicide) = 60%

Chlorpirifos (Insecticide) =50% Picloram+2,4D (Herbicide) = 60%

Similar results are expected for 12 other ingredients being tested in 2015 from an active pipeline of over 40 molecules to be tested over the next two years.


A G R O - C H E M I C A L S T O D AY

For over 50 years the agriculture industry norm has been to apply AC pesticides and fertilizers for crop protection and yield increase, creating significant environmental and health related problems worldwide:

▪ Agriculture: Resistance to ACs by weeds and plagues have led to overuse or the continued development of ACs with increasing levels of toxicity

▪ Soil & Water: About 75% of soil and water quality problems originate from AC uses

▪ Biodiversity: Overuse of ACs has gravely increased the threat of biodiversity collapse, impacting beneficial species of insects, fishes, birds, microorganisms and others

▪ Human Health: Many studies link direct and indirect exposure of ACs to higher risks of cancer, autoimmune diseases, endocrine disorders, and others

IBEX believes that the EPACs it is producing will contribute to the remediation of this situation and implementation of more sustainable industry norms for Agriculture and other environmentally affected areas.


M A R K E T C O N S I D E R AT I O N S

The worldwide AC market of about US$200 billion in 2012 is underpinned by high growth rates, particularly in Latin America (LatAm).

IBEX’s efforts started in LatAm to take advantage of one of the world’s largest regional AC markets and the expertise found in Colombia for the development and production of IBEX’s products:

▪ A team of 6 experienced scientists support our R&D and operational efforts

▪ LatAm AC market of about US$50 billion in 2012 represented 25% of the global market

▪ LatAm has the world's fastest growing demand for AC, recently about 25% annually

Increasing dissemination of scientific findings and studies linking a number of serious illnesses and adverse health conditions to AC exposure are putting growing pressure on growers, manufacturers and regulatory agencies to find more sustainable solutions for a safer and more environmentally friendly agricultural model, resulting in:

▪ Growing broad market demand for environmentally safer solutions and products ▪ Government AC concentration regulations becoming stricter on a global basis


M A R K E T C O N S I D E R AT I O N S

23%

24%

4%

15%

25%

9%

World AC Industry Segmentation

Europe

Asia

Africa

North America

Latin America

Australia


H O W E PA C S W O R K

Agricultural EPACs aim to potentiate : Herbicides Fungicides Insecticides Fertilizers

Each EPAC has a specific formulation and mode of action particular to the main active ingredient being potentiated

The EPACs mode of action can be broken down into three functions:


CONTACT • ABSORPTION • TRANSLOCATION



Pesticides first penetrate the surface of the target host, be it an insect, plant, or fungus.

Conventional Mode of Action and Problems

• The common molecules of conventional pesticides (made up mostly of Oxygen, Nitrogen, Phosphorous and Sulfur) have strong intermolecular attraction, creating a large superficial area, complicating solid contact with the host due to its surface morphology. • A small percentage of the AC is absorbed by the host, while most of it either remains inactive on

the surface or gets introduced into the environment by falling onto the soil or evaporating into the atmosphere.

EPAC Advantage

• The EPACs organic composition breaks the intermolecular bond of the AC, and forces them to bond with the additive instead, creating a more stable molecule. • A better distribution on the host’s surface and a more stable molecule aids with product

penetration. • This increases efficacy with a lesser amount of the active ingredient and reduces environment

contamination and residuality as a result of run off or evaporation.

CONTACT

H O W E PA C S W O R K CONTACT: Herbicide

!

!

EPAC!

Herbicide!

Intermolecular!forces!!are!ruptured!and!covalent!bonds!are!formed!with!the!EPAC!

Herbicide!

Herbicide!bonds!with!

itself!

Small!amounts!of!molecules!penetrate!

the!leaf!

Intermolecular!forces!are!ruptured!

EPAC!

Easier!product!prenetration!into!the!leaf!

Conventional*Herbicide* Herbicide*Additivized*by*EPAC*


H O W E PA C S W O R K CONFIDENTIAL DOCUMENT

For Internal Use Only

CONTACT: Insecticide


Conventional Mode of Action and Problems

When an AC is able to penetrate the surface, the host’s defense mechanisms attack it in order to lessen its effects. This resistance makes it necessary for larger amounts of AC to be used in order to be effective.

EPAC Advantage

• EPACs are composed of secondary and tertiary metabolites, resulting from an already registered pending patent process, that are recognized by the hosts as compatible nutrients for themselves.

• These metabolites mask the AC from the host’s defenses, the “nutrient” is absorbed and the host’s defense mechanisms are bypassed.

• As the potentiated compound is absorbed, it is introduced into the host’s active and passive nutrition transportation system, more effectively transporting the AC through the host and facilitating it’s action.


ABSORPTION



ABSORPTION: Herbicides

!

Cellular!Membrane!

Herbicide!EPAC!



ABSORPTION: Insecticides


EPAC Advantage

As the potentiated compound enters the host and the AC begins to interrupt vital physiological processes, the EPAC inhibits the host’s enzymatic detoxification system. Normally, this system would create antibiotics or other metabolites to counteract the effects of the AC, but by inhibiting the host’s system, the potentiated compound is able to carry out its intended purpose more efficiently.


TRANSLOCATION

H O W E PA C S W O R KTRANSLOCATION:Herbicide


H O W E PA C S W O R KTRANSLOCATION: Insecticide



• The EPACs secondary and tertiary metabolites are compatible with the host’s organic molecules, thus being recognized as nutrients and facilitating absorption

• The EPACs organic composition optimizes the AC’s effect, thus reducing the amount of AC required by 50% to as much as 75%

• Substantial active ingredient reduction goes hand in hand with reduced environmental contamination and residuality

• Avoids loss of the AC due to chemical oxidation or through rejection or run-off that would result from low adhesion of the products

• Products containing EPAC can be classified as Clean Development Mechanisms (CDM) by reducing the amount of ACs that evaporate into the atmosphere


OVERALL BENEFITS OF EPAC -POTENTIATED ACs

I N T E L L E C T U A L P R O P E R T Y

▪ An in depth search with patent attorneys and the IBEX technical team has found no products or patents similar to the EPACs in mode of action, function or manufacturing process

▪ The EPAC products have been registered under the Patent Cooperation Treaty (PCT), providing patent protection in 148 countries and are Patent Pending.


E PA C M A R K E T I N G P L A N

• Work is already underway with a leading AC manufacturer in Colombia on two fronts:

(i) existing product launch in Colombia, including a large scale marketing campaign to educate the end user, which started in March 2015

(ii) test 32 additional active ingredients, in order to establish percent reduction and field dosage for each AC for the development of future products

• Similar relationships are being sought with other leading AC manufacturers in Mexico, Ecuador, Peru, Argentina, Panama, Bolivia, and Brazil


EPACs are disruptors that promise to establish a new sustainable industry norm

E PA C M A R K E T I N G P L A N

▪ EPACs will be sold to leading AC manufacturers or mixers (MoMs) with established AC product sales and distribution in their own respective markets

▪ EPACs will initially be sold as a finished product for mixing with the proper AC by the individual end-user. Eventually, it will be sold as an input product for pre-mixing by the MoM, with the potentiated AC sold as the finished product

▪ The long term goal is to test all commercially viable ACs and to expand distribution globally as the EPACs are first technologically established and commercially proven in LatAm


M A N A G E M E N T & T E A M A D V I S O R Y B O A R D


Meyer Minski

• President of Originates Inc. since 1976. • Originates is a global supplier of high quality sustainably-

sourced Omega-3 fish oil concentrates

Otto J. Reich

• Latin America Business Consultant • Former US Assistant Secretary of State for Western

Hemisphere and former U.S. Ambassador to Venezuela

Kim A. Wise

Jose Alejandro Rodriguez CTO

• Pioneer in the field of Bionomics. Developer and inventor of IBEX Bionomics Products • Founder and owner of QBL Laboratories for 21 years until its merger with IBEX Bionomics. QBL developed the bionomic approach to organic products for use in human health, bio-industry, environmental remediation and agriculture • Has filed process patents covering 24 products, developed over the past two decades, in the area of bionomics

Waldir Bohorquez Marketing Director

• 10 years a new products Manager for Tecnnoquimicas, SA, second largest agrochemical producer in Colombia • 3 years as Sales Manager for Polymers Crop S.A., increasing company sales by over 90% • Co-Founder and Strategy Manager of Walper S.A.S., veterinary products company

Jose F. Rosado CEO

• Over 35 years of investment banking and corporate development and management experience • Former CEO of Shearson Loeb Rhoades’ International Real Estate Investment Banking Division • Former CEO of IBEX Institutional Advisors - for 15 years was Institutional Advisor to CalPERS and other institutions, including Princeton University, University of Pennsylvania, and Washington State Retirement System • Over $750 million of real estate acquisitions, asset management, and dispositions for institutional and international investors

• President of Natures Products, Inc. since 1986. • NPI is a world leader in the development and

manufacturing of vitamins, minerals, nutritional supplements & botanical remedies

Jose Minski

• Real Estate Developer & Entrepreneur with 35 years of experience

enzymatic potentiators for agro-chemicals (epacs)

Documents

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bispyribac herbicide

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atrazine herbicide

glyphosate herbicide

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executive summary

enzymatic potentiators