Thyroid GlandBy: Kristin Komnick

References

Follicular Cells 2,3

Parafollicular Cells 1,3

Endothelial Cells 5

Adipocytes 1

Pathological State: Grave’s Disease 1. "Chapter 44 Thyroid." Histology for Pathologists. Ed.

Stacy E. Mills. 3rd ed. N.p.: Lippincott Williams & Wilkins, 2007. N. pag. Print.2.http://alf3.urz.unibas.ch/pathopic/e/getpic-fra.cfm?id=0048463. Chapter 20 Endocrine Glands. Junqueira’s Basic Histology Text and Atlas. Mescher, AnthonyL. 13th Edition. McGraw Hill 2013. Pages 420-4234.http://www.britannica.com/science/parafollicular-cell5. Atsushi Kawakami, et al. “Endothelial cells stimulate proliferation of human thyroid epithelial cells”6. http://www.mayoclinic.org/diseases-conditions/graves-disease/basics/symptoms/con-200258117.http://ntp.niehs.nih.gov/nnl/endocrine/thyroid/follpigm/index.htm8.http://www.lab.anhb.uwa.edu.au/mb140/moreabout/endothel.htm

• Also called Thyrocytes• Range in shape from squamous to low

columnar.• Surrounded by hormone rich fluid called

colloid• The size varies, depending on cellular

activity, usually between 10-15µm in diameter

• Responsible for production and secretion of T3 and T4 hormones which are transported through the blood and work to control metabolism

• Also called C Cells • Found in clusters between the

follicular cells.• Range in size between 15-

20µm in diameter, usually a little bit larger then the follicular cells

• Secrete Calcitonin • Calcitonin reduces the amount

of calcium in the blood

• Not always common• Range in size, between

50-100µm in diameter• Usually the result of

normal cells being converted to fat cells, also called adipose metaplasia

• Found in abundance in blood vessel walls

• Range in size, usually between 10-20 µm in diameter8

• Help the follicular cells proliferate, or grow.

• Provide thyroid with nutrients, and oxygen from blood

• Autoimmune disorder, a form of hyperthyroidism

• Autoantibodies bind to follicular cells and produce a chronic growth of them.

• The amount of colloid is reduced due to intense secretion into blood.

• Follicles become much larger and not as uniform in shape. 3

• Unique symptoms include: enlargement of thyroid (goiter) and bulging eyes (Graves ophthalmopathy) 6

HM Image of Grave’s Disease in thyroid gland in H&E Stain2

Scanning magnification in H&E stain7LM image of follicular cells in H&E stain

HM Image of Parafollicular cells surrounded by Follicular cells in H&E stain

LM image of adipocytes in thyroid gland in H&E stain

Colloid