12

Enalapril + hydrochlorothiazide beats enalapril alone in Korean patients with hypertension

Although ' ... enalapril is effective in treating essential hypertension in Korean patients, combination with a small amount of HCTZ {hydrochlorothiazide} offers a significantly greater reduction in blood pressure and no increase in side effects, and allows for lower dosages and cost'.

25 evaluable Korean patients with essential hypertension were randomised to receive enalapril 10-20 mg/day alone (n = 12) or in combination with hydrochlorothiazide 25 mgjday for 12 weeks in a double-blind fashion, following a I-week washout period.

BP was reduced to a significantly greater extent with combination therapy compared with enalapril monotherapy. Goal diastolic BP (~ 90mm Hg) was achieved in 77% of combination therapy recipients with a mean daily enalapril dose of 13mg, and in 67% of those using monotherapy with a mean daily enalapril dose of 18.8mg. Of the patients in whom BP was controlled, 7/8 receiving monotherapy and 3/10 receiving combination therapy required enalapril 20 mgjday. Jones ow. Sands CD. Treatment of essential hypertension in Asians: enalapril as monotherapy versus combination therapy with hydrochlorothiazide. Pharmacotherapy II: 127-130, No.2 1991 ""

_ 1 Ju" 1991 INPHARMA'" ISSN 0156-2703/91/0601-0012/0$01.00/0 ro Adi! I"ter"atio"al Ltd