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he corresponding results for cetirizine 20 mg were 24%, 31%nd 36%.

Conclusion: ‘Wind/Wind-Cold invading the lung’ andHeat/Wind-Heat invading the lung’ were the most frequent CMiagnoses in this trial. On average, patients in the acupunctureroup were treated with more needles but received less rescueedication.

ttp://dx.doi.org/10.1016/j.eujim.2012.07.632

P-138

he efficacy and safety of a Chinese herbal product (Xiao-eng-San) for the treatment of refractory atopic dermatitis:randomised, double-blind, placebo-controlled trial

heng Hui-Man, Chiang Leih-Chin, Jan Ya-Min, Li Tsai-hung, Chen Guang-Wei

China Medical University Hospital, and China Medical Uni-ersity, Taichung, Taiwan

Background: Severe and widespread atopic dermatitis oftenails to respond adequately to topical steroids and oral antihis-amines and requires immunomodulatory drugs which, althoughffective, have undesirable toxic effects.

Aim: To investigate whether the traditional Chinese herbaledicine Xiao-Feng-San (XFS) could be an alternative choice

f therapy for severe, refractory, extensive and non-exudativetopic dermatitis.

Methods: In this prospective, randomised, double-blind,lacebo-controlled trial, 71 patients with severe intractabletopic dermatitis were given an 8-week treatment with oral Xiao-eng-San (XFS 47 patients) or placebo (24 patients). Total lesioncore, erythema score, surface damage score, pruritus, score andleep score were measured at 4-weeks of inter-XFS (47 patients)r placebo (24 patients). Total lesion score, erythema score, sur-ace damage score, pruritus score and sleep score were measuredt 4-week intervals.

Results: Fifty-six patients completed both the treatment andollow-up periods. The decrease in the total lesion score in thereatment group at 8 weeks was significantly greater than thatf the placebo group (79.7 ± 5.8% vs. 13.5 ± 7.64%, p < 0.001).here was also a statistically significant difference between the

reatment and placebo groups with regard to erythema, surfaceamage, pruritus and sleep scores. The difference between thewo groups was still significant, for all outcome measures excepthe erythema score at the 12-week follow-up, 4 weeks after the-week treatment had ended. Patients reported no side effectsrom treatment, although some commented on the unpalatabilityf the medication.

Conclusion: Our study results suggest that the traditionalhinese herbal medicine XFS may be an alternative choicef therapy for severe, refractory, extensive and non-exudative

topic dermatitis.

ttp://dx.doi.org/10.1016/j.eujim.2012.07.633

pmotd

tegrative Medicine 4S (2012) 9–123 69

P-139

ffect of Apis Mellifica on histamine skin test itchy swelling

acrì Francesco, Moretti Matteo, Massaccesi Valerio, Peparinilaria, Lambiase Caterina, Tromba Valeria

‘Sapienza’ University of Rome, Rome, Italy

Background: Apis Mellifica (Apis) is a homeopathic rem-dy obtained by the body of soaked bees, containing thereforehe main enzymes held by hymenoptera venom (phospholipase,yaluronidase, tryptase, etc.), which is used to resolve oede-ata in the organism, at level of skin, parenchymal structures

nd mucosae.Aims: This study aimed at checking the effect of different

pis dilutions on the disappearance speed of the itchy swellingaused by skin tests with histamine.

Methods: Five groups of 20 paediatric patients, followedn private setting for respiratory symptoms and accustomed toomeopathic therapy, have been studied during the carrying outf ordinary allergy tests (skin prick test, SPT). The patients wereivided by randomisation. Informed consent for participatingas achieved. At the moment of the test reading, for the purposef the study, only the size of swelling caused from histamine,sed as positive control routinely in allergologic test setting,as registered. At the same time, patients assumed Apis at 5H, 15 CH and 30 CH dilutions in the first, second and thirdroup, respectively. Patients belonging to the fourth group tookve pellets of 15 CH Apis 1 h before the test execution. Patientselonging to the fifth group did not take any medicine (controlroup). T/2, time for reducing by 50% the size of histaminewelling, was then evaluated.

Results: Compared to the control group, T/2 significantlyecreases within the 1st, 2nd and 3rd group, from 14.50 mincontrol group) to 10.75, 9.55 and 11.00 min, respectivelyp = 0.038, p = 0.005, p = 0.031). The second group (15 CH Apis)hows a more pronounced effect. The fourth group presents at/2 not significant extension, equal to 20.05 min, compared to

he 14.5 of the control group (p = 0.169).Conclusion: The homeopathic substance Apis Mellifica

ssumed in extremely diluted preparation is active in reducinghe skin responses at histamine inoculation.

ttp://dx.doi.org/10.1016/j.eujim.2012.07.634

P-140

sthma in traditional Chinese medicine

uccioli Massimo 1, Luppini Camillo 1, Matteucci Angelo 2

Scuola Tao, PiacenzaIstituto Pinus, Ravenna, Italy

The article focusses on the analysis of the aetiology, patho-hysiology and treatment of asthma in traditional Chineseedicine (TCM), in both adults and children. The mechanisms

f energy weakness of the organs involved in the syndrome andhe external and internal factors responsible for the phenomenayspnoeic are analysed. The external pathogens under consid-