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October 9 th , 2012 Emerging Markets: Developing Supply Chain Capabilities Health and Personal Care Logistics Conference

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Page 1: Emerging Markets: Developing Supply Chain Capabilitiesb.hpclcnet.org/wp-content/uploads/2012/04/Session-4-ATK.pdf · Emerging Markets: Developing Supply Chain Capabilities ... medical

October 9th, 2012

Emerging Markets: Developing Supply Chain Capabilities

Health and Personal Care Logistics Conference

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A.T. Kearney 2

Vishal Bhandari

Principal

Mike Wise

Partner

Summary of experience

• Over 12 years of consulting experience

• Worked with companies across pharmaceutical, biotech, medical devices and pharmacy sectors

• Specific experience in pharmaceutical supply chain (procurement, planning, distribution) and M&A

• Worked across US, Europe and Asia

Summary of experience

• Over 20 years of consulting experience

• Member of A.T. Kearney Healthcare practice leadership

• A.T. Kearney global account partner; accountable for quality of all work conducted

• Experience across the entire supply chain

Introductions

[email protected] [email protected]

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A.T. Kearney 3

A.T. Kearney – Helping our clients achieve immediate impact and growing advantage

Middle East • Dubai

Asia/Pacific • Bangkok • Beijing • Hong Kong • Jakarta • Kuala

Lumpur • Melbourne • Mumbai • New Delhi • Seoul • Shanghai • Singapore • Sydney • Tokyo

North America • Atlanta • Chicago • Dallas • Detroit • Mexico City • New York • S. Francisco • Toronto • Washington

South

America • Sao Paulo

Europe • Madrid • Milan • Moscow • Munich • Oslo • Paris

• Frankfurt • Helsinki • Istanbul • Lisbon • Ljubljana • London

• Amsterdam • Berlin • Brussels • Bucharest • Copenhagen • Düsseldorf

• Prague • Rome • Stockholm • Stuttgart • Vienna • Warsaw • Zurich

A.T. Kearney‟s Global Reach

Firm Facts

• Top global management consultancy – 80 years of history – 50+ offices in over 30

countries – 2700+ global

colleagues

• Unique approach – Industry expertise,

strategic insight, and operational know-how

– A collaborative working style

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A.T. Kearney 4

What is the recipe for growing in Emerging Markets?

Source: CIA World Factbook. 2. http://asiancorrespondent.com/76351/how-many-languages-are-spoken-in-india/ 3..http://www.blackrock.es/content/groups/uksite/documents/literature/1111106088.pdf

Recipe Ingredients:

• 3.8 Bn healthcare consumers speaking 100‟s of languages

• Still-developing Infrastructure (rails, roads, harbors)

• No real-time cold chain/temperature monitoring

• Uncertain regulatory environment

• Fragmented distribution and pharmacy structure

• Complexity of local partnerships

• Add additional spices, according to taste…and place in oven

Emerging Markets Cookbook

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A.T. Kearney 5

Key Messages for Today

1. Rapid Growth in Emerging Markets is one of six fundamental disruptors reshaping pharmaceutical business and operating models

2. Many supply chain clients feel they are playing catch up developing capabilities to support forecasted/desired growth

3. There is no one size fits all, Emerging Markets vary widely in their market maturity, customer expectations and supply chain challenges

4. Conventional solutions often do not work – market capabilities, human talent and business case are often lacking

5. Creative solutions and new competencies are required to thrive in these markets

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A.T. Kearney 6

Healthcare Disruptors

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A.T. Kearney 7

Research Inputs to A.T. Kearney Disruptors Study

Emerging realities that will disrupt future Health Operations

Disruptors

FUTURISTS (Game changing trends

in macro forces)

ACADEMICIANS (External view of

disruptors and trends)

PHARMA EXECUTIVES

(Inside out view of disruptors to industry)

Inputs into Disruptors of Future Health

Operations GLOBAL BUSINESS POLICY COUNCIL

(Global macro-economic perspectives)

A.T. KEARNEY EXPERTS

(Cross Industry input)

SECONDARY RESEARCH

(Informs and supports developing theories)

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A.T. Kearney 8

Drivers for the New Pharmaceutical Industry Paradigm

These forces are profoundly impacting Pharma Operations

6 Fundamental Forces are reshaping the healthcare landscape

Disruptors

The balance of power is shifting: payers; generics; regulator transparency decreasing

Increased access to clinical data impact care & reimburse –ment

Traditional innovation insufficient to maintain growth

Cost pressure will increase current system is un-sustainable

Value Chain activities Increasingly complex with low visibility

C A E D B Emerging markets create new growth opportunities

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A.T. Kearney 9

Traditional innovation is no longer sufficient

Source: BioPharm Insight; CMAJ.ca; Journal of Health Economics; A.T. Kearney analysis

C A E D B

7.9

9.8

12.7

14.7

0

5

10

15 1.4

1.2

1.0

0.8

0.6

0.4

0.2

0.0

05-‟09 00-‟04 95-99 90-94

“It‟s a cruel model.” CFO, Global Pharmaceutical Manufacturer

– In Years – $ (000‟s) MM

Avg. Length of Market Exclusivity & Development Cost

There is demand to develop products & services for evolving health needs

Disruptors

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A.T. Kearney 10

Value chain activities increasingly complex – visibility limited

Source: Business Insights, A.T. Kearney analysis

“The world is so small and interwoven – we don‟t know our own blind spots,” Former CEO, Pharmaceutical Company

Multiple Levels of Business Complexity

Product science, genesis & idea sourcing increasingly complex

Research Manufacturing

Outsourced activities & tighter control/regulation varies by market

Supply Chain

Diverse supply base, complex portfolio delivered across worldwide network

C A E D B

Disruptors

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A.T. Kearney 11

C A E D B

Clinical data drives new protocols and reimbursement decisions

“Outcomes data will start dictating standards of care and what treatments get approved for reimbursement”, President, Biotech Firm

1. Represents the number of unique trade name products/variations that have received FDA approval Source: FDA.gov; BioPharm Insight; A.T. Kearney analysis

Allergies Glaucoma

33

12

2015 2010 1990

? ?

Approved Rx Products on the Market1 – Examples –

45

13

2015 2010 1990

Disruptors

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A.T. Kearney 12

Source: A.T. Kearney interviews with pharma executives

Balance of power is rapidly shifting between industry players

Physicians : Key Decision Makers

Branded Medications

Regulators : Collaborative Partner

Regulators : „Black Box‟

Payers : Key Decision Makers

Generic Medications

Shifts from: To: “Balance of power clearly

shifting to the payers”

“Biosimilars causing Wall

Street to recalculate

biotech‟s revenue models”

“Worry about role of

international regulators”

C A E D B

Disruptors

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A.T. Kearney 13

Existing healthcare models are not sustainable

“Must integrate Health Economic Research early in trial design”, Director of Alliance Management, Global Pharmaceutical Manufacturer

Source: United Nations, World Health Organization; A.T.Kearney analysis

Dependency Ratios in Developed Countries Are Out of Balance

Most health systems were designed for this demographic…

…but will have to deal with this reality

= Retirement age

USA UK Germany

1950

2020

Japan

= Working age

C A E D B

Disruptors

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A.T. Kearney 14

The Emerging Realities for Future Pharma Operations

A world of virtual partners

where orchestration is an

essential competency

Emerging Reality #1:

Vertical Integration is Dead

A world of rapid commoditization where differentiation based on efficiencies rules the day

Emerging Reality #2: Race to the Bottom

Two emerging realities are “disrupting” pharma operations

How is your company responding to these new realities?

Discussion

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A.T. Kearney 15

While existing business models are being disrupted – “pharmerging” markets are expanding

“Pharmerging” markets defined

Note: 1. Pharmarging defined by IMS 2. Developed markets are defined as the U.S., Japan,Top 5 Europe countries (Germany, France, Italy,Spain, UK), Canada and South Korea. Source: IMS Institute for Healthcare Informatics “Global Use of Medicines: Outlook through 2015” May 2011

Definition >$1Bn absolute spending

growth 2011-2015 GDP per

capita of < $25,000

Countries China, Brazil, India, Russia,

Mexico, Turkey, Poland,

Venezuela, Argentina,

Indonesia, South Africa,

Thailand, Romania, Egypt,

Ukraine, Pakistan and Vietnam

Emerging Markets

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A.T. Kearney 16

Global pharmaceutical market is expected to reach $1.3 trillion by 2016; emerging markets are gaining share

129 133 137 141145 149

101

US

EU

Japan

Pharmerging

ROW

2016

1,310

540

117

397

106

2015

1,219

508

114

351

2014

1,133

477

111

312

93

2013

1,053

448

107

277

83

2012

982

421

104

248

76

2011

912

396

101

222

64

11%

3%

12%

6%

CAGR

3%

Global Pharmaceutical Market, $ bn (2011–2016)

Source: IMS, Espicom

Pharmerging markets expected to account for 43% of market growth over the next five years

Emerging Markets

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A.T. Kearney 17

Government Healthcare

Infrastructure Investments

Growing Middle Class

Growth of Western Style

Diseases

The growing middle class is a key driver of emerging markets

Growth Drivers in Emerging Markets

1

2

3

Emerging Markets

Source: 1. IMS 2. http://money.cnn.com/2012/06/26/news/economy/china-middle-class/index.htm 3. http://blog.pharmexec.com/2012/07/12/can-emerging-markets-emerge-fast-enough/

$760

$316$280

$3,000

2010 2000 1990 1980 Annual Disposable Income, per capita

China‟s growing middle class

Since 1980, yearly earnings for an average Chinese household multiplied ten times over – fueling expenditure in healthcare

Disposable Income , per capita (USD)

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A.T. Kearney 18

Government Healthcare

Infrastructure Investments

Growing Middle Class

Growth of Western Style

Diseases

Growth Drivers in Emerging Markets

1

2

3

Emerging Markets

Western style diseases are becoming more prevalent in emerging geographies

% of Population Overweight or Obese

Growth of “Western” Style Chronic Diseases

“The challenge is to activate demand given an underdeveloped infrastructure”, Global CFO, Pharmaceutical Manufacturer

68

2134

22

73

29

57

31

+41%

Advanced Economics

Low Income Countries

China India

+7%

+38%

+68%

2015 2005

Source: European Community Respiratory Health Study, International Study of Asthma and Allergies in Children, World Health Organization ; “Global Prevalence of Diabetes,” World Health Organization, Diabetes Action Now

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A.T. Kearney 19

Government Healthcare

Infrastructure Investments

Growing Middle Class

Growth of Western Style

Diseases

Growth Drivers in Emerging Markets

1

2

3

Emerging Markets

Massive government investment fuels growth opportunities for healthcare companies

Government Investment: China‟s 12th 5-year plan

Between 2009-2011, the Chinese government invested $124 Bn in health care reforms

Note: 1. 125% Compound Annual Growth Rate

Source: Epsicom, IMS, 2. http://www.newswire.ca/en/story/1015133/china-increases-budget-for-rural-healthcare-spending

“China's network of rural diagnostic labs has increased from 86 in two provinces in 2009 to 977 in nine provinces, installed or under contract in 2012,“

- Wilson Yao, CEO, China Health 86

977

2012 2009

No. of Clinics – China

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A.T. Kearney 20

.

.

Emerging markets are a key focus for the industry

Source: http://www.merckserono.com/corp.merckserono_2011/en/images/20120606_en_tcm1494_94968.pdf 2. http://online.wsj.com/article/PR-CO-20120813-909881.html

"Pfizer is continuing to enhance the value of our Consumer Healthcare business, through its

strong connection to…Emerging Markets and pharmacy customers worldwide”

- Ian Read, Pfizer Chairman and CEO, August 13, 2012

Selected Executive Remarks

“Emerging Markets already account for a fifth of our sales, and this percentage is certain to rise…Diagnostic sales in China were up 27% for the year, and pharma sales by 35%”

- Severin Schwan, CEO, Roche

.

“…We expect to generate 1/3 of our revenue in emerging markets in 2012…already in

2011, 75% of our organic growth was from emerging markets. And not by chance. We

have an operating model that is conducive to success in emerging markets.”

- Stefan Oschmann, CEO of Merck Serono, May 2012

Emerging Markets

How do you define emerging markets and what are your aspirations?

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A.T. Kearney 21

Market Dynamics

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A.T. Kearney 22

Succeeding in these markets requires a deep understanding of market dynamics

Market Dynamics

Market Dynamics

Key Questions

Healthcare Maturity and Delivery

• What are the health needs and priorities?

• How is healthcare delivered – where and what kind of delivery systems?

• How does your product portfolio align with market needs

Market Complexity

• Is regulatory environment conducive? What are the pitfalls?

• How developed is the physical infrastructure necessary for our supply chain?

Market Attractiveness

• How large is the market size and what are the affordability considerations?

• What segments of the are market expected to grow?

• What cost structure is required to be competitive?

Channel Sophistication

• How is the distribution model structured – single/multi-tier and degree of fragmentation?

• How are pharmacies organized – chains vs. independents?

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A.T. Kearney 23

Healthcare Market Maturity

Health Needs and Delivery Evolution

Health Needs

Healthcare Delivery

Nascent Mature

Disease Areas

Therapy Focus

• Infectious diseases

• Maternal / Perinatal • Nutritional deficiency

• Chronic heart • Diabetes

• Cancer, Rare diseases • Chronic respiratory

• Treating disease • Preventing disease • Prolonging life • Preventing death

Care providers

Route to Care Provider

• Govt.s / NGOs • Alternative medicine

• Primarily small clinics

• Hospitals • Pharmacies

• Hospital networks • Pharmacy chains

• Govt. agencies • Fragmented distributor base

• Multiple tiers of distributors

• Consolidated distributor base

Delivery Systems

• Bulk • Standard dosages

• Customized dosage • Customized packaging

• Personalized medicine

Market Dynamics - Market Maturity

Countries follow a similar path of evolution – understanding current position on the continuum can help define current and future requirements

Market Maturity

US W. Europe

Industrialized China

Rural China

Ghana

Picture 1

• Direct to Customer

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A.T. Kearney 24

By 2016, the top-8 Pharmerging markets will represent >80% of a nearly 400 Billion market

8%

4%

20%

5%

14%

15%

CAGR

10%

10%

Market Attractiveness - Market Size and Growth, $ Bn (2011-2016)

42

62

24

19

1816

China

Brazil

Russia

India

Mexico

2016

397

145

45

44

32

11

2011

222

58

35

23

16

12 10

7

Turkey

Poland

Indonesia

All other Pharmerging

1. Note: “All other Pharmerging” includes: Argentina, Egypt, Pakistan, South Africa,Thailand, Romania, Ukraine, Venezuela and Vietnam Source: Espicom, IMS

8%

Picture 2

Market Dynamics - Market Attractiveness

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A.T. Kearney 25

Pharmacy fragmentation much greater in Emerging Markets

% Pharmacy Chains (PoS) Persons per pharmacy

9,320

5,217

4,360

3,666

3,473

3,040

3,000

2,219

1,950

Indonesia

Poland

United States

Mexico

China

Turkey

Brazil

Russia

India

Source: Espicom, IMS, A.T. Kearney analysis

Pharmerging

Channel Sophistication - Pharmacy Concentration

Baseline

58%

35%30%

5%4%0%0%0% 0%

Me

xic

o

Ch

ina

Un

ited

Sta

tes

Po

lan

d

Tu

rke

y

Ind

ia

Ru

ss

ia

Ind

on

es

ia

Bra

zil

Increasing trends towards market consolidation in many markets

Market Dynamics - Channel Sophistication

Picture 3

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A.T. Kearney 26

Distribution and Wholesalers are evolving

Distribution / Wholesaler Layers Pharmacies per wholesaler2

Layers Countries Supply Chain Impact

One

• Mexico • Brazil • Russia • Turkey • Indonesia • U.S.

• Distributor selection is a more straightforward process - all reasonably sized distributors serve pharmacies directly

• Decision based on value-add /

customers served

Multiple • India • China • Poland

• 2 or 3 layers of distribution (e.g. national to regional to local to pharmacy/hospital)

• Governments in some cases

dictate specific layers/distributors

1. Mexico and Saudi Arabia have 2 distribution layers that run in parallel as opposed to stacked (a separate distribution system for government delivery) 2. In some countries (e.g. Ukraine) the top wholesalers control significant market share despite overall fragmentation of the wholesaler market Source: Espicom, IMS

Channel Sophistication - Distributor / Wholesaler

83

64

28

22

12

8

U.S. 20,000

Mexico 833

Brazil 217

Turkey

Russia

China

Poland

India

Indonesia Pharmerging

Baseline

Market Dynamics - Channel Sophistication

Picture 3

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A.T. Kearney 27

The regulatory and legal environments are unique and challenging

4.3

3.7

3.0

3.0

3.0

2.7

2.7

2.0

2.0

Turkey

China

Indonesia

India

U.S.

Brazil

Poland

Mexico

Russia

Insights

India Patent protection remains controversial

Indonesia Plagued by counterfeit drugs; inadequate IPR laws

China China remains on the USTR‟s Priority Watch List

Turkey Turkey is harmonizing regulatory environment w/ EU

Russia “Circulation of Pharmaceuticals” legislation now law

Mexico COFEPRIS to simplify procedures to increase

competitiveness

Poland EU Regulations now enforced

Brazil ANVISA‟s recent measures to increase drug safety

United

States Patent reform in discussion to strengthen IPR

protection

Regulatory and Legal Rating (1-5)1

Pharmerging

Baseline

1. Espicom rating of regulatory rigor and legal protection (1 is poor / low and 5 is strong / high) Source: Espicom, A.T. Kearney analysis

Market Complexity - Regulatory Environment

Picture 4

Market Dynamics - Market Complexity

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A.T. Kearney 28

Infrastructure competitiveness varies

5.7

4.6

4.5

4.0

4.0

3.8

3.6

3.4

4.4

U.S.

China

Russia

Turkey

Brazil

Mexico

Indonesia

India

Poland

Insights

Poland Poor quality of roads

India Strong rail infrastructure, poor roads

Indonesia Port infrastructure lagging, rail advanced

Mexico Road network is the most advanced

Brazil Road & port infrastructure in bad state

Turkey Port infrastructure is lagging

Russia Solid rail infrastructure, road n/w deteriorating

China Heavy investment in rail and airports

United

States Advanced road network, aging infrastructure

Infrastructure Competitiveness (1-7)1

1. Executives in each country were asked to rate infrastructure competitiveness (1-7) by all components of infrastructure (rail, road, port, airport etc.) Source: World Economic Forum

Market Complexity - Infrastructure Competitiveness Pharmerging

Baseline

Picture 4

Market Dynamics - Market Complexity

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A.T. Kearney 29

Despite country level variation, distinct segments emerge

89

47

16

11

54

9

8

Ma

rke

t C

om

ple

xit

y

(reg

ula

tio

ns &

in

fra

str

uc

ture

)

Distribution / POS Concentration

540

United States (10% actual size)

Ukraine

Egypt

Pakistan Romania Poland

Thailand South Africa

Vietnam Argentina

Venezuela

24 Mexico 18

Turkey

145 China

32 India

8

44 Russia 45 Brazil

Indonesia

High Low

Lo

w

Hig

h

III

I II

Pharmerging Market Clusters

Source: A.T. Kearney Analysis

2016 Market Sizes, $ Bn

Industrialized China

Industrialized Russia

Industrialized India

Emerging Markets Framework

Approaching these markets in clusters helps define a high level initial strategy

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A.T. Kearney 30

Markets in each of these clusters share key characteristics and supply chain implications are similar

Emerging Markets Framework

Clusters and Level of Difficulty

Shared Characteristics Supply Chain Implications

Cluster I: “Extreme”:

Russia, Thailand, Egypt, Poland, Romania, Vietnam and Rural China, India, Russia

• Extremely fragmented POS • High market complexity

Focus on getting products most cost effectively to customers – heavy reliance on local partners

Cluster II: “Middle of Road”:

Brazil, Argentina, Ukraine, Venezuela, Pakistan, South Africa, Indonesia, Turkey

• Emerging industrialization • Medium POS / Distribution

concentration • Moderate market complexity

Increasing service and cost focus – Leverage a mix of own SC footprint and tiered distribution network

Cluster III: “Moderate”

Mexico and Industrialized Russia, China, India

• Industrialized, large markets • Increasing POS/ Distribution

concentration • Lower market complexity

Approaching similarities w/ mature markets – e.g. differentiating on service by collaborative relationships with POS chains

Source: A.T. Kearney Analysis

Do you apply similar segmentation to understand and approach these emerging markets? What other approaches have you used?

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A.T. Kearney 31

Russia Case Study

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A.T. Kearney 32

Retail sales breakdown by regions, 2010

Source: Pharmexpert, A.T. Kearney analysis

0.9 (1.17)

2.3

(0.84)

3.9

(0.78) 2.5

(0.77)

2.2

(0.76)

2.0

(0.84)

7.2

(1.0)

2.5 (0.77)

price index (Moscow is taken as the basis)

sales (bn $)

In Russia – understanding geographic focus is key

Sales and price indices by federal regions, 2011

N. Novgorod

Novosibirsk

Samara

Ufa

Sverdlovsk region

Krasnodar

Ekaterenburg

Moscow region

St.-Petereburg

Moscow

42%

1% 1%

2% 2%

2% 2% 2%

6%

7%

18%

TOP-10 regional markets

Which segments should the pharma co. target based on size, growth and affordability considerations?

Russia Case Study– Market Attractiveness

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A.T. Kearney 33

Companies choose supply model according to their strategic priorities and plans for Russia

1. In Central Federal region, all channels; Prescription pharma only Source: Press analysis, CHEManager Europe, Pharmexpert, A.T. Kearney

Supply practice of non-local companies on the Russian market

Russia Case Study – Manufacturing

Market share1) Import Packaging Partnership

Own production

GlaxoSmithKline 3.2%

Pfizer 2.2%

Orion 0.2%

Johnson & Johnson 2.8%

Servier 2.4%

Krka 1.6%

Stada 1.7%

AstraZeneca 2.0%

Novartis 7.1%

Nycomed 2.5%

Aurobindo Pharma 0.7%

Bayer Healthcare 3.2%

Gedeon Richter 2.0% - Existing

Companies with manufacturing facilities in Russia can benefit from government protectionist policies

- Planned

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A.T. Kearney 34

Pharmaceutical Companies

Pharmacies

Hospitals Patients Distributors

< 3%

~97-98%

~ 80%

~ 20%

E-pharmacy (insignificant)

Source: CMI Pharmexpert

Structure of the Russian market

Wholesalers are key, the current distribution model presents significant limitations

Russia Case Study – Distribution

• Limited control over commercial terms to pharmacies

• Low granularity, accuracy and no timely sales info.

• No relationship with pharmacies / point of sales

• High exposure to concentration of wholesalers market

• Limitations on ability to do pharmaceutical care programs in PoS

Limitations of current model

Can / should Pharma‟s have a different model than market standard? Can / should they have a different model for certain drugs?

58% 24% 10%* To

p 5

Ma

rket

Sh

are

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A.T. Kearney 35

Source: A.T. Kearney

There are several alternative distribution models that Pharma Co. can consider

Russia Case Study – Distribution

Alternative distribution models

•Direct distribution to pharmacies, using a selected number or sole wholesaler / 3PL as out-source provider on a fee for service and agency basis

•Appoint a number of preferred, exclusive wholesale providers on preferential negotiated economic and service terms

•Development of a payer-specific ePharmacy and Mailorder pharmacy service •Appointment of a preferred, accredited ePharmacy provider

DTP / Agency Scheme (Whole portfolio)

Reduced Wholesaling / Special Arrangements

E-Mail order Pharmacy

DTP / Agency Scheme (Product / part portfolio)

•Direct distribution to pharmacies, for specific product(s) using a sole wholesaler / 3PL as out-source service provider on a fee for service basis

•Delivery of product direct to ward (acute) or point-of-administration (specialist) Direct to Hospital Ward / Point of Admin.

Direct To Patient / Home •Delivery of therapy in home settings, may include nurse supported administration

•Physicians submit prescription to mail ordering company •Products are physically delivered to patient

Direct To Patient through mail order co.

There is a trend towards direct distribution models across the globe, but it needs to be assessed which fits best Pharma Co. in Russia and to what drugs

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A.T. Kearney 36

20

11 T

urn

ove

r, $

bn

20

11 M

ark

et S

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Yo

Y M

ark

et sh

are

in

cre

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(decre

ase)_

Client base Relative market share by region Operations

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Katren 3,5 15% +14% 42,0 55 624 14,2 No

0,38 0,81 0,87 0,57 0,92 1,00 0,87 0,96

83,0 28 2 580

Protek 3,0 13% -12% 19,0 44 860 15,0 No

0,61 0,87 1,00 0,29 1,00 0,90 0,78 0,84

160,0 85 5 500

Rosta 2,1 9% -12% 15,0 n/d 440 n/d Yes

<0,31 0,84 0,51 <0,1 0,62 0,98 1,00 1,00

n/d 43 1 800

SIA Int‟l 3,2 14% +17% n/d 28 875 12,0 Yes

1,00 <0,57 0,87 <0,1 0,60 0,76 0,67 0,50

>45,0 38 15 000

Alliance

Healthcare 2,0 9% -10% 16,0 n/d n/d n/d No

0,31 <0,57 0,30 1,00 0,42 0,68 0,46 <0,21

33,4 44 2 000

Selecting the right distribution partners is key

1. Proxy based on sales in Central Federal Region 2. Imperia-Farma is the largest distributor in the region Source: “The World Pharmaceutical Markets Fact Book 2011”, Pharmexpert, A.T. Kearney

From the +1000 wholesalers in Russia, what is the right number and profile of partners?

Russia Case Study – Distribution

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A.T. Kearney 37

Local distributors might be stronger – esp in particular regions

Interregional and regional distributors

• Due to the size of the country even national distributors don‟t have sufficient coverage in all regions of Russia

• Some regions, especially South Russia, are dominated by the local distributors

• Exclusive contracts with retailers are rare, each pharmacy is usually supplied by 5-10 wholesalers

• Local distributors often have close relationship with local authorities and healthcare organizations

Source: Pharmexpert, company data, A.T. Kearney

Revenue bn. $

Geography

R-Pharm 1.5 European part of Russia

Oriola 2.1 S.-Petersburg, Novosibirsk, Yekaterinburg, N. Novgorod, Chelyabinsk, Irkutsk, Kazan, Stavropol, Rostov

FK Puls 2.0 Western part of Russia, Povolzye, Western Siberia

Imperia Pharma

1.6 Moscow, Rostov-na-Donu, Novosibirsk, S.-Petersburg

Medexpert N/a

Omsk

Vitta company

N/a Moscow, Moscow region

Inte

rre

gio

na

l R

eg

ion

al

What should be the geographic coverage of promotion and distribution? How does promotion targeting affect distribution and vice versa?

Russia Case Study – Distribution

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A.T. Kearney 38

Building Competencies to Serve Emerging Markets

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A.T. Kearney 39

Supply Chain Competencies

SC Competencies

Succeeding in these markets requires building key supply chain competencies

Need for the Competency

Building and Scaling capabilities

• Need to tightly manage investments and returns

• Challenge to time investment with growth

• Managing risks associated with investments

Managing Complexity

• Large number of SKUs driven by multiple languages and regulatory considerations

• Large number of potential partners – e.g. 1000s of local / regional distributors

Orchestrating a virtual supply chain

• Limited established supply chain networks that a pharma company can simply “plug into”

• Cannot be vertically integrated in new markets from early stages

Integrated Strategic Planning

• Rapid pace of change in market dynamics and commercial plans

• No one set way of reaching the market - options need joint Commercial and SC evaluation

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A.T. Kearney 40

Robust linkage between commercial and supply chain plan is critical

Commercial Inputs

Growth plans - target channels and mix

Product portfolio evolution

Customer trade channels

Non-traditional „route to market‟

Customer expectations on service levels

& value added services

Linkages between Commercial and Supply Chain Plans

SC Competencies - Integrated Strategic Planning

Supply Chain Inputs

Supply network capabilities required for

planned growth & portfolio

Investment & time required in

developing these capabilities

Alternative options for „route to market‟ &

their evaluation

Partner requirements for re-designing

„route to market‟

Impact on customer service levels &

other expectations

Joint planning processes bring these inputs into continuous and active dialogue (vs. a one-way communication)

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A.T. Kearney 41

Complexity in emerging markets, if not managed well, can spiral out of control

Complexity in Emerging Markets

SC Competencies - Managing Complexity

Complexity Drivers

Mature Market Emerging Markets

SKUs • 1 language label • Standard packaging –

e.g. majority bottles

• Country specific labels • Specific packaging

preferences – e.g. Bottles vs. Blisters

Regulatory • 1 body – FDA • Robust legal

environment

• Country specific regulatory bodies

• Evolving regulations • Complex legal

environment

SC Partners

Top 3 concentration • Distributors 90-95% • Pharmacy chain ~60%

Top 3 Concentration • Distributors China ~18% • Pharmacy chains India

<5% share

Managing complexity

• Optimizing SKU portfolio

– Consolidating multiple country requirements

– Launching with subset of portfolio

• Postponement strategy

• Local partnerships to navigate local regulatory & legal environment

• Creating virtual supply chain networks suited for own portfolio

Note: 1. McKesson, AmerisourceBergen and Cardinal Health (big 3 U.S. Distributors) 2. big 3 Pharmacy U.S. includes Walgreens, CVS Caremark & Rite Aid 3. 3PL‟s U.S. includes UPS

logistics, C.H. Robinson, Expeditors, EGL, inc, Bax Global, UTI 4. big 3 Shanghai Pharmaceuticals, Sinopharm, and China Resources contribute 18% Source: A.T. Kearney Research 2. http://www.urchpublishing.com/publications/pharma_industry_trends/pharmaceutical_distribution_us.html 3. http://www.business-

standard.com/taketwo/news/apollo-pharmacy-betslarge-stores/482204/ 4. http://www.scribd.com/doc/61665600/3PL-Report-Frost-Sullivan

Picture 2

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A.T. Kearney 42

Hospitals

Pharm-acies

TPMs

Suppliers Tier 1-x

Distributors

Carriers

3PLs

CROs

Supply Chain

Suppliers and Contract Mfg.

Pharma Manufacturers

Distributors

Pharmacies

Mature Markets: Established Model New Reality: The Orchestrator Model

Direct Partner to Partner Communication

Illustrative

Orchestrating partnerships with multiple diverse partners to create a virtual supply chain is critical

SC Competencies - Orchestrating a Virtual Supply Chain

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A.T. Kearney 43

Scaling investments to synchronize with business growth

Phased approach to investments

SC Competencies - Building and Scaling Capabilities

Rely on import

agents to get

products into

market

Develop partnerships with next tier of local

distributors

Temp IT systems for local

SC tracking

Establish local

packaging facility

Establish own

automated DCs

Sales Growth and Market Maturity

Phased investment over time - Illustrative

HR Limited FTEs for tactical coordination

Robust local SC organization

Physical Assets

None Own DCs, Own packaging facilities

IT Simple / temp solutions

ERP systems

Nascent Mature Market Maturity

None Significant Sales Growth

Considerations

Investment areas

Illustrative

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A.T. Kearney 44

Iterative Approach for Building Supply Chain Capabilities

SC Competencies - Roadmap

Source: A.T. Kearney Analysis

A structured and phased approach can be used to build supply chain capabilities in the emerging markets

1

Understand commercial plans and SC

capabilities required

2

Develop plans to build capabilities

3

Mobilize resources and build capabilities

Re-evaluate needs

4

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A.T. Kearney 45

Questions?

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A.T. Kearney 46

Americas Atlanta

Calgary

Chicago

Dallas

Detroit

Houston

Mexico City

New York

San Francisco

São Paulo

Toronto

Washington, D.C.

Asia Pacific Bangkok

Beijing

Hong Kong

Jakarta

Kuala Lumpur

Melbourne

Mumbai

New Delhi

Seoul

Shanghai

Singapore

Sydney

Tokyo

Europe Amsterdam

Berlin

Brussels

Bucharest

Budapest

Copenhagen

Düsseldorf

Frankfurt

Helsinki

Istanbul

Kiev

Lisbon

Ljubljana

London

Madrid

Milan

Moscow

Munich

Oslo

Paris

Prague

Rome

Stockholm

Stuttgart

Vienna

Warsaw

Zurich

Middle East

and Africa

Abu Dhabi

Dubai

Johannesburg

Manama Riyadh

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