endogenous pigmentation

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ENDOGENOUS MELANOCYTIC PIGMENTATION FARAKATH KHAN.M Guided by Dr. Tatu Joy

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ENDOGENOUS PIGMENTATION

ENDOGENOUS MELANOCYTIC PIGMENTATION

FARAKATH KHAN.MGuided byDr. Tatu Joy

MELANIN

CLASSIFICATION

FOCAL DIFFUSEMELANOSIS ASSOCIATED WITH SYSTEMIC OR GENETIC DISEASE

IDIOPATHIC PIGMENTATION

ORAL MUCOSA

ORAL MUCOSA

The normal color represents the combined effect of a number of factors:

The concentration and state of dilation of capillaries in the underlying connective tissue, The thickness of the epithelium, The degree of keratinization, And the amount of melanin pigment in the epithelium.

ENDOGENOUS PIGMENTATION

Hemoglobin, hemosiderin, melanin represent the most common endogenous source of mucosal color change.

HEMOGLOBINHAEMOGLOBIN & IRON ASSOCIATED PIGMENTATIONEcchymosisPurpura / PetechiaeHemochromatosis

melanin TYROSINE - DOPAMELANOCYTES(BASAL LAYER)MELANOSOMESMELANINEUMELANINPHEOMELANINTYROSINASE

CLEAR CELLS

MELANIN

MELANIN

MELANIN

MELANOCYTES

MELANIN

MELANIN INCONTINENCEMelanin is seen free or within melanophages in sub epithelial connective tissue.

CLASSIFICATION

FOCAL MELANOCYTIC PIGMENTATION

DIFFUSE PIGMENTATION FRECKLE/EPHELIS ORAL MELANOTIC MACULE ORAL MELANOACANTHOMA MELANOCYTIC NEVUS MALIGNANT MELANOMAPHYSIOLOGIC PIGMENTATIONDRUG-INDUCED MELANOSISPOST INFLAMMATORY PIGMENTATIONMELASMA(CHLOASMA)

MELANOSIS ASSOCIATED WITH SYSTEMIC OR GENETIC DISEASE

HYPOADRENOCORTICISM (ADDISONS DISEASE)CUSHINGS SYNDROMEHYPERTHYROIDISMPRIMARY BILIARY CIRRHOSISVITAMIN B 12 DEFICIENCYPEUTZ JEGHERS SYNDROMECAF AU LAIT PIGMENTATIONHIV/AIDS ASSOCIATED MELANOSIS

IDOPATHIC PIGMENTATIONLAUGIER-HUNZIKER PIGMENTATION

FRECKLE

FRECKLEAsymptomatic, small (1-3 mm), well circumscribed, tan or brown color macule.Sun exposed facial and perioral skinLight skinned, red or light blond haired individualsETIOLOGYDevelopmental in originPolymorphism in MCIR gene.Ch 4q32-q34.( Increase melanin production without concomitant increase in no of melanocytes)

ORAL/LABIAL MELANOTIC MACULE

ORAL/LABIAL MELANOTIC MACULE

Benign pigmented lesion that has no dermal counterpart.Most common oral lesion - melanocytic originEtiology trauma?Females - lower lip gingiva.