Transcript
Page 1: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

DNA Repair

Page 2: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Cell Cycle Checkpoint activation

DNA Repair:

Base Excision Repair

Nucleotide excision repair

Mismatch repair

DSB repair

SENESCENCE/

APOPTOSIS

CANCER

Page 3: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Source of Damage

Endogenous: Replication Errors Reactive Oxygen Species

Exogenous: UV radiation, IR.. Mutagenic chemicals

Page 4: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Type of Damage- Endogenous

Oxidation of bases Methylation of bases Hydrolysis of bases Mismatch of bases

Damage mostly on DNA bases, causing point mutations:

Page 5: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Type of Damage- Exogenous

UV light- pyrimidine dimers IR- Breaks in DNA strands Chemicals (found in smoke, soot and tar)-

diversity of DNA damages including crosslinking of DNA.

Damage mostly on helix structure:

Page 6: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS
Page 7: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

DNA MutationDNA Damage ≠

Page 8: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

The cellular DNA damage response

Transducers

Mediators

Sensors

EffectorsCell cycle arrest

DNA repair ApoptosisDNA repair

DNA damage

Page 9: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

DNA Repair Mechanisms

Page 10: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

DNA Mismatch repair

Page 11: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS
Page 12: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS
Page 13: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS
Page 14: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Base Excision Repair

Page 15: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Nucleotide excision repair

Page 16: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Nucleotide Excision Repair in Eukaryotes

Page 17: DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Xeroderma Pigmentosum


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