OBJECTIVE: To evaluate ART pregnancy outcomes by infertility diag-nosis.

DESIGN: Historical cohort.MATERIALS AND METHODS: ART data on women who were

treated and gave birth in Massachusetts were linked to vital recordsand hospital utilization data. ART pregnancies were limited to thosewith only a single infertility diagnosis. Live births were categorizedby eight mutually-exclusive ART diagnoses. Risks of prematurity,low birthweight (LBW), small-for-gestation (SGA), large-for-gestation(LGA), pregnancy hypertension, gestational diabetes, prenatal hospital-izations, and primary cesarean delivery were modeled using logisticregression, adjusted for parental characteristics, treatment parameters,and plurality (adjusted odds ratios, AORs, and 95% confidence inter-vals); the reference group were pregnancies with the diagnosis ofmale factor.

RESULTS: Among the 7,354 singleton and twin pregnancies, there werenonsignificant differences in the risks for LBW, SGA, and LGA. Womenwith ovulation disorders were more likely to develop gestational diabetes(AOR 1.80, 95% CI 1.35-2.41) and deliver preterm (AOR 1.36, 95% CI1.08-1.71); women with the diagnosis of other factors were also more likelyto deliver preterm (AOR 1.33, 1.05, 1.67). Emergency room visits weregreater for women with diminished ovarian reserve (AOR 1.45, 95% CI1.01-2.08); prenatal hospital admissions were greater for women with the di-agnoses of endometriosis, tubal and other factors, ovulation disorders, anduterine factors (AORs 1.66-2.68).Womenwith the diagnosis of uterine factorwere twice as likely to deliver by primary cesarean (AOR 1.96, 95% CI 1.15,3.36).

CONCLUSION: Although the infant outcomes of LBW, SGA, and LGAwere generally similar across diagnosis groups, specific diagnoses hadgreater risks for prematurity, gestational diabetes, prenatal hospital utiliza-tion, and primary cesarean delivery.

Supported by: NIH R01 HD064595 and R01 HD067270.

P-609 Wednesday, October 22, 2014

THEEFFECTOFLOWBODYMASS INDEXONPREGNANCYOUT-COMES AND OOCTYE QUALITY IN IVF CYCLES. M. Brower,a,b

E. Wang,b C. Alexander,b D. Hill,c H. Danzer,c M. Surrey,c M. Pisarska.baObstetrics and Gynecology, University of California Los Angeles, Los Angeles,CA; bObstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles,CA; cSouthern California Reproductive Center, Beverly Hills, CA.

OBJECTIVE: Prior studies examining the impact of low body mass in-dex (BMI) on in vitro fertilization (IVF) outcomes have shown conflict-ing results with some demonstrating lower pregnancy rates and othersshowing no difference compared to normal weight women. We previ-ously demonstrated that women with a low BMI have a significantlyhigher prevalence of poor quality oocytes. The aim of this study wasto determine if women with a low BMI have poorer pregnancy outcomeswith IVF compared to normal weight women and determine if under-weight women produce poorer quality oocytes or embryos in anexpanded cohort.

DESIGN: Cross-sectional study.MATERIALS AND METHODS: Data for 422 women undergoing

their first IVF or oocyte cryopreservation cycle at a single center be-tween 2011-2012 were analyzed. Participants were classified into twogroups based on BMI % 19 kg/m2 (n¼69) and 19.1-25 kg/m2(n¼353). The primary outcome was clinical pregnancy rate. Secondaryoutcomes included the number of oocytes retrieved, fertilization rate,blastulation rate, implantation rate and ongoing pregnancy rate. A sec-ondary analysis for oocyte quality was done of 301 women who hadthe cumulus cells removed from the oocytes at the time of oocyteretrieval. Oocytes described as being granular or having vacuoles,dark cytoplasm, debris or inclusions were considered poor quality. Lo-gistic and count regression analyses adjusted for age, day 3 FSH andethnicity were used to determine the association between BMI and out-comes of interest.

RESULTS: When controlling for age, day 3 FSH and ethnicity the clinicalpregnancy rates were not different between underweight and normal weightwomen (37% vs. 41%, P¼0.68). The multivariate model confirmed being un-derweight was associated poor oocyte quality (31% vs. 18%, P¼0.05) and a

e338 ASRM Abstracts

trend towards fewer oocytes retrieved (10.6 vs. 12.1, P¼0.08) in theexpanded cohort. There were no differences in the fertilization rate, blastula-tion rate, implantation rate or ongoing pregnancy rates between the twogroups.CONCLUSION: Underweight women have a significantly higher preva-

lence of poor quality oocytes and a strong trend toward fewer oocytesretrieved compared to normal weight women. The poor quality of the oocytesdid not significantly impact embryo development or pregnancy rates in un-derweight women undergoing IVF.Supported by: The Helping Hand of Los Angeles, Inc.

P-610 Wednesday, October 22, 2014

EFFECT OF ETHNICITY ON IMPLANTATION AND CLINICALPREGNANCY RATES AFTER INVITRO FERTILIZATION OR IN-TRACYTOPLASMIC SPERM INJECTION TREATMENT.M. A. Akhtar, N. Tsampras, K. Majumder, E. Edi-Osagie, Y. Sajjad.Reproductive Medicine, St Marys Hospital, Central Manchester UniversityHospitals NHS Trust, Manchester, United Kingdom.

OBJECTIVE: To assess the relationship and determine whether ethnicityof women has any role to play in the clinical success rate of in vitro fertiliza-tion (IVF) or intracytoplasmic sperm injection (ICSI) treatment.DESIGN: Retrospective Observational Cohort Study in one of the largest

National Health Service (NHS) fertility unit.MATERIALS AND METHODS: All of the women who underwent

their first fresh cycle of assisted reproduction in year 2013. A total of656 women, of which 502 were white European and 154 were of ethnicminority group mainly south Asians. Data analysed with SPSS 16 forwindows (Statistical Package for Social Sciences; IBM, Chicago, IL,USA).RESULTS: The pre-treatment variables (age, basal follicle stimulating,

anti-mullerian hormone and antral follicle count) were slightly favourablein the ethnic group, but the implantation rate were lower (30.51%) in theethnic group compared with white European group (42.62%). Clinical preg-nancy rates were also lower in ethnic group (22.07%) compared to white Eu-ropean group (33.66%). These results remained similar even if woman hadsingle or double embryo transfer or day of embryo transfer during assistedreproduction treatment.CONCLUSION: Implantation rate and clinical pregnancy rate

following first fresh IVF or ICSI treatment were lower in ethnic minoritygroup compared with white European women. Ethnicity is also animportant determinant of success following assisted reproduction treat-ment. Further research is needed to look into this very important issueand to estimate the degree of variation in success rates of IVF treatmentfrom a much larger database. This would help us in better understandingof relationship between ethnicity and IVF outcome, leading to modifica-tions in the clinical strategies to achieve equivalent success rates amongall ethnic groups.

P-611 Wednesday, October 22, 2014

ABSTRACT WITHDRAWN

P-612 Wednesday, October 22, 2014

OVULATION TRIGGER WITH LESS THAN 3 FOLLICLES INSTIMULATED IN-VITRO FERTILIZATION (IVF) CYCLES: ARETROSPECTIVE STUDY. C. Roumain,a,b N. Dean,a F. Dzineku,a

I.-J. Kadoch,a,b S. Phillips,b L. Lapensee.a,b aCentre de Procr�eation Assist�ee,Centre Hospitalier Universit�e deMontr�eal, Montreal, QC, Canada; bCliniqueOvo, Montreal, QC, Canada.

OBJECTIVE: In stimulated IVF cycles, ovulation trigger is usually per-formed in the presence of 3 or more mature follicles. This minimal numberis based on clinical experience rather than on strong literature, and obtainedby weighing the probability of implantation and pregnancy versus the risk ofnot reaching embryo transfer when so few mature follicles are present. This

Vol. 102, No. 3, Supplement, September 2014