ee disruptive technologies in healthcare dec2015

Emerging Edges Consultants Pvt Ltd.

Disruptive Technologies in Healthcare

Padmaja Krishnan

December 2015

[email protected]

mailto:[email protected]


“One must learn by doing, for though you think you know it, you have no certainty

until you do it.” - Aristotle

Born in 384 BC, Aristotle was a Greek Philosopher and Scientist in the Macedonian city of Stagira, Chalkidice, on the northern periphery of

Classical Greece


Healthcare is an Ancient Science

In 1000 BC, the only early test for diabetes was whether urine

attracted ants


Developments in Science & Technology

have revolutionized Healthcare and a highly specialized Vertical

known as Healthcare Industry

is growing Rapidly


Consumer Perspectives

• The healthcare industry has complex medical ecosystem

• Slow to adopt innovations • The pace of New Technologies is impacting our

everyday lives at lightning speeds • People get used to technology easily: For 30% of

average urban population their phone is the first thing and last thing they look at everyday :

• Technologies can enable Healthcare to offer cheaper, faster and more efficient patient care than ever before

• Fast innovations in technology is causing fast changes and disruptions in Healthcare

http://www.slideshare.net/ValaAfshar/6297-top50megatrends-v3







• When care is complex, expensive and inconvenient, many afflictions simply go untreated

• If consumers and providers are given equal choices, the use of disruptive technologies will help those applications that can create value for both



• Healthcare Industry leaders should work with insurers, regulators, managed care organizations, hospitals and health professionals to facilitate disruption, instead of uniting to prevent it

• Instead of working to preserve the existing methods, healthcare industry should enable the disruptive innovations to evolve and help in the process of healthcare



• Lack of Interdisciplinary Skills

• Medical-technology companies had tried to develop non-invasive POC testing systems but could not succeed in the past

• Failure in such endeavors is common, due to lack of interdisciplinary skills

ATM was created by A Banker and A Technologist in collaboration

They could not have done it on their own


Lead to Advances that will transform

Life

Business

and

Global Economy

(McKinsey Global Institute)

Disruptive Technologies


Independent Research Twelve potential disruptive technologies

By McKinsey Global Institute analysis

• Mobile Internet

Inexpensive and capable mobile computing devices with Internet connectivity

• Automation of knowledge work

Intelligent software systems that can perform knowledge work, tasks involving unstructured commands and subtle judgments

• The Internet of Things

Networks of low-cost sensors and actuators for data collection, monitoring, decision making, response & process optimization


Independent Research contd.

• Cloud technology Use of computer hardware and software resources

delivered over a network or the Internet, often as a service (on demand)

• Advanced robotics Increasingly capable robots with enhanced senses,

dexterity, and intelligence used to automate tasks or augment humans

• Autonomous and near-autonomous vehicles Vehicles that can navigate and operate intelligently

with reduced or no human intervention



• Next-generation genomics Fast, low-cost gene sequencing, advanced big data

analytics, and synthetic biology (“writing” DNA)

• Energy storage Devices or systems that store energy for later use,

including batteries

• 3D printing Additive manufacturing techniques to create

objects by printing layers of material based on digital models



• Advanced materials Materials designed to have superior characteristics

(e.g., strength, weight, conductivity) or functionality

• Advanced oil and gas exploration & recovery Exploration and recovery techniques that make

extraction of unconventional oil and gas economical

• Renewable energy Generation of electricity from renewable sources

with reduced harmful impact on climate


Transformations till date

• In 1000 BC, the only early test for diabetes was whether your urine attracted ants

• In 2012, 25.8 million people with diabetes have spent USD 245 billion on diabetes in US alone, a figure presently rising by 7% per annum.

- Forbes Article Sept 2014


Transformations till date contd.

• Cost of testing blood-sugar levels is rapidly falling - - A handheld device at home can replace the laboratory visit and analysis.

• Home blood-sugar monitors, are early examples of “point-of-care” (POC) technology, that obviate expensive testing in health-care facilities.

• This trend will only continue and grow

- Forbes Article Sept 2014


Point of Care Technology

Exponential growth & business opportunities in health care may be possible due to two factors:

• (a) the emergence of newer POC technologies that

lower the costs of diagnostics and replace health-care workers and professionals

• (b) increase in chronic disease and the opportunities this offers for lifelong use of products for diagnosis and treatment

Healthcare may become the world’s most lucrative

industry


Google & Novartis Partners for “Smart lens”

• Google along with pharmaceutical giant Novartis is working on a smart contact lens project , to help patients manage diabetes - announced by Google in January 2014

• The project aims to assist people with diabetes by constantly measuring the glucose levels in their tears. The project is currently being tested using prototypes.


Smart Lens


Organ on a Chip

• Researchers have started working on a technology they call Organ-on-a-Chip.

• An Organ-on-a-Chip is a multi-channel 3-D microfluid cell-culture chip that simulates the activities, mechanics, and physiological response of entire organs and organ systems

• It mimics the structure and functions of a living human organ, on a clear, flexible microchip. The chips are subjected to the physiological conditions that take place inside the human body, and respond to infection, inflammation, environmental toxins, and drugs.

• Perhaps this can abolish the need for animals in drug development and toxin testing by replacing it altogether with procedures using human tissue


Organ on a Chip

Wyss Institute at Harvard University predicts that the results will be

• More accurate than those obtained through testing on animals

• With the twin benefits of better success rate in clinical trials & enabling us to stop harming the animals in the name of science.


Organs on Chips (Biomedical Engineering)


Organs-on-Chips

• The responses of Organs-on-Chips are far more predictably pertinent to human physiology than are non-human animals’ responses

• They have the potential to

– Eliminate poor drug formulations at the pre-clinical stage

– Shorten the drug-development process & effort: Lower Time & Cost

– Provide A Disruptive Technology that can help eliminate the demand for animal lives by testing drugs directly on artificial human organs.

• Potential revolution exists: of creating an Organ-on-a-Chip that is uniquely suited to an individual

• This may help customize a drug to individual’s physiology

• Organ-on-a-Chip eventually represents a potential world of new possibilities in the field of customized medicine.


3D Printed Bio-Materials Seven applications of 3D printers in healthcare that could have an important impact in the future:

1. Embryonic Stem Cells: These cells have already been successfully printed in a lab and could be one-day use to create tissue that could help test drugs and assist in the growth of new organs.

2. Printing Skin: There have been many advances in the areas of developing skin to help burn victims and skin disease patients, 3D printers can help further jumpstart these advances with the addition of laser-printed skin cells.

3. Blood Vessels & Heart Tissue: Organovo is a company that has already successfully printed blood vessels and sheets of cardiac tissue that actually beat along just like a real heart.

4. Replacing Cartilage & Bone: 3D printers have also helped scientists and doctors create stem cells that could eventually develop into both bone and cartilage in the long-term.

5. Studying Cancer: Printing cancer cells is a way of growing these cells on tissue in a lab to study, test drugs on and to eventually find a cure for.

6. Patching a Broken Heart: Printing cells with a 3D printer proves useful in a recent study of rats that had previously suffered heart attacks and were given these patches of cells to help slowly help improve their heart function overtime.

7. Replacement Organs: Printing new part for organs or entire organs all together will help solve an ongoing medical need and help save hundred of thousands of people every year waiting for an organ donation to come thru.

http://www.livescience.com/5977-device-prints-human-tissue.html

http://thethinkering.com/articles/2013/09/06/3-d-printing-human-tissue

http://thethinkering.com/articles/2013/09/06/3-d-printing-human-tissue


What is 3-D Printing

An idea can go directly from 3D-design file to finished part

or product (& possibly skip traditional manufacturing

steps)

3D printing enables on-demand production, which has interesting implications for supply chains and spare

parts : A major cost for manufacturers

3D printing can reduce the amount of material wasted in

manufacturing and create objects that are difficult or impossible to produce with

traditional techniques

Scientists have “bio-printed” organs, using an inkjet

printing technique to layer human stem cells along with

supporting scaffolding


Digestible Sensors

A digestible sensor transmits information about a patient to medical professionals to help them customize

patient care as well as the care provided to other individuals

experiencing similar health conditions or ailments.

Provide healthcare professionals with information about the human

body and how various treatment solutions affect each system of

organs.

Monitors body systems and wirelessly transmits information to devices like

smart-phone or computer for review by doctor. Latest innovations with

digestible sensors don’t require a battery source - they solely rely on the

human body for energy.

An innovation of this nature can help detect diseases and

conditions at earlier stages in people digesting these sensors

that are in turn, constantly monitored wirelessly


Cloud-based Solutions

Communication within Healthcare is an easy problem

• Yet not solved fully for many decades …

• Referrals - Treatment - Progress updates - Insurance authorizations are all communications : But cost money & delays to patients & liabilities to healthcare provider

• Over 50 percent of referrals do not reach specialty care providers : Patients miss treatment and healthcare providers lose money

• A simple Cloud based solution can connect doctors & patients with a Robust Referral Management platform & communicate across all entities


Impact on Society, Business & Economies

Implications for individuals and societies – Changes quality of life, health, and environment – Changes patterns of consumption – Changes nature of work

Creates opportunities for entrepreneurs Implications for established businesses & organizations

– Creates new products and services – Innovative Material & Supply Chain Management in the industries – Changes organizational structures

Implications for economies and governments – Drives growth or productivity – Game Changing comparative advantages for nations – Affects current ways of employment – Poses new regulatory and legal challenges


Global Market Trends

• According to May 2014 figures of BCC Research, the global POC market has steadily grown from 2007 to 2013

• Average compounded annual POC growth rate is 4.5%, and annual revenue is expected to reach at least USD 19 billion by 2018

• Healthcare Industry will shift Focus towards: – better treatment, lower costs-time-expense, and

reducing animal suffering due to drug development

– and to development of patient-specific drugs


Disruptive Technologies will impact

Society, Businesses & Economies and therefore

will impact Every Industry Sector

The Key lies in embracing the Change and Evolving with it

Thank You !

ee disruptive technologies in healthcare dec2015

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