Low-dose nifedipine/atenolol therapy for hypertension
• ... Us~ of a ollc~-dail}' ngim~II of t"~ fix~d combillatioll of atellolol 50mg pills slow-,~/~IIS~ IIifedipill~ 20mg pro,id~d a significant additional anti"y~rt~nsi,~ ~ff~ct U "OIlTS aft~' dosing compa,~d wit" atenolol 50mg alone.' A multicentre, doubleblind study was conducted in which 153 evaluable patients with hypertension (sitting diastolic BP ~ 95mm Hg) randomly received ate nolo I 50mg/day or a fixed combination of ate nolo I 50mg/day and slow release nifedipine 20mg/day for 3 months. following a 4-week runin period in which patients received atenolol 50mg/day.
Compared with patients who received atenolol alone. fixed combination recipients had a significant additional reduction in mean sitting and standing BP of 10/7 and 9/5mm Hg. respectively. at 24 hours. There was a similar incidence of adverse effects in both treatment groups, with headache being most commonly reported. FitLsimons TJ. Han W. von Frankenberg H. Sanderson JE. Joy MD. et al. Low-dosc atenolol and nifedipine for the treatment of hypenension. Journal of Drug Development 3: 13-19. Apr 1990
16 ISSN 01S6-170J/90/0728-0001/0S01.00/0 e> Adisl.terutiDlUII Ltd
