1998 other natural products

other natural productsU 0800

27 - 289Facile Synthesis of Allixin and Its Related Compounds. — In orderto investigate the structure–activity relationship of allixin-related compounds, aconvenient five-step synthesis is worked out. Key steps are the electrochemicaloxidation of the alcohol derived from (I)/(II) and subsequent acid-catalyzedtransformation of (IV) giving the ketone (V) in good yield in a one-pot procedurefrom (I). — (MATSUMURA, Y.; SHIRAI, K.; MAKI, T.; ITAKURA, Y.;KODERA, Y.; Tetrahedron Lett. 39 (1998) 16, 2339-2340; Fac. Pharm. Sci.,Nagasaki Univ., Bunkyo, Nagasaki 852, Japan; EN)

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