The Late Oligocene Creede Flora, Colorado. Dan-iel I. Axeirod. University of California Press, Berkeley,CA, 1987. x, 235 pp., illus. Paper, $24. University ofCalifornia Publications in Geological Sciences, vol. 130.The Law as a System of Signs. Roberta Kevelson.

Plenum, New York, 1988. xiv, 331 pp. $45. Topics inContemporary Semiotics.Lehrbuch der Theoretlschen Physik. Vol. 5, Sta-

tische Physik, pt. 1. L. D. Landau and E. M. Lifschitz.7th ed. Akademie-Verlag, Berlin, G.D.R., 1987. xviii,517 pp., illus. DME 36. Translated from the Russianedition (Moscow, 1976).

Linear Estimation and Design of Experiments. D.D. Joshi. Wiley, New York, 1987. xvi, 288 pp. $24.95.Macroeconomic Theory. Thomas J. Sargent. 2nd

ed. Academic Press, Orlando, FL, 1987. xxii, 510 pp.,illus. $44.50. Economic Theory, Econometrics, andMathematical Economics.Mammals. Their Reproductive Biology and Popula-

tion Ecology. J. R. Flowerdew. Arnold, Baltimore, MD,1987. vi, 241 pp., illus. Paper, $27.50.Mass Spectrometry. Reg Davis and Martin Frear-

son. Published for Analytical Chemistry by Open Learn-ing by Wiley, New York, 1987. xviii, 603 pp., illus.Paper, $35.95.Mathematical Geophylcs. A Survey of Recent De-

velopments in Seismology and Geodynaamics. N. J. Vlaaret al., Eds. Reidel, Dordrecht, 1987 (U.S. distributor,Kluwer, Norwell, MA). x, 407 pp., illus. $49. ModernApproaches in Geophysics.Maximum and Minimum Principles. A Unified

Approach, with Applications. M. J. Sewell. CambridgeUrnversity Press, Sew York, 1988. xvi, 468 pp., illus.$79.50; paper. $34.50.Maya Postolasslc State Formation. Segmentary

Lineage Migration in Advancing Frontiers. ohn W.Fox. Camrbndge University Press, New York, 1988. xvi,310 pp., illus. $44.50. New Studies in Archaeology.The Meaning of Quantum Gravity. H.-H. von

Borneszkowski and H.-J. Treder. Reidel, Dordrecht,1987 (U.S. distributor, Kluwer, Norwell, MA). viii, 132pp. $48. Fundamental Theories of Physics.Mediterranean Coasts of Israel and Sinai. Holo-

cene Tectonism from Geology, Geophysics, and Archae-ology. D. Neev, N. Bakler, and K. 0. Emerv. Taylor andFrancis, Philadelphia, 1987. xiv, 130 pp., ihus $22.A Modem Day Yankee In a Connecticut Court.

And Other Essays on Science. Alan Lightman. Penguin,New York, 1988. viii, 183 pp. Paper, $6.95.Molecular Design of Tautomeric Compounds. V.

I. Minkin, L. P. Olekhnovich, and Yu. A. Zhdanov.Rcidel, Dordrecht, 1987 (U.S. distributor, Kluwer,Norwell, MA). x, 280 pp., illus. $98.50. UnderstandingChemical Reactivity. Translated from the Russian.Molecular Neurobiology. Endocrine Approaches.

Jerome F. Strauss III and Donald W. Pfaff, Eds. Academ-ic Press, Orlando, FL, 1987. xii, 350 pp., illus. $85.Current Topics in Membranes and Transport, vol. 31.Moral Mazes. The World of Corporate Managers.

Robert Jackall. Oxford University Press, New York,1988. xii, 249 pp. $21.95.Motion Understanding. Robot and Human Vision.

W. N. Martin and J. K. Aggarwal, Eds. Kluwer, Nor-well, MA, 1988. xxiv, 432 pp., illus. $76. KluwerInternational Series in Engineering and Computer Sci-ence, vol. 44.Music as Cognition. The Development of Thought

in Sound. Mary Louise Serafine. Columbia UniversityPress, New York, 1988. xii, 247 pp., illus. $35.Neurolmmunomodulation. J. Region Perez-Polo et

al., Eds. Liss, New York, 1988. xii, 266 pp., illus. $90.Neutral Models In Biology. Matthew H. Nitecki and

Antoni Hoffman, Eds. Oxford University Press, NewYork, 1987. x, 166 pp., illus, $29.95.New Directions in Physics. The Los Alamos 40th

Anniversary Volume. N. Metropolis, D. M. Kerr, andGian-Carlo Rota, Eds. Academic Press, Orlando, FL,1987. xii, 292 pp., ilius. $34.95.The New Environmental Age. Max Nicholson.

Cambridge University Press, New York, 1987. xiv, 232pp., illus. $27.95.The New Unionism. Employee Involvement in the

Changing Corporation. Charles C. Heckscher. BasicBooks, New York, 1988. xii, 302 pp. $22.95. A Twenti-eth Century Fund Book.New Vaccines and Chemotherapy. Edouard Kur-

stak t al., Eds. Plenum Medical, New York, 1988. xxii,306 pp., illus. $49.50. Applied Virology Research, vol.1.Next. The Coming Era in Science. Holcomb B. No-

ble, Ed. Little, Brown, Boston, MA, 1988. xii, 190 pp.$17.95; paper, $9.95.

29 JULY I988

On Evolution and Fossil Mammals. Bjorn Kurten.Columbia University Press, New York, 1988. xviii, 301pp., illus. $40. Reprinted papers, with a foreword by thelate G. G. Simpson.Optics of Charged Particles. Hermann Wollnik.

Academic Press, Orlando, FL, 1987. x, 293 pp., illus.$60.The Other Nomads. Peripatetic Minorities in Cross-

Cultural Perspective. Apama Rao, Ed. B6hlau, Cologne,F.R.G., 1987. xiv 391 pp., illus. DM 96.

Parallel Computation and Computers for Artifi-cial Intelligence. Janusz S. Kowalik, Ed. Kluwer, Nor-well, MA, 1987. xxvi, 291 pp., illus. $58.95. KluwerInternational Series in Engineering and Computer Sci-ence.

Perceptrons. An Introduction to Computational Ge-ometry. Marvin Minsky and Seymour Papert, 2nd ed.MIT Press, Cambridge, MA, 1988. xvi, 292 pp., illus.Paper. $12.50.

Perturbation Bounds for Matrix Elgenvalues. Ra-jendra Bhatia. Longman Scientific, Harlow, U.K., andWiley, New York, 1987. xiv, 129 pp. Papr, $41.95.Pitman Research Notes in Mathematics, vol. 162.Phase Conjugation of Laser Emission. N. G.

Basov, Ed. Nova Science, Commack, NY, 1988. viii, 240pp., illus. $76. Proceedings of the Lebedev PhysicsInstitute, vol. 172. Translated from the Russian edltion(Moscow, 1986) by Kevin S. Hendzel.The Physics of Laser Plasma interactions. Wil-

liam L. Kruer. Addison-Wesley, Reading, MA, 1988. xx,182 pp., illus. $37.95. Frontiers in Physics, vol. 73.Plans and Situated Actions. The Problem of Hu-

man-Machine Communication. Lucy A. Suchman. Cam-bridge University Press, New York, 1987. xii, 203 pp.$34.50; paper, $11.95.

Policies for America's Public Schools. Teachers,Equity, and Indicators. Ron Haskins and Duncan Ma-crae, Eds. Ablex, Norwood, NJ, 1988. xiv, 303 pp., illus.$39.50. Child and Family Policy, vol. 6. Based on acolloquium series, Chapel Hill, NC, 1985.

Pollution Threat of Heavy Metals in Aquatic Envi-ronments. GeoffreyMance. Elsevier Applied, New York,1987. xii, 372 pp., illus. $86.50. Pollution MonitoringSeries.

Postglacial Vegetation of Canada. J. C. Ritchie.Cambridge University Press, New York, 1987. xiv, 178pp., illus. $70.

Principles and Applications of Photogeology.Shiv N. Pandey. Wiley, New York, 1987. xvi, 366 pp.,illus. $29.95.

Principles of Environmental Sampling. LawrenceH. Keith, Ed. American Chemical Society, Washington,DC, 1988. xxiv, 458 pp., illus. Paper, $59.95. ACSProfessional Reference Book.

Principles of String Theory. Lars Brink and MarcHenneaux. Plenum, New York, 1988. xiv, 297 pp.,$62.50. Series of the Centro de Estudios Cientificos deSantiago.

Probability and Causality. Essays in Honor ofWes-ley C. Salmon. Reidel, Dordrecht, 1987 (U.S. distribu-tor, Kluwer, Norwell, MA). xviii, 353 pp. $79. SyntheseLibrary, vol. 192.Problems in Physics. Mechanics. Brian Williams.

Omega Scientific, Wallingford, U.K., 1987. xii, 346 pp.,illus. Paper, £18.75.Psychobiology of Reproductive Behavior. An

Evolutionary Perspective. David Crews, Ed. Prentice-Hall, Engiewood Cliffs, NJ, 1987. xiv, 350 pp., illus.Paper, $20. Intended for upper-division undergraduateand first-year graduate students.The Psychology of Love. Robert J. Steinberg and

Michael L. Bames, Eds. Yale University Press, NewHaven, 1988. xii, 383 pp., illus. $29.95.The Psychology of Sex Roles. David J. Hargreaves

and Ann M. Colley, Eds. Hemisphere (Harper andRow), New York, 1987. xiv, 323 pp. $35.Radon and Projection Transform-Basd Com-

puter Vision. Algorithms, A Pipeline Architecture, andIndustrial Applications. J. L. C. Sanm, E. B. Hinkle, andA. K. Jain. Springer-Verlag, New York, 1988. viii, 132pp., illus. $39. Springer Series in Information Sciences,vol. 16.

Rationing Medicine. Robert H. Blank. ColumbiaUniversity Press, New York, 1988. xiv, 290 pp. $25.Reasoning In Medicine. An Introduction to Clinical

Inference. Daniel A. Albert, Ronald Munson, and Mi-chael D. Resnik. Johns Hopkins University Press, Balti-more, MD. 1988. xiv, 263 pp. $30. Johns HopkinsSeries in Contemporary Medicine and Public Health.Research on Laser Theory. A. N. Orayevskiy, Ed.

Nova Science, Commack, NY, 1988. viii, 288 pp., illus.$92. Proceedings of the Lebedev Physics Insititute, vol.

171. Translated from the Russian edition (Moscow,1986) by Kevin S. Hendzel.Restoration Ecology. A Synthetic Approach to Eco-

logical Research. William R. Jordan mT, Michael E.Gilpin, and John D. Aber, Eds. Cambridge UniversityPress, New York, 1988. x, 342 pp., illus. $39.50.

Rethinking Psychological Anthropology. Conti-nuity and Change in the Study ofHuman Action. PhilipK. Bock. Freeman, New York, 1988. xii, 254 pp., illus.Paper, $12.95. Revision of Continuities in PydodogicalAnthropolgy.The Rewiring of America. The Fiber O tics Revolu-

tion. C. David Chaffee. Academic Press, Orlando, FL,1987. xii, 241 pp., illus. $24.95.Rhinos. Endangered Species. Malcolm Penny. Facts

on File, New York, 1988-. x, 116 pp., illus., + plates.$19.95.Risk Assesment and Management. Lester B.

Lave, Ed. Plenum, New York, 1987. xii, 740 pp., illus.$125. Advances in Risk Analysis, vol. 5. From a meeting,Washington, DC, Nov. 1985.The Role of Fire In Ecological Systems. L. Tra-

baud, Ed. SPB, The Hague, 1987. viii, 157 PP., ilus.Paper, $29.50. From a symposium, Syracuse, NY, Aug.

Science and Objectivity. Episodes in the History ofAstronomy. Norriss S. Hethenngton. Iowa State Uni-versity Press, Ames, 1988. xii, 168 pp. illus. $24.95.

Self-Organizing Systems. The Emergence ofOrder.F. Eugene Yates, Ed. Plenum, New York,1987. xxii, 661pp., illus. $95. Life Science Monographs.Seleced Scientific Papers of Alfred Land*. A. 0.

Barut and A. van der Merwe, Eds. Reidel, Dordrecht,1987 (U.S. distributor, Kiuwer, Norwell, MA). xii, 557pp., illus. $99. Fundamental Theories of Physics.Sequence Analysis In Molecular Biology. Trea-

sure Trove or Trivial Pursuit. Gunnar von Heijne. Aca-demic Press, Orlando, FL, 1987. xiv, 188 pp., illus.$27.95.

Social Loeaming. Psychological and Biological Per-spectives. Thomas R. Zentall and Bennett G. Galef, Jr.Erlbaum, Hillsdale, NJ, 1988. xii, 357 pp., illus. $45;paper, $24.95.

Special Functions of Mathematical Physics. AUnified Introduction with Applications. Arnold F. Niki-forov and Vasilii B. Uvarov. Birkhauser, Basel, 1988.xviii, 427 pp. $119. Translated from the Russian edition(Moscow, 1978) by Ralph P. Boas.Studies In Neotropical Mammalogy. Essays in

Honor of Philip Hershkovitz. Bruce D. Patterson andRobert M. Timm, Eds. Field Museum of Natural His-tory, Chicago, 1987. viii, 506 pp., illus. Paper, $35.Fieldiana: Zoology, no. 39.

Survival and Dormancy of Microorganisms. YigalHenis, Ed. Wiley-Interscience, New York, 1987. xii, 355pp., illus. $49.95.Techniques of Mei Crystallization. Gilbert J. Sloan

and Andrew R. McGhie. Wiley-Interscience, New York,1988. xii, 532 pp., illus. $85. Techniques of Chemistry,vol. 19.Technology and Contemporary Life. Paul T. Dur-

bin, Ed. Reidel, Dordrecht, 1987 (U.S. distributor,Kluwer, Norwell, MA). viii, 320 pp. $69. Philosophyand Technology, vol. 4.Test-Tube Conception. A Blend of Love and Sci-

ence. E. Peter Volpe. Mcrcer Univcrsity Press, Macon,GA, 1987. x, 111 pp., illus. $24.95; paper, $14.95.The Theory of Target Compression by Longwave

Laser Emission. G. V. Sklizkov, Ed. Nova Science,Commack, NY, 1987. vi, 167 pp., illus. $73. Proceed-ings of the Lebedev Physics Institute of the Academy ofSciences of the USSR, vol. 170. Translated from theRussian edition (Moscow, 1986) by Kevin S. Hendzel.

Tides, Surges and Mean Sea-Level. David T.Pugh. Wiley, New York, 1987. xiv, 472 pp., illus. $101.Tippecanoe and Trinkets Too. The Matcrial Cul-

ture of American Presidential Campaigns, 1828-1984.Roger A. Fischer. University of Illnois Press, Urbana,IL, 1988. x, 322 pp., ilus. $34.95.Using Literature. Stuart James. Published for Ana-

lytical Chemistry by Open Learning by Wiley, NewYork, 1987. xvi, 598 pp. Paper, $37.95.Why Work. Leading the New Generation. Michael

Maccoby. Simon and Schuster, New York, 1988. 270pp. $18.95.Work Experience and Psychological Develop-

ment Through the Life Span. Jeylan T. Moriimer andKathryn M. Borman, Eds. Published for the AmericanAssociation for the Advancement of Science by West-view, Boulder, CO, 1988. viii, 306 pp., Paper, $29.95;to AAAS members, $23.96. AAAS Selected SymposiaScrics, vol. 107.

BOOK REVIEWS 607

POSITIONS WANTED

Biocheniucal Engineer, Biophysicist, Ph.D. 20 years ofresearch and industrial experience in monitoring andoptimization of fermentation processes. Knowledgeablein UV/VIS/IR and fluorescence spectroscopy, off-gasand wet chemical analysis, HPLC, GLC, TLC methods.Immigrated to the U.S.A., January 1988: Russian native.Employment authorized. Will relocate. Box 119, SCI-ENCE.

Ph.D. (Microbiology), 1988. Seeks immediate post-doctoral position. Research interests include but notrestricted to: molecular (chemical and genetic) aspects ofcellular (prokaryotic and eukaryotic) adhesion. Experi-ence with microbial physiology/biochemistry; microbialexopolymer chemistry related to adhesion; HPLC; TLC;column chromatography, gas chromatography/massspectrometry; electron microscopy. Working knowledgeof PC-based and mainframe productivity programs. Box122, SCIENCE.

6o8

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Ccll Biologist. Ph.D. Extensive experience in academicand biotechnology research and development in tumorcells, large scale tissue culture, lymphocyte biology, andimmune-mediated tumor cell cytotoxicity. Seeking in-dustrial research position. Box 124, SCIENCE.

Imagc Processing and Machine Vision. Expert in thedesign and construction of practical computing systems,especially devices for image analysis and machine vision.Extensive experience in medicine and biology but knowl-edgeable in other areas. Have worked in both commer-cial and university settings. Interested in consulting onproblems of both hardware and software design. RobertS. Schehr, Ph.D., P.O. Box 109, Lake Placid, NY 12946.Telephone: 518-523-9086.

Molecular Biologist, Ph.D. Research in gene regulationofoncogenes and Ig genes. Broad knowledge in a varietyof technigues used in cell culture, immunology, molecu-lar genetics and transgenic mice. Seeks group leaderposition in academic industrial laboratory in Europe.Excellent publication record. Box 117, SCIENCE.

Toxicologist. Ph.D., Board-certified with extensive in-dustrial and governmental experience (laboratory andnon-laboratory). Seeks industrial/consulting position in

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POSITIONS OPEN

ASSISTANT LABORATORY DIRECTOR: TheGenetics & IVF Institute invites applications for perma-nent position with reproductive cryopreservation labora-tory in Houston, Texas. Applicants should have B.S. orM.S. and experience in semen or embryo cryopreser-vation, artificial insemination, embryo transfer, or IVFprocedures. Salary commensurate with experience andeducation. Send resume to: Dr. Edward F. Fu r, TheGenetics & IVF Institute, 3020 Javier Road, Fairfax,VA 22031. Telephone: 703-698-7355.

The USDA, Agricultural Research Service is seekingcandidates for the position of AGRICULTURALADMINISTRATOR, GM-401-15. The successful can-didate will serve as Center Director of the Red RiverValley Agricultural Research Center, Fargo, North Da-kota. Responsibilities include planning, coordinating,and evaluating research programs and providing leader-ship and management of programs. Applicants mustmeet specified education and/or experience requirements.Ph.D. degree in biological sciences, agricultural, naturalresource management, or allied disciplines plus profes-sional experience directly related to the position is de-sired. Knowledge of biological and physical sciences, andresearch methods in relation to crop production, grainprocessing, and genetic and biochemical processes associ-ated with pesticide metabolism of plants and animals isdesired. Knowledge of research planning and evaluationand skill in resource management desirable. Salary range$54,907 to $71,377 based on experience. For informa-tion about the position, contact: Dr. T. J. Army,Telephone: 303-229-5557. For filing procedures, con-tact: Cathleen Enuton, 301-344-3138. Responsedeadline is 31 August 1988. Must be U.S. citizen. AnEqual Opportunity Employer.

ASSISTANT PROFESSOR OFMEDICAL ONCOLOGY

The University ofTexas Health Science Center at SanAntonio, Department ofMedicine, will fill a tenure-trackposition in 1988. The successful candidate will have anM.D. degree and be Board-certified or eligible in medicaloncology and have a strong postdoctoral research record.Preference will be given to candidates with molecularapproaches to oncology problems. Applicants shouldsubmit curriculum vitae, a letter discussing current andfuture research plans, and three letters ofreference to:Dr. William L. McGuire, Department of Medicine,Division of Oncology, University of Texas HealthScience Center, 7703 Floyd Curl Drive, San Antonio,TX 78284-7884. An Equal Opportunity/AffirmativeAction Employer.

UNIVERSITY OF CALIFORNIADEPARTMENT OF DERMATOLOGY

Applications are invited for a Ph.D.-level ADJUNCTASSISTANT PROFESSOR to coordinate an NIHresearch project on sphingolipid metabolism in culturedkeratinocytes. Prior experience in lipid biochemistry andmetabolism essential. Salary: Negotiable.

Contact: Dr. Peter M. Elias, Professor and Vice-Chairman, Department of Dermatology, VAMC,4150 Clement Street, San Francisco, CA 94121.

The University of Califomia is an Affirmative Action/EqualOpportunity Employer.

ASSISTANT PROFESSOR BIOPHYSICALCHEMISTRY/MEMBRANE BIOLOGY

The Department of Pathology and Laboratory Medi-cine at Hahnemann University invite applications frombiochemists, biophysicists, or physiologists who are in-terested in joining our Membrane Biology Laboratory.The candidate should have a strong background in eitherbiophysical techniques (e.g., fluorescence, magnetic reso-nance) or in molecular mechanism ofbiological transportwith an interest in bioenergetics, proton transport andcalcium transport. Existing research projects include:proton transport in mitochondria, calcium regulation inthe brain, and alcohol effects on membranes. The appoin-tee is expected to participate in these projects, with anopportunity to develop an independent project. Thelaboratory is well equipped and endowed for thesestudies. In addition, the appointee's duties may includeteaching, supervision of students and technicians, andsome laboratory administration. Salary is competitive.Submit application, including recent reprints and thenames and addresses of three references to: Dr. Hagai

Rottenberg, Department of Pathologv and Labora-tory Medicine, lahnemann University, Broad andVine, Philadelphia, PA 19102.

DEPARTMENT OF MICROBIOLOGYNORTH CAROLINA STATE UNIVERSITY

RALEIGH, NORTH CAROLINAThe Department of Microbiology, North Carolina

State University, has available a newly created researchand teaching position as ASSISTANT PROFESSORIN IMMUNOLOGY. A Ph.D. degree in immunologyand postdoctoral experience are required. The position isa 12-month tenure-track appointment and includes con-

tinuing institutional research support. The successfulcandidate is expected to develop a vigorous researchprogram in basic immunology and to direct graduatestudents. Excellent opportunities exist for collabrationwith other immunologists on campus and in the Re-search Triangle Area.

Applicants are invited from qualified individuals withexpertise in immunology. Included in the applicationshould be a statement of research interest, curriculumvitae and list of publications. Have three letters ofrecommendations submitted and indicate your profes-sional association with these individuals. Applicationmaterials should be sent to:

Dr. Geraldine LuginbuhlImmunology Search CommitteeDepartment of Microbiology

Box 7615North Carolina State University

Raleigh, NC 27695-7615The closing date for applications is 30 September

1988 or until a suitable candidate is selected.North Carolina State University is an Equal Opportunity

Employer.

The Department of Neurological Surgery at the Uni-versity of Virginia School of Medicine announces theavailability of a full-time position as ASSISTANTPROFESSOR OF NEUROLOGICAL SURGERY.The candidate must be Board-certified or Board-eligiblewith a primary interest in stereotaxic pain and epilepsysurgery. Applicants should send curriculum vitae andbibliography to: John A. Jane, M.D., Ph.D., Depart-ment ofNeurological Surgey, University ofVirginia,School of Mcdicine, Box 212, Charlottesville, VA22908. The University of Virginia is an Affirmative ActionlEqual Opportunity Employer.

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POSITIONS OPEN

rTenure Track Staff Positionsat the Biological ResponseModifiers Program, NCI Scient.st

The Clinical Research Branch, Biological Response ModifiersProgram, Division of Cancer Treatment, the National Cancer TUmorIColi BologyInstitute, National Institutes of Health, Public Health Service, is riton Biosciences Inc. has an opening for a Staff

accepting applications for two staff positions. Positions are Scientist to take charge of our tumor/cell biologyavailable to physicians who are either Board eligible or Board group. This group is engaged ina variety of projectscertified in medical oncology. intheareas of tumor biology, growthfactors, growth

factor receptors, lymphokines, and oncogenes.The incumbent will be responsible for primary patient care and

f

the design and conduct of clinical trials utilizing biological Wedesireanindividualwithanestablishedrecordresponse modifiers. Emphasis is also placed on continuity of of research in one or more of the above fields. It ispatient care, prnciples of patient management, and correlation of ant5caPatedthatxthen sccessful candid ateowillhavedinical response with changes in immunologic parn 5-yearsae eriencewbeyondthe pos-doctorllevel

and preferencewilbe givento tose havingindusStaff Fellows are eligible for benefits including health insurance, trial experience, incluing responsibility for a

life insurance options, vacation, and sick leave. In addition, travel researc group.

expenses for the Fellow to his duty staton are available. Triton Biosciences Inc., is an emerging, fully inte-grated pharmaceuticaland diagnosticscompany

For furter information and application procedures, please contact: located in the San Francisco Bay Area. We offercompetitie salaries and benefits including a full

't- I/S Ronald G. Steis, M.D. relocation package. For consideration, please;:::h, Medical Pavilion send your C.V. and names of three references to:

Frederick Memorial Hospital Triton Biosciences Inc., Box JJM, 1501 Harbor BayZ 335 Park Avenue Parkway, Alameda, CA 94501. Triton is an Equal

O,P sb Frederck, Maryland 21701 Opporht ity Employer.h EP\V (301)698-5929

An NIH Associate Training ProgramNIH is an Equal Oppornity Employer Triton Biosciences Inc.

FACULTY,APPOINTIMENT

GASTROINTESTINAL JapanThe Asia-Pacific Research-Center for Monsanto Agri-

RVESEcARCH Company is seeking a Reseach Biologist Ap-

plicants with a Ph.D. are preferred although M.S. applicantswith exceptional experience will be seriously considered.

Major university/medical center seeks and Qualified applicants must have 5-10 years experience andindividual experienced in G.I. physiolo- possess a background in pbnt science (plant pathology,

crop science, plant physiology or agronomy) research.gy/pharmacology/arachidonic acid metabo- Research responsibilities are product odriene and will

lism to work with the Chairman of the include allaspects of the discovery, advanced evaluation andDepartment of Medicine. Candidate must initial development of crop protection products. The suc-be capable of independent work. M.D. or cessful candidate will work closely with research colleaguesbe capableof.independentwork. M.D. or

in the U.S. and Europe and with marketing and productPh.D. required. This position will provide a development in the Asia-Pacific region. Applicants should

faculty appointment in the Department of have strong technical and communication skills, the abilityMedicine plus a competitive salary and to work within a product oriented multidisciplinaryteam, and

*fringe benefits. Send resumes, to: Donald E. | vmust be fluent in verbal and written Japanese. Written andE.verba English proficiency is required.

Wilson, M.D., Chairman, Department ofWilson,M.D., Chairman, Department of The Asia-Pacific Research Center was opened in 1984 and isMedicine, SUNY Health Science Wilson located about 60 kmn northeast of Tokyo and about 20 km

Center at Brooklyn, 450 Clarkson Avenue, southeast of Tsukuba Science City. A group of 22 perma-Box #50, Brooklyn, NY 11203. nent staff does crop protecton product discovery and

Box #50, Brooklyn, product support re rch in biology, formulation chemis-try, and environmental chemistry. For confidential consider-

Un| of N w YMonsanto Japan Ltd., 520 Kokusai Bldg.,1M-1, MarunouchiHEALTH SCIENCE CENTER 3-chome, Chiyoda-ku, Tokyo 100 Japan. Equal OpportunityAT BROOKLYN E mploye

ElI DMC #C-0197EO/AA Employer

POSITIONS OPEN

ASSISTANT PROFESSOR, POSiTONSDIVISION OFP PHYSIOLOGY

DEPARTMENT OF CELL BIOLOGYDUE UNIVERSITY MEDICAL CENTERTwo tenure-track appointments are available to candi-

dates with a Ph.D. and/or M.D. who have postdoctoralcxperience and are strongly comnmitted to a program inthe areas, of sys!enic andgimtegrativc physiology. Prefer-ence will be given to canetes w arch willcompkement eusting prgrams in cell physiology andbiophysics. Teaching responsibilities wilfrequimr partia-paton in the medical and graduatc school courses inareas that relate to integrative rspiratory, cardiovascularand/or renal physiology. Please send curriculum vitae,statement of rch plan, teaching experience and thenames of at least thre rerences o: Phyol SearchCrm ittee, Duke Uniersity Media Center, Box3709-E, Du m, NC 2771. Duke University is anEqual Opportanity/Afrmatve Action Employer.

ASSISa PROFESSORTOfCOLOGY

The Toxicology Program at North Carolina StateUniversity invites applications for a 12-month tenure-track position that is available to investigatc the mecha-nisms ofxenobiotic toxicit,y utilng a molcular/celularapproach. The successful candidate will have a Ph.D. intoxicology or relited fidd and postdocioral cxperience.The applicant will b expected to develop an mdcpendent, competitively funded research proam in mofecu-lar and/or celular toxicology and particpate in graduatestudent eductidon. Submit curricwum vitae, pertinentreprints, a statement of rescarch interests, and the namesofthre references by 15 September 1988 to:

Dr. Ernest HodpgsnToxicol Proam

?4orth Carolina StatiJuivershtyCAMps 1to 7633

Rallgh,2C 27695-7633North Carolina State University is an Equal Opportunity

Employer and operates under Affirmative Action Policy. TheUniversity strongly encourages all qualified applicants.

Applications are invited fron suitable qualified indi-viduas for ASSISTANT PROPESSORS OF ANI-MAL SCIENCE, and AGRICULTURAL ECO-NOMICS. Tenute-track 12-month employment (initial-h, a 3-year contract). Major activity is research. Indudessome teaching and extcnsion work in both positions.Minitnu qualifications: Ph.D. degree in animal scienceand agricultural economics respecvely. Send rdsumdand request threc referees to send their cvaluations to:Mr. Jose T. Barcias,Ac en, Collge of Agri-culture and Life Sciaec,niversity of Guam, Mxii-gilao, Guam 96923.

ASSISTANT RESEARCH PROFESSOR TheDeparunent of Biochemistry is seeking a person withsignificant expenence in the characterization of proteinsand the investigation of protein-protein and protein-ioninteractiotils by various physical means; including analyti-cai ultracentrifation,- viscosity, light scattering and uvand fluorescenc spectoscopy. A Ph.D. in chemistry orbiochemistry and postdoctoral experience for 3 years ormore preferred. Experience with nplk roteins a dcfiniteplus. Salary ang $32,00. to $40,000 per year. OnlyU.S. citizt nmay apply. Applicants should provide curric-ulum vitae and names of three references by 19A t1988. Send applications to: Dr. Chatles Slatery, -pare entf ochmit, School ;ofMedicne, LomaLinda University, Loma Linda, CA 9235U.

Fels Institute ofCancer Research and Molecular Biolo-gy is lookinig for outstanding candidates at the levels ofASSOCIATE AND ASSISTANT PROFESSOR inthe field of human retrovirology. The candidate shouldhave an outsianding track record in molecular studies ofhuman retroviruses induding HIV and are expected todevelop strong independcent research programs. Theapplicants should submit curriculum vitae and a briefption of their research interests to: FELS Institute

of Cancer Rrewalch and Moleclar Biology, TempleUniversi Scool of Medidne, Medical ResearchBWildng, 3420 Norti Brod Set, Phidephia PA19140. An Equal Opportunity/Afirmative Action Employer.

610

Research Opportunities at PfizerPfizer, a U.S. based multinational pharmaceutical company, is seeking qualified scien-tists to join our Central Research facility in Groton, Connecticut. Immediate openingsare available in the following disciplines:

Molecular NeurobiologyParticipate in multidisciplinary approaches to therapy for CNS disorders and neu-rodegenerativediseases in our Molecular Neurobiology group. You should possessanMS or BS degree in Biochermistry, Molecular Biology or a related field. You shouldalo have laboratory experience in two or more of the following areas: Receptor bind-ing; Enzymatic assays; ELISA; Molecular biology; Tissue culture.

Molecular GeneticsApply your strong background and skills in molecular biology to exploratory biomed-ical.research in our Molecular Genetics research group. You should possess an MSor BS degree with significant laboratory research experience. You should also beskilled in basic recombinantDNA techniquesand have additional experience in oneor all of the following: Mammalian cell culture; mRNA isolation, Characterization; Eu-caryotic transcription regulation methodology; Protein purification.Pfizer offers a stimulating scientific research environment with the opportunity to in-teract with scientists from several disciplines. In addition, Pfizer has a competitivecompensation/benefit package a4long with relocation assistance to this southeasternConnecticut shoreline community. Please send a resume indicating position of in-terest, a description of your research experience, and names of three references to:Mrs. Lorraine Corr, Personnel Associate, PfizerCentral Research, Eastern Point Road,Groton, CT 06340.

An equal opportunity employer

Senior Investigator,Medicinal ChemistryA health care company that markets prescription and proprietaryproducts for human and animal health care has an opening for aSenior Investigator in its Department of Medicinal Chemistry at itsresearch and development facIlity in King of Prussia, Pennsylvania.The principal duties of the position include (i) Conceiving, planningand executing synthetic/organic medicinal chemical research aimedat the discovery of Inhibitors f enzymes involved in the cholesterolbiosynthesis, prostatic groithfctors and trophic factors of hormonallysupported tumors; (ii) utiliing molecular modeling techniques, asym-metric synthesis, photochemistly and manipulation of phosphorous andfluorine containing molecules to pursue such research; (iii) collaborat-ing with other research groups in the development of biological orbiochemical assays to evalluate the potential of the synthesized com-pounds as novel drugs; (iv) direcling a team of Senior Chemists incarrying out the re isite research; (v) compiling and evaluating theexperimental data generated and reporting on research findings in-cluding, where appropriate, in national and interational professionaljournals and (vi) evaluating the work of Senior Chemists who arealready members of the research team and hiring of additionalpersonnel to serve as team members.The minimum requirements for the position are a Ph.D. degree inChemistry and seven years experience In synthetic/organic mnedicinalchemical research designing and synthesizin9 complex moleculessuch as enzyme inhibitors that serve as new drugs to lower serumcholesterol levels and to treat benign prostatic hypertrophy and breastcancer, including three years experience in molecular manipulation ofphosphorous and fluorine containing molecules.Salary of $56,937 with liberal employee benefits. Qualified applicantsshould submit resume or curriculum vitae to Philadelphia Job Bank,N. 3rd Street, Philadelphia, PA 19123 and refer to Order Number4192905. Equal Opportunity Employer, M/F/H/V.

El I.

Argonne National LaboratoryPostdoctoralResearch AppointmentThe Biological, Environmental, and Medical ResearchDivision has a postdoctoral position available in the areaof biochemical/molecular toxicology. The focus of theresearch will be to examine the molecular basis forcadmium-induced bone loss that has been identified inboth in vitroand in vivosystemsthatare relevanttostudy-ing mechanisms of postmenopausal osteoporosis.Candidates should have experience in biochemistry/physiology, preferably related to this research. Competi-tive salary iscommensurate with experience. Fortechnicalinformation, contact Dr. Maryka H. Bhattacharyya,(312) 972-3923. Applications should include curriculumvitae and the names of three references. They should beforwarded to:

Rosalie L. BottinoI>ON A L Employment and Placement

0 Box D-BEM-POSTDOC-55Argonne National Laboratory

0 9700 South Cass AvenueArgonne, Illinois 60439-4844.

t*^rc+'tt Argonne is an affirmativeaction/equal opportunityemployer.

Agricultural US Department of AgricultureResarch Eastern Regional Research CenterService 600 E. Mermaid Lane

Philadelphia, PA 19118

POSTDOCTORAL RESEARCH ASSOCIATEPOSITIONS

Four ,RESEARCH ASSOCIATE appointments are available immediatelyfor conducting research at this large, state-of-the-art, multidisciplinaryresearch facility in' suburban Philadelphia. Areas of research are:Enzymatic reactions In supercritical fluid: proteolysis of wool Insupercritical carbon dioxide. Ph.D. in Chemistry or Biochemistry withexpertise in enzymatic reactions or in biopolymers. Contact Dr.-WilliamN. Marmer; refer to position RA-88-20.Novel us of carbohydrates for inhibition of enzymatic browning Infruit and vegetables;'applied, basic, analytical and biochemicalaspects. Ph.D. in' Biochemistry, Chemistry, Food Science or PlantPhysiology. Contact Dr. Kevin B. Hicks; refer to position RA-88-19.Interaction of aluminum Ions with purified plasma membrane ofplant root cells. Ph.D. in Biochemistry or Plant Physiology with exper-tise in membrane structure an,d function. Contact Dr. Shu-l Tu; refer toposition RA-88-25.Rduced virulence of Salmonella and other foodborne organismsthrough induced cell surface alterations. Ph.Q. in Microbiology orBchemistry wifth knawldge of pathogenic microbiology and biochemicaisolation/purification. Contact Dr. Robert C. Benedict; position RA-88-27.

Appointments are for up to two years. Generally, new Federal employ-ees are hired at the first salary level, or step,'of the General Schedule(GS) grade. The salaries associated with the first steps of these'GS-11and GS-12 positions are $27,716 and $33,218, respectively. Candidatesmust have obtained a' relevant Ph.D., preferably within the last threeyears. Applicants shou!d send resumes, -which include the names andaddresses of three'references, to the appropriate contact at the-aboveaddress. Further directions for application will be provided' by thecontact. For information, call (215) 233-6400.

-ARS IS AN EQUAL OPPORTUNITY EMPLOYER -- WOMENAND MINORITIES ARE ENCOURAGED TO APPLY-

U.S. Department of EnergyFossil Energy

Postgraduate ResearchProgram

METC conducts research in fossil energyconversion and utilization. Several post-graduate positions available in systemsanalysis of fossil energy technologies,applied sciences research, engineeringR&D, and project management.

- Graduate degreewithin last 3 yearsScience orengineering background 100Stipend based ondegree and research areaU.S. citizens and PRAs eligible I iInfomiaton and applications

j 7, >Fossil Energy Postgraduate Programn,,0>University Programs DivisionLig.J Oak Ridge Associated Universities

g W Oak RlTNP.O.Box 117Oak Ridge, TN 37831-0117(615) 576-3456

Research Assistants'Assocae

Genentech, Inc., a leader in the field of biotechnology, hasa number of opportunities available for Research Assis-tants/Associates. Working on programs to discover newhuman pharmaceuticals, these positions offer a challengingopportunity to be a 'key team participant.

Typical requirements include a BS/MS in Biochemistry,Molecular Biology, or closely related scientific field, and aminimum of 2 years' experience in one or more of the fol-lowing: molecular biology techniques, assay development,biochemical techniques, tissue culture techniques, proteinsequencing and characterization, and hybridomatechniques.Genentech, Inc. offers an excellent salary and benefitspackage coupled with the opportunity to make a signfficantcontribution to our organization. For consideration, pleasesend your resume to Yvonne Davino, Human ResourcesDepartment XX,- Genentech, Inc., 460 Point San BrunoBlvd., South San Francisco, CA 94080. An equal oppor-tunity employer.

GeI ntech,I.0U13O

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POSITIONS OPEN

BIOCHEMIST. Research scientist position in a dy-namic biotechnology company at its research facility mRochester Hills, Michigan. Ph.D. in biochemistry andexperience in protein purification and mammalian cellcuture are required. Unique opportunities for profes-sional growth. Competitive salary and benefits. Forfiuther information call 313-852-8815 or send a resumeand names of three references to: Director of Rescarch,Oxford Biomedical Research, Inc., 1858 Starr BattDrive, Rochester Hills, MI 48309.

BIOCHEMISTRY FACULTY POSMIIONUNIVERSITY OF WISCONSIN-MADISONThe Biochemistry Department, University of Wiscon-

sin-Madison invites applications for a tenure-track posi-tion at the assistant professor level. We are particularlyinterested in applications from individuals whose re-search emphasizes chemical approaches to fundamentalproblems in biochemistry or molecular biology. Potentialareas include enzymology, bioorganic chemistry, thechemistry of proteins, nucleic acids, complex carbohy-drates, or of low-molecular weight compounds. Thesuccessfil candidate is expected to develop a vigorousindependent research programs and participate in theundergraduate and graduate teaching programs of thedepartment. Applications, induding curricnum vitae, listof publications, summary of past work and accomplish-ments and a statement of plans for future research,should be sent to: Professor William S. ReznikoffChairman, Department of Biochemistry, Universityof WisconsiMadison, 420 Henry Mall, Madison,WI 53706. In addition, applicants should arrange forthree letters of reference to be mailed to the sameaddress. To assure consideration, all application materialsshould be received by 1 October 1988. The University ofWisconsin-Madison is an Affirmative Action/Equal Opportuni-ty Employer, and encourages applications from women andminorities.

CANCER RESEARCH TECHNOLOGIST. For-ty hours per week. 8:00 a.m. to 5:00 p.m. $23,462 peryear salary. To process tissues for histological, histo-chemical, and immunochemical studies; perform electronmicroscopy and high resolution electron microscopicautoradiography. Prepate special diets containing carcm-ogens and maintain animals for long-term immunogenicstudies and transplant and maintain rats bearing pancre-atic and liver carcinoma; photography; printing anddeveloping electron microscopy; morphometric analysis.Education required, Bachelor Degree Arts and Science.Major field ofstudy in medical technology. Two years ofexperience. Must be registered in Illinois and have passedthe test required by the American Society of ClinicalPathologists. (ASCP) Metropolitan Chicago area. Sendresumes to: Illinois Department of Employment Se-curity, 401 South State Street-3 South, EIL60605, Attention: Marie E. Ninneman. Reference #7950-N. Employer paid ad.

CHAIRMAN, DEPARTMENT OF OTOLAR-YNGOLOGY AND HEAD AND NECK SUR-GERY-Georgetown University School of Medicineseeks an experienced academician to lead new depart-ment with established residency. Candidates should haveactive research program and be prepared to assumeteaching and patient care responsibilities. Send curricu-lum vitae to: Louis F. Rittelmeyer, M.D., Chairman,Search Committee, Deprtment of Psychiatry,Georgetown University Ho it Washington, DC20007. Affirnative Action/Equal Opportunity Employer.

CHAIRMANDEPARTMENT OF PHARMACOLOGY

Jefferson Medical College ofThomas Jefferson Univer-sity invites applications and nominations for the positionof Professor and Chairman of the Department of Phar-macology. Candidates must have a distinguished recordof achievement in a field of research of current impor-tance, and demonstrated commitment to teaching atgraduate and undergraduate levels. The position offers anexcellent opportunity to develop an outstanding depart-ment in an atmosphere of strong University commitmentto academic and scientific growth. Applications andnominations with a complete curriculum vitae should bcsent to: Emanuel Rubin, M.D., Search Committee forPharmacology, Jefferson Medical College, 1020 Lo-ams Street, Room M-63, Philadelphia, PA 19107. AnAffirmative Aaion/Equal Opportunity Employer.

CHAIRPERSON,DEPARTMENT OF ANATOMYSCHOOL OF MEDICINE AND

HEALTH SCIENCESTHE GEORGE WASHINGTON

UNIVERSITYThe George Washington University School of Medi-

cine and Health Sciences in Washington, D.C. invitesapplications/nominations for the position ofChairpersonof its Department ofAnatomy which will be vacant at theend of the current academic year. The successful candi-date will possess an active research program and anoutstanding record of scholarly achievement and teach-ing skills in the anatomical disciplines; the leadershipqualities and administrative skills necessary to developthe diverse educational and research programs of thedepartment; and a broad appreciation ofthe multifacetedneeds of modem anatomy departments with particularemphasis on the neurosciences. The Department is re-sponsible for teaching medical students, residents, gradu-ate students and health specialists in anatomy and rele-vant areas ofthe neurosciences. The George WashingtonUniversity Medical Center is strongly committed toresearch.

The George Washington University Medical Center is anAfirmative Action/Equal Opportunity Employer. Inquiriesand curricula vitae should be directed to: Dr. Robert M.Allman, Department of Radiology, Chairperson, De-partment of Anatomy Scarch Committee, TheGeorge Washington University Medical Center, 90123rd Street, N.W., Washington, DC 20037.

CHAIRPERSON OF ANATOMY AND CELLBIOLOGY. The University ofKansas Medical Center isseeking a chairperson for the Department of Anatomyand Cell Biology. The Department presently has a di-verse research program with strength in neuroscience andcellular development. The successful candidate must havean active research program and a national reputation inone of these areas, though candidates with superiorqualifications in other areas will be considered. Previousadministrative experience is desirable. Nominations, let-ters of inquiry, and applications (to include curriculumvitae and bibliography, a description ofresearch activitiesand administrative experience, and the names of threereferences) should be sent to: Dr. David Morrison,Chairman, Department of Microbiology, Universityof Kansas Medical Center, Kansas City, KS 66103.The University ofKansas Medical Center is an Equal Opportu-nity/Afirmative Action Employer.

_IMMUNOMEDICSDIRECTOR, IMMUNOCHEMISTRY

Immunomedics, the pioneer Company in the use ofantibodies for cancer imaging and therapy, is expandingits Immunochemistry Department.

Reporting to the Group Director ofImmunology andChemistry, responsibility will be to direct a team ofscientists developing reagents for clinical trials.

Applicants should have experience in the purificationand characterization ofmonoclonal antibodies/fragmentsunder GMP for in vivo use. Experience in writingspecifications for IND/PLA FDA submissions preferred.We offer an attractive employment package including

paid health/dental, a 401K retirement plan, and theopportunity for stock and stock option merit rewards.

Please send curriculum vitae, salary requirements andcareer objectives to:

Personnel DirectorImmunomedics, Inc.150 Mt. Bethel Road

CN #4918Warren, NJ 07060

Equal Opportunity Employer MIF.

DIRECTOROF GASTROENTEROLOGYANDHEPATOLOGY-The Departrnent of Medicine of theJefferson Medical College is seeking a Director for theDivision of Gastroenterology and Hepatology. Respon-sibility for research, teaching and clinical programs atThomas Jefferson University. Please forward mquiriesand curriculum vitae to: Willis C. Maddrey, M.D.,Chairman, Departent of Medicine, Jefferson Medi-cal College ofThomas Jefferson University, 1025Walnut Street, Philadelphia, PA 19107. Equal Oppor-tunity/Affirmative Action Employer.

CLINICAL PATHOLOGY. The Department ofPathology at the University of California, Los Angeles(UCLA) School ofMedicine has JUNIOR FACULTYPOSITIONS available in hematopathology and micro-biology beginning on or after 1 January 1989 and clinicalchemistry/toxicology-therapeutic drug monitoring andtransfusion medicine beginning 1 July 1989. Qualifica-tions include an M.D. degree, certification in clinical orspecialty pathology or equivalent experience, demon-strated research ability and potential for the developmentof an independent research program. Applications in-cluding curriculum vitae, summary of research interests,and names and addresses of four references should besent to: P. A. Cancilla, M.D., Chairman, Departmentof Pathology, UCLA School of Medicine, Los Ange-les, CA 90024-1732. UCLA is dn Equal Opportunity!Affirmative Action Employer. Minority and women candidatesare encouraged to apply.

FACULTY POSMON INENVIRONMENTAL CHEMISTRYJOHNS HOPKINS SCHOOL OFHYGIENE AND PUBLIC HEALTH

The Division of Environmental Chemistry invites ap-plications for a tenure-track faculty position in environ-mental chemistry. Emphasis will be placed on an ap-pointment at the assistant professor level although theappointment of an established investigator at an ad-vanced rank will be considered. The candidate shouldhave a strong background in chemistry, biochemistry, ormolecular biology and research interests in environmen-tal chemistry. The appointee will be responsible forexpanding the research and training program in environ-mental chemistry at the School and will interact withfaculty in the division, other divisions ofthe DepartmentofEnvironmental Health Sciences and with other depart-ments of the School and the University.Training and Research in the Division ofEnvironmen-

tal Chemistry represents an interdisciplinary approach tounderstanding the basic molecular mechanisms of theinteraction of physical and chemical agents with biologi-cal macromolecules, which is reflected in genetic damageor in inhibition of cellular functions.

Qualified individuals should send curriculum vitae andthe addresses of three references to: Dr. Tercnce H.Risby, Acting Division Director of EnvironmentalChemisty, The Johns Hopkins University School ofHygiene and Public Health, 615 North Wolfe Street,Baltimore, MD 21205.

The Johns Hopkins University is an Equal Opportunity!Affirmative Action Employer.

SCIENCE, VOL. 241

DEPARTMENT OF BIOCHEMISTRYTHE UNIVERSITY OF ARIZONA

FACULTY POSITIONSIN X-RAY CRYSTALLOGRAPHY

Applications are invited for two tenure-trackpositions in x-ray crystallography for macromo-iecular systems, one of which can be at a seniorlevel This is part ofan ongoing effort to developan exceptionally strong program in structuralbiology. Applicants will be expected to carry outa vigorous research program with ample oppor-tunities for collaboration, as well as to contributeto our graduate and undergraduate teachingprograms. Well-equipped crystallography facili-ties are available, including a diffractometer, arotating anode generator, Evans and SutherlandPS390 molecular graphics system andVAX com-puter systems. Additional funds will be providedor te purchase of another anode generator andan AREA detector, as well as other equipment.Applicants should submit curriculum vitae, listof publications, a short statement of researchgos and the names of at least three referencesto: Dr. Gordon Tollin, Chairperson, SearchCommittee, Department of Biochemistry,The University of Arizona, Tucson, AZ85721.Review of applications will begin 1 October

1988 but the positions will remain open untilfilled.The University ofArizona is an Equal Employment

Opportunity/Afirmative Action Employer.

6I2

POSITIONS OPEN POSITIONS OPEN

POSITIONS OPEN

DOCTORATES, any field considered. Mature atti-tude, excellent teaching ability, congenial personality,and professional presence necessary. Wc train you forintensive laboratory instruction of surgeons. Permanentinstruction sites in New York City, West Palm Beach, orChicago (Arlington Heights). Some travel required. Nota sales position. Salary: $40,000. Write for applicationinformation to: Director, Midas Rex Institute, 2929Race Stroet, Fort Worth, TX 76111. New applicantsonly, please.

ENCLOSURE REPRODUCTIVE PHYSIOLO-GIST. Postdoctoral research associate-for research onbovine embryo development and cloning by nucleartransfer. Need Ph.D. and experience with embryo cultureand development or micromanipulation. Salary $20,000to $30,000, depending upon experience. Apply to: Dr.N. L FPirst, University of Wsconsin, 1675 Observa-tory Drive, Madison, WI 53706. Telephone: 608-264308.

FACULTY POSMIIONHEMOTROPIC DISEASES

The Department of Vetcrinary Pathobiology, Collegcof Veterinary Mcdicine, University of Illinois is commit-ted to continuing the rcsearch program in hemotropicdiseases currently led by Professor Miodrag Ristic. Dr.Ristic's impending retirement creates a vacancy for atenure-track faculty member. Applicants should exhibit astrong commitment to hemotropic disease rcscarch, es-pecy biochemical and immunological aspects of pro-tective immunity, and have familiarnty with the appca-tion of modem techniques in parasitology, epidemiol-ogy, pathology and molecular biology. Candidatesshould exhibit evidence of administrative and organiza-tional skills, and have an interest in continuing currentprograms in hemotropic diseases. Applicants should havea Ph.D. and/or clinical professional degree, e.g., D.V.M.or M.D., and at least 2 years of postdoctoral experience.Salary and rank are commensurate with training andexpenence. To receive maximum consideration applica-tions should be received by 15 October 1988. Theposition will be filled as soon as possible thereafter.Submit applications and the names of three references to:

Dr. Ronald D. Smith, ChairmanHemotropic Disease Search Committee

College ofVatrinzy MedicaneUJivrstyof Ikiois2001 South LincolnUrbana, IL 61801

Telephone: 217-333-3290The University of Illinois is an Equal Opportunityl

Ajfirmative Acion Employer.

FOREST TREE MOLECULAR BIOLOGISTWestvaco Corporation is seeking a scientist to fill a

molecular biology position in our Forest Research orga-nization. Building upon a strong conventional tree-breeding program, we are expandmg our genetic pro-gram in moecular biology and plant transformationtechnology.The duties of our molecular biology position are to

explore the use ofmolecular tools to advance our conven-tional breeding program, especially RFLP's to finger-print germplasm and to study the inheritance ofquantita-tive traits m trees; and to work with our cell and tissueculture scientists to obtain genetic transformations.We seek an individual actively engaged in plant molec-

ular biology research; with a Ph.D. or postdoctoralexnence in plant molecular biology or related fields,with a strong background, training and experience inmolecular doning, RFLP techniques, and plant transfor-mation in technology; has experience working in aresearch team environment where colleagues are encour-aged to besupporve ofone another yet individualy areexpected to do independent research; and with an out-standing record of research accomplishment. In addition,it would be desirable to have cxperience with woodyplants and a plant breeding and genetics background.

This position will be located at our Forest ResearchHeadquarters in Summerville, South Carolina. Summer-ville lies 20 miles northwest of Charleston. For consider-ation, pleasc send your r6sumd, college transcripts, andthree letters of recommendation before 16 September1988 to: Mr. Ted Bush, Personnel Department, West-vaco Corporation, P.O. Box 1950, Sommerilie, SC29484. Equal Opportnity Employer MIF.

29 JULY 1988

SAFETYASSESSMENT/TOXICOLYINFORMATION-SPECIALIST

The Parke-Davis, a Division of Warner-Lambert Co., has an immediate openingin its Pathology and Experimental Toxicology Department for an experienced tox-icologist to participate in the compilation of verbal and written communiques as-sociated with department projects. The summarization of study results andpresentation of findings in safety assessments is a major responsibility of thisposition. This requires the collation of published data pertinent to subject com-pounds and therapeuticcategories. This individual will also serve as a participantin departmental associated research which includes serving as a study direc-tor for in-house studies and as a study monitor for contracted studies. The de-sign of studies to address unforseen circumstances is required.Requirements for this position include a Ph.D. in toxicology or related disciplinewith several years of experience; effective communication skills; a backgroundin toxicology research; experience with GLP requirements; and, effective infor-mation gathering skills.This position is located at our research facilities in Ann Arbor, Michigan, adja-cent to the University of Michigan campus. The successful candidate will par-ticipate in dynamic drug discovery and development teams, and enjoy an excel-lent salary, benefits, professional development and living and working environ-ment.Qualified candidates send response, salary requirements and reference list inconfidence to: Ms. M. Wolin, Parke-Davis, 2800 Plymouth Road, Ann Arbor,Ml 48105.

"EOUAL OPPORTUNITY IN ACTION"

PARKE-DAVISDIVISION OF WARNER-LAMBERT COMPANY

Senior Investigator,ImmunologyA health care company that markets prescription and proprietaryproducts for human and animal health care has an opening for aSenior Investigotor, Immunology, in its Department of Immunology at itsresearch and development facility in King of Prussia, Pennsylvania.The principal duties of the position include (i) planning and designingexperments in mast cell immunology and biochemisty aimed atdefining new molecular targets and mechanisms for the pharma-cologic manipulation of most cell responses, (ii) supervising suchexperiments Including performing non-routine, specialized work, (iii)investigating, adopting, developing and implementing appropriate invitro and in vivo methodologies and mechanisms for the discovery anddevelopment of novel anti-allergic agents which have a high speci-ficity towards inhibiting human most cell actMation and degranulationand (iv) coordinating, evaluating and drawing conclusions fromexperimental data and recommending curtailment or expansion ofcurrent projects and programs as well as the initiation of new projectsand programs.The minimum requirements for the position are a Ph.D. degree inChemistry/Biology and six (6) years experience (i) in mast cell bio-chemistr and immunology including second messenger pathways ofmast cell activiation/ inhibition, most cell growth factors and thedevelopment of mast cell lines; (ii) in immunopharmacology of mastcells and mediators of inflammation and models of allergic andinflammatory diseases and (iii) in protein purification Including HPLCand FPLC methods.Salary of $45,600 with liberal employee benefits. Qualified applicantsshould submit resume or curriculum vitae to Philadelphia Job Bank,444 N. 3rd Street, Philadelphia, PA 19123 and refer to Order Number4192958. Equal Opportunity Employer, M/F/H/V.

Research Employment Department 6L822404 Pennsylvania Avenue

Evansvifle, IN 47721An Equal Opportunity Employer MIFIHN

RESESARCH AIN CEBLL BIOLOGY

Amgen is a dynamic and growing organization that is arecognized leader in advanced biotechnology. Ourleadership in the development of Erythropoietin hasplaced us firmly at the fefront of the industry. Ourcontinued growth has created immediate opportunitiesfor Research Associates in Cell Biology.Qualffied applicants should have a BS or MS in CellBiology, or a related discipline, and 2-4 years ofexperience in mammalian cell culture. Responsibilitesfor these positions will include maintaining mammaliancell lines as well as performing a variety of IN VITRObio-assays to support on-going exploratory researchprojects. Some familiarity with molecular biologicaltechniques is highly desirable.

Amgen offers a stimulating and challenging researchenvironment as well as an attractive location one hournorthwest of Los Angeles.Amgen also offers an excellentcompensation and benefits package. Qualified applicantsshould send a resume and a list of 3 references, inconfidence, to:

RecruItment, Dept. #29AMGEN1900 Oak Terrace Lane

Thousand OaksCA 91320EquW q MP%

LIFECODESCORPORATION

NUCLEIC ACID CHEMISTPh.D. Level

Ufecodes Corp., a leading company in the use of DNA probesfor human genetic diagnostics, is undergoing expansion and iscommitted to building a strong and innovative Department ofNucleic Acid Chemistry. To that end we are seeking a nucleicacid chemist at the Ph.D. level. Candidates would be expectedto have a thorough understanding in the basics of organicchemistry, and research experience in either odigonudeotide ornucleic acid chemistry would be a definite asset

Ufecodes, a wholly-owned subsidiary of Ouantum ChemicalCorp., is located in attractive, modem fadlities just 30 minutesfrom New York City in Westchester County.

For the right indMdual we offer an extremely attractive salary/benefits package, including a complete medical plan, 401-Ksavings and pension plans, and a stock bonus plan.

If interested, please send your curriculum vitae with the namesand telephone numbers of at least two references to:

NUCLEIC ACID CHEMISTRY DEPARTMENTUFECODES CORPORATIONSaw Mil RIver RoadValhall, NY 10595

PILOT PLANTMANAGER

If you're interested in a career with a leading healthcare company, why not begin your search with a com-pany respected the world-over for its profound com-mitment to care, to quality, and to innovation? BaxterHealthcare Corporation has demonstrated that commit-ment for over 30 years.

Currently, our Baxter Hyland Division is seeking aqualiffied individual to support manufacturing by manag-ing the planning and implementation of programs toimprove quality and yield of therapeutic proteins;coordinate and implement projects from inception tocompletion; conduct feasibility studies; organize scale-up activities; and provide support for transfer of tech-nology into production. Atechnical degree or equivalentexperience (Ph.D. in BioChemistry or an M.S. with 7+years protein purification experience desirable); strongsupervisory, communication, and project organizationexperience and knowledge of manufacturing scale-uptechniques for protein purification by methods such aschromatography and ultra-filtration required.

Baxter offers a fast-paced, stimulating work environ-ment, attractive benefit and compensation plans, andthe opportunity to work for a world-class leader in thehealth care industry. For consideration, please send acurrent resume with salary history to: Ms. VickieThrashe, BaxEteHr d DMslon, 4501W ColoadoBlvd., Los Angels CA 90039. PRINCIPALS ONLYPLEASE. Equal Opportunity Employer.

Hyland Division

Baxter

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PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTHNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

RESEARCH TRIANGLE PARK, NORTH CAROLINADIRECTOR, DIVISION OF INTRAMURAL RESEARCH

A SENIOR EXECUTIVE SERVICE VACANCYThe National Institute of Environmental Health Sci-ences (NIEHS) invites nominations and applica-tions for the position of Director, Division of Intramu-ral Research. This is a Civil Service position in theSenior Executive Service (SES) with a salary rangeof $65,994 to $73,400 per annum. In addition, M.D.candidates may be eligible for a Physician's Com-parability Allowance up to $20,000 per year. (Alter-natively, candidates may be eligible for appointmentin the Commissioned Corps of the U.S. PublicHeaith Service.) A one-year probationary periodmust be served if the individual selected is notcurrentiy in the SES.The Division of Intramural Research plans and

conducts the Institute's basic laboratory researchprograms which encompass the areas of cellularand molecular pharmacology, genetics, molecularbiophysics, molecular carcinogenesis, moleculargenetics, molecular and integrative neurosciences,pulmonary pathobiology, reproductive and devel-opmental toxicology and an animal facility.As Director for the Division of Intramural Re-

search, the incumbent manages and directs a staffof approximately 397 employees and manages abudget of approximately $17.5 million. DIR is com-posed of eight laboratories and a branch conductingbench research in-house and by contract. Theincumbent evaluates research efforts and estab-lishes Programs' priorities; allocates funds, space,and personnel ceilings and integrates ongoing andnew research activities into Programs' structure;collaborates with other organizations, and NIH pro-grams; and provides advice to the Institute Directorand staff on matters of scientific interest. As anational expert in the field of environmental health,the incumbent serves as expert consultant withinthe United States and abroad.

Candidates must meet the following professionaland managerial qualffications:Mandatory Qualification RequirementsThis is a multid,sciplinary position. All candidatesmust (1) meet the minimum educational require-ments for either; (a) Biologist, GS-401, (b) Chemist,GS-1 320, (c) Medical Officer, GS-602, (d) Pharma-cologist, GS-405, (e) Microbiologist, GS-402, (flPhysiologist, GS-413, or (g) Geneticist, GS-440, asdescribed in the U.S. Office of Personnel Manage-ment Handbook X-1 18 (Qualification Standards forPositions under the General Schedule) which isavailable in Federal Job Information Centers andFederal Personnel Offices; and (2) Biomedical re-search experience at the GS/GM-1 5 grade level orequivalent which reflects demonstrated abilities todevelop, implement and administer intramural re-search programs using the multidisciplinary re-search approaches to environmental heaith; con-siderable experience involving research, analysisand evaluation of data related to the study of biologi-cal and hazardous effects of chemical, physical andbiological substances found in the environment.Mandatory Managerial/ExecutiveQualificationsThe incumbent must have had extensive expe-

rience of sufficientscope to carry outthe managerialduties of the position. Experience must have in-cluded progressively responsible experience in di-recting, guiding and managing complex researchprojects and/or programs. Must have demonstratedpossession of (1) a broad knowledge of and demon-strated ability to apply management practices andprinciples related to planning, organizing, staffing,directing, allocation of resources and coordinatingcomplex research programs; (2) ability to developpolicy and establish short-term and long-term goals,

priorities and objectives for complex programs; (3)ability to deal with diverse and complex problemsthrough application of analytical and decision-mak-ing skills; (4) ability to select, develop and utilize asubordinate staff, including a demonstrated positiveattitude regarding the implementation of an equalopportunity program; (5) ability to represent theorganization and deal effectively with high levelgovernmental officials, the scientific and academiccommunities, national/intemational professional or-ganizations and societies and the general public;and (6) skill and ability to conduct analysis andevaluation of programs.

Candidates who meet the mandatory qualifica-tions will be further evaluated on the following fac-tors: training and education; research experienceand leadership ofa research program in or related toenvironmental health; scientific reputation/peerrecognition; honors and awards; and additionalmanagerial/executive qualifications in excess of themandatory level.

Further information about the position and qualifi-cation requirements may be obtained by callingBruce Wiggins, Supervisory Personnel Manage-ment Specialist at 919-541-3317. U.S. Citizenshipis required.Resumes are not acceptable applications for

entrance into the Senior Executive Service. Appli-cations, SF-171 (available at all Federal Job Infor-mation Centers and Federal Personnel Offices)accompanied by a current curriculum vitae andbibliography should be submitted not later thanAugust 19, 1988 to:

Bruce Wiggins (Code: HNV2)NIEHS Personnel OfficeP.O. Box 12233Research Triangle Park, NC 27709

NIH IS AN EQUAL OPPORTUNITY EMPLOYER

* National Research Conseil nationalCouncil Canada de recherches Canada

MOLECULAR BIOLOGIST/GENETICIST(Halifax, Nova Scotia)

The Atlantic Research Laboratory of the National Research Council of Canada requires a Molecular Biologist/Geneticist towork in its Marine Biosciences Section.

The incumbent will participate in the planning, development and implementation of molecular biology studies on marinealgae, with a long-term view to future biotechnology applications; conduct independent research of high calibre;collaborate with colleagues at the Atlantic Research Laboratory and other research institutions; and contribute to thesupervision of technicians and post-doctoral fellows.

Applicants will have a Ph.D. in molecular genetics or an appropriate area of biochemistry, with at least 2 years of post-doctoral laboratory experience in mo.ecular biology/genetics. Candidates must be dynamic individuals able to contributescientific and intellectual leadership in molecular biology research. They must also be able to perform all fundamentalmolecular genetic techniques such as DNA isolation, restriction mapping, construction of plasmid and phage libraries,construction and use of probes and vectors, and nucleic acid transfer and blotting techniques using radioisotopes.Computers experience as related to accessing data bases for sequence comparisons and previous research experiencewith algae would be important assets.

Send your curriculum vitae, transcripts, and three letters of reference before 16 September 1988 to: The Personnel Office,Atlantic Research Laboratory, National Research Council of Canada, 1411 Oxford Street, Halifax N.S., Canada B3H 3Z1.Please quote reference AR-87-02 (SC).

POSITIONS OPEN

UNIVERSITY OFSOUTHERN CALIFORNIAFACULTY POSITION

Applications are invited for a tenure-track assistant/associate professor position at the School of Pharmacy,Division of Pharmaceutics. Outstanding candidates withresearch interests in the mechanisms or kinetics of drug/peptide transport or processing are sought to join ourstrong multidisciplinary programs in drug targeting,pharmacokinetics, and cancer pharmacology. Participa-tion in team teaching in graduate and professional pro-grams is required. Please submit curriculum vitae, select-ed reprints, statement of research objectives and thenames of three references by 30 September 1988 to:Vincent H. L. Lee, Ph.D., University of SouthernCalifornia, John Stauffer Pharmaceutical SciencesCenter, 1985 Zonal Avenue, Los Angeles, CA90033-1086. Equal Opportunity Employer/M/F/H.

FACULTY POSImTONS, NEPHROLOGY. TheSection of Nephrology at the Yale University School ofMedicine seeks individuals to establish independent re-search programs utilizing cell or molecular biologicapproaches to study issues of relevance to renal physiolo-gy or pathology. Applicants should have appropriateclinical training in internal medicine and nep rology toserve as teaching attendings. Positions will be based atthe Yale School of Medicine or the West Haven V.A.Hospital. Tentative starting date, 1 July 1989, withinitial term or tenured appointment as assistant profes-sor, associate professor, or professor depending on quali-fications. Women and members ofminority groups are particu-larly encouraged to apply. Applicants should send curricu-lum vitae before 1 October 1988 to: Peter S. Aronson,M.D., Section of Nephrology, Department of Inter-nal Medicine, Yale University School of Medicine,Box 3333, New Haven, CT 06510. Yale University is anEqual Opportunity/Affirmative Action Employer.

INSTRUCTOR (Western Medicine) for a universityOriental medicine/acupuncture program. Teach under-graduate and graduate courses including courses in phar-macology, western medical diagnosis, Western medicalterminology, histology, endocrnology, neuroanatomy,physiology, psychiatry, pathology, clinical medicine,clinical sciences including obstetrics/gynecology, urolo-gy, radiology, and infectious diseases, with requisiteknowledge thereof.

Prepare and deliver lectures/demonstrations to stu-dents, stimulate discussion, compile, administer, andgrade exams, direct research. Undertake postgraduatework/training in California and qualify therefore. Serveon committees. M.D. or equivalent required.No smoking on the job. Medical education must not

be from medical schools black listed by California Boardof Medical Quality.Monday through Friday 1:30 p.m. to 10:00 p.m.

(Teaching hours 6:00 p.m. to 10:00 p.m., administrativework at other times.) Salary: $28,000 per annum. Jobsite and interview: Garden Grove, Califomia.Send this ad and a r6sum= or letter stating your

qualifications to: Job # NOF #297, P.O. Box 9560,Sacramento, CA 92823-0956 not later than 14 Au-gust 1988.

MACROMOLECULAR STRUCTUREThe Agouron Institute, a multidiseiplinary non-profit

research organization located in La Jolla, California, isseeking a SCIENTIST to pursue independent researchin the general area of macromolecular structure-functionanalysis. The applicant should demonstrate a strongresearch record in either protein x-ray crystallography orbiophysical chemistry have a broad perspective o thebiological relevance of this research. The Agouron offersamnple opportunity for, and encourages, interdisciplinaryresearch in the fields of x-ray crystallography, computa-tional chemistry, and molecular biology and is equippedwith state-of-the-art instrumentation and facilities. Pleasesend curriculum vitae including the names of threereferees to:

Search CommitteeAgouron Institute

505 Coast Boulevard SouthLa Jolla, CA 92037

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The Department of Molecular Genetics of theSmithKline Animal Health Products is seek-ing a Postdoctoral Scientist to perform inves-tigative studies on the Reagent Specific Im-mune Response to Rabies Virus. The specificarea of research will focus on the recombi-nant DNA expression of rbies proteins andthe differential immune response to thoseproteins. Candidates will be expected to pub-lish their findings in scientific joumals andmake presentations at both local and na-tional meetings.Candidates for the position should hold aPh.D. in Immunology/Molecular Virology ora reated disciplne. Experience in the cell-mediated immune responses to protein anti-gens is desirable.The appointment is fuil time for a period oftwo years and is part of a research agree-ment between SmithKline Beckman AnimalHealth Products and the Centers for DiseaseControl (CDC) in Atlanta, GA. The success-ful candidate will work within the RabiesLaboratory of the Division of Viral Diseasesat the CDC, in Atlanta, GA. Applicants shouldsend curriculum vitae, including relevant re-prints and names of three references to: Dr.William J. Bellini, Mailstop G-13, Centers forDisease Control, CID/DVD/VRZB, 1600 Clif-ton Rd., Atlanta, GA 30333. An Equal Oppor-tunity Employer, M/F/H/V.

s Natural Sciences and EngineeringI+I Research Council of CanadaConseil de recherches en sciencesnaturelles et en g6nie du Canada

RESEARCH FELLOWSHIPS1989

The Natural Sciences and Engineering Research Council of Canada (NSERC) offers research fellowships toexpand career opportunities for a select number of promising researchers in the natural sciences andengineering. These awards are tenable in universities or industries in Canada.

Eligibility: Canadian citizens or permanent residents of Canada holding a doctorate in science or engineering,preferably with post-doctoral research experience of not more than five years.

Nature of Appointment: Fellows will be employees of the university or industrial firm for the duration of theaward and will be engaged in research or development.

Duration of Appointment: a) University Research Fellowships: Up to five years based on satisfactoryperformance; possibility of renewal for a second 5-year term.

b) Industrial Research Fellowships: Up to two years based on satisfactory performance.

Remuneration: a) University Research Fellowships: Salary is determined by the university; NSERC willreimburse the university up to $30,500 per annum towards the cost of each fellow's salary; fellows will receive athree-year research grant.

b) Industrial Research Fellowships: Salary is determined by the industrial firm; NSERC will reimburse the firm$25,000 per annum towards the fellow's salary.

Application Procedures: Contact the Canadian university or industrial firm of your choice to carry outappropriate negotiations concerning research plans, terms and conditions of appointment, salary, etc.Nominations must be submitted to NSERC by universities or industrial firms, as the case may be. Applicationssubmitted directly to NSERC by candidates cannot be accepted.

Date of Submission: a) 1 November 1988 for University Research Fellowships.

b) anytime for Industrial Research Fellowships.

For more information, contact the:

Research Fellowships OfficerNatural Sciences and Engineering Research Council200 Kent StreetOttawa, OntarioCanadaKIA 1H5Telephone: (613) 996-2009 Caniad'a

FACULTY POSITION INMOLECULAR BIOLOGYDepartment of Dermatology

University of MichiganFaculty position available for scientistwith experience in molecular biology ofgrowth differentiation and immune regu-lation. Candidate will be expected toinstitute an independent reseorch pro-gram emphasizing moleculor biologicaltechniques and to colloborate with cur-rent faculty on the regulation of growthand differentiation of humon epidermis.Current foculty research interests include:regulotion of cytokine and growth foctorgene expression, biochemistry of signoltronsduction, arochidonic acid metobo-lism, and immunodermatology. Reseorchprogram should be compatible with stud-ies on inflammatory hyperplastic skindiseases such as psoriasis. Applicantsshould send curriculum vitae, bibliogra-phy and statement of reseorch interestsand names of three references to:

Professor John J. Voorhees, ChairmanDepartment of DermatologyUniversity of Michigan Medical Center1910 Taubmon Health Care ConterBox 0314, Ann Arbor, MI 48109-0314

POST DOCTORALFELLOW/RESEARCH ASSOCIATEThe Hospital for Sick Children, one of theworld's leading paediatric research and carecentres, is seeking a recent Ph.D. graduatewith an indepth background in proteinchemistry. You have a demonstrated workingknowledge of enzyme purification,preparation and use of mono and poly-clonalantibodies. You should also have hadexperience in molecular biology.Remuneration will reflect your training andlevel of expertise. Please send yourcurriculum vitae, quoting File #C072 andincluding 3 letters of recommendation, nolater than August 29, 1988, to: Ms. CelesteD. Walton-Ruzic, Recruitment Officer,Department of Human Resources.In accordance with Canadian immigrationrequirements, priority will be given toCanadian citizens and permanent residentsof Canada.

555 University AvenueToronto, Ontario M5G 1X8

THHE]iOSPIlALFOR SICK CHILDREN

U

DEPARTMENT OF HEALTH AND HUMAN SERVICESU.S. PUBLIC HEALTH SERVICE

FOOD AND DRUG ADMINISTRATIONCENTER FOR FOOD SAFETY AND APPLIED NUTRITIONThe Food and Drug Administration is seeking Staff Fellow applicants with astrong background in analytical chemistry of pesticide residues or otherchemical contaminants in foods and knowledge of application of immunoas-say techniques to small molecules such as pesticides. The successful applicantwill apply immunoassay techniques in development of pesticide residueanalytical methodology.Candidates should have a Ph.D. or have been certified by a university asmeeting all requirements leading to such a doctorate in chemistry or closelyrelated discipline. (Candidates holding a masters degree will also beconsidered.)A current curriculum vitae and bibliography are to be sent to Dr. MarionClower, Jr., Division of Contaminants Chemistry (HFF-426), Food and DrugAdministration, 200 C St. SW, Washington, DC 20204, not later thanAugust 20, 1988.

The Food and Drug Administration is seeking Staff Fellow applicants toconduct research on food package integrity with emphasis on new packagingsystems. The successful applicant will design testing methods and performresearch in areas such as seal integrity, container integrity, and migration ofcomponents of packaging material into food.Candidates must have at least a masters degree in one of the followingdisciplines: Chemical or Food Engineering, Food Technology, Food Scienceor closely related disciplines with emphasis on food packaging.A current curriculum vitae and bibliography are to be sent to Dr. PatriciaSchwartz, Division of Food Chemistry and Technology (HFF-4 10), Food andDrug Administration, 200 C St. SW, Washington, DC 20204, not later thanAugust 20, 1988.

Staff Fellowships are excepted appointments in the Federal service. Candi-dates must have a masters degree, doctoral degree or have been certified bya university as meeting all requirements leading to a doctorate in a health-related science. Candidates must be United States citizens or resident alienseligible for naturalization within four years. Initial appointments will be for aminimum 2 years. Salary ($22,907 to $42, 135) is based on qualifications.

THE FOOD AND DRUG ADMINISTRATION IS SMOKE FREETHE FOOD AND DRUG ADMINISTRATION IS AN

EQUAL OPPORTUNITY EMPLOYER

POST-DOCTORAL POSITIONSOne position is available for study of the en-zymes that participate in the metabolism ofxenobiotics, including drugs. Interest is pres-ently directed at hydrolytic enzymes that fallinto the category of enzymes of detoxication.Send Curriculum Vitae to William B. Jakoby.

A position is available for study of the bio-chemistry of inherited disorders, e.g. the lyso-somal storage diseases, utilizing techniquesof molecular biology and protein chemistry.Facility with these methods is favored but isnot essential. Send Curriculum Vitae toRachel Myerowitz.

Both can be reached at:

National Institutes of Health,A Laboratory of Biochemistry and

Metabolism, NIDDK- Building 10, Room 9N-1 14

9000 Rockville PikeBethesda, Maryland 20892

NIH IS AN EQUAL OPPORTUNITY EMPLOYER

Principal Scientist!Group LeaderContribute tosome of the most advanced projects inpharmacology at Schering-Plough, a worldwide leaderin the research, manufacture and marketing of phar-maceutical and personal care products.This is your opportunity to expand your expertise with ateam of leading scientists. Your background shouldinclude methods development for complex dissolutionassays and familiarity with proteins. A PhD in AnalyticalChemistry/Pharmaceutical Science with 3 years' rele-vant work experience or an MS with 10 years' relevantwork experience required. Good oral and written skillsalong with previous management experience arenecessary.

We offer a very competitive salary and benefits. Forprompt confidential consideration, send your resumewith salary history to: Ms. I. Brenneman, Box 87-52,Schering-Plough Corporation, E-1 7, K-6-1, 2000 Gallop-ing Hill Road, Kenilworth, NJ 07033. We are an equalopportunity employer.

Q$3 Schering-Ploughm

POSITIONS OPEN

The Institute for Medical Microbiology ofthe Univer-sity of Beme, Switzerland annoutnces positions for JUN-IOR POSTDOCTORALS as from October, 1988.Research concerns virus-induced cell-cell fusion. Appli-cants must have M.D. or Ph.D.; research experience inmolecular biology, microbiology or protein/membranechemistry is preferred. Please send letter of interest andcurriculum vitae to: Hans Koblet, Professor, Institutefor Medical Microbiology, FriedbOhlstrasse 51, CH-3010 Berne, Switzerland.

MOLECULAR BIOLOGISTNorthern California reference laboratory seeks dynam-

ic individual to fiuther develop and expand our Divisionof Clinical Molecular Biology. This exciting and chal-lenging opportunity requires a doctoral level scientist(Ph.D.) with broad experience in microbiology, virolo-gy, immunology and recombinant DNA technology.Areas of interest includc diagnosis of infectious diseaseand molecular oncology.

For confidential consideration, please submit yourcurriculum vitae and three references to: Box 121,SCIENCE.

MOLECULAR BIOLOGIST with extensive experi-ence in nucleic acid electrophoresis and DNA sequencingto work full-time in the Research and DevelopmentDepartment. Duties indude testing of existing and pro-totype instruments used in the separation sciences, andapplications development. Applicants must be interestedin instrumentation and be technicaLly competent in theuse of equipment. Send resumts to: Hoeer ScientificInstruments, Attention: Carol Yamasaki, 654 Minne-sota Street-PO Box 77387, San Francisco, CA94107.'

MOLECULAR/CELLULAR NEUROSCIENCEDIVISION OF NEUROBIOLOGY

BARROW NEUROLOGICAL INSTITUTEApplications are invited for a tenure-track, staff scien-

tist position at the assistant or associate professor level inthe basic research division of a unique and dynamicinstitution. The appointee will be expected to establishan independent and vigorous research program utilizingcontemporary approaches. Some preference will be givento applicants who are interested in development of themammalian CNS and/or who are experienced in molecu-lar biological applications. AmplI opportunities exist forinteraction with basic and clinical investigators in arapidly developing neuroscientific community. Send cur-riculum vitae, names and addresses for three references,and a brief statement of research experience and objec-tives to: R. J. Lukas, Division of Neurobiology, Bar-row Nesrological Institute, 350 West Thomas Road,Phoenix, AZ 85013. Equal Opportunity Employer.

Ph.D. BIOSTATISTICIANDevelop methodology, consultation, supervise gradu-

ate students. Statistical, leadership, communication skills.Work with cancer prevention project. Affiliate appoint-ment, Biostat Departnent, University of Washington.Send curriculum vitae and names of three references to:Dr. Dan Cherkin; Center for Health Studies, GroupHealth Cooperative, 521 Wall. Street, Scattle, WA98121.

PLANT PATHOLOGIST-The U.S. Departmentof Agriculture, Cooperative State Research Service, isseeking an established, highly qualified scientist to serveas stafexpert for plant pathology programs. Knowlkdgeof nicroorgaism genetics and epidemiology is' helpful.Individual to be selected must be able to work well withscientists and administrators of state and Federal pro-grams. This is a full-time permanent position providingeadership and direction to national research programsand projects. Starting GM-15 salary is $54,967 to$71,377 based on experience and salary history. FullFederal benefits package is induded. For further infor-mation call Wayne Winer at 2024754811. Send SF-171 form de g experience and training plus listing ofcourses taken to USDA, ES, PMSD, Room 3547-S,14th Street and Independece Avenue S.W., Wash-ington, DC 20250-900. Reference announcement395-A. Applications must be postnarked by 22 August1988. USDA is an Equal Opportunity Employer.

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POSITIONS OPEN

PHARMACOLOGIST/CELL PHYSIOLOGISTPATCH-CLAMP ELECTROPHYSIOLOGISTNatural Product Sciences (NPS) Inc. is a rapidly

growing company involved in basic and applied researchon compounds of non-human biological origin. We areseeking two Ph.D.-level'scientists with expertise in cellphysiology/pharmacology or electrophysiology to join agroup investig;ting the effects of such compounds. Ap-plicants for the irst position should have experiencestudying responses to drugs in neural or cardiovasculartissues; the second position requires experience in patch-clamp analysis of responses in neuronafor cardiovascularcells. Both positions offer the opportunity to work with awide range of novel compounds in an exciting andcomprehensive program involving pharmacology, chem-istry, and molecular biology. The successful. applicantwil b given major responsibility for directing his or herown efZZorts and will be expected to contribute to evaluat-ing and guiding the general research program. Qualifiedapphcants will also be eligible for faculty appointments inthe Umversity ofUtah Department ofPhysiology, whichis adjacent to the company's facility.NPS offers competi-tive salaries and a full benefits Package. Please send aresume and the names ofthree references to: Dr. HunterJackson, Natural Product Sciences Inc., 420 ChipetaWay, Salt Lake City, UT 84108. Natural Product SciencesInc. is an Equal Opportunity Employer.

OIMMUNOMEDICSPh.D., M.S., AND B.S. SCIENTISTS

IMMUNOCHEMISTRYImmunomedics, the pioneer company in the use of

antibodies for cancer imaging and therapy, is expandingits product/process development department.

Reporting to the Group Director ofImmunology andChemistry, responsibility will be for development ofreagents for clinical trials.

Candidates should have experience in the purificationand characterization of monoclonal antibocheslfrag-ments, or in the conjugation ofmonoclonal antibodies tochelates/polymers/enzymes.We offer an attyactive employment package including

paid health/dental, a 401K retirement plan, and theopportunity for stock and stock option merit rewards.

Please send curriculum vitae, salary requirements, andcareer objectives to:

Personnel Directormmunolnedics, Inc.150 Mt. Bethel Road

CN #4918Warren, NJ 07060

Equal Opportunity Employer MIF.

University of Michiga: Unexpected immediate op-portunity for POSTDOCTORALFELLOW with sy-thetic or organometallic chemistry background to re eradiometal labeling of monoclonal antibodies. Well-equipped laboratory with multidisciplinary environment.Ideal position for the chemist desiring to apply chemicalsolutions to biological systems. Position is NIH-fundedand applicants must be U.S. citizen or Permanent resi-dent. Please send curriculum vitae with name of tworeferences to: Richard L. Wahl, M.D., Division ofNuclear Medicine, University of Michigan MedicalCenter, Ann Arbor, MI 48109-0028. The University ofMichigan is a non-discriminatory, Affirmative Action Employer.

POSTDOCTORAL FELLOW (associate) positionin cancer pharmacology/tumor biology laboratory. Mustbe experienced in cell culture and tumor stem cell assay.Working knowledge of molecular biology, HPLC, orbiofluorescence techniques an asset. Salary to $25,000depending on experience. Please send a letter describingresearch experience and curricilum vitae to: Dr. ThomasChan, Lynn Hall, Purdue University, West La&yette,IN 47907. Purdue University is an Equal Opportunity!Affirmative Action Employer.

POSTDOCTORAL POSITION available immedi-ately to study mechanisms ofosmotolerance in lactobacil-li. Candidates should have a Ph.D. in microbiology,biochemistry, or equivalent. Experience in molecularbiology techniques preferred. Send curriculum vitae andnames of three references to: Dr. E. R. Kashket, De-partnent ofMicrobiology, Boston University Schoolof Medicine, 80 East Concord Street, Boston, MA02118. Affirmative Action/Equal Opportunity Employer.

POSITIONS OPEN

POSTDOCTORAL ASSOCIATESMOLECULAR BIOLOGISTSCOMPUTER SPECIALISTSDNA SEQUENCERS

LABORATORY TECHNICIANSTo join rescarch team for megabase sequencing tech-

nolog. Send resume to: Sequencing Technology=erc Committee, University of W"iconsin, 445HenryMal, Room 210, Madison,WI 53706. Afinna-tive Action/Equal Opportunity Employment.

POSTDOCTORAL FELLOW-OSTEOPOROSISThe Regional Bone Center at Helen Hayes Hospital is

seeking a postdoctoral fellow to participate in studies onthe mode of action, regullation, and ontogeny of theosteodlast (Project Director: Dr. David Dempster). Thesuccessful candidate will join a roup of investigatorsengaged in basic and clinical studies on osteoporosis aspart of a national Specialized Center of Research inOsteoporosis funded through Health Research, Inc. bythe NH (Principal Investigator: Dr. Robert Lindsay).Studies will be based on an established in vitro model ofisolated osteoclast activity. Preference will be iven tocandidates with a strong background in cell biofogy andexperience in cell and tissue culture. Formal training inimmunology, hematology, or biochemistry would alsobe advantageous. Starting salary range: $20,000 to$25,000, depending on experience, with excellent fringebenefits. The position is available for 4 years in the firstinstance. Helen Hayes Hospital is a Columbia Universi-ty-affiliated, New York State Department of Healthfacility located within easy reach of New York City.Resumes should be submitted to: Human Resources,Helen Hayes Hospital, Route 9W, West Haverstraw,NY 10993. Health Research, Inc. is an Equal Opportunity!Afirmative Action Employer.

POSTDOCTORAL FELLOW-Schering-Plough'sDepartmnent of Chemotherapy offers an outstandingPh.D. scientist an opportunity to pursue research on thecharacterization and loning of novel aminoglycosideresistance genes. The successful candidate wil have abackground in microbiology or genetics; additionalexperiencc in molecular biolofy and/or clinical microbiology preferred. To explore, pease send curriculum vitaeto: R. Blackburn, Box TM8845, Schri Research,60 Orange Street, Bloomfield, NJ 07003. We are anEqual Opportunity Employer.

POSTDOCTORAL POSTIIONBIOCHEMISTRY/MOLECULAR BIOLOGYStudy protein:DNA interactions involved in the

positive regulation of prokaryotic transcription bya putative Zn2+ binding protein. Applicants should havea strong background in either protein biochemistry ormolecular genetics. This is a grant-funded position avail-able for up to 3 years, beginning in September 1988.Send curriculum vitae and names of three references to:Dr. Gail E. Christie, Department of Microbiologyand Immunology, Virnia Commonwealth Universi-ty, Box 678 MCV Station, Richmond, VA 23298-0678.

MOLECULAR/CELL BIOLOGY POSTDOC-TORALPOSMON available immediately to study therole of extracellular matrix, cell-cell interactions andgrowth factors in regulating programs ofgene expressionthat control he atocyte growth and differentiation.Experience in c biology and/or molecular biology isdesirable. Please send curriculum vitae and names oftworeferences to either: Dr. Stephen R. Farmer, Depart-ment of Biochemistry or Dr. Nancy L. R Bucher,Depart ent of Pathology, Boston University Schoolof Medicine, 80 East Concord Street, Boston, MA02118.

PHILADELPHIA, PENNSYLVANIAPOSTDOCTORAL POSMON-The Graduate

Hospital's Research Department has a position availablefor someone to study inositol lipid metabolism in intactvascular smooth muscle from normal and hypertensiverats. Training in biochemistry essential. Candidatesshould send curricula vitae and the names of threereferences to: Edward F. LaBelle, Ph.D., Bockus Re-search Institute, Graduate Hospital, 19th and Lom-bard Streets, Philadephia, PA 19146. Equal Opportuni-ty Employer M/F/H/V.

SCIENCE, VOL. 241

POSITIONS OPEN

POSTDOCTORAL POSMON available (15 Au-gust 1988) in biochemical pharmacology of cancer che-motherapeutic agents: (i) enzymatic mechanisms of bio-reductve activation of drugs and combinations, and (ii)their ctotoxic selectiviy in a ls. Training or recentexpenence in experintal cancer chemotherapy withstrong biochemistry background is desirable. Competi-tive stipend based on experience. Application may bemade to: Dr. Herbert S. Schwartz, Dement of

ental Theapeutics, Roswell Pad MemorialIntuate, Elm and Cal*on Steets, Buffalo,. NY14263. Equal Opportunity Employer/Afirmative Acion.

POSTDOCTORAL POSMIION available immedi-ately in virus assemnbly. Biochemical and recombinantDNA techniques will be used to study replication andgenomic packaging ofdsRNA phage, and assembly of itssimple membrane structure. Send r6sumd and referencesto: Leonard Mindich, Public Health Research Insti-tute, 455 First Avenue, New York, NY 10024.

POSTDOCTORAL POSMIION available for stud-ies of protein-nudeic acid interactions involved in generegulation, combining protein crystallography and muta-genesis. Individuals with experience in crystallography orprotein chemistry are encouraged to apply. The labora-tory is equipped with state-of-the-art equipment forprotein isolation. x-ray diffraction, computer graphics,etc. Send curriculum vitae and names of three referencesto: Dr. Kadtryn Ely, cdo North ingield, La JollaCancer Research Foundation, 10901 North TorreyPines Road, La Jolla, CA 92037. Equal OpportunityEmployer.

POSTDOCTORAL POSMON-HUMAN MO-LECULAR GENETICS, available 1 October. 1988, toapply the direct sequencig techniques of GAWTS andRAVVTS to stuy spontaneous germlinc mutations mhumans [Stoflet e al., Science 239, 491 (1988); Sarkarand Sommer, Nucleic Acids Res. 16, 5197 (1988)]. NIHNRSA funding is available for 2 to 3 years; U.S.citizenship or permanent residency is required. Appli-cants should submit curriculum vitae, sekcted reprints,and names, of three references to: Steve S. Sornme,M.D., Ph.D. Departent of Biochemistry and Mo-kcular Biolog Myo Clinic/Foundatio School ofMedidne, Rochester, MN 55905. An Equal Opportuni-ty/Ajrmatitve Action Institution.

POSTDOCTORAL POSITION/RESEARCHASSOCIATE availablc to study human disorders ofvisual-oculonmotor systems. Candidates with a Ph.D., arcsearch background in oculomotor systems, vision psychophysics or motor control systems are preferred. Theposstion is sponsored by the Department of Neurology,Stanford Univetsity. Send rdsume and three letters ofreference to: John Hotson, M.D., Department ofNeurology, Santa Cara Vally Medical Center, 751South Basom Avenue, San Jose, CA 95128. EqualOpportunityl/Airmative Action Employer.

POSTDOCTORAL POSITIONSTwo postdoctoral positions are available in Fall 1988

to investigatc the biochemical and molecular biologicalbasis ofincreased plant growth, NH3 assimilation and N2fixation in kgumes. These effec on the legumes accom-pany a selective, partial inhibition of plant glutaminesynthetase in the 1egume nodules. An initial report ofthese findings is in press, in Science 1988. Highly moti-vated individuals with experience in either pro or eu-karyotic metabolism/nezymology or molecuar biologyare sought to join active research efforts characrizingthis system. Dr. P. Langston-Unkefer of Los AlamosNational Laboratory, Mail Stop C345, Los AlamosNM 87545 leads the overall project with emphasis onthe biochenical investigation. IDr. C. Sengupta-Gopa-lan of the Plant Gcentic Engineering Laboratory,New Mexico State University, La Crisces, NM88003 leads the molecular biological investigation. Con-tact either researcher directly for addiional ionnation.To formally apply, send rdsumd, employment applica,

tion, undergraduate and graduate transcrpts, and threelette of refernce to: Carol Rich, Human ResourcesDeveiopmentDivision PD-88-028, Los-Alaumos Na-tional tory, Los Alamo., NM 87545. Los Ala-mos National Laboratory is an Ajlrmative Action/Equal Op-portunity Employer.

29 JULY 1988

DirectorWoods Hole.

Oceanographic InstitutionThe Trustees Search Committee of the Woods Hole Oceanographic Institutioninvites nominations and applications for the position of Director.The Woods Hole Oceanographic Institution is a privately endowed research andeducational institution with a. scientific and technical staff of 235, a total personnelcomplement of 800, and a current operating budget of 55 million.dollars. TheIristitution operates a fleet of reseach vessels engaged in world-wide oceanographicresearch. Research includes all aspects ofocean-related work, geology, geophysics,physical oceanography, biology, chemistry, engineering and marine policy. AGraduate Program in Oceanography/Oceanographic Engineering is offeredjointlywith the Massachusetts Institute of Technology.The Director is the chief executive officer of the Institution and isaccountable to theBoard of Trustees. Generally responsible for all scientific, fiscal and operatingactivities of the Institution, the Director is also expected to participate inrelationships with various Federal agencies and to be responsible for fund-raisingactivities iri the private sector.The Search Committee expects that candidates will have a distinguished record ofscientific accomplishment and administrative experience in research and/or acad-emic institutions. A strong commitment to the furtherance of research in the oceansis essential.Address communications to: ,.tOpG4s

Mr. Guy W. Nichols, ChairmanTrustees Search Committee

Woods Hole Oceanographic InstitutionBox 54P

Woods Hole, MA 02543An Equal Opportunity Empbyer MWF/H/V

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Assoc:iate SeniorInmvestigatoor-Synthetic ChemistryA health care company that mrrkets prescrption and proprietaryproducts forhuman and animal health care has on opening for anAssociate Senior Investigator - Orgonic Radiochemical Synthesis at itsresearch and development facility in King of Prussia, Pennsylvania.Prihcipal duties are planninQconducting, supervising, and evaluatinglaboratory exWriments utiUzing isotopically labeled organic com-pounds often reefered -to as organic radlochemical synthesis aimed atdesi'gring synthetic compounds which can be used as health careproducts. Such research involes the pparation and anolysis ofisotopically la,beled-candidate drug compounds and research toolcomppinds and exploi rng these comnpouds ith the goal of synthe-sizing,princip01ythrough molecular manipulation new chemicalstructures whichi may be substituted for specfc natural products suchas hormones, vitamins or for existing drugs.Ph.D. Degree in Chemistry with eight (8) years experience in syntheticch emistry inc,uding (i) three (3) years experience in synthesizingradioactv sterols, sterods ana peptides, leukotiene inhibitors andheterocycles and (Ii) wo (2)Years experience planning, conductinrg,supervising and evaluatirn aI atory experiments including the use ofisotopically labeled organic compounds and the operation of highfield multinuclear nuclear magnetic resonance (NMR) and interpre-tation of. the resulting data.Salary of.$42,000 with .liberal benefits. Qualified applicants shouldsubmit resume or. curiculum vitae to Philadelphia.Job Bank, 444 N. 3rdStreet, Philadelphia, PA 19123 and refer to Order Number 4191991.Equal Opportunity Employer, M/F/H/N.

CNS RESEARCH

POSTDOCTORAL POSITION AVAILABLE ATTHE NATIONAL INSTITUTES OF HEALTH, PHS

The Human Motor Cosol Scction in the Medical Neurology Brancl%at the National nsute of Nerlogical and Commumcative Disodes and

Stroke (NINCDS) has an openng for a 2-3 yea potdoctrl feiwsip.We would expect this persomto be a neurophysiologist familiar with EvokedPotentials and to study noal volunteers and patients with differentneurological disorders. We are looking for an individuil capable ofinteracting in an interdisciplinury group intaested in topographic bainmapping and evaluation of plastic changes in human motor and sensorycortex using noninvasive techniques. Skills in rocording and analyzingevoked potentials, programming in languages such as FORTRAN,assmbly, Pascal and C, and usmg PDP 11 with t-1l operaing system andMicroVAX with VMS operaing systn cmputers are derble.

Candidates must be U.S. citizens d have compted docte

training with no more than 3 yewas postdoctl experince. Stipends beginat $24,000 but may be adjused depending on the cwndidaes postdoctoralexperience. Appointments would be as an intramural reseah trainingassociate (IRTA).

Tec NINCDS is lcated at the National Institutes of Health in Bethesda,Maryland just north of Washington, D.C. If you have an in this

position, please send a letter describing yourself and include a statem ofscientific and/or clinical interest, a resume, and three lete of reference to:

tAIL .lUUf euu A P e t;1nJ j1Ur-tAUCnllOMI JrosaGocxor rostUOn ApPUMlld/o Leonado G. Cohen, MD.Human Mtor Cnrol SectionMcdical Neurology Branch-NINCDS-NIH9000 Rockville PikeBuilding 10, Room 5N226etheada, Maryland 20g92.

Phone: (301) 496-0219

"For furthe infotnaton on benefits, contact: Wallace HollandNINCDS Pesmel Office (301) 496.6334."

NIH IS AN EQUAL OPPORTUNITY EMPLOYER

PIPN1

Dynamic, expanding diagnostics company and Euro-pean leader in Coagulation is looking for a

MANAGER RESEARCH &DEVELOPMENT COAGULATIONin order to head a small research team.

You are an expert in Thrombosis and Hemostasis andwill lead our growing team in the development ofchromogenic and immunological based assays forclotting factors.

Ideally you have a Ph.D. in Biochemistry or equiva-lent and proven experience in the commercial assay

development in this field.

Please send your C.V. to Mrs. M. von Anacker,Manager Human Resources, Baxter Dade AG, Bonn-strasse 9, CH-3186 Dudingen/Switzerland, phone (41Int.) 37/43 91 11.

Baxter Dade AG

Baxter

Senior ScenceProJect Manager

Cambridge NeuroScience Research, Inc. is an exciting, young,private company focusing on neurobiolWgy and its applications. Weare looking for,a Senior Science Project Manager with a Ph.D. in arelevant scientific discipline and a minimum of 5 years' experiencein the pharmaceutical industry.The candidate wiNl have deveioped a working relationship withpathologyltoxicology labs and be well-versed ih the Ataes andregulatory requirements of preclinical and clinical drug development.Responsibilities. would include: designing product developmentstrategies; ensuring th.at projects remain on scheduie;,establishingclose rapport and effective working relationships with proct teammembers as well as outside lratories; coordinating and manag-ing the submission of development plans, progress reports toManagement and IND applications. The Senior Science ProjectManager would report directly to the Head of Research and wouldprovide administrative direction to selWcted research projects.CNS Research is located in Cambridge, .Massachusetts and offersa. stimulating research environment with competitive salaries and ex-cellent benefits, including Founders stock.

Plaes send curriculum vItae, lncluding the names of tworeferences, to: CNS Research, Human Resources Manager, OneKendall Square, Building 700, Cambrldge, MA 02139.

BUILDING ANEW LAB?

LET THE SCIENCE FREE PRODUCTINFORMATION SERVICE PUT YOU INTOUCH WITH THE VENDORS WHOSEPRODUCTS YOU WILL NEED.

SIMPLY WRITE US A LETTER STATINGTHE SPECIFICS ABOUT YOUR PROPOSEDLAB AND WE WILL DO THE REST.

WRITE TO:

SCIENCE MAGAZINENEW LAB SERVICE DEPT.1515 BROADWAYNEW YORK, N.Y. 10036

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Glaxo Inc. is not only one of the Top 10 ethicalpharmaceuticalfirms in America, we're also thefastest growing research -oriented company in thecountry. As such, we can offer exceptional careeropportunities, state-of- the-artfacilities, and afirm commitment to producing the most effectivepharmaceuticals that experience, imagination,and advanced technology can create. Join Glaxo,and apply your knowledge and career ambitionswhere they'll do you the most good.We currently have thefollowing positionavailable at our Corporate Headquarters locatedin Research Triangle Park, N.C.

POSTDOCTORALPOSITION INBIOCHEMICALTOXICOLOGYThe department ofdrug metabolism has aposition for a recent Ph.D. graduate inBiochemistry, Pharmacology, Toxicology, or arelated discipline. The postdoctoral fellow wouldpropose independent research relevant andcomplementary to in vitro drug metabolism andbiochemical toxicology. Current research interestsinclude tissue specific regulation ofdrugmetabolizing enzymes and the bisynthesis ofleukotriene C4 in the lung. A background inbiochemical and molecular biological techniquesis desirable.

At Glaxo, growth opportunities and up-to-datefacilities are complemented by a location(Raleigh-Durham) that has excellent resources inclose proximity. Prestigious universities, scenicvistas, lively recreational areas, and excitingcultural opportunities are all a part of the dailylife of the Glaxo professional. Further, we rewardtalent and creativity with an excellent salary andbenefitspackage(including a completelyequipped, on-siteathleticfacility). Candidatesinterested in thisposition, please send resumeincluding salary history, to:

Human Resources DepartmentJob #8625X928

Glax:o Inc.PO Box 13398

Researcb Mangle Park, N.C. 27709(No Phone Calls, Please)

No Private Agency Referrals, Please

An Equal Opportunity Employer M/F/H/V

Paving the way to a healthier worli

r

PERMANENT ANDPOSTDOCTORALMOLECULARBIOLOGISTS

Battelle, Pacific Northwest Laboratories,is seeking applicants for two permanentstaff and four postdoctoral positions.Molecular Biologist with experience ineukaryotic systems to work in growing pro-gram on the molecular biology of radiationcarcinogenesis. At least two years ofpostdoctoral research experience inmolecular biology is required, but wewelcome applications from more seniorinvestigators. Experience in the areas ofdevelopment, oncogenes, mutation orgene expression is desired.

Molecular Biologist required to work atour Marine Sciences Laboratory at Se-quim, Washington. The position requiresat least two years of postdoctoral ex-perience in molecular biology research.The applicants should have a desire todevelop a research program which ap-plies molecular biology techniques tomarine biology research.

Postdoctoral Positions are available inmolecular biology of carcinogenesis withan emphasis on examining the role of on-cogene activation in radiation-inducedtumors. Applicants should be recentPhD's with a background in molecular orcellular biology or biochemistry; ex-perience in recombinant DNAtechniquesis desired. The stipend for these positionswill be $25-30K per year depending onqualifications; group health insurance isincluded.

The Pacific Northwest Laboratories inRichland, Washington, are operated byBattelle Memorial Institute for the Depart-ment of Energy and have a staff of about3,000 with approximately 350 in the LifeSciences Center. Send resume, salaryhistory, current salary requirements andreferences to: Manuel Chavallo, Battelle,Pacific Northwest Laboratories, P.O.Box 999, Department 048, Richland,WA 99352. U.S. citizenship required. AnEqual Opportunity Employer M/F.

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POSITIONS OPEN

POSTDOCTORAL POSITION IN IN VIVONMR-The Pennsylvania State University College ofMedicine, Department of Radiology has a position avail-able immediately at the postdoctoral level for an individ-ual with interest/experience in in vivo NMR spectrosco-py/imaging in a number of projects in animals and man.Additional experience in biochemistry, physiology, or rfelectronics is highly desirable. Applicants shoul submitletter of application, curriculum vitae, and the names ofat least three references to: Dr. Michael B. Smith,Department of Radiology, P.O. Box 850, Hershey,PA 17033. An Ajfirmative Action/Equal Opportunity Em-ployer. Women and Minorities encouraged to apply.

THREE POSTDOCTORAL POSITIONS tostudy (i) skin cytochrome P-450 and mechanisms of skintumorigenicity, (ii) skin photosensitization and photody-namic therapy of skin cancer, and (iii) immunodermato-logy and photoimmunology. Ph.D. with relevant experi-ence desirable. Send curriculum vitae with names ofreferences to: Dr. Hasan Mukhtar, Research Director,Department of Dermatology, Case Western ReserveUniversity, Cleveland, OH 44106.

TWO POSTDOCTORAL POSITIONS availablefor studies of the role of calcium and physiologicalmetabolism in myocardial regulation in physiological andpathological states, including irreversible ischemic injuryin heart and cultured myocytes. One position will investi-gate the role of phospholipases in these processes utiliz-ing biochemical techniques and phospholipase inhibi-tors. The other will utilize fluorescent indicators, such asfura-2, and cellular imaging techniques to study thedynamic changes in calcium metabo sm in myocytes.Our laboratory is well-funded and these positions are for3 years. U.S. citizens or permanent residents send curric-ulum vitae with names and telephone numbers of threereferences to: Drs. L. M. Buja and H. K. HRaler, H2-130 Pathology, University of Texas SouthwesternMedical Center, 5323 Harry Hines Boulevard, Dal-las, TX 75235-9072. An Equal Opportunity Institution.

POSTDOCTORAL RESEARCH ASSOCIATEAvailable immediately for studies on glycation and

oxidation of proteins in diabetes and aging. Prefer Ph.D.in biochemistry with experience in bioanalytical/bioor-ganic chemistry or protein chemistry, and workingEnowledge ofHPLC or GC/MS for project on character-ization of products of modification of proteins by glu-cose and oxidative reactions. Send curnculum vitae to:Professor John W. Baynes, Department of Biochem-istry, University of South Carolina, Columbia, SC29208. Telephone: 803-777-7272.

POSTDOCTORAL RESEARCH ASSOCIATES

(i) To study the mechanism of pH-regulated geneexpression in E. coli. Experience with DNA analysis,microbial genetics, or bacterial physiology required. (ii)To construct and analyze mutants of a small drug

resistant dihydrofolate reductase. Experience with DNAmutagenesis technology, protein overproduction, or pro-tein stability required. Opportunity to collaborate onenzymology and biophysical studies. Send curriculumvitae and fetters of refrence to: G. N. Bennett, Depart-ment of Biochemistry, Rice University, P.O. Box1892, Houston, TX 77251.

POSTDOCTORAL RESEARCH ASSOCI-ATE(S): Positions available Autumn, 1988 for (i) cell

biologist/biochemist to study phagocytic leukocytes. Ar-eas of interest include cell stimulation, surface receptors,and endocytosis. Experience in enzyme analysis, cellfractionation, and electrophoresis desirable. And (ii) cellbiologist to study endocytosis and vesicular transport inendothelial cells. Experience in electron microscopy andimmunocytochemistry desirable. Send curriculum vitaewith description of research background and names andaddresses ofthree references to: Dr. John M. Robinson,Department ofAnatomy, The Ohio State University,4072 Graves Hall, 333 West 10th Avenue, Colum-bus, OH 43210. An Equal Opportunity/Affinnative ActionEmployer.

POSTDOCTORAIJRESEARCH ASSOCIATEposition available to study RNA Processing in animalcells and viruses. Background either in biochemistry,microbiology or molecular biology needed. Experiencein recombinant DNA technology desirable. Salary nego-tiable. Send r6sumr with two names for references to:Dr. Mary Edmonds, Department of Biological Sci-ences, University of Psttsburgh, Pittsburgh, PA15260. Equal Opportunity/Affirmative Action Employer.

HOWARD HUGHES MEDICALINSTITUTE-PHILADELPHIA

Position available July 1989 for POSTDOCTORAL(M.D. or Ph.D.) RESEARCH ASSOCIATE to carryout molecular studies of chromosomal fragile sites. Can-didate must have documented research experience andproven expertise in (i) cytogenetic analysis ofhuman andsomatic cell hybrid lines, (ii) in situ hybridization ofsingle copy DNA, and (iii) cloning of large genomicfragments in S. cerevisiae using artificial chromosomevectors. Send curriculum vitae to:

Robert L. Nussbaum, M.D.HHMI-Philadelphia

Department of Human GeneticsUniversity of Pennsylvania School of Medicine

37th and Hamilton WalkPhiladelphia, PA 19104-6072

POSTDOCTORAL RESEARCH POSITIONavailable immediately (M.D. or Ph.D.) for research onthe intestine: control of intestinal differentiation, celladhesion to basement membrane, deterrninants of cellpolarity and plasma membrane glycoprotein synthesis,basement membrane synthesis and the roles ofvitamin Dand A in the control of enterocyte differentiation. Sendcurriculum vitae, names, and addresses of three refer-ences to: Dr. Milton M. Weiser, State University ofNew York at Buffalo (SUNY), Division of Gastroen-terology, Buffalo General Hospital, Kimberly Build-ing, 100 High Street, Buffalo, NY 14203. SUNY is anEqual Opportunity and Affirmative Action Employer.

Associate Senior Investigator -Cardiovascular PharmacologyA health care company that markets prescription and proprietaryproducts for human and animal health care has an opening for anAssociate Senior Investigator, Cardiovascular Pharmacology in itsDepartment of Cardiovascular Pharmacology at its research anddevelopment facility in King of Prussia, Pennsylvania.The principal duties of the position include planning, conducting,supervising, and evaluating pharmacologic research directed atfinding pharmacological entities which provide a rational basis forthe design of new cardiovascular drugs capable of preventin9 andretarding hypertension, congestive heart failure and myocardialinfarction. Such research includes (i) studyina the vasoconstrictoreffects of platelet-derived growth factors ("PDGF"), (ii) investigatingthe mechanism of action for the antihypertensive effects of novelcompounds, (iii) studying the mechanism by which certainchemical agents produce vasoconstriction in the cardiovascularsystem and (iv) studying the mechanism by which coronary arteryreperfusion exacerbates myocardial infarction and discoveringchemical agents to inhibit this process.The minimum requirements for the position are a Ph.D. degree inCardiovascular Pharmacology and four years experience in cardio-vascular pharmacologic research including two years pharmaco-logic research (i) characterizing a adrenoceptors in the cardio-vascular system, (ii) studying the vasoconstrictor effects of platelet-derived growth factors and (iii) experience in studying mechanismsof myocardial infarction.Salary of $42,000 with liberal employee benefits. No fee charged.Qualified applicants should submit resume or curriculum vitae toPhiladelphia Job Bank, 444 N. 3rd Street, Philadelphia, PA 19123and refer to Order Number 4192904. Equal Opportunity Employer,M/F/H/V.

The INSTITUTE OF MEDICINE isseeking a staff officer to direct the newlyestablished Roundtable on the Develop-ment of Drugs and Vaccines AgainstAIDS. The Roundtable will convene pri-vate and public sector participants indrug and vaccine development, to helpspeed research, testing, and the avail-ability of therapy for HIV infection.Responsibilities include planning commit-tee meetings, workshops and symposia;preparing background materials; writingmeeting summaries and related papers;and participating in other AIDS-relatedactivities. Applicants should have aPh.D., M.D., or equivalent and at leastfour years of research or policy experi-ence. Familiarity with government andprivate institutions involved in drug andvaccine development (e.g., FDA, NIH,academic institutions), expertise in abiomedical science, excellent oral andwritten communication skills, and theability to work with expert committeesrequired.The NRC offers a competitive startingsalary and excellent benefits includingpaid relocation to the Washington, D.C.area. Interested persons should send aresume in confidence to:INSTITUTE OF MEDICINE,RW-AIDS Activities, IENAS2101 Constitution Ave., NAEN.W, Washington, D.C. IOM20418. EOE.

POSITIONS OPEN POSITIONS OPEN

Opport.unities in.BiotechnologyRepligen Corporation is a leader in the appli-cation of Biotechnology to the health careand personal care markets. We are currentlydeveloping an AIDS vaccine and AIDS thera-peutic products, products for the treatmentof infectious diseases, cancer therapies, andnovel biocompatible personal care products.We take pride in the high caliber of our scien-tific staff and our collaborations with majorresearch institutions and corporate partnersin Europe and the United States. The expan-sion of our efforts has created the followingopportunities:

Protein ChemistryResearch Scientist Ph.D with 2-4 years' post-doctoral experience. We are seeking a creativeindividual to lead protein structure-functionprojects in the area of retroviral infection andimmunomodulation. Experience with physicalmethods of protein characterization andcomputer modeling of protein structure isrequired. The successful candidate will havea proven record of creative research andaccomplishment.Research ScientlstlAssoclate Scientist Weare looking for a recent Ph.D in ProteinChemistry with extensive experience in proteinisolation, purification, and characterization.

ImmunologyResearch ScientIt/Associate Scientist Ph.D.in Immunology or closely related field with 1-3years' post-doctoral experience. Two positionsexist for scientists with extensive backgroundsin cellular immunology or direct experiencewith hybridomas and monoclonal antibodies.

Repligen Corporation offers a competitivesalary, excellent benefits, and equity partici-pation. Please submit a cover letter, resume,and references to Barbara Fleming, Recruiter,Repligen Corporation, One Kendall Square,Bldg. 700, Cambridge, MA 02139.

An Equal Opportunity Employer.

N; 5~wmaUU

R & D PROJECTTEAM LEADERBIOCHEMISTRY/

MOLECULAR BIOLOGYFMC BioProducts, a major manufacturer of agarose andother fine materials for biotechnology and life scienceresearch, is recrulting a project leader for its Research andDevelopment department. The project leader will be respon-sible for the scientific and administrative direction of pro-duct development for specified areas of the research market.The successful candidate will have a PhD orequivalent andfive or more years of postdoctoral experience, at least two ofwhich must be In industry. Previous supervisory or ad-ministrative experience Is required. Areas of professional ex-pertiselexperience should Include molecular biology andprotein chemistry. Experience in polysaccharide, polymer orphysical chemistry is highly desirable. The successful can-didate will possess strong communication skills and be will-ing to travel up to 20%.This position is located in FMCs facilities in Rockland,Maine. Our beautiful coastal location offers relaxed butrelatively cosmopolitan small-town living, with excellentschools and easy access to outdoor recreation. FMC offerma competitive salary and excellent fringe benefits.Applicants must be US Citiens or permanent residents. Ap-plications from female and minority candidates are stronglyencouraged. Send your resume in confidence (no later thanSeptember 23) to: Human Resources Dopartment, FMCBPaldct, Box 308, Rockland, ME 04841. Equal Opportuni-ty Employer, M/F.

Research Assistant!Associt

Genentech, Inc., a leader in the field of biotechnology, hasthe following opportunity available in our PharmacologicalSciences group.An individual with 3-5 years of post- graduate experienceis sought to assist with radioreceptor binding technologyand assay development for novel drug discovery projects.This opportunity requires experience with computer-assistedanalyses of receptor binding data, such as the Lundonprogram, as well as a background in enzyme inhibitionstudies. Knowledge of HPLC and invivo receptor bindingtechniques is desirable. An MS in Biology/Chemistry orPharmacology or equivalent is preferred.Genentech, Inc. offers an excellent salary and benefits pack-age coupled with the opportunity to make a significant con-tribution to our organization. For consideration, please sendyour resume to Carol B.G. Deasy, Human Resources Depart-ment, Genentech, Inc., 460 Point San Bruno Blvd., South SanFrancisco, CA 94080. An equal opportunity employer.

(moehW Oan.0Genentech, Inc.(2(E (S(h On(BO

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POSITIONS OPEN

POSTDOCTORAL RESEARCH ASSOCIATE.Position available immediately to study tobacco smokeuptake and carcinogenic potential. Experience in immu-noassay, HPLC and autoradiography essential. Proposedstudies include animal assays and clinical protocols toevaluate biomarkers of active and passive smoking. Pleasesend curriculum vitae a brief description of prior re-search, and names of three references to: Dr. N. J.Haley, Division of Nutrition and Endocrinology,American Health Foundation, 1 Dana Road, Valhal-la,NY 10595. An Equal Opportunity Employer M/F/H/V.

YALE MEDICAL SCHOOLDEPARTMENT OF CELLULAR AND

MOLECULAR PHYSIOLOGYAn NIH POSTDOCTORAL TRAINING

GRANT POSMON is available immediately to studythe molecular biology of the Ca-gated K channel (Gar-dos) as expressed in red blood cells and other cell lines.Approaches include labeling, purifications, antibiotics,probes, cloning, expression, reconstitution and transportfunction. Background in biochemistry and cellular physi-ology desirable. Send curriculum vitae and two letters ofreference by 15 August to: Joseph F. Hoffman, Depart-ment of Cellular and Molecular Physiology, YaleMedical School, 333 Cedar Street, New Haven, CT06510. Yale University is an Equal Opportunity Employer.

PREDOCTORAL AND POSTDOCTORALFELLOWSHIPS AVAILABLE

IN TOXICOLOGYPositions to be filled in the following areas: percutane-

ous absorption, cutaneous toxicology, metabolism andtoxico-kinetics; mechanisms of comparative toxicity;mechanisms of xenobiotic interactions; monooxygenaseenzymes; molecular basis of enzyme specificity; mecha-nisms of tumor promotion. Applicants should submit astatement of research interests and curriculum vitae, to:

Chairman, Toxicology ProgramNorth Carolina State University

Box 7633Raleigh, NC 27695

North Carolina State University is an Affirnative ActionUniversity.

PRODUCT MANAGERPromega Corporation, based in Madison, Wisconsin

and a leading manufacturer ofmolecular biological prod-ucts for research and industrial scientists, is seeking atalented individual for the position of Product Manager.This position has product management responsibility forPromega's existing Research Products line. Responsibil-ities include advertising and promotion of current prod-ucts, competitive comparisons, sales aids, product linepricing and forecasts, as well as profit and loss monitor-mg by product. This position requires a M.S. degree orequivalent in a molecular biology related field with ammnimum of 3 years of industrial experience in a productmanagement role. Extensive travel is required. PromegaCorporation offers a competitive salary, comprehensivebenefits program, and a challenging environment inwhich to apply your professional skills. To apply, pleaseforward a resume and references to:

Promega CorporationPersonnel Dpartment

2800 South Fish Hatche RoadMadison, WI 53711-5305

Promega Corporation is an Equal Opportunity Employer.

U.S. DEPARTMENT OF AGRICULTUREFOREST SERVICESOUTHERN FOREST

EXPERIMENT STATIONPROJECT LEADER/SUPERVISORY RE-

SEARCH PLANT PATHOLOGIST. USDA-FS,Southem Forest Experiment Station, is seeking a re-search plant pathologist to lead a team of researchers onfusiform rust, needl cast diseases (a new one withunknown causes(s)) and nursery diseases (replacementfor methyl bromide). Knowledge of plant or fungalgenetics and forest pathology are required. Salary rangeis GM-13/14 ($39,501 to $46,679). Information con-ceming the position may be obtained from: PersonnelManagement, Room T-10210, USPSB, 701 LoyolaAvenue, New Orleans, LA 70113. Telephone: 504-589-3921. The USDA is an Equal Opportunity Employer.

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HARVARD MEDICAL SCHOOLPROFESSOR OF

BIOLOGICAL CHEMISTRY ANDMOLECULAR PHARMACOLOGY

Applications are invited for the position ofprofessor ofbiological chemistry and molecular pharmacology, Har-vard Medical School. Candidates should have strongcredentials in the area of eukaryotic molecular geneticsand gene regulation. Major responsibilities will includesupervision of an active research program in this area andteaching of biochemistry to graduate and medical stu-dents. Applicants should submit curriculum vitae andbibliography to: Dr. Priscilla A. Schaffer, Chairpersonof the Search Committee, Dana-Farber Cancer Insti-tutc, 44 Binney Street, Boston, MA 02115.

Harvard Medical School is an Equal Opportunity/Affirma-tive Action Employer. Qualifiedfeemale and minority applicantsare encouraged to apply.

RECEPTOR EXCITATIONAND ADAPTATION

POSTDOCTORAL POSMIION available 1 Sep-tember 1988 to join group identifying pathways regulat-ing the excitation and adaptation of photoreceptor outersegments, a model for many other receptor systems.Research areas include kinetic modeling, electrophysiol-ogy, and enzymological studies of permeabilized cells.Send curriculum vitae and names of three references to:Dr. Deric Bownds, Laboratory ofMolecular Biolog,V1525 Linden Drive, University of Wisconsin-Madi-son, Madison, WI 53706.An Equal Opportunity Employer M/F.

RESEARCH AND POLICY ANALYSISMajor corporation providing technical support to the

U.S. Environmental Protection Agency in the area ofglobal climate change hasopenings for JUNIOR ANDMID-LEVEL ANALYSTS in the fields of:-ncnrgy programns* energy efficiency analysis* altemative energy sources

-global agriculture and forestry-climate modeling-global tropospheric and stratospheric chemistryRequirements: minimnum of mastcers degree and 2 to 5

years of experience. Familiarity with economics andsystems analysis is desirable.

Candidates should send a resume to:The Bruce Company

Suite 4103701 Massachusetts Avenue, NW

Washington, DC 20016

RESEARCH ASSOCIATE. Ph.D. in physics orbiophysics with 2 years of training in electron microsco-pyand2 years of experience in x-ray crystallography orelectron image processing to conduct research into thestructure and functions of CaATPase. Ability to preparesarcoplasmic reticulum membranes required. Forty hoursper week. Salary: $17,500. Apply to: EmploymentSecurity Commission, 516 North Mangum Street,Durham, NC 27701 or your local Job Service Office.Refer to Job Order Number NC7103017, DOT Code090.227-010. Affirmative Action/Equal Opportunity Em-ployer.

RESEARCH ASSOCIATEThe Laser and Applied Technology Laboratory, Char-

lotte Memorial Hospital and Medical Center, invitesapplications for a full-time research associate position.The position will involve research in cardiovascular appli-cations of lasers. Individuals applying should have previ-ous experience in small animal cardiac surgery, cardiaccatheterization, cardiopulmonary bypass perfusion ofcanines, and the use of lasers. A 2- or 4-year degree in arelated field is also required. Salary range $24,063.20 to$36,004.80. Interested applicants should submit curricu-lum vitae and letters of recommendation by 15 Septem-ber 1988 to:

George TatsisHeineman MedicalResearch LaboratoryP.O. Box 32861

Charlotte, NC 28232Equal Opportunity Employer

RESEARCH ASSOCIATE (MANHATTAN):Applying principles of bacteriology, immunology, tissueculture techniques and detailed knowledge of the patho-genesis of rheumatic fever, researches the immunologicaland genetic aspects of rheumatic fever. Researches rela-tionship between streptococcus bacterium and rheumaticfever to develop a diagnostic test to predict how childrenare susceptible to rheumatic fever. Requirements: Ph.D.in bactenology/immunology plus 1 year of experience onjob. Salary $23,000 per year, 40 hours per week. Sendresume in duplicate to: RG #309, Room 501, OneMain Street, Brooklyn, NY 11201.

RESEARCH ASSOCIATE: BIOPHYSICIST/PHYSICIST with knowledge of biological macromol-ecules needed to participate in NIH-supported studyaimed at determination of molecular structure of lipid:protein systems. Experience in dealing with x-ray andneutron diffraction results required. Please send curricu-lum vitae and threc letters of recommendation by 1October 1988 to: Dr. Leonard J. Banaszak, Depart-ment of Biological Chenmistry, Washington Universi-ty School of Medicine, Box 8094, St. Louis, MO63110. Affirmative Action/Equal Opportunity Employer.

RESEARCH ASSOCIATE POSMON availableimmediately to conduct research on ocular surface epi-thelium. Position involves establishing immortalized ortumor cell lines representative ofcertain epithelial pheno-types and using the cells to study the structure, function,and regulation of ocular specific components. Work willbe conducted in collaboration with Drs. John R. Has-sell, Richard A. Thoft and other members of theDepartment ofOphthalmology, University ofPittsburghSchool of Medicine and The Eye & Ear Institute. Thework will utilize both clinical and basic resources. Appli-cants should have a Ph.D., 2 years of postdoctoralexperience and experience in cell culture. Familiarity withimmunological techniques, molecular biology, chroma-tography and virology desirable. Send curriculum vitae, abrief statement of research interests, and three letters ofreference to: Mary Ann Masullo, Administrative Co-ordinator, The Eye & Ear Institute of Pittsburgh,203 Lothrop Street, Pittsburgh, PA 15213.

The University of Pittsburgh is an Equal Opportunity/Affirmative Action Employer.

RESEARCH ASSOCIATE POSMON availableimmediately for Ph.D. to study the molecular biologyand regulation of the kidney vacuolar H+ATPase. Back-ground in either recombinant DNA work or in proteinpurification required. [Recent work: see PNAS 85, 3004(1988); JBC 262, 15780 (1987); Nature 331, 622(1988).] Excellent salary and comprehensive benefitpackage. Send curriculum vitae and names of threereferences to: Dr. Stephen Gluck, Jewish Hospital/Washington University School of Medicine, 216South Kingshighway, St. Louis, MO 63110.

RESEARCH Ph.D.Immediate opening for Ph.D. with interest in basic

and clinical research work in cardiac physiology, electro-physiology/biochemistry. The successful candidateshould have interest and experience in cardiovascularanimal research. Experience in handling various bio-chemical techniques like HPLC, RIA spectropho-tometry desirable. This challenging position offers op-portunity for growth in clinical as well as basic cardiovas-cular research. Winthrop-University Hospital is a 533-bed teaching affiliate of SUNY, Stony Brook School ofMedicine, offering competitive salary, comprehensivebenefit package and a professional working environment.The institution has state-of-the-art animal research, elec-trophysiology, invasive cardiac and cardiac surgical facili-ties. Send resume or contact:

Steven Zeldis, M.D., or Kul D. Chadda, M.D.WVmthrop-University Hospital

259 First StreetMineola, Long Island, NY 11501

or call: The Human Resources Department, Tele-phone: 516-663-2351.

Equal Opportunity Employer M/F/H

SCIENCE, VOL. 241

POSITIONS OPEN POSITIONS OPEN

POSITIONS OPEN

RESEARCH ASSOCIATE wanted to join an active,pediatrically based research group working on the molec-ular biological aspects of skeletal tissue remodeling, inparticular, gene expression in bone resorption. The suc-cessful candidate will hold a doctoratc in a biological orbiochemical discipline, and have 2 to 5 years ofpostgrad-uate experience in research related to the mission of thelaboratory. The associate will be expected to help super-vise trainees/technicians, and to undertake some indepen-dent research. Interested parties should send curriculumvitae, a description of laboratory experience, and thenames and addresses ofthree referees to: Dr. A. J. Kahn,Director, Pediiatric Research Institute, 3662 ParkAvenuc, St. Louis, MO 63110. An Equal OpportunityEmployer.

RESEARCHASSOCIATE-NEUROBIOIOGY.Position in established laboratory to study neurobiologyof peripheral and central auditory and vestibular process-es. Exjperience in receptor binding, inimunocy-tochemistry, recombinant DNA techniques, or peptide/protein microchemistry required. Salary commensuratewith experience. Duration: 2 to 3 years, renewed annual-ly. Send curriculum vitae, representative publications,and names of three references to:

Dr. Dennis DrescherLaboratory of Bio-otologyWayne State UniversityrSchool of Medicane

540 East Canfield AvenueDetroit, MI 48201

Wayne State University is an Equal Opportunity/Afinrma-tive Action Employer.

RESEARCH POSMON available as senior staff orjunior faculty, depending on qualifications. We seek anindividual to wor with a research group concerned withthe molecular mechanism of action of steroids on iontransport in epithelia. Candidate should haye experiencewith primary cell cultures and monoclonal antibodies toprepare immunodissected cultures. A background inmembrane transport is desired but not required. Sendletter of application, curriculum vitae, and names andaddresses of three references to: John P. Hayslett,MD., Yale University, Department ofInternal Medi-cine, 333 Cedar Strcet, New Haven, CT 06510.

RESEARCH SCIENTIST: Develop non-radioac-tive receptor ligand binding assays animal models forstudying cellular differentiation; ligand binding assaysfor growth-inhibitory peptides and assays studying signaltransduction pathways such as protein phosphoryl-ation-dephosphorylation and study gene expression incells during terminal differentiation using knowledge ofthe following techniques: Cellular differentiation of epi-dermal and leukemia cells, roduction and characteristicsof polydonal and monocFonal antibodies, synthesis ofoligopeptides and oligonucleotides using Applied Bio-systems peptide and DNA synthcsizers, Southern,Northern and Western blottings, gene cloning and DNAsequencing and tissue culture for human Keratinocytes.

Ph.D. in biomedical sciences with concentration inpharmnacology plus 3 years of cxperience required. Fortyhours per week; $41,800 per year. Send resume to: JobService Technical Unit, Connectit Departent ofLabor, 200 Foliy Brooks Boulevard, Wetersfield,CT 06109. Refer to Job Order #3024764.

RESEARCH SCIENTIST POSMONIN MOLECULAR VIROLOGY

A position is available in the Department of MedicalMicrobiology and Immunology at The Ohio State Uni-versity Medical Center to study the molecuiar biology ofEpstein-Barr virus, particularly in regard to its associa-tion with nasopharyngeal carcinoma. Applicants shouldhave a Ph.D. or M.D. degree and postdoctoral trainingin molecular virology. Experience with herpesviruses ispreferable but not required. Salary will be dependentupon experience. Send curriculum vitae and three lettersof reference to: Ronald Glaser, Ph.D., Professor andChairman, Department ofMedical Microbiology andI^mmunology, The Ohio State University College ofMedicne, 333 West 10th Avenue, Columbus, OH43210. Deadline for applications is 31 August 1988. TheOhio State University is an Equal Opportunity/AffirmativeAction Employer.

29 JULY I988

*fl^ Government* TE*of Canada

Gouvernementdu Canada

VISITING FELLOWSHIPSIN

CANADIAN GOVERNMENT LABORATORIES198990

The Governrhent of Canada offers visiting fellowships in Canadian Government Laboratories toprovide promising young scientists with the opportunity to work with well-established researchgroups and leaders in their fields. These fellowships are tenable in the laboratories of thefollowing departments and agencies:

Agriculture Canada Fisheries and Oceans CanadaAtomic Energy of Canada Limited Health and Welfare CanadaCommunications Canada National DefenceEnergy, Mines and Resources National Museums of CanadaEnvironment Canada National Research Council Canada

Eligibility: Applicants should have received a doctorate from a recognized university within thelast five years or a master's degree followed by at least two years of research experience and ademonstrated capability to conduct independent research.There are no citizenship restrictions. However, successful candidates who are not Canadians orpermanent residents of Canada must satisfy Canadian immigration requirements.Stpend: Fellowships have an annual value of $28,992 plus a travel allowance.Duration of Tenure: Appointments are made for one year; renewals for a second year arepossible.Date of Submission: The deadline for receipt of applications is December 15, 1988.For further information, contact the:

Visiting Fellowships OfcerNatural Science and Engineering Reearch Council200 Kent StrWtOttawa, Ontario

KIA IHSTelephone: (613) 996.4363 C n d

IASSISTANT IASSOCIATERESEARCH SCIENTISTS

Anti-Cancer ResearchProgress in anti-cancer research is accelerating at Bristol-Myers' pharmaceut-ical research facility in Wallingford, Connecticut. It's a setting that encouragesinterdisciplinary cooperation and rewards individual achievement. Thefollowing positions are now available:

Molecular Biology/Gene RegulationThis immediate opening for a Research Assistant/Associate requires a BS/MSin biological sciences. You'll enjoy active and original participation in a researchprogram exploring the molecufar basis of cancer. The primary focus will beon identifying cis and trans-acting factors involved in regulating growthfactors and oncogenes. Experience in molecular biology and/or proteinpurification preferred.Molecular Biology/Immunology

The Research Associate we seek will have a BS/MS and several years ex-perience in several of the following: cDNA cloning, DNA sequencing, mRNAanalysis, eukaryotic gene expression, cell culture, or immunological techni-ques. You will be studying the growth regulation of lymphocytes usingmolecular biological approaches.Bristol-Myers offers sustained growth, highly competitive salaries, extensivebenefits and career support. Our countyside location is convenient to NewHaven and Hartford, Connecticut, New York City and New England. Pleasesend resume with salary history to: BRISIOL-MYERS COMPANY, Phar-maceutical Research & Development Division, P.O. Box 5100, 5 ResearchParkway, Wallingford, Cl 06492. An Equal Opportunity Employer M/FIHIV.

* Bristol-Myers CompanyExplore with us.

POSITIONS OPEN

BIOHYERID TECHNOLOGIES INC.RESEARCH TECHNICIAN

BioHybrid Tchnologies is a small research corpora-tion currently focusing on the development of an artifi-cial pancreas composed of isolated isfet cells. Responsi-

bilities will incude small aninal surgery, glucose toler-ance testing and pancreatic islet implantation. Must becapable of- working independently and able to workflcxible hours including some weekends. Sterile tech-nique and previous tissue culture experience helpful.M.S./B.S. and rdelvant experience required. Send resu-nim, names of three refercnces, and salary history andrequirements to: BioHybrid Technolges Inc., 910Turnpike Road, Shrewsbury, MA 0155.

TUFTS UNIVERSITY-MEDICAL SCHOOL

SENIOR FACULTY POSMONIN PATHOLOGY

JEDDAH, SAUDI ARABIAApplicants are being solicited for a pathologisttowork

in Saudi Arabia under a U.S. Treasury-sponsored pro-

gram in conjunction with Ttifts University to providctechnical assistancc to King Abdulaziz University, Jed-dah, Saudi Arabia. Candidate must possess an M.D. withAnatomic Pathology training, cxperience in- diagnosticElectron Microscopy, teaching and research are desir-able. The selected candidate should be able to providehigh-quality teaching and training of Saudi faculty andstaff and to serve as a consultant to the medical facultyand hospital personnel.

The project provides overseas allowances, housing,vehcde, eucational allowance for children, round trip air

fare tickets for the family, shipping of household items,and others. The appointment IS for 1 year,commencing 1

Septcmber 1988 or as soon after as possible, with anopportunity for renewal. Salary will becommensurate

with qualifications and experience. Candidates for theposition must submit a detailed r6sumc and threc lettersof recommendation to:

Martin H. Flax, M.D., Ph.D.ProfesQr and Chairman

Department of Patholg

Tufts University Scool of edicine

136 Harrisoi Avenue

Boston,MA 02111Tufts University is an Equal Opportunity Employer.

SENIOR RESEARCH POSITIONDEPARTMENT OF MEDICINEHARVARD MEDICAL SCHOOL

We are seeking a molecular bioiogist to join a multidis-ciplinary laboratory investigatingtheregulation of cellu-lar receptors for adhesive molecules. Applicants shouldhave a minimum of 2 years of postdoctoral work, astrong background in rbcombinant DNA techniques

and evidence of scientific accomplishments. In. additionto participating in exsting projects, the applicant.will beencouraged to,develop indendent resarch within thebroad scQpeC of cell adhesion biology. Faculty appoint-mcnt and salary will be commensurate with backgroundand experience. Send curriculum vitae, statement ofresearch interests, and names of three references to:

Dr. Jac Haawier.Division of n t;ll MedicNew lasadXeaconess Hospital

Medlical School

18SP RLoadB so ,02215

SENIOR SAFETY ANDHEALTH SPECLALIST

The University of Florida (UF) Division of Environ-mental Health and Safet has-an imte opeiung.Duties includc general laoratory safety and biosaty.UF has 1500+ research laboratories in various colleges.

B.A. in environmental health or an alLd field plus 1 year

of cxperience or master degree in above mentioned area.

Salary is negotiable ($21,000 to $35,000)..Send r6sumnto: Cmentr Employment Center, 4th Floor Stdim,University of Florida, Gainesvill FL 32611 by 12August 1988. Rcefr to ID #22577. Equal Opportunity!Alfrmative Action Employer.

626

POSITIONS OPEN

SENIOR RESARCH ASSOCIATEAn individual is sought to participate in an active

laboratory engaged in research related to the microbiolo-gy or oral disease. The successfill applicant will beresponsible for a smal research proup m studies of theprogression of the microbiota m periodontal disease.This individual will also have input into studies ofthe celisurface ofGram-negative anaerobes, as well as having theopportunity to undertAke some independent research.Research training is esential, as well as a strong back-ground in dlinical microbiology. Must be able to work inadose oup setting, and to nteract in a positive fashionwith ochers. Requies a Ph.D. or equivalent in generaliicrobiology. Send curriculum vitac to: Office of Hu-

manl Reore/mloyment, TeUniversit of Tex-as Health Scienve Center at San Antonio, 7703 FloydCurl Drive, San Antonio, T 782847972.

Equal Oppontunity/AJfirmative Acton Employer

CONFERENCES

4th ASM CONFERENCE ONGENETICS AND

MOLECULAR BIOLOGYOF

INDUSTRIAL MICROORGANISMS2oo 7 October 1988Bloomington, Indiana

The confecrcnce will focus on the geneticsbiochemistry, and molecular biology of industri-al micoo ms, with an empasis on bothbacteria and eucaryotes. Contributed pers willbe presented in poster format. For registrationinformation and abstract foms, contact: Meet-ings Department, icrican Socty for Mi-iobiology, 1913 Eye Street, N.W, Washing-ton, DC 20006. Teephone: 202-833-9680.

.FELLOWSHIPSPOSTDOCTORAL FELLOWSHI

Available immediately to study mechanisms involvedin macrophagc activation and the regulation of cykinesecreton. Research experienc in signal transductionmechanisms is desirable. Send curriculum vitae to: Dr.Donald Beeahotl,bory ofMacop Biolo-gy, Guthrie R Institute, Se, PA 18840.

STAFF ELLOWSiwS INBIOMEDICAL RESEARCH

DHHS, PHS, Food and Drui Administration, Centerfor Biobgics Evaluation aind Reseach, Divisions ofBacterial Products and Biological Investigational NewDrugs ar seeking applications for Staff Felowships fromoustanding candidates with Medical Degrees. mTis pro-gram oftrs an initial 2-year felowslup focusing rcsearchand regulatory revicvciorts in the area of vaccincdevelopment. These individuals will play a vital role inthe development of clinical research on new vaccines.

Candidates must have a strong bcground in cellularand molecular biology, immunoogy, and/or clinical re-search. These individuals will s?end approximately one-halfof their time with the Division ofBiological Investi-gational New Drugs, Rockvillc, Maryland, r andparticpating in regulatory review of new vaccine pro-ducts, characterization data, plans for clinical investiga-tion and/or markceting approval applications. The rc-maining onc-half time wllU be dircted towards thedevdopmnent of laboratory skils laring a varicty oflaboratory techniques, participating in one ofa variety ofongoing research programs in the Division of BactcrialProducts, located gn the campus of the National Insti-tutes of H;alth in Bethcsda, Maryland

Salary range for candidates with a Medical Degree isfrom $24,000 to $50,744. Salary, research support andlevel of responsibility arc conmensurate with educationand experince. Applicants must be U.S. citizens or residentaliens eligible.frr dtizenship within 4 years.

Intcrested candidates should send acurent curriculumvitae and bibliography to: FDA, Center for BioloicsEvaluation and Reeac ilding 29, 11--P8800 Rockille Pike, BethesdaD 20892. For fur-ther information, call: Ms. Boyer or Ms. Hutelis on301-496-5394. FDA is an Equal Opporunity Employer.

FELLOWSHIPS

VUniversity of Michigan: POSTDOCTORAL FEL-LOWSHP availablc ror recent Ph.D; or M.D., Ph.D. jnimmunology or relevant related field with expertise ininmunoglobulin genetics and protein cxpression. Specif-ic project involves cloning, modifiring and expressingDNA for a murine monoclonal antibody with high-levelreactivity with many carcinomas, for eventual argedcancer therapy. Multidisciplinarv laboratory with sup-port available at various levels or the proposed workMMD. applicants, program may be tailored to allow

for eventual board certication in nuclear medicine.Opportuniy greatest for the venturesome. Please sendcurriculum vitae and names of two refrences to: Rich-ard L. Wahl, M.D., Division of Nuclear Medicine,Univity of Mihigan Medical Center, Ann Arbor,MI 43109-0028. Applicants must be U.S. dtizen orpennanent resident. The University of Michigan is a Nondis-criminatory, Afirmative Action Employer.

FELLOWSHIPS IN EYE-IMMUNOLOGY, Vi-sion-Immunology Center, University of ConnecticutHcalth Ceter, Farmington, Connecticut. Research inoqular aspecs of mmation and rpair with emphasison cell and molecular biology, coagulation, fibrin metab-olism, plasmnino activator rgltion and transplanta-tion. Ph.D., M.D. or equivalent; expeience in cell ormolecular aspects of inflammation, immunology or cellbiolog preferred. Available Januar 1989. Applicantsmustbe eligible fior NIH Tr Grant salary support.Sendcurriculum vitae and requests for information to:Dr. Donald L. Kretzer, Vision-Iimunology Center,Universiy of Connecticut Health Cnter, Faqington, CT 06032. An Afirmative Action/Equal OpportunityEmployer M/W/H.

TRAINING PROGRAM

POSTDOCTORAL POSMONSIN MOLECULAR BIOLOGY

A diversified, interdisciplinary TRAINING PRO-GRAM in Molecular Biology with morc than 20 re-search teams with excellent research support. Areas ofresearchinclude:TUMOR VIROLOGYMMTV and B cell differentiationTumor cell surface glycoproteins in mammary cancerSV40 and adenovirus genc expressionMolecular virology of AIDS

ONCOGENESAdenovirus and heat-shock genesChromosomal mappingEffect on cell-cell communicationDevelopmental expression of oncogenes

GROWTH FACTORSin muscle cell developmentPolypeptide hormonesColony-stimulating factor, granulopoiesis and cell

differentiationInterleiukin-2 receptorThis 3-year program is designed for Ph.D., Ph.D./

M.D. or MI). candidates with academic-rescarch objec-tiveS. M.D.'s may enter a combined molecular biology-residency program. Highly successfil candidates will beencouraged to compete for independentrsearch supportand may be considered for future faculty positions.Salaries negotiable. Open only to U.S. citizens orpermanentresidents. Send curriculum vitae and references to: Dr.Carlos Goldenber University of Miami School ofMedidine, DepartiLent of Microbiology and Immu-nology, P.O. 016960 (R138),Miami, FL 33101.Afinnative Action/Equal Opportunity Employer.

PRE- AND POSTOCTORALTRAINIG PROGRAM IN

TOXICOLOGYThe Graduate Proram in Toxicology at the Universi-

ty ofMississippi Me icalCenter offers pe- and postdoc-toral traimng m these areas of toxiclogy: pul[moary,liver, CNS, ncuromuscular and synaptc transmission,endocrine and cardiovascular system. Requires U.S. dii-zenship or pennnet residence visa in United States. We areseeking applicationsfrom all qualified candidates and especillyfiom the minority students. Candidates should write to: Dr.H. M. hendale, Progam Director,TraiingP m,Dtteto i

Jackson,IS 39216- 4505. Equal p ity Enployer,M/F/H/V.

SCIENCE, VOL. 24.1

POSTDOCTORAL FELLOWSHIPS

IN CYSTIC FIBROSIS;The Cystic Fibrosis Foundation announces the availability of postdoctoralfellowships for M.D.s, Ph.D.s, and M.D./Ph.D.s interested in conducting basic orclinical research related to cystic fibrosis.Awards will be offered through the Foundation's network of research centers orthrough individual applications submitted to the Foundation. Stipends for theseawards are $30,000 (first year); $31,000 (second year); and $33,000 (optionalthird year).

INSTrlTTONAL AWARDSResearch areas at the centers indude, but are not limited to, ion genetics,

immunology, and the mcnms of ation. Participating scientists areavailable to serve as sponsors for postdoctoral training at these institutions.

Interested individuals should contact the following program directors to obtainapplication information:

Case Western Reserve UniversityColumbia UniversityHospital for Sick Children-TorontoStanford UniversityUniversity of Alabama at BirminghamUniversity of California, Los AngelesUniversity of California, San FranciscoUniversity of ChicagoUniversity of IowaUniversity of North Carolina at Chapel HillUniversity of UtahUniversity of Washington, Seattle

Pamela Davis, M.D., Ph.D.Samuel Silverstein, M.D.Jack Riordan, Ph.D.Merton Bernfield, M.D.B. R. Brinkley, Ph.D.Larry Shapiro, M.D.Jay Nadel, M.D.Harry Fozzard, M.D.Michael Welsh, M.D.Richard Boucher, M.D.Raymond White, Ph.D.Arnold Smith, M.D.

(216) 844-3267(212) 305-3546(416) 598-7054(415) 723-5904(205) 934-0982(213) 533-3751(415) 476-1105(312) 702-1481(319) 335-7619(919) 966-1077(801) 581-4330(206) 526-2116

INDIVIDUAL AWARDSA limited number of individual awards are available to support high-qualityapplicants interested in working on CF-related projects outside of the researchcenter network. Preference will be given to applicants expressing a long-termcommitment to CF-related research. The application deadline for individualawards is October 1, 1988.

For further information on these opportunities, please contact the program directors listed above orRobertJ. Beall, Ph.D., Executive Vice President for Medical Affairs:

eyaFoundton

6931 Arlington RoadBethesda, MD 20814(301) 951-4422

L

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The Venrfication Challenge: Problems and Promise of Scribner and Robert Travis Scott. A comprehensiveStrategic Nuclear Arms Control Verification. By Richard guide to literature that is suitable for class or researchA. Scrinr Theodore J. Ralston, and William D1 Metz. use. Cross-referenced by subiect. 1985; 90 pp.; softcover

An authoritative examination of strategic nuclear arms $7.50 ($6.00 forAAAS members); AAAS #85-8.control verification. Addresses principles and tasks of

verification, technology and monitoring, compliance ControlVrificationTrms and

issues, and future verification needs. 1985; 249 pp.; Concepts: A Glossary. By Richard A. Scribner and

softcover $18.75 ($15.00 for AAAS members); AAAS Kenneth N. Luongo. A comprehensive glossary of#85--31. weapons technology, arms control, and treaty

terminology. 1985; 42 pp. softcover $2.50 ($2.00 for1986 Colloquium Reader- Science and Security: The AAAS members) AAAS #85-2

Futre of Arms Control. Edited by W. Thomas Wander,Richard A. Scribner, and Kenneth N. Luongo. Morethan 40 essays by leading experts. Examines key issues in Nuclear and Conventional Forces in Europe:arms control and national security. 1986; 205 pp.; Implicatons for Secui and Arms Control. Edited

sofftcover $8.00 ($6.40 forAAAS membes); A S W. Thoma Wander. Original essays on major issues#86-16' related to European security. 1987; 220pp.; softcover

$10.00 ($8.00 forAAAS members); AAAS #87-18.1986 Colu Pee igScence andSecurity: The Future of Arms Control. Edited by W. Emerging Technologies and the ConventionalThomas Wander and Kenneth N. Loo. The edited Defense of NATO. By Jonathan B. Tucker. Examines theproceedings from the first Annual AAAS Science, Arms broad range of issues in the debate over high technologyContrl,ant d National Security Colloquium. 1987; 326 pp. conventional weapons and their implications for NATOsoftcover $15.00 ($12.00 for AAAS members); AAAS defense. 1987; 74pp.; softcover $7.00 ($5.60 for AAAS#87-17. members); AAAS #87-20.

The Strategic Defense Initiative: Some Arms Control Strat AntiSubmain Warf Teh and

Implications. By Richard A. Scribnerand Jeffrey egy. Sanik a oreiew of

Boutwell. A concise overview of topical SDI issues. 1987 ttechnologies, operations, and implications of strategic(2nd ed.); 44pp., softcover $2.50 ($2.00 forAAAS anti-submarine warfare. 1988; 60pp.; $5.00 ($4.00 for

AAAS members); available in Fall 1988; AAAS #87-19.

Preventing Nuclear War: Steps That Can Be TakenNo6w. Edite Rihard A. Scribnr A survey of recent Fear of Cheating, Fear of Spyng: A Videotape andproposals for reducing the risk of nuclear war. It includes Companion Guide. Prepared by Richard A. Scribneran extnsive bibl1iography and glossary. 1987k 80 pp.; and Shelly Alpem. This 40-minute videotape addressessfcer $4.00 ($320 foAAAS mmbers); AAAS the politics and technology of nuclear arms control#87-10. verification with a special emphasis on the current

compliance controversy. 1986; $60.00 for VHS or Beta,Strategic Nuclear Arms Control Verficaton: An $75.00 for U-matic (please specify format); AAAS

Anrnotated Bibliography, 1977-1A984. By Richard A. #86-10.

Order from: AAAS Marketing Dept. SG, 1333 H Street, NW, Washington, DC 20005. Please specify the appropriateAAAS #(s) add $2.00 postage & :handli per order; and allow 4-6 weeks for delivery. VISA and MasterCard accepted.For shipments to add pflicable sales tax.

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