environmental health, toxicology, & risks

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Environmental Health, Toxicology, & Risks some parts of Eastern Europe and the former USSR, u 90% of all children suffer from environmentally lin eases. 1

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Environmental Health, Toxicology, & Risks. In some parts of Eastern Europe and the former USSR, up to 90% of all children suffer from environmentally linked diseases. 1. Terminology. - PowerPoint PPT Presentation

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Page 1: Environmental Health, Toxicology,  & Risks

Environmental Health, Toxicology, & Risks

In some parts of Eastern Europe and the former USSR, upto 90% of all children suffer from environmentally linked diseases.

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Page 2: Environmental Health, Toxicology,  & Risks

Terminology

Pollution – unwanted change in the environment caused by introducing harmful material, or by producing harmful conditions.

Contamination – introduction of undesirable material to one or more of the “spheres” making it unfit.

Toxicology – science that studies chemicals that are toxic, or could be toxic .

Pollutants – e.g., • infectious agents, • toxic heavy metals, • organic compounds & persistent organic pollutants (POPs), • hormonally active agents (HAA), • nuclear radiation, • thermal pollution, • particulates, • electromagnetic fields (EMF), • noise pollution, • etc.

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Page 3: Environmental Health, Toxicology,  & Risks

FACTBOXWorld's 10 Most Polluted Places

February 2, 2009 Below are the world's 10 most polluted places listed,

according to Time/CNNhttp://www.time.com/time/specials/2007/article/0,28804,1661031_1661028_1661016,00.html

1. Linfen,China (6) - auto/industrial coal/air particulates 2. Tianying, China - mining/processing lead/heavy metals3. Sukinda, India - chromium mining/processing heavy

metals4. Vapi, India - industrial chemicals & heavy metals5. La Oroya, Peru (5) - mining/processing Pb, Cu, Zn, SO2

6. Dzerzhinsk, Russia (2) - chemical weapons toxic byproducts7. Norilsk, Russia (8) - Ni/metal mining/processing air

pollution8. Chernobyl, Ukraine (1) - nuclear meltdown radiation9. Sumgayit, Azerbaijan - petrochem/indust organic/oil/heavy

metals10. Kabwe, Zambia (4) - Pb mining/processing Pb & Cd

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Previous in 2007:Haina, Dominican Republic (3), Mailuu-Suu, Kyrgyzstan (7),

Ranipet, India (9), Rudnaya Pristan, Russia (10)

Page 4: Environmental Health, Toxicology,  & Risks

What is Health?

• Health defined by the World Health Organization as: the state of complete physical, mental, & social well-being – not just absence of disease.

• Disease - a abnormal change in the body’s condition that impairs important physical and psychological functions in response to an environmental factor (nutrition, chemicals, biological agents, etc)

• Morbidity – illness or disease

• Mortality – death rate4

Page 5: Environmental Health, Toxicology,  & Risks

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smoking?

Deforestation causes insect vectors to move to cities

Infectious diseases used

to be the primary cause of death in the past and has

been replaced by

cardiovascular diseases and

cancers

Page 6: Environmental Health, Toxicology,  & Risks

Morbidity and Quality of Life

• Death rates do not tell everything about burden of disease.

• What is the total social burden of diseases?– Total economic and social consequences of

diseases are difficult to obtain.• Disability-Adjusted Life Year (DALY) combines

premature deaths and loss of healthy life resulting from illness or disability. It attempts to evaluate the total cost of disease, not just from premature mortality.

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Page 7: Environmental Health, Toxicology,  & Risks

Disruption to quality of life & economic productivity caused by premature deaths & loss of healthy life caused by illness/disability.

• Problems occurring when people live in poverty - eg, 90% DALY losses in the world occur in developing countries.

• Also when living in crowded conditions – New global mega-cities where managing human-generated wastes is poor.

Morbidity and Quality of Life in Poor Households(Disability-

Adjusted Life Years)

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DALY burden(Millions of yrs lost each yr)*

Page 8: Environmental Health, Toxicology,  & Risks

At any given time, about 2 billion people suffer fromworms, protozoans, and other internal parasites.

Elephantiasis – caused by parasitic worm (& sometimes persistent volcanic ash exposure)

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Page 9: Environmental Health, Toxicology,  & Risks

Emergent Diseases

• An emergent disease is one never known before, OR has been absent for at least 20 years.– An important factor in the spread of many

diseases is speed and frequency of modern travel.• Foot and Mouth Disease• Ebola

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Page 10: Environmental Health, Toxicology,  & Risks

Recent outbreaks of lethal infectious diseases

At least 30 new infectious diseases have appeared in the past two decades while many well-known have reappeared in more virulent, drug-resistant forms. 10

Page 11: Environmental Health, Toxicology,  & Risks

Factors Contributing to the Spread of Contagious Diseases

• High population densities• Contact with water or food that has been

contaminated by human waste• Settlers pushing into remote areas• Human-caused environmental change

(elimination of predators increasing rodents, use of fertilizers & pesticides, deforestation, etc)

• Speed and frequency of modern travel11

Page 12: Environmental Health, Toxicology,  & Risks

Emerging Ecological Diseases

• Domestic animals and wildlife also experience sudden and widespread epidemics.– Distemper (Seals)

– Chronic Wasting Disease (Deer and Elk)• Transmissible Spongiform Encephalopathies

– Black Band Disease (Coral)

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Page 13: Environmental Health, Toxicology,  & Risks

Emerging Disease

Distemper in Seals

• Virus

• Causes Labored breathing, neurological problems and fever

• Seals suffer from immunity defect - caused by toxic waste

Chronic Wasting Disease in Deer and Elk

• Virus - Neurological disease

• Produces lesions in the brain

• Similar to Mad Cow disease

• Transmitted through contact

• Transmission through contaminated water or soil

Page 14: Environmental Health, Toxicology,  & Risks

Antibiotic and Pesticide Resistance

• Indiscriminate use of antibiotics and pesticides – perfect recipe for natural selection– Protozoan that causes malaria now resistant

to most antibiotics, and mosquitoes have developed resistance to many insecticides

– Drug resistance: TB, Staph A (eg, flesh-eating bacteria)

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Page 16: Environmental Health, Toxicology,  & Risks

Toxic Chemicals• Hazardous chemicals – dangerous (eg, flammables,

explosives, irritants, acids, etc)• Toxins – poisonous, kills cells• Allergens – activate the immune system• Neurotoxins – metabolic poisons affecting nerve cells• Mutagens – chemicals or radiation that damage/alter

genetic material (DNA)• Teratogens - chemicals or other factors that cause

abnormalities during embryonic growth & development• Carcinogens – substances that cause cancer (out of

control cell growth)

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Page 17: Environmental Health, Toxicology,  & Risks

Toxins: Movement, Distribution, Fate

Depends upon:• molecular size,• solubility, • stability, &• reactivity, Organisms affected by:• amount of dose,• route of entry,• timing of exposure, &• sensitivity of organisms 17

Page 18: Environmental Health, Toxicology,  & Risks

(Brennan & Withgott 2005)

Many routes of synthetic chemicals traveling through the environment

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Page 19: Environmental Health, Toxicology,  & Risks

• Bioaccumulation – selective absorption & storage of molecules; dilute toxins in the environment can reach dangerous levels inside cells and tissue

• Biomagnification - large number of organisms at a lower trophic level accumulates toxin and toxin is concentrated in a predator at a higher trophic level(concentrates as it moves up the food chain)

Bioaccumulation and

Biomagnification

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DDT (dichloro, diphenyl, trichloroethane

pesticide

Page 20: Environmental Health, Toxicology,  & Risks

Rachel Carson - A Voice for Nature

• In 1962, Silent Spring alerted the public to the dangers of indiscriminate pesticide use.

• Carson called for selective, ecologically sound use of pesticides.

• All 12 of the most toxic agents in her book were banned or severely restricted.

Page 21: Environmental Health, Toxicology,  & Risks

Peregrine falcons disappeared from the eastern U.S. in 1960s due to excess pesticide use 21

Page 22: Environmental Health, Toxicology,  & Risks

“DDT (dichlorodiphenyltrichloroethane) Powerful Insecticide, Harmless to

Humans”

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Page 23: Environmental Health, Toxicology,  & Risks

(More exposure to pesticides)

Pesticides and Child Development in Mexico’s Yaqui Valley• Elizabeth Guillette (anthropologist) – 1994

• Valley farmers used pesticides but foothill farmers continued traditional farming

• Valley children were far behind foothill children developmentally in:

Coordination Physical endurance Long-term memory Fine-motor skills (Brennan & Withgott 2005)

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(Less exposure to pesticides)

Page 24: Environmental Health, Toxicology,  & Risks

Minimizing Toxic Effects• Every material can be poisonous under some

conditions• Taken in small doses, most toxins can be

broken down or excreted before they do much harm – belief in 1800s, arsenic (Napoleon)

• Liver - primary site of detoxification• Tissues and organs - high cellular

reproduction rates replace injured cells - down side: tumors, cancers possible

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Page 25: Environmental Health, Toxicology,  & Risks

Measuring Toxicity

• Most commonly used and widely accepted

• Expensive - hundreds of thousands of dollars to test one toxin at low doses

• Time consuming

• Often very inhumane

• Difficult to compare toxicity of unlike chemicals or different species of organisms

Animal Testing

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Page 26: Environmental Health, Toxicology,  & Risks

A Typical Dose/Response Curve

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Page 27: Environmental Health, Toxicology,  & Risks

It is useful to group materials according to their relative toxicity. (~ 31 billion ng/oz)

mouse

rat

Acute Lethal Doses for Some Toxic Organic Chemicals

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Page 28: Environmental Health, Toxicology,  & Risks

Acute Versus Chronic Doses and Effects

• Acute effects - immediate health effect caused by a single exposure to a toxin (effects are reversible if survive)

• Chronic effects - long lasting (or permanent) health effect caused by:– a single exposure to a very toxic substance

(experiments generally done this way), OR – continuous or repeated sub-lethal exposures to a

toxin (experiments using this level are expensive and time consuming)

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Page 29: Environmental Health, Toxicology,  & Risks

Risk Assessment and Acceptance

• Risk = probability of harm X probability of exposure

• A number of factors influence how we perceive relative risks associated with different situations– interests as industrialist vs environmentalist,– understanding probability,– personal experience,– our abilities to control our fate,– news media biases,– fear of technology

• Accepting risks - we go to great lengths to avoid some dangers, while gladly accepting others

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Page 30: Environmental Health, Toxicology,  & Risks

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Risks of Death

Page 31: Environmental Health, Toxicology,  & Risks

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Page 32: Environmental Health, Toxicology,  & Risks

McKinney & Schoch

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Page 33: Environmental Health, Toxicology,  & Risks

Establishing Public Policy

• Combined effects of exposure to many different sources of damage (synergistic effects of different toxins, eg the smoking & asbestos effects on lung cancer rates)

• Different sensitivities of members of the population

• Effects of chronic as well as acute exposures

In setting standards for environmental toxins, we need to consider:

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Page 34: Environmental Health, Toxicology,  & Risks

Regulatory Decisions – EPA framework

The Science Specific to the Problem

Other Factors Not Specific to the Problem

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Page 35: Environmental Health, Toxicology,  & Risks

• How do we determine what the risk is from different physical/ chemical changes in the environment?

• How much of the ranking is based on our values –

• do they reflect the science?

• do they reflect concern for the environment?35

Relative Risks to Human Welfare

How about RISKS to the environment regardless of effects on humans?

Relative Risks to Human Welfare

Cunningham & Cunningham 2002

Page 36: Environmental Health, Toxicology,  & Risks

Summary:• Environmental Health Hazards

– Infectious Organisms– Emergent Diseases– Antibiotics and Pesticide Resistance– Toxic Chemicals

• Distribution and Fate of Toxins

• Minimizing Toxic Effects

• Measuring Toxicity

• Risk Assessment

• Public Policy36