dopamine receptor - file.medchemexpress.com · d2 receptor antagonist and 5-ht1a receptor agonist...

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www.MedChemExpress.com 1 Dopamine Receptor Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.

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Page 1: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

wwwMedChemExpresscom 1

Dopamine Receptor

Dopamine Receptors are a class of G protein-coupled receptors thatare prominent in the vertebrate central nervous system (CNS) Theneurotransmitter dopamine is the primary endogenous ligand fordopamine receptors Dopamine receptors are implicated in manyneurological processes including motivation pleasure cognitionmemory learning and fine motor control as well as modulation ofneuroendocrine signaling Abnormal dopamine receptor signalingand dopaminergic nerve function is implicated in severalneuropsychiatric disorders Thus dopamine receptors are commonneurologic drug targets antipsychotics are often dopamine receptorantagonists while psychostimulants are typically indirect agonists of

dopamine receptors There are at least five subtypes of dopamine receptors D1 D2 D3 D4 and D5 The D1 and D5receptors are members of the D1-like family of dopamine receptors whereas the D2 D3 and D4receptors aremembers of the D2-like family

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

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Dopamine Receptor Inhibitors amp Modulators

Bioactivity (+)-Dihydrexidine hydrochloride is a dopamine D1 receptoragonist with an of 72plusmn 21 nMEC50

Bioactivity (+)-PD 128907 hydrochloride is a selective dopamine D D2 3receptor agonist with of 17 084 nM for human and rat DK si receptors 179 770 n M for human and rat D receptors3 3

respectively

Bioactivity (plusmn)-Methotrimeprazine (D6) is the deuterium labeledMethotrimeprazine which is a D3 dopamine and Histamine H1receptor antagonist

Bioactivity 5-HT67 antagonist 1 is a multifunctional ligand thatantagonizes and receptors without5-HT672A D2interacting with M1 receptors and hERG channels

Bioactivity A-381393 is a potent selective brain penetrate dopamine antagonist with s of 15 19 and 16 nM forD receptor4 Ki

human dopamine D D and D receptor44 42 47respectively gt2700-fold selectivity over D D D 1 2 3

Bioactivity A-437203 is a selective receptor antagonist with ofD3 Ki71 16 and 6220 nM for D D and D receptors2 3 4respectively

Bioactivity Abaperidone is a potent antagonist of and5-HT receptor2A with s of 62 and 17 nMdopamine D receptor2 IC50

Bioactivity ABT-670 is a selective oral bioavailable agonist of with of 89 nM 160 nM anddopamine D receptor4 EC50

93 nM for humanD ferretD and ratD respectively4 4 4

Bioactivity Adoprazine a potential atypical antipsychotic bearing potentD2 receptor antagonist and 5-HT1A receptor agonist properties

Bioactivity Alizapride hydrochloride is a antagonistdopamine receptorwith prokinetic and antiemetic effects which can also be usedin the treatment of nausea and vomiting includingpostoperative nausea and vomiting

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(+)-Dihydrexidine hydrochloride (DAR-0100 hydrochloride) Cat No HY-101299

(+)-PD 128907 hydrochloride Cat No HY-110000

(plusmn)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6) Cat No HY-19489S

5-HT67 antagonist 1 Cat No HY-101622

A-381393 Cat No HY-116941

A-437203 (Lu201640 A37203) Cat No HY-U00185

Abaperidone Cat No HY-101619

ABT-670 Cat No HY-19483

Adoprazine (SLV313) Cat No HY-14782

Alizapride hydrochloride Cat No HY-A0125A

wwwMedChemExpresscom 3

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Bioactivity Amisulpride is a antagonist withdopamine D D receptor2 3s of 28 and 32 nM for human and Ki dopamine D2 D3

respectively

Bioactivity Amisulpride hydrochloride is a dopamine D D receptor2 3antagonist with s of 28 and 32 nM for human Ki dopamine

and respectivelyD2 D3

Bioactivity Asenapine maleate an antipsychotic is a (1A 1B 2A5-HT2B 2C 5A 6 7) and receptorDopamine (D D D )2 3 4antagonist with values of 003-40 nM for 5-HT and 13Ki042 11 nM for Dopamine receptor respectively

Bioactivity Azaperone (R-1929) acts as a dopamine antagonist but also hassome antihistaminic and anticholinergic properties Azaperoneis a pyridinylpiperazine and butyrophenone neuroleptic drugwith sedative and antiemetic effects which is used mainly asa tranquilizer in veterinary medicine

Bioactivity Benzamide Derivative 1 is a benzamide derivative from patentEP0213775A1 compound 18 Benzamide Derivative 1 may be usefulin treatment of gastrointestinal disorders

Bioactivity Blonanserin(AD-5423) is a D25-HT2 receptor antagonistatypical antipsychotic Target D2 receptor 5-HT2 receptorBlonanserin(AD-5423) is a relatively new atypicalantipsychotic for the treatment of schizophrenia Blonanserinbelongs to a series of 4-phenyl-2-(1-piperazinyl)pyridines andhellip

Bioactivity BP 897 is a potent and selective dopamine D3 receptoragonist and a weak antagonist withdopamine D2 receptor

s of 092 nM and 61 nM for D3 and D2 receptors and showsKilow affinities at D1 and D4 receptors ( s 3 and 03hellipKi

Bioactivity Brexpiprazole is a partial agonist of human and5-HT1A with s of 012 nM and 03 nMdopamine receptor Ki

respectively Brexpiprazole is also a receptor5-HT2Aantagonist with a of 047 nMKi

Bioactivity Bromocriptine mesylate is a potent dopamine D2D3 receptoragonist which binds D2 dopamine receptor with ofpKi805plusmn02

Bioactivity Bromopride is a dopamine antagonist with prokineticproperties widely used as an antiemetic

Amisulpride (DAN 2163) Cat No HY-14545

Amisulpride hydrochloride (DAN 2163 hydrochloride) Cat No HY-14545A

Asenapine hydrochloride Cat No HY-16567

Azaperone (R-1929) Cat No HY-B1470

Benzamide Derivative 1 Cat No HY-U00415

Blonanserin (AD-5423) Cat No HY-13575

BP 897 Cat No HY-106660

Brexpiprazole (OPC-34712) Cat No HY-15780

Bromocriptine mesylate (CB-154) Cat No HY-12705A

Bromopride Cat No HY-B1164

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Bioactivity Cabergoline is an ergot derived-dopamine D -like receptor2agonist that has high affinity for and D2 D3 5-HT2Breceptors ( =07 15 and 12 respectively)Ki

Bioactivity Cariprazine is a novel antipsychotic drug candidate thatexhibits high affinity for the ( =0085 nM) and (D3 Ki D2

=049 nM) receptors and moderate affinity for the Ki 5-HT1Areceptor ( =26 nM)Ki

Bioactivity Cariprazine hydrochloride is a novel antipsychotic drugcandidate that exhibits high affinity for the ( =0085D3 KinM) and ( =049 nM) receptors and moderate affinityD2 Kifor the receptor ( =26 nM)5-HT1A Ki

Bioactivity CGP 25454A is a novel and selective presynaptic dopamineautoreceptor antagonist

Bioactivity Chlorpromazine D6 hydrochloride is the deuterium labeledChlorpromazine Chlorpromazine is an inhibitor of dopaminereceptor 5-HT receptor potassium channel sodium channel

Bioactivity Chlorpromazine Hydrochloride is an antagonist of the and dopamine D2 5HT2A potassium channel sodium

Chlorpromazine binds with D2 and 5HT2A with s of 363channel KinM and 83 nM respectively

Bioactivity Chlorprothixene has strong binding affinities to dopamine andhistamine receptors such as D1 D2 D3 D5 H1 5-HT2 5-HT6and 5-HT7 with Ki of 18 nM 296 nM 456 nM 9 nM 375 nM94 nM 3 nM and 56 nM respectively

Bioactivity Clebopride malate is a dopamine antagonist drug withantiemetic and prokinetic properties used to treat functionalgastrointestinal disorders

Bioactivity Clocapramine is an antagonist of the D2 5-HT2Areceptors

Bioactivity Clocapramine hydrochloride hydrate is an antagonist of the and D2 5-HT receptors2A

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Cabergoline (FCE-21336) Cat No HY-15296

Cariprazine (RGH-188) Cat No HY-14763

Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A

CGP 25454A Cat No HY-100454

Chlorpromazine D6 hydrochloride Cat No HY-B0407AS

Chlorpromazine hydrochloride Cat No HY-B0407A

Chlorprothixene Cat No HY-B0274

Clebopride malate Cat No HY-B1613A

Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073

Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A

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Bioactivity Clomipramine HCl is a serotonin transporter (SERT)norepinephrine transporter (NET) dopamine transporter (DAT)blocker with Ki of 014 54 and 3 nM respectively Target5-HT Receptor Clomipramine hydrochloride (Anafranil) is ahydrochloride salt of clomipramine which is a serotoninhellip

Bioactivity Clozapine (HF 1854) is an antipsychotic used to treatschizophrenia Clozapine is a potent antagonist of dopamineand a number of other receptors with a of 95 nM for Ki M1

receptor

Bioactivity Dexpramipexole(KNS-760704) also known as R-(+)-Pramipexoleis a neuroprotective agent and weak non-ergoline dopamineagonist IC50 Value

Bioactivity Dexpramipexole dihydrochloride also known asR-(+)-Pramipexole is a neuroprotective agent and weaknon-ergoline dopamine agonist IC50 Value Target DopamineReceptor Dexpramipexole has been found to have neuroprotectiveeffects and is being investigated for treatment of amyotrophichellip

Bioactivity Dicarbine blocks in various brain partsdopamine receptorsand prevents the depression of the conditioned defencereflexes caused by stimulation of the mesencephalic portion ofthe reticular formation Dicarbine could be used to treatpatients with schizophrenia and alcoholic psychosis inhellip

Bioactivity Domperidone is a dopamine blocker and an antidopaminergicreagent

Bioactivity Dopamine HCl is a catecholamine neurotransmitter present in awide variety of animalsAnd a dopamine D1-5 receptors agonistTarget Dopamine Receptor Dopamine (or34-dihydroxyphenethylamine) is a neuroendocrine transmitterin the catecholamine and phenethylamine families that plays ahellip

Bioactivity Dopamine serotonin antagonist-1 is a dual anddopamine receptor antagonist with s of 200 2500 420 39serotonin Ki

84 40 nM for dopamine D1 D2D4 and serotonin S2A S2C S3respectively

Bioactivity Droperidol is a Dopamine-2 Receptor Antagonist Bioactivity Fenoldopam(SKF 82526) is a drug and synthetic benzazepinederivative which acts as a selective D1 receptor partialagonist

Clomipramine hydrochloride Cat No HY-B0457

Clozapine (HF 1854) Cat No HY-14539

Dexpramipexole ((R)-Pramipexole R-(+)-Pramipexole KNS-760704) Cat No HY-17355B

Dexpramipexole dihydrochloride ((R)-Pramipexole

(dihydrochloride) hellip) Cat No HY-17355A

Dicarbine Cat No HY-127086

Domperidone (R33812) Cat No HY-B0411

Dopamine hydrochloride (ASL279) Cat No HY-B0451A

Dopamine serotonin antagonist-1 Cat No HY-42110

Droperidol (Dehydrobenzperidol) Cat No HY-B1240

Fenoldopam (SKF 82526) Cat No HY-B0735

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Bioactivity Fenoldopam(SKF 82526) mesylate is a drug and syntheticbenzazepine derivative which acts as a selective D1 receptorpartial agonist

Bioactivity Fluphenazine dihydrochloride is a phenothiazine-class D1DR andD2DR inhibitor used to deliver Fluphenazine to biologicalsystems in studies probing the effects and metabolic fates ofthis commonly used dopamine antagonist

Bioactivity Foscarbidopa (Carbidopa 4prime-monophosphate) is a prodrug ofCarbidopa acts as a agonist dopamine receptor [1] [2]

Bioactivity Foslevodopa is a agonist dopamine receptor [1]

Bioactivity GSK163090 is a potent selective and orally active 5-HT1ABDreceptor antagonist with pKi of 948597 and 6367 for5-HT1ABD and dopamine D2D3 respectively

Bioactivity GSK598809 is a potent and selective dopamine D3 Receptor antagonist with a of 89(DRD3) pKi

Bioactivity Haloperidol is a potent antagonistdopamine D2 receptorwidely used as an antipsychotic

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol hydrochloride is a potent dopamine D2 receptorantagonist widely used as an antipsychotic

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Fenoldopam mesylate (Fenoldopam methanesulfonate SKF-82526 mesylate) Cat No HY-B0735A

Fluphenazine dihydrochloride Cat No HY-A0081

Foscarbidopa (Carbidopa 4prime-monophosphate) Cat No HY-109131

Foslevodopa (Dopa 4-Phosphate 3-Hydroxy-O-phosphono-L-tyrosine) Cat No HY-109132

GSK163090 Cat No HY-14348

GSK598809 Cat No HY-19654

Haloperidol Cat No HY-14538

Haloperidol D4 Cat No HY-14538S

Haloperidol D4 Cat No HY-14538S1

Haloperidol hydrochloride Cat No HY-14538A

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Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

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Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg

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Bioactivity Iloperidone(HP 873) is a D25-HT2 receptor antagonist whichis an atypical antipsychotic for the treatment ofschizophrenia symptoms

Bioactivity Iloperidone (hydrochloride) is a D(2)5-HT(2) receptorantagonistis which is an atypical antipsychotic for thetreatment of schizophrenia symptoms

Bioactivity L-DOPA is a natural form of DOPA used in the treatment ofParkinsons disease L-DOPA is the precursor of dopamine andproduct of tyrosine hydroxylase Target Dopamine ReceptorL-DOPA (L-34-dihydroxyphenylalanine) is a chemical that ismade and used as part of the normal biology of humans somehellip

Bioactivity Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiridewhich is a D2 receptor a antagonist an atypical antipsychoticdrug of the benzamide class

Bioactivity Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki =054 nM) a partial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32 nM) and aSERT blocker (Ki = 61 nM) IC50 value 054 nM (Ki for 5-HT2Areceptor ) Target 5-HT2A receptor Lumateperone also possesseshellip

Bioactivity Lurasidone (SM-13496) is an antagonist of both dopamine and with s of 168 and 0495 nMD2 5-HT7 IC50

respectively Lurasidone (SM-13496) is also a partial agonistof receptor with an of 675 nM5-HT1A IC50

Bioactivity Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is anantagonist of both and with s ofdopamine D2 5-HT7 IC50168 and 0495 nM respectively Lurasidone (Hydrochloride)(SM-13496 (Hydrochloride)) is also a partial agonisthellip

Bioactivity Metoclopramide is a dopamine D2 antagonist that is used as anantiemetic IC50 Value Target D2 Receptor Metoclopramide isa dopamine receptor antagonist which has been used fortreatment of a variety of gastrointestinal symptoms over thelast thirty years In various countries metoclopramide is thehellip

Bioactivity Metoclopramide hydrochloride hydrate is a dopamine D2antagonist that is used as an antiemetic IC50 Value TargetD2 Receptor Metoclopramide is a dopamine receptor antagonistwhich has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years Inhellip

Bioactivity Molindone is a therapeutic antipsychotic used in thetreatment of schizophrenia works by blocking the effects ofdopamine in the brain leading to diminished psychoses

Iloperidone (HP 873) Cat No HY-17410

Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A

L-DOPA (Levodopa 34-Dihydroxyphenylalanine) Cat No HY-N0304

Levosulpiride (RV-12309 S-(-)-Sulpiride) Cat No HY-B1059

lumateperone Tosylate (ITI-007) Cat No HY-19733

Lurasidone (SM-13496) Cat No HY-B0032A

Lurasidone Hydrochloride (SM-13496 (Hydrochloride)) Cat No HY-B0032

Metoclopramide Cat No HY-17382

Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) Cat No HY-17382A

Molindone hydrochloride (EN-1733A) Cat No HY-B1017

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

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Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

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Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

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Purity gt98Clinical Data LaunchedSize 10 mg

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Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

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Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

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10 mg 50 mg 100 mg 200 mg 500 mg

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Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

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Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 2: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9813Clinical Data Phase 1Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity 9883Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Dopamine Receptor Inhibitors amp Modulators

Bioactivity (+)-Dihydrexidine hydrochloride is a dopamine D1 receptoragonist with an of 72plusmn 21 nMEC50

Bioactivity (+)-PD 128907 hydrochloride is a selective dopamine D D2 3receptor agonist with of 17 084 nM for human and rat DK si receptors 179 770 n M for human and rat D receptors3 3

respectively

Bioactivity (plusmn)-Methotrimeprazine (D6) is the deuterium labeledMethotrimeprazine which is a D3 dopamine and Histamine H1receptor antagonist

Bioactivity 5-HT67 antagonist 1 is a multifunctional ligand thatantagonizes and receptors without5-HT672A D2interacting with M1 receptors and hERG channels

Bioactivity A-381393 is a potent selective brain penetrate dopamine antagonist with s of 15 19 and 16 nM forD receptor4 Ki

human dopamine D D and D receptor44 42 47respectively gt2700-fold selectivity over D D D 1 2 3

Bioactivity A-437203 is a selective receptor antagonist with ofD3 Ki71 16 and 6220 nM for D D and D receptors2 3 4respectively

Bioactivity Abaperidone is a potent antagonist of and5-HT receptor2A with s of 62 and 17 nMdopamine D receptor2 IC50

Bioactivity ABT-670 is a selective oral bioavailable agonist of with of 89 nM 160 nM anddopamine D receptor4 EC50

93 nM for humanD ferretD and ratD respectively4 4 4

Bioactivity Adoprazine a potential atypical antipsychotic bearing potentD2 receptor antagonist and 5-HT1A receptor agonist properties

Bioactivity Alizapride hydrochloride is a antagonistdopamine receptorwith prokinetic and antiemetic effects which can also be usedin the treatment of nausea and vomiting includingpostoperative nausea and vomiting

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(+)-Dihydrexidine hydrochloride (DAR-0100 hydrochloride) Cat No HY-101299

(+)-PD 128907 hydrochloride Cat No HY-110000

(plusmn)-Methotrimeprazine (D6) (dl-Methotrimeprazine D6) Cat No HY-19489S

5-HT67 antagonist 1 Cat No HY-101622

A-381393 Cat No HY-116941

A-437203 (Lu201640 A37203) Cat No HY-U00185

Abaperidone Cat No HY-101619

ABT-670 Cat No HY-19483

Adoprazine (SLV313) Cat No HY-14782

Alizapride hydrochloride Cat No HY-A0125A

wwwMedChemExpresscom 3

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9938Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9977Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 25 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9958Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9939Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Purity 980Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Bioactivity Amisulpride is a antagonist withdopamine D D receptor2 3s of 28 and 32 nM for human and Ki dopamine D2 D3

respectively

Bioactivity Amisulpride hydrochloride is a dopamine D D receptor2 3antagonist with s of 28 and 32 nM for human Ki dopamine

and respectivelyD2 D3

Bioactivity Asenapine maleate an antipsychotic is a (1A 1B 2A5-HT2B 2C 5A 6 7) and receptorDopamine (D D D )2 3 4antagonist with values of 003-40 nM for 5-HT and 13Ki042 11 nM for Dopamine receptor respectively

Bioactivity Azaperone (R-1929) acts as a dopamine antagonist but also hassome antihistaminic and anticholinergic properties Azaperoneis a pyridinylpiperazine and butyrophenone neuroleptic drugwith sedative and antiemetic effects which is used mainly asa tranquilizer in veterinary medicine

Bioactivity Benzamide Derivative 1 is a benzamide derivative from patentEP0213775A1 compound 18 Benzamide Derivative 1 may be usefulin treatment of gastrointestinal disorders

Bioactivity Blonanserin(AD-5423) is a D25-HT2 receptor antagonistatypical antipsychotic Target D2 receptor 5-HT2 receptorBlonanserin(AD-5423) is a relatively new atypicalantipsychotic for the treatment of schizophrenia Blonanserinbelongs to a series of 4-phenyl-2-(1-piperazinyl)pyridines andhellip

Bioactivity BP 897 is a potent and selective dopamine D3 receptoragonist and a weak antagonist withdopamine D2 receptor

s of 092 nM and 61 nM for D3 and D2 receptors and showsKilow affinities at D1 and D4 receptors ( s 3 and 03hellipKi

Bioactivity Brexpiprazole is a partial agonist of human and5-HT1A with s of 012 nM and 03 nMdopamine receptor Ki

respectively Brexpiprazole is also a receptor5-HT2Aantagonist with a of 047 nMKi

Bioactivity Bromocriptine mesylate is a potent dopamine D2D3 receptoragonist which binds D2 dopamine receptor with ofpKi805plusmn02

Bioactivity Bromopride is a dopamine antagonist with prokineticproperties widely used as an antiemetic

Amisulpride (DAN 2163) Cat No HY-14545

Amisulpride hydrochloride (DAN 2163 hydrochloride) Cat No HY-14545A

Asenapine hydrochloride Cat No HY-16567

Azaperone (R-1929) Cat No HY-B1470

Benzamide Derivative 1 Cat No HY-U00415

Blonanserin (AD-5423) Cat No HY-13575

BP 897 Cat No HY-106660

Brexpiprazole (OPC-34712) Cat No HY-15780

Bromocriptine mesylate (CB-154) Cat No HY-12705A

Bromopride Cat No HY-B1164

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data LaunchedSize 1 mg

Purity 9946Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9952Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Purity 9983Clinical Data LaunchedSize 1 g 5 g

Purity 990Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg 50 mg

Purity 9989Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Bioactivity Cabergoline is an ergot derived-dopamine D -like receptor2agonist that has high affinity for and D2 D3 5-HT2Breceptors ( =07 15 and 12 respectively)Ki

Bioactivity Cariprazine is a novel antipsychotic drug candidate thatexhibits high affinity for the ( =0085 nM) and (D3 Ki D2

=049 nM) receptors and moderate affinity for the Ki 5-HT1Areceptor ( =26 nM)Ki

Bioactivity Cariprazine hydrochloride is a novel antipsychotic drugcandidate that exhibits high affinity for the ( =0085D3 KinM) and ( =049 nM) receptors and moderate affinityD2 Kifor the receptor ( =26 nM)5-HT1A Ki

Bioactivity CGP 25454A is a novel and selective presynaptic dopamineautoreceptor antagonist

Bioactivity Chlorpromazine D6 hydrochloride is the deuterium labeledChlorpromazine Chlorpromazine is an inhibitor of dopaminereceptor 5-HT receptor potassium channel sodium channel

Bioactivity Chlorpromazine Hydrochloride is an antagonist of the and dopamine D2 5HT2A potassium channel sodium

Chlorpromazine binds with D2 and 5HT2A with s of 363channel KinM and 83 nM respectively

Bioactivity Chlorprothixene has strong binding affinities to dopamine andhistamine receptors such as D1 D2 D3 D5 H1 5-HT2 5-HT6and 5-HT7 with Ki of 18 nM 296 nM 456 nM 9 nM 375 nM94 nM 3 nM and 56 nM respectively

Bioactivity Clebopride malate is a dopamine antagonist drug withantiemetic and prokinetic properties used to treat functionalgastrointestinal disorders

Bioactivity Clocapramine is an antagonist of the D2 5-HT2Areceptors

Bioactivity Clocapramine hydrochloride hydrate is an antagonist of the and D2 5-HT receptors2A

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Cabergoline (FCE-21336) Cat No HY-15296

Cariprazine (RGH-188) Cat No HY-14763

Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A

CGP 25454A Cat No HY-100454

Chlorpromazine D6 hydrochloride Cat No HY-B0407AS

Chlorpromazine hydrochloride Cat No HY-B0407A

Chlorprothixene Cat No HY-B0274

Clebopride malate Cat No HY-B1613A

Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073

Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A

wwwMedChemExpresscom 5

Purity gt98Clinical Data LaunchedSize 10 mg

Purity 9929Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9979Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9952Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize

Purity 9801Clinical Data Phase 3Size 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data Phase 3Size 10 mg 50 mg

Purity 9997Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg 5 g

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Bioactivity Clomipramine HCl is a serotonin transporter (SERT)norepinephrine transporter (NET) dopamine transporter (DAT)blocker with Ki of 014 54 and 3 nM respectively Target5-HT Receptor Clomipramine hydrochloride (Anafranil) is ahydrochloride salt of clomipramine which is a serotoninhellip

Bioactivity Clozapine (HF 1854) is an antipsychotic used to treatschizophrenia Clozapine is a potent antagonist of dopamineand a number of other receptors with a of 95 nM for Ki M1

receptor

Bioactivity Dexpramipexole(KNS-760704) also known as R-(+)-Pramipexoleis a neuroprotective agent and weak non-ergoline dopamineagonist IC50 Value

Bioactivity Dexpramipexole dihydrochloride also known asR-(+)-Pramipexole is a neuroprotective agent and weaknon-ergoline dopamine agonist IC50 Value Target DopamineReceptor Dexpramipexole has been found to have neuroprotectiveeffects and is being investigated for treatment of amyotrophichellip

Bioactivity Dicarbine blocks in various brain partsdopamine receptorsand prevents the depression of the conditioned defencereflexes caused by stimulation of the mesencephalic portion ofthe reticular formation Dicarbine could be used to treatpatients with schizophrenia and alcoholic psychosis inhellip

Bioactivity Domperidone is a dopamine blocker and an antidopaminergicreagent

Bioactivity Dopamine HCl is a catecholamine neurotransmitter present in awide variety of animalsAnd a dopamine D1-5 receptors agonistTarget Dopamine Receptor Dopamine (or34-dihydroxyphenethylamine) is a neuroendocrine transmitterin the catecholamine and phenethylamine families that plays ahellip

Bioactivity Dopamine serotonin antagonist-1 is a dual anddopamine receptor antagonist with s of 200 2500 420 39serotonin Ki

84 40 nM for dopamine D1 D2D4 and serotonin S2A S2C S3respectively

Bioactivity Droperidol is a Dopamine-2 Receptor Antagonist Bioactivity Fenoldopam(SKF 82526) is a drug and synthetic benzazepinederivative which acts as a selective D1 receptor partialagonist

Clomipramine hydrochloride Cat No HY-B0457

Clozapine (HF 1854) Cat No HY-14539

Dexpramipexole ((R)-Pramipexole R-(+)-Pramipexole KNS-760704) Cat No HY-17355B

Dexpramipexole dihydrochloride ((R)-Pramipexole

(dihydrochloride) hellip) Cat No HY-17355A

Dicarbine Cat No HY-127086

Domperidone (R33812) Cat No HY-B0411

Dopamine hydrochloride (ASL279) Cat No HY-B0451A

Dopamine serotonin antagonist-1 Cat No HY-42110

Droperidol (Dehydrobenzperidol) Cat No HY-B1240

Fenoldopam (SKF 82526) Cat No HY-B0735

Purity gt98Clinical Data LaunchedSize 100 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9973Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9995Clinical Data Phase 2Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize

Purity gt98Clinical Data No Development ReportedSize

Purity 9996Clinical Data LaunchedSize 100 mg

Purity 9985Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Fenoldopam(SKF 82526) mesylate is a drug and syntheticbenzazepine derivative which acts as a selective D1 receptorpartial agonist

Bioactivity Fluphenazine dihydrochloride is a phenothiazine-class D1DR andD2DR inhibitor used to deliver Fluphenazine to biologicalsystems in studies probing the effects and metabolic fates ofthis commonly used dopamine antagonist

Bioactivity Foscarbidopa (Carbidopa 4prime-monophosphate) is a prodrug ofCarbidopa acts as a agonist dopamine receptor [1] [2]

Bioactivity Foslevodopa is a agonist dopamine receptor [1]

Bioactivity GSK163090 is a potent selective and orally active 5-HT1ABDreceptor antagonist with pKi of 948597 and 6367 for5-HT1ABD and dopamine D2D3 respectively

Bioactivity GSK598809 is a potent and selective dopamine D3 Receptor antagonist with a of 89(DRD3) pKi

Bioactivity Haloperidol is a potent antagonistdopamine D2 receptorwidely used as an antipsychotic

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol hydrochloride is a potent dopamine D2 receptorantagonist widely used as an antipsychotic

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Fenoldopam mesylate (Fenoldopam methanesulfonate SKF-82526 mesylate) Cat No HY-B0735A

Fluphenazine dihydrochloride Cat No HY-A0081

Foscarbidopa (Carbidopa 4prime-monophosphate) Cat No HY-109131

Foslevodopa (Dopa 4-Phosphate 3-Hydroxy-O-phosphono-L-tyrosine) Cat No HY-109132

GSK163090 Cat No HY-14348

GSK598809 Cat No HY-19654

Haloperidol Cat No HY-14538

Haloperidol D4 Cat No HY-14538S

Haloperidol D4 Cat No HY-14538S1

Haloperidol hydrochloride Cat No HY-14538A

wwwMedChemExpresscom 7

Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg

Purity 9933Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9921Clinical Data Phase 3Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data LaunchedSize 200 mg 1 g

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Iloperidone(HP 873) is a D25-HT2 receptor antagonist whichis an atypical antipsychotic for the treatment ofschizophrenia symptoms

Bioactivity Iloperidone (hydrochloride) is a D(2)5-HT(2) receptorantagonistis which is an atypical antipsychotic for thetreatment of schizophrenia symptoms

Bioactivity L-DOPA is a natural form of DOPA used in the treatment ofParkinsons disease L-DOPA is the precursor of dopamine andproduct of tyrosine hydroxylase Target Dopamine ReceptorL-DOPA (L-34-dihydroxyphenylalanine) is a chemical that ismade and used as part of the normal biology of humans somehellip

Bioactivity Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiridewhich is a D2 receptor a antagonist an atypical antipsychoticdrug of the benzamide class

Bioactivity Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki =054 nM) a partial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32 nM) and aSERT blocker (Ki = 61 nM) IC50 value 054 nM (Ki for 5-HT2Areceptor ) Target 5-HT2A receptor Lumateperone also possesseshellip

Bioactivity Lurasidone (SM-13496) is an antagonist of both dopamine and with s of 168 and 0495 nMD2 5-HT7 IC50

respectively Lurasidone (SM-13496) is also a partial agonistof receptor with an of 675 nM5-HT1A IC50

Bioactivity Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is anantagonist of both and with s ofdopamine D2 5-HT7 IC50168 and 0495 nM respectively Lurasidone (Hydrochloride)(SM-13496 (Hydrochloride)) is also a partial agonisthellip

Bioactivity Metoclopramide is a dopamine D2 antagonist that is used as anantiemetic IC50 Value Target D2 Receptor Metoclopramide isa dopamine receptor antagonist which has been used fortreatment of a variety of gastrointestinal symptoms over thelast thirty years In various countries metoclopramide is thehellip

Bioactivity Metoclopramide hydrochloride hydrate is a dopamine D2antagonist that is used as an antiemetic IC50 Value TargetD2 Receptor Metoclopramide is a dopamine receptor antagonistwhich has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years Inhellip

Bioactivity Molindone is a therapeutic antipsychotic used in thetreatment of schizophrenia works by blocking the effects ofdopamine in the brain leading to diminished psychoses

Iloperidone (HP 873) Cat No HY-17410

Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A

L-DOPA (Levodopa 34-Dihydroxyphenylalanine) Cat No HY-N0304

Levosulpiride (RV-12309 S-(-)-Sulpiride) Cat No HY-B1059

lumateperone Tosylate (ITI-007) Cat No HY-19733

Lurasidone (SM-13496) Cat No HY-B0032A

Lurasidone Hydrochloride (SM-13496 (Hydrochloride)) Cat No HY-B0032

Metoclopramide Cat No HY-17382

Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) Cat No HY-17382A

Molindone hydrochloride (EN-1733A) Cat No HY-B1017

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg 1 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9855Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9966Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9814Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9924Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg

Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 3: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

wwwMedChemExpresscom 3

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9938Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9977Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 25 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9958Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9939Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Purity 980Clinical Data LaunchedSize 100 mg 200 mg 500 mg

Bioactivity Amisulpride is a antagonist withdopamine D D receptor2 3s of 28 and 32 nM for human and Ki dopamine D2 D3

respectively

Bioactivity Amisulpride hydrochloride is a dopamine D D receptor2 3antagonist with s of 28 and 32 nM for human Ki dopamine

and respectivelyD2 D3

Bioactivity Asenapine maleate an antipsychotic is a (1A 1B 2A5-HT2B 2C 5A 6 7) and receptorDopamine (D D D )2 3 4antagonist with values of 003-40 nM for 5-HT and 13Ki042 11 nM for Dopamine receptor respectively

Bioactivity Azaperone (R-1929) acts as a dopamine antagonist but also hassome antihistaminic and anticholinergic properties Azaperoneis a pyridinylpiperazine and butyrophenone neuroleptic drugwith sedative and antiemetic effects which is used mainly asa tranquilizer in veterinary medicine

Bioactivity Benzamide Derivative 1 is a benzamide derivative from patentEP0213775A1 compound 18 Benzamide Derivative 1 may be usefulin treatment of gastrointestinal disorders

Bioactivity Blonanserin(AD-5423) is a D25-HT2 receptor antagonistatypical antipsychotic Target D2 receptor 5-HT2 receptorBlonanserin(AD-5423) is a relatively new atypicalantipsychotic for the treatment of schizophrenia Blonanserinbelongs to a series of 4-phenyl-2-(1-piperazinyl)pyridines andhellip

Bioactivity BP 897 is a potent and selective dopamine D3 receptoragonist and a weak antagonist withdopamine D2 receptor

s of 092 nM and 61 nM for D3 and D2 receptors and showsKilow affinities at D1 and D4 receptors ( s 3 and 03hellipKi

Bioactivity Brexpiprazole is a partial agonist of human and5-HT1A with s of 012 nM and 03 nMdopamine receptor Ki

respectively Brexpiprazole is also a receptor5-HT2Aantagonist with a of 047 nMKi

Bioactivity Bromocriptine mesylate is a potent dopamine D2D3 receptoragonist which binds D2 dopamine receptor with ofpKi805plusmn02

Bioactivity Bromopride is a dopamine antagonist with prokineticproperties widely used as an antiemetic

Amisulpride (DAN 2163) Cat No HY-14545

Amisulpride hydrochloride (DAN 2163 hydrochloride) Cat No HY-14545A

Asenapine hydrochloride Cat No HY-16567

Azaperone (R-1929) Cat No HY-B1470

Benzamide Derivative 1 Cat No HY-U00415

Blonanserin (AD-5423) Cat No HY-13575

BP 897 Cat No HY-106660

Brexpiprazole (OPC-34712) Cat No HY-15780

Bromocriptine mesylate (CB-154) Cat No HY-12705A

Bromopride Cat No HY-B1164

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data LaunchedSize 1 mg

Purity 9946Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9952Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Purity 9983Clinical Data LaunchedSize 1 g 5 g

Purity 990Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg 50 mg

Purity 9989Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Bioactivity Cabergoline is an ergot derived-dopamine D -like receptor2agonist that has high affinity for and D2 D3 5-HT2Breceptors ( =07 15 and 12 respectively)Ki

Bioactivity Cariprazine is a novel antipsychotic drug candidate thatexhibits high affinity for the ( =0085 nM) and (D3 Ki D2

=049 nM) receptors and moderate affinity for the Ki 5-HT1Areceptor ( =26 nM)Ki

Bioactivity Cariprazine hydrochloride is a novel antipsychotic drugcandidate that exhibits high affinity for the ( =0085D3 KinM) and ( =049 nM) receptors and moderate affinityD2 Kifor the receptor ( =26 nM)5-HT1A Ki

Bioactivity CGP 25454A is a novel and selective presynaptic dopamineautoreceptor antagonist

Bioactivity Chlorpromazine D6 hydrochloride is the deuterium labeledChlorpromazine Chlorpromazine is an inhibitor of dopaminereceptor 5-HT receptor potassium channel sodium channel

Bioactivity Chlorpromazine Hydrochloride is an antagonist of the and dopamine D2 5HT2A potassium channel sodium

Chlorpromazine binds with D2 and 5HT2A with s of 363channel KinM and 83 nM respectively

Bioactivity Chlorprothixene has strong binding affinities to dopamine andhistamine receptors such as D1 D2 D3 D5 H1 5-HT2 5-HT6and 5-HT7 with Ki of 18 nM 296 nM 456 nM 9 nM 375 nM94 nM 3 nM and 56 nM respectively

Bioactivity Clebopride malate is a dopamine antagonist drug withantiemetic and prokinetic properties used to treat functionalgastrointestinal disorders

Bioactivity Clocapramine is an antagonist of the D2 5-HT2Areceptors

Bioactivity Clocapramine hydrochloride hydrate is an antagonist of the and D2 5-HT receptors2A

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Cabergoline (FCE-21336) Cat No HY-15296

Cariprazine (RGH-188) Cat No HY-14763

Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A

CGP 25454A Cat No HY-100454

Chlorpromazine D6 hydrochloride Cat No HY-B0407AS

Chlorpromazine hydrochloride Cat No HY-B0407A

Chlorprothixene Cat No HY-B0274

Clebopride malate Cat No HY-B1613A

Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073

Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A

wwwMedChemExpresscom 5

Purity gt98Clinical Data LaunchedSize 10 mg

Purity 9929Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9979Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9952Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize

Purity 9801Clinical Data Phase 3Size 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data Phase 3Size 10 mg 50 mg

Purity 9997Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg 5 g

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Bioactivity Clomipramine HCl is a serotonin transporter (SERT)norepinephrine transporter (NET) dopamine transporter (DAT)blocker with Ki of 014 54 and 3 nM respectively Target5-HT Receptor Clomipramine hydrochloride (Anafranil) is ahydrochloride salt of clomipramine which is a serotoninhellip

Bioactivity Clozapine (HF 1854) is an antipsychotic used to treatschizophrenia Clozapine is a potent antagonist of dopamineand a number of other receptors with a of 95 nM for Ki M1

receptor

Bioactivity Dexpramipexole(KNS-760704) also known as R-(+)-Pramipexoleis a neuroprotective agent and weak non-ergoline dopamineagonist IC50 Value

Bioactivity Dexpramipexole dihydrochloride also known asR-(+)-Pramipexole is a neuroprotective agent and weaknon-ergoline dopamine agonist IC50 Value Target DopamineReceptor Dexpramipexole has been found to have neuroprotectiveeffects and is being investigated for treatment of amyotrophichellip

Bioactivity Dicarbine blocks in various brain partsdopamine receptorsand prevents the depression of the conditioned defencereflexes caused by stimulation of the mesencephalic portion ofthe reticular formation Dicarbine could be used to treatpatients with schizophrenia and alcoholic psychosis inhellip

Bioactivity Domperidone is a dopamine blocker and an antidopaminergicreagent

Bioactivity Dopamine HCl is a catecholamine neurotransmitter present in awide variety of animalsAnd a dopamine D1-5 receptors agonistTarget Dopamine Receptor Dopamine (or34-dihydroxyphenethylamine) is a neuroendocrine transmitterin the catecholamine and phenethylamine families that plays ahellip

Bioactivity Dopamine serotonin antagonist-1 is a dual anddopamine receptor antagonist with s of 200 2500 420 39serotonin Ki

84 40 nM for dopamine D1 D2D4 and serotonin S2A S2C S3respectively

Bioactivity Droperidol is a Dopamine-2 Receptor Antagonist Bioactivity Fenoldopam(SKF 82526) is a drug and synthetic benzazepinederivative which acts as a selective D1 receptor partialagonist

Clomipramine hydrochloride Cat No HY-B0457

Clozapine (HF 1854) Cat No HY-14539

Dexpramipexole ((R)-Pramipexole R-(+)-Pramipexole KNS-760704) Cat No HY-17355B

Dexpramipexole dihydrochloride ((R)-Pramipexole

(dihydrochloride) hellip) Cat No HY-17355A

Dicarbine Cat No HY-127086

Domperidone (R33812) Cat No HY-B0411

Dopamine hydrochloride (ASL279) Cat No HY-B0451A

Dopamine serotonin antagonist-1 Cat No HY-42110

Droperidol (Dehydrobenzperidol) Cat No HY-B1240

Fenoldopam (SKF 82526) Cat No HY-B0735

Purity gt98Clinical Data LaunchedSize 100 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9973Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9995Clinical Data Phase 2Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize

Purity gt98Clinical Data No Development ReportedSize

Purity 9996Clinical Data LaunchedSize 100 mg

Purity 9985Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Fenoldopam(SKF 82526) mesylate is a drug and syntheticbenzazepine derivative which acts as a selective D1 receptorpartial agonist

Bioactivity Fluphenazine dihydrochloride is a phenothiazine-class D1DR andD2DR inhibitor used to deliver Fluphenazine to biologicalsystems in studies probing the effects and metabolic fates ofthis commonly used dopamine antagonist

Bioactivity Foscarbidopa (Carbidopa 4prime-monophosphate) is a prodrug ofCarbidopa acts as a agonist dopamine receptor [1] [2]

Bioactivity Foslevodopa is a agonist dopamine receptor [1]

Bioactivity GSK163090 is a potent selective and orally active 5-HT1ABDreceptor antagonist with pKi of 948597 and 6367 for5-HT1ABD and dopamine D2D3 respectively

Bioactivity GSK598809 is a potent and selective dopamine D3 Receptor antagonist with a of 89(DRD3) pKi

Bioactivity Haloperidol is a potent antagonistdopamine D2 receptorwidely used as an antipsychotic

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol hydrochloride is a potent dopamine D2 receptorantagonist widely used as an antipsychotic

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Fenoldopam mesylate (Fenoldopam methanesulfonate SKF-82526 mesylate) Cat No HY-B0735A

Fluphenazine dihydrochloride Cat No HY-A0081

Foscarbidopa (Carbidopa 4prime-monophosphate) Cat No HY-109131

Foslevodopa (Dopa 4-Phosphate 3-Hydroxy-O-phosphono-L-tyrosine) Cat No HY-109132

GSK163090 Cat No HY-14348

GSK598809 Cat No HY-19654

Haloperidol Cat No HY-14538

Haloperidol D4 Cat No HY-14538S

Haloperidol D4 Cat No HY-14538S1

Haloperidol hydrochloride Cat No HY-14538A

wwwMedChemExpresscom 7

Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg

Purity 9933Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9921Clinical Data Phase 3Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data LaunchedSize 200 mg 1 g

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Iloperidone(HP 873) is a D25-HT2 receptor antagonist whichis an atypical antipsychotic for the treatment ofschizophrenia symptoms

Bioactivity Iloperidone (hydrochloride) is a D(2)5-HT(2) receptorantagonistis which is an atypical antipsychotic for thetreatment of schizophrenia symptoms

Bioactivity L-DOPA is a natural form of DOPA used in the treatment ofParkinsons disease L-DOPA is the precursor of dopamine andproduct of tyrosine hydroxylase Target Dopamine ReceptorL-DOPA (L-34-dihydroxyphenylalanine) is a chemical that ismade and used as part of the normal biology of humans somehellip

Bioactivity Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiridewhich is a D2 receptor a antagonist an atypical antipsychoticdrug of the benzamide class

Bioactivity Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki =054 nM) a partial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32 nM) and aSERT blocker (Ki = 61 nM) IC50 value 054 nM (Ki for 5-HT2Areceptor ) Target 5-HT2A receptor Lumateperone also possesseshellip

Bioactivity Lurasidone (SM-13496) is an antagonist of both dopamine and with s of 168 and 0495 nMD2 5-HT7 IC50

respectively Lurasidone (SM-13496) is also a partial agonistof receptor with an of 675 nM5-HT1A IC50

Bioactivity Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is anantagonist of both and with s ofdopamine D2 5-HT7 IC50168 and 0495 nM respectively Lurasidone (Hydrochloride)(SM-13496 (Hydrochloride)) is also a partial agonisthellip

Bioactivity Metoclopramide is a dopamine D2 antagonist that is used as anantiemetic IC50 Value Target D2 Receptor Metoclopramide isa dopamine receptor antagonist which has been used fortreatment of a variety of gastrointestinal symptoms over thelast thirty years In various countries metoclopramide is thehellip

Bioactivity Metoclopramide hydrochloride hydrate is a dopamine D2antagonist that is used as an antiemetic IC50 Value TargetD2 Receptor Metoclopramide is a dopamine receptor antagonistwhich has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years Inhellip

Bioactivity Molindone is a therapeutic antipsychotic used in thetreatment of schizophrenia works by blocking the effects ofdopamine in the brain leading to diminished psychoses

Iloperidone (HP 873) Cat No HY-17410

Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A

L-DOPA (Levodopa 34-Dihydroxyphenylalanine) Cat No HY-N0304

Levosulpiride (RV-12309 S-(-)-Sulpiride) Cat No HY-B1059

lumateperone Tosylate (ITI-007) Cat No HY-19733

Lurasidone (SM-13496) Cat No HY-B0032A

Lurasidone Hydrochloride (SM-13496 (Hydrochloride)) Cat No HY-B0032

Metoclopramide Cat No HY-17382

Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) Cat No HY-17382A

Molindone hydrochloride (EN-1733A) Cat No HY-B1017

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg 1 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9855Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9966Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9814Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9924Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg

Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

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Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 4: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data LaunchedSize 1 mg

Purity 9946Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9952Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Purity 9983Clinical Data LaunchedSize 1 g 5 g

Purity 990Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg 50 mg

Purity 9989Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9935Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Bioactivity Cabergoline is an ergot derived-dopamine D -like receptor2agonist that has high affinity for and D2 D3 5-HT2Breceptors ( =07 15 and 12 respectively)Ki

Bioactivity Cariprazine is a novel antipsychotic drug candidate thatexhibits high affinity for the ( =0085 nM) and (D3 Ki D2

=049 nM) receptors and moderate affinity for the Ki 5-HT1Areceptor ( =26 nM)Ki

Bioactivity Cariprazine hydrochloride is a novel antipsychotic drugcandidate that exhibits high affinity for the ( =0085D3 KinM) and ( =049 nM) receptors and moderate affinityD2 Kifor the receptor ( =26 nM)5-HT1A Ki

Bioactivity CGP 25454A is a novel and selective presynaptic dopamineautoreceptor antagonist

Bioactivity Chlorpromazine D6 hydrochloride is the deuterium labeledChlorpromazine Chlorpromazine is an inhibitor of dopaminereceptor 5-HT receptor potassium channel sodium channel

Bioactivity Chlorpromazine Hydrochloride is an antagonist of the and dopamine D2 5HT2A potassium channel sodium

Chlorpromazine binds with D2 and 5HT2A with s of 363channel KinM and 83 nM respectively

Bioactivity Chlorprothixene has strong binding affinities to dopamine andhistamine receptors such as D1 D2 D3 D5 H1 5-HT2 5-HT6and 5-HT7 with Ki of 18 nM 296 nM 456 nM 9 nM 375 nM94 nM 3 nM and 56 nM respectively

Bioactivity Clebopride malate is a dopamine antagonist drug withantiemetic and prokinetic properties used to treat functionalgastrointestinal disorders

Bioactivity Clocapramine is an antagonist of the D2 5-HT2Areceptors

Bioactivity Clocapramine hydrochloride hydrate is an antagonist of the and D2 5-HT receptors2A

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Cabergoline (FCE-21336) Cat No HY-15296

Cariprazine (RGH-188) Cat No HY-14763

Cariprazine hydrochloride (RGH188 hydrochloride) Cat No HY-14763A

CGP 25454A Cat No HY-100454

Chlorpromazine D6 hydrochloride Cat No HY-B0407AS

Chlorpromazine hydrochloride Cat No HY-B0407A

Chlorprothixene Cat No HY-B0274

Clebopride malate Cat No HY-B1613A

Clocapramine (Clocarpramine 3-Chlorocarpipramine) Cat No HY-B2073

Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate) Cat No HY-B2073A

wwwMedChemExpresscom 5

Purity gt98Clinical Data LaunchedSize 10 mg

Purity 9929Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9979Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9952Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize

Purity 9801Clinical Data Phase 3Size 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data Phase 3Size 10 mg 50 mg

Purity 9997Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg 5 g

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Bioactivity Clomipramine HCl is a serotonin transporter (SERT)norepinephrine transporter (NET) dopamine transporter (DAT)blocker with Ki of 014 54 and 3 nM respectively Target5-HT Receptor Clomipramine hydrochloride (Anafranil) is ahydrochloride salt of clomipramine which is a serotoninhellip

Bioactivity Clozapine (HF 1854) is an antipsychotic used to treatschizophrenia Clozapine is a potent antagonist of dopamineand a number of other receptors with a of 95 nM for Ki M1

receptor

Bioactivity Dexpramipexole(KNS-760704) also known as R-(+)-Pramipexoleis a neuroprotective agent and weak non-ergoline dopamineagonist IC50 Value

Bioactivity Dexpramipexole dihydrochloride also known asR-(+)-Pramipexole is a neuroprotective agent and weaknon-ergoline dopamine agonist IC50 Value Target DopamineReceptor Dexpramipexole has been found to have neuroprotectiveeffects and is being investigated for treatment of amyotrophichellip

Bioactivity Dicarbine blocks in various brain partsdopamine receptorsand prevents the depression of the conditioned defencereflexes caused by stimulation of the mesencephalic portion ofthe reticular formation Dicarbine could be used to treatpatients with schizophrenia and alcoholic psychosis inhellip

Bioactivity Domperidone is a dopamine blocker and an antidopaminergicreagent

Bioactivity Dopamine HCl is a catecholamine neurotransmitter present in awide variety of animalsAnd a dopamine D1-5 receptors agonistTarget Dopamine Receptor Dopamine (or34-dihydroxyphenethylamine) is a neuroendocrine transmitterin the catecholamine and phenethylamine families that plays ahellip

Bioactivity Dopamine serotonin antagonist-1 is a dual anddopamine receptor antagonist with s of 200 2500 420 39serotonin Ki

84 40 nM for dopamine D1 D2D4 and serotonin S2A S2C S3respectively

Bioactivity Droperidol is a Dopamine-2 Receptor Antagonist Bioactivity Fenoldopam(SKF 82526) is a drug and synthetic benzazepinederivative which acts as a selective D1 receptor partialagonist

Clomipramine hydrochloride Cat No HY-B0457

Clozapine (HF 1854) Cat No HY-14539

Dexpramipexole ((R)-Pramipexole R-(+)-Pramipexole KNS-760704) Cat No HY-17355B

Dexpramipexole dihydrochloride ((R)-Pramipexole

(dihydrochloride) hellip) Cat No HY-17355A

Dicarbine Cat No HY-127086

Domperidone (R33812) Cat No HY-B0411

Dopamine hydrochloride (ASL279) Cat No HY-B0451A

Dopamine serotonin antagonist-1 Cat No HY-42110

Droperidol (Dehydrobenzperidol) Cat No HY-B1240

Fenoldopam (SKF 82526) Cat No HY-B0735

Purity gt98Clinical Data LaunchedSize 100 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9973Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9995Clinical Data Phase 2Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize

Purity gt98Clinical Data No Development ReportedSize

Purity 9996Clinical Data LaunchedSize 100 mg

Purity 9985Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Fenoldopam(SKF 82526) mesylate is a drug and syntheticbenzazepine derivative which acts as a selective D1 receptorpartial agonist

Bioactivity Fluphenazine dihydrochloride is a phenothiazine-class D1DR andD2DR inhibitor used to deliver Fluphenazine to biologicalsystems in studies probing the effects and metabolic fates ofthis commonly used dopamine antagonist

Bioactivity Foscarbidopa (Carbidopa 4prime-monophosphate) is a prodrug ofCarbidopa acts as a agonist dopamine receptor [1] [2]

Bioactivity Foslevodopa is a agonist dopamine receptor [1]

Bioactivity GSK163090 is a potent selective and orally active 5-HT1ABDreceptor antagonist with pKi of 948597 and 6367 for5-HT1ABD and dopamine D2D3 respectively

Bioactivity GSK598809 is a potent and selective dopamine D3 Receptor antagonist with a of 89(DRD3) pKi

Bioactivity Haloperidol is a potent antagonistdopamine D2 receptorwidely used as an antipsychotic

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol hydrochloride is a potent dopamine D2 receptorantagonist widely used as an antipsychotic

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Fenoldopam mesylate (Fenoldopam methanesulfonate SKF-82526 mesylate) Cat No HY-B0735A

Fluphenazine dihydrochloride Cat No HY-A0081

Foscarbidopa (Carbidopa 4prime-monophosphate) Cat No HY-109131

Foslevodopa (Dopa 4-Phosphate 3-Hydroxy-O-phosphono-L-tyrosine) Cat No HY-109132

GSK163090 Cat No HY-14348

GSK598809 Cat No HY-19654

Haloperidol Cat No HY-14538

Haloperidol D4 Cat No HY-14538S

Haloperidol D4 Cat No HY-14538S1

Haloperidol hydrochloride Cat No HY-14538A

wwwMedChemExpresscom 7

Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg

Purity 9933Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9921Clinical Data Phase 3Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data LaunchedSize 200 mg 1 g

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Iloperidone(HP 873) is a D25-HT2 receptor antagonist whichis an atypical antipsychotic for the treatment ofschizophrenia symptoms

Bioactivity Iloperidone (hydrochloride) is a D(2)5-HT(2) receptorantagonistis which is an atypical antipsychotic for thetreatment of schizophrenia symptoms

Bioactivity L-DOPA is a natural form of DOPA used in the treatment ofParkinsons disease L-DOPA is the precursor of dopamine andproduct of tyrosine hydroxylase Target Dopamine ReceptorL-DOPA (L-34-dihydroxyphenylalanine) is a chemical that ismade and used as part of the normal biology of humans somehellip

Bioactivity Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiridewhich is a D2 receptor a antagonist an atypical antipsychoticdrug of the benzamide class

Bioactivity Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki =054 nM) a partial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32 nM) and aSERT blocker (Ki = 61 nM) IC50 value 054 nM (Ki for 5-HT2Areceptor ) Target 5-HT2A receptor Lumateperone also possesseshellip

Bioactivity Lurasidone (SM-13496) is an antagonist of both dopamine and with s of 168 and 0495 nMD2 5-HT7 IC50

respectively Lurasidone (SM-13496) is also a partial agonistof receptor with an of 675 nM5-HT1A IC50

Bioactivity Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is anantagonist of both and with s ofdopamine D2 5-HT7 IC50168 and 0495 nM respectively Lurasidone (Hydrochloride)(SM-13496 (Hydrochloride)) is also a partial agonisthellip

Bioactivity Metoclopramide is a dopamine D2 antagonist that is used as anantiemetic IC50 Value Target D2 Receptor Metoclopramide isa dopamine receptor antagonist which has been used fortreatment of a variety of gastrointestinal symptoms over thelast thirty years In various countries metoclopramide is thehellip

Bioactivity Metoclopramide hydrochloride hydrate is a dopamine D2antagonist that is used as an antiemetic IC50 Value TargetD2 Receptor Metoclopramide is a dopamine receptor antagonistwhich has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years Inhellip

Bioactivity Molindone is a therapeutic antipsychotic used in thetreatment of schizophrenia works by blocking the effects ofdopamine in the brain leading to diminished psychoses

Iloperidone (HP 873) Cat No HY-17410

Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A

L-DOPA (Levodopa 34-Dihydroxyphenylalanine) Cat No HY-N0304

Levosulpiride (RV-12309 S-(-)-Sulpiride) Cat No HY-B1059

lumateperone Tosylate (ITI-007) Cat No HY-19733

Lurasidone (SM-13496) Cat No HY-B0032A

Lurasidone Hydrochloride (SM-13496 (Hydrochloride)) Cat No HY-B0032

Metoclopramide Cat No HY-17382

Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) Cat No HY-17382A

Molindone hydrochloride (EN-1733A) Cat No HY-B1017

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg 1 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9855Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9966Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9814Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9924Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg

Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

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Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 5: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

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Purity gt98Clinical Data LaunchedSize 10 mg

Purity 9929Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9979Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9952Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize

Purity 9801Clinical Data Phase 3Size 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data Phase 3Size 10 mg 50 mg

Purity 9997Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg 5 g

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Bioactivity Clomipramine HCl is a serotonin transporter (SERT)norepinephrine transporter (NET) dopamine transporter (DAT)blocker with Ki of 014 54 and 3 nM respectively Target5-HT Receptor Clomipramine hydrochloride (Anafranil) is ahydrochloride salt of clomipramine which is a serotoninhellip

Bioactivity Clozapine (HF 1854) is an antipsychotic used to treatschizophrenia Clozapine is a potent antagonist of dopamineand a number of other receptors with a of 95 nM for Ki M1

receptor

Bioactivity Dexpramipexole(KNS-760704) also known as R-(+)-Pramipexoleis a neuroprotective agent and weak non-ergoline dopamineagonist IC50 Value

Bioactivity Dexpramipexole dihydrochloride also known asR-(+)-Pramipexole is a neuroprotective agent and weaknon-ergoline dopamine agonist IC50 Value Target DopamineReceptor Dexpramipexole has been found to have neuroprotectiveeffects and is being investigated for treatment of amyotrophichellip

Bioactivity Dicarbine blocks in various brain partsdopamine receptorsand prevents the depression of the conditioned defencereflexes caused by stimulation of the mesencephalic portion ofthe reticular formation Dicarbine could be used to treatpatients with schizophrenia and alcoholic psychosis inhellip

Bioactivity Domperidone is a dopamine blocker and an antidopaminergicreagent

Bioactivity Dopamine HCl is a catecholamine neurotransmitter present in awide variety of animalsAnd a dopamine D1-5 receptors agonistTarget Dopamine Receptor Dopamine (or34-dihydroxyphenethylamine) is a neuroendocrine transmitterin the catecholamine and phenethylamine families that plays ahellip

Bioactivity Dopamine serotonin antagonist-1 is a dual anddopamine receptor antagonist with s of 200 2500 420 39serotonin Ki

84 40 nM for dopamine D1 D2D4 and serotonin S2A S2C S3respectively

Bioactivity Droperidol is a Dopamine-2 Receptor Antagonist Bioactivity Fenoldopam(SKF 82526) is a drug and synthetic benzazepinederivative which acts as a selective D1 receptor partialagonist

Clomipramine hydrochloride Cat No HY-B0457

Clozapine (HF 1854) Cat No HY-14539

Dexpramipexole ((R)-Pramipexole R-(+)-Pramipexole KNS-760704) Cat No HY-17355B

Dexpramipexole dihydrochloride ((R)-Pramipexole

(dihydrochloride) hellip) Cat No HY-17355A

Dicarbine Cat No HY-127086

Domperidone (R33812) Cat No HY-B0411

Dopamine hydrochloride (ASL279) Cat No HY-B0451A

Dopamine serotonin antagonist-1 Cat No HY-42110

Droperidol (Dehydrobenzperidol) Cat No HY-B1240

Fenoldopam (SKF 82526) Cat No HY-B0735

Purity gt98Clinical Data LaunchedSize 100 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9973Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9995Clinical Data Phase 2Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize

Purity gt98Clinical Data No Development ReportedSize

Purity 9996Clinical Data LaunchedSize 100 mg

Purity 9985Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Fenoldopam(SKF 82526) mesylate is a drug and syntheticbenzazepine derivative which acts as a selective D1 receptorpartial agonist

Bioactivity Fluphenazine dihydrochloride is a phenothiazine-class D1DR andD2DR inhibitor used to deliver Fluphenazine to biologicalsystems in studies probing the effects and metabolic fates ofthis commonly used dopamine antagonist

Bioactivity Foscarbidopa (Carbidopa 4prime-monophosphate) is a prodrug ofCarbidopa acts as a agonist dopamine receptor [1] [2]

Bioactivity Foslevodopa is a agonist dopamine receptor [1]

Bioactivity GSK163090 is a potent selective and orally active 5-HT1ABDreceptor antagonist with pKi of 948597 and 6367 for5-HT1ABD and dopamine D2D3 respectively

Bioactivity GSK598809 is a potent and selective dopamine D3 Receptor antagonist with a of 89(DRD3) pKi

Bioactivity Haloperidol is a potent antagonistdopamine D2 receptorwidely used as an antipsychotic

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol hydrochloride is a potent dopamine D2 receptorantagonist widely used as an antipsychotic

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Fenoldopam mesylate (Fenoldopam methanesulfonate SKF-82526 mesylate) Cat No HY-B0735A

Fluphenazine dihydrochloride Cat No HY-A0081

Foscarbidopa (Carbidopa 4prime-monophosphate) Cat No HY-109131

Foslevodopa (Dopa 4-Phosphate 3-Hydroxy-O-phosphono-L-tyrosine) Cat No HY-109132

GSK163090 Cat No HY-14348

GSK598809 Cat No HY-19654

Haloperidol Cat No HY-14538

Haloperidol D4 Cat No HY-14538S

Haloperidol D4 Cat No HY-14538S1

Haloperidol hydrochloride Cat No HY-14538A

wwwMedChemExpresscom 7

Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg

Purity 9933Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9921Clinical Data Phase 3Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data LaunchedSize 200 mg 1 g

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Iloperidone(HP 873) is a D25-HT2 receptor antagonist whichis an atypical antipsychotic for the treatment ofschizophrenia symptoms

Bioactivity Iloperidone (hydrochloride) is a D(2)5-HT(2) receptorantagonistis which is an atypical antipsychotic for thetreatment of schizophrenia symptoms

Bioactivity L-DOPA is a natural form of DOPA used in the treatment ofParkinsons disease L-DOPA is the precursor of dopamine andproduct of tyrosine hydroxylase Target Dopamine ReceptorL-DOPA (L-34-dihydroxyphenylalanine) is a chemical that ismade and used as part of the normal biology of humans somehellip

Bioactivity Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiridewhich is a D2 receptor a antagonist an atypical antipsychoticdrug of the benzamide class

Bioactivity Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki =054 nM) a partial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32 nM) and aSERT blocker (Ki = 61 nM) IC50 value 054 nM (Ki for 5-HT2Areceptor ) Target 5-HT2A receptor Lumateperone also possesseshellip

Bioactivity Lurasidone (SM-13496) is an antagonist of both dopamine and with s of 168 and 0495 nMD2 5-HT7 IC50

respectively Lurasidone (SM-13496) is also a partial agonistof receptor with an of 675 nM5-HT1A IC50

Bioactivity Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is anantagonist of both and with s ofdopamine D2 5-HT7 IC50168 and 0495 nM respectively Lurasidone (Hydrochloride)(SM-13496 (Hydrochloride)) is also a partial agonisthellip

Bioactivity Metoclopramide is a dopamine D2 antagonist that is used as anantiemetic IC50 Value Target D2 Receptor Metoclopramide isa dopamine receptor antagonist which has been used fortreatment of a variety of gastrointestinal symptoms over thelast thirty years In various countries metoclopramide is thehellip

Bioactivity Metoclopramide hydrochloride hydrate is a dopamine D2antagonist that is used as an antiemetic IC50 Value TargetD2 Receptor Metoclopramide is a dopamine receptor antagonistwhich has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years Inhellip

Bioactivity Molindone is a therapeutic antipsychotic used in thetreatment of schizophrenia works by blocking the effects ofdopamine in the brain leading to diminished psychoses

Iloperidone (HP 873) Cat No HY-17410

Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A

L-DOPA (Levodopa 34-Dihydroxyphenylalanine) Cat No HY-N0304

Levosulpiride (RV-12309 S-(-)-Sulpiride) Cat No HY-B1059

lumateperone Tosylate (ITI-007) Cat No HY-19733

Lurasidone (SM-13496) Cat No HY-B0032A

Lurasidone Hydrochloride (SM-13496 (Hydrochloride)) Cat No HY-B0032

Metoclopramide Cat No HY-17382

Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) Cat No HY-17382A

Molindone hydrochloride (EN-1733A) Cat No HY-B1017

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg 1 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9855Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9966Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9814Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9924Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg

Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 6: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

Purity gt98Clinical Data LaunchedSize 100 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9973Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9995Clinical Data Phase 2Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize

Purity gt98Clinical Data No Development ReportedSize

Purity 9996Clinical Data LaunchedSize 100 mg

Purity 9985Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Fenoldopam(SKF 82526) mesylate is a drug and syntheticbenzazepine derivative which acts as a selective D1 receptorpartial agonist

Bioactivity Fluphenazine dihydrochloride is a phenothiazine-class D1DR andD2DR inhibitor used to deliver Fluphenazine to biologicalsystems in studies probing the effects and metabolic fates ofthis commonly used dopamine antagonist

Bioactivity Foscarbidopa (Carbidopa 4prime-monophosphate) is a prodrug ofCarbidopa acts as a agonist dopamine receptor [1] [2]

Bioactivity Foslevodopa is a agonist dopamine receptor [1]

Bioactivity GSK163090 is a potent selective and orally active 5-HT1ABDreceptor antagonist with pKi of 948597 and 6367 for5-HT1ABD and dopamine D2D3 respectively

Bioactivity GSK598809 is a potent and selective dopamine D3 Receptor antagonist with a of 89(DRD3) pKi

Bioactivity Haloperidol is a potent antagonistdopamine D2 receptorwidely used as an antipsychotic

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol D4 is deuterium labeled haloperidol and thelatter is a potent antagonistdopamine D2 receptor

Bioactivity Haloperidol hydrochloride is a potent dopamine D2 receptorantagonist widely used as an antipsychotic

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Fenoldopam mesylate (Fenoldopam methanesulfonate SKF-82526 mesylate) Cat No HY-B0735A

Fluphenazine dihydrochloride Cat No HY-A0081

Foscarbidopa (Carbidopa 4prime-monophosphate) Cat No HY-109131

Foslevodopa (Dopa 4-Phosphate 3-Hydroxy-O-phosphono-L-tyrosine) Cat No HY-109132

GSK163090 Cat No HY-14348

GSK598809 Cat No HY-19654

Haloperidol Cat No HY-14538

Haloperidol D4 Cat No HY-14538S

Haloperidol D4 Cat No HY-14538S1

Haloperidol hydrochloride Cat No HY-14538A

wwwMedChemExpresscom 7

Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg

Purity 9933Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9921Clinical Data Phase 3Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data LaunchedSize 200 mg 1 g

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Iloperidone(HP 873) is a D25-HT2 receptor antagonist whichis an atypical antipsychotic for the treatment ofschizophrenia symptoms

Bioactivity Iloperidone (hydrochloride) is a D(2)5-HT(2) receptorantagonistis which is an atypical antipsychotic for thetreatment of schizophrenia symptoms

Bioactivity L-DOPA is a natural form of DOPA used in the treatment ofParkinsons disease L-DOPA is the precursor of dopamine andproduct of tyrosine hydroxylase Target Dopamine ReceptorL-DOPA (L-34-dihydroxyphenylalanine) is a chemical that ismade and used as part of the normal biology of humans somehellip

Bioactivity Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiridewhich is a D2 receptor a antagonist an atypical antipsychoticdrug of the benzamide class

Bioactivity Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki =054 nM) a partial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32 nM) and aSERT blocker (Ki = 61 nM) IC50 value 054 nM (Ki for 5-HT2Areceptor ) Target 5-HT2A receptor Lumateperone also possesseshellip

Bioactivity Lurasidone (SM-13496) is an antagonist of both dopamine and with s of 168 and 0495 nMD2 5-HT7 IC50

respectively Lurasidone (SM-13496) is also a partial agonistof receptor with an of 675 nM5-HT1A IC50

Bioactivity Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is anantagonist of both and with s ofdopamine D2 5-HT7 IC50168 and 0495 nM respectively Lurasidone (Hydrochloride)(SM-13496 (Hydrochloride)) is also a partial agonisthellip

Bioactivity Metoclopramide is a dopamine D2 antagonist that is used as anantiemetic IC50 Value Target D2 Receptor Metoclopramide isa dopamine receptor antagonist which has been used fortreatment of a variety of gastrointestinal symptoms over thelast thirty years In various countries metoclopramide is thehellip

Bioactivity Metoclopramide hydrochloride hydrate is a dopamine D2antagonist that is used as an antiemetic IC50 Value TargetD2 Receptor Metoclopramide is a dopamine receptor antagonistwhich has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years Inhellip

Bioactivity Molindone is a therapeutic antipsychotic used in thetreatment of schizophrenia works by blocking the effects ofdopamine in the brain leading to diminished psychoses

Iloperidone (HP 873) Cat No HY-17410

Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A

L-DOPA (Levodopa 34-Dihydroxyphenylalanine) Cat No HY-N0304

Levosulpiride (RV-12309 S-(-)-Sulpiride) Cat No HY-B1059

lumateperone Tosylate (ITI-007) Cat No HY-19733

Lurasidone (SM-13496) Cat No HY-B0032A

Lurasidone Hydrochloride (SM-13496 (Hydrochloride)) Cat No HY-B0032

Metoclopramide Cat No HY-17382

Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) Cat No HY-17382A

Molindone hydrochloride (EN-1733A) Cat No HY-B1017

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg 1 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9855Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9966Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9814Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9924Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg

Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

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Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

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Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 7: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

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Purity 9992Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9987Clinical Data LaunchedSize 10 mg 50 mg 100 mg 200 mg 500 mg

Purity 9933Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9921Clinical Data Phase 3Size 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity gt98Clinical Data LaunchedSize 200 mg 1 g

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Iloperidone(HP 873) is a D25-HT2 receptor antagonist whichis an atypical antipsychotic for the treatment ofschizophrenia symptoms

Bioactivity Iloperidone (hydrochloride) is a D(2)5-HT(2) receptorantagonistis which is an atypical antipsychotic for thetreatment of schizophrenia symptoms

Bioactivity L-DOPA is a natural form of DOPA used in the treatment ofParkinsons disease L-DOPA is the precursor of dopamine andproduct of tyrosine hydroxylase Target Dopamine ReceptorL-DOPA (L-34-dihydroxyphenylalanine) is a chemical that ismade and used as part of the normal biology of humans somehellip

Bioactivity Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiridewhich is a D2 receptor a antagonist an atypical antipsychoticdrug of the benzamide class

Bioactivity Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki =054 nM) a partial agonist of presynaptic D2 receptors and anantagonist of postsynaptic D2 receptors (Ki = 32 nM) and aSERT blocker (Ki = 61 nM) IC50 value 054 nM (Ki for 5-HT2Areceptor ) Target 5-HT2A receptor Lumateperone also possesseshellip

Bioactivity Lurasidone (SM-13496) is an antagonist of both dopamine and with s of 168 and 0495 nMD2 5-HT7 IC50

respectively Lurasidone (SM-13496) is also a partial agonistof receptor with an of 675 nM5-HT1A IC50

Bioactivity Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is anantagonist of both and with s ofdopamine D2 5-HT7 IC50168 and 0495 nM respectively Lurasidone (Hydrochloride)(SM-13496 (Hydrochloride)) is also a partial agonisthellip

Bioactivity Metoclopramide is a dopamine D2 antagonist that is used as anantiemetic IC50 Value Target D2 Receptor Metoclopramide isa dopamine receptor antagonist which has been used fortreatment of a variety of gastrointestinal symptoms over thelast thirty years In various countries metoclopramide is thehellip

Bioactivity Metoclopramide hydrochloride hydrate is a dopamine D2antagonist that is used as an antiemetic IC50 Value TargetD2 Receptor Metoclopramide is a dopamine receptor antagonistwhich has been used for treatment of a variety ofgastrointestinal symptoms over the last thirty years Inhellip

Bioactivity Molindone is a therapeutic antipsychotic used in thetreatment of schizophrenia works by blocking the effects ofdopamine in the brain leading to diminished psychoses

Iloperidone (HP 873) Cat No HY-17410

Iloperidone hydrochloride (HP 873 hydrochloride) Cat No HY-17410A

L-DOPA (Levodopa 34-Dihydroxyphenylalanine) Cat No HY-N0304

Levosulpiride (RV-12309 S-(-)-Sulpiride) Cat No HY-B1059

lumateperone Tosylate (ITI-007) Cat No HY-19733

Lurasidone (SM-13496) Cat No HY-B0032A

Lurasidone Hydrochloride (SM-13496 (Hydrochloride)) Cat No HY-B0032

Metoclopramide Cat No HY-17382

Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) Cat No HY-17382A

Molindone hydrochloride (EN-1733A) Cat No HY-B1017

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg 1 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9855Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9966Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9814Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9924Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg

Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

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Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 8: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg 1 g

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9855Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9966Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9814Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity 9924Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

1 mg 5 mg 10 mg 25 mg

Purity 9991Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 25 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Bioactivity NEO 376 is a selective modulator of 5-HT1 receptor GABA and with anti-psychoticreceptor dopamine receptor

actively

Bioactivity Neuromedin N is a potent modulator of dopamine D2 receptoragonist binding in rat neostriatal membranes

Bioactivity NMI 8739 is a agonist which isdopamine D autoreceptor2an amine conjugate of the DHA carrier and the neurotransmitterdopamine

Bioactivity Nomifensine is a norepinephrine-dopamine reuptake inhibitorincreases the amount of synaptic norepinephrine and dopamineavailable to receptors by blocking the dopamine andnorepinephrine reuptake transporters

Bioactivity Nomifensine maleate is a selective inhibitor of dopamineuptake used in adult attention deficit disorder

Bioactivity NRA-0160 is a selective antagonistdopamine D4 receptorwith a value of 048 nM and with negligible affinity forKi

( gt10000 nM) (dopamine D2 receptor Ki D3 receptor

39 nM) rat ( 180 nM) and ratKi 5-HT2A receptor Ki

Bioactivity Nuciferine is an antagonist at ( =478 nM)5-HT2A IC50 ( =131 nM) and ( =1 μM) an inverse5-HT2C IC50 5-HT2B IC50

agonist at ( =150 nM) a partial agonist at (5-HT7 IC50 D2=64 nM) ( =26 μM) and ( =hellipEC50 D5 EC50 5-HT6 EC50

Bioactivity Ocaperidone is an effective antipsychotic agent acting as apotent and antagonist and a 5-HT2 dopamine D2 5-HT1Aagonist with s of 014 nM 046 nM 075 nM 16 nM and 54KinM for 5-HT a -adrenergic receptor dopamine D 2 1 2

Bioactivity Org-10490 is an antagonist of anddopamine D1 receptor used for the treatment fordopamine D2 receptor

psychiatric disease

Bioactivity Oxidopamine (hydrobromide) an antagonist of the is a widely used neurotoxinneurotransmitter dopamine

that selectively destroys dopaminergic neurons

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NEO 376 (SPI-376) Cat No HY-101583

Neuromedin N (Neuromedin N (rat mouse porcine canine)) Cat No HY-P0079

NMI 8739 Cat No HY-101540

Nomifensine ((plusmn)-Nomifensin) Cat No HY-B1110

Nomifensine maleate ((plusmn)-Nomifensine maleat) Cat No HY-B1110A

NRA-0160 Cat No HY-101641

Nuciferine Cat No HY-N0049

Ocaperidone (R79598) Cat No HY-101094

Org-10490 Cat No HY-U00077

Oxidopamine hydrobromide (6-Hydroxydopamine hydrobromide 6-OHDA hydrobromide)Cat No HY-B1081A

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

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Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 9: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

wwwMedChemExpresscom 9

Purity gt98Clinical Data LaunchedSize 10 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9844Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity 9889Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data Phase 3Size 5 mg 10 mg 50 mg 100 mg

Purity 9909Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg 500 mg

Bioactivity Paliperidone (9-hydroxyrisperidone is a dopamine antagonist ofthe atypical antipsychotic class of medications

Bioactivity Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist (IA =50 and 67 respectively) and 5-HT1A receptor (pKi = 85)full agonist (IA = 100) also binds to D4 (pKi = 78)hellip

Bioactivity Pardoprunox hydrochloride is a novel partial dopamine D2 andD3 receptor agonist and serotonin 5-HT1A receptor agonist D2(pKi = 81) and D3 receptor (pKi = 86) partial agonist and5-HT1A receptor (pKi = 85) full agonist

Bioactivity PD-168077 maleate is a selective dopamine receptorD4agonist with a of 9 nMKi

Bioactivity Pentiapine is a novel inhibitordopamine release Bioactivity Pergolide Mesylate is an antiparkinsonian agent whichfunctions as a dopaminergic agonist Target Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-baseddopamine receptor agonist used in some countries for thetreatment of Parkinsons disease Pergolide mesylate functionshellip

Bioactivity Perphenazine is a typical antipsychotic drug inhibits5-HT receptor Alpha-1A adrenergic receptor Dopamine2A

and receptor D2D3 D2L receptor Histamine H1 receptorwith values of 56 10 0765013 34 and 8 hellipKi

Bioactivity Perphenazine D8 Dihydrochloride is the deuterium labeledPerphenazine which is a typical antipsychotic drug(5-HTDopamine receptor ligand)

Bioactivity PF-592379 is a potent agonist withdopamine D receptor3an of 21 nMEC50

Bioactivity Pimethixene is antihistamine and antiserotonergic compoundacts as an antimigraine agent Pimethixene is a highly potentantagonist of 5-HT 5-HT 5-HT 5-HT 1A 2A 2B 2Chistamine H dopamine D and D as well as muscarihellip1 2 44

Paliperidone (9-hydroxyrisperidone) Cat No HY-A0019

Pardoprunox (SLV-308 DU-126891) Cat No HY-14958

Pardoprunox hydrochloride (SLV-308 hydrochloride DU-126891 hydrochloride) Cat No HY-14958A

PD-168077 maleate Cat No HY-21098A

Pentiapine (CGS 10746) Cat No HY-100143

Pergolide mesylate (Pergolide methanesulfonate LY127809) Cat No HY-13720A

Perphenazine Cat No HY-A0077

Perphenazine D8 Dihydrochloride Cat No HY-A0077AS

PF-592379 Cat No HY-U00400

Pimethixene (Pimetixene) Cat No HY-B1101

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

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Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

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Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 10: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

Purity gt98Clinical Data No Development ReportedSize 1 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9976Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 25 mg 50 mg 100 mg

Purity 980Clinical Data LaunchedSize 10mM x 1mL in Water

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9990Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg 200 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg

Bioactivity Pimethixene maleate is antihistamine and antiserotonergiccompound acts as an antimigraine agent Pimethixene maleateis a highly potent antagonist of 5-HT 5-HT 5-HT 1A 2A 2B5-HT histamine H dopamine D and D as wellhellip2C 1 2 44

Bioactivity Pimozide is a antagonist with s ofdopamine receptor Ki14 nM 25 nM and 588 nM for dopamine D2 D3 and D1receptors respectively and also has affinity at

with a of 39 nM Pimozide also inhibhellipα1-adrenoceptor Ki

Bioactivity Piperidine-MO-1 is a modulator of dopamine receptorextracted from patent WO2005121087A1 compound example 2exhibits an of 68 μmolkg on increase of DOPAC in theED50rat striatum

Bioactivity Piribedil is a ( ) agonistdopamine D receptor2 D R2which also displays antagonist property at hα -adrenoceptor1A( )hα -AR1A

Bioactivity Piribedil D8 is the deuterium labeled Piribedil which is anantiparkinsonian agent

Bioactivity Pramipexole is a dopamine agonist of the non-ergoline classindicated for treating Parkinsons disease (PD) and restlesslegs syndrome (RLS)

Bioactivity Pramipexole 2Hcl is a partialfull D2S D2L D3 D4 receptoragonist with a Ki of 39 22 05 and 51 nM for D2S D2LD3 D4 receptor respectively IC50 Value 39 nM(D2S) 22nM(D2L) 05 nM(D3) 51 nM(D4) Target Dopamine ReceptorPramipexole dihydrochloride is a dopamine receptor agonisthellip

Bioactivity Pridopidine a ( ) stabilizer acts as a lowdopamine DAaffinity ( ) antagonistdopamine D2 receptor D2RPridopidine exerts high affinity towards sigma 1 receptor( ) with between 70 and 80 nM which is ~100times higherS1R Kithan its affinity toward D2R

Bioactivity Prochlorperazine D8 is the deuterium labeled Prochlorperazinewhich is a dopamine (D2) receptor antagonist

Bioactivity Prochlorperazine D8 dimeleate is the deuterium labeledProchlorperazine which is a dopamine (D2) receptorantagonist

10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Pimethixene maleate (Pimetixene maleate) Cat No HY-B1101A

Pimozide (R6238) Cat No HY-12987

Piperidine-MO-1 Cat No HY-19845A

Piribedil Cat No HY-12707

Piribedil D8 (ET-495 D8) Cat No HY-12707S

Pramipexole Cat No HY-B0410

Pramipexole dihydrochloride Cat No HY-17355

Pridopidine (ACR16 ASP2314 FR310826) Cat No HY-10684

Prochlorperazine D8 Cat No HY-B0807S

Prochlorperazine D8 dimeleate Cat No HY-B0807S1

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

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Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 11: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

wwwMedChemExpresscom 11

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg 100 mg

Purity 9916Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity 9776Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity 9996Clinical Data LaunchedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg 100 mg

Purity 9954Clinical Data LaunchedSize 10mM x 1mL in DMSO

1 g 5 g

Purity 980Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9972Clinical Data LaunchedSize 10mM x 1mL in Water

100 mg

Bioactivity Promazine (hydrochloride) is a D2 dopamine receptorantagonist belongs to the phenothiazine class ofantipsychotics used to treat schizophrenia

Bioactivity Quetiapine D4 fumarate is the deuterium labeled Quetiapinewhich is an atypical antipsychotic

Bioactivity Quetiapine fumarate is an atypical antipsychotic used in thetreatment of schizophrenia bipolar I mania bipolar IIdepression bipolar I depression

Bioactivity Quinagolide hydrochloride is a selective dopamine D2 receptoragonist also is a prolactin inhibitor Target dopamine D2receptor prolactin Quinagolide is a selective D2 receptoragonist (or prolactin-release inhibitor) that is used for thetreatment of elevated levels of prolactin Quinagolide ishellip

Bioactivity Quinpirole (Hydrochloride) is a high-affinity agonist receptordopamine D2D3

Bioactivity rac-Rotigotine Hcl is a high potency and selectivity agonistfor D-2 receptor with Ki of 069 nM

Bioactivity Raclopride is a antagonistdopamine D2 D receptor3which binds to and s with dissociationD2 D receptor3constants ( s) of 18 nM and 35 nM respectively but has aKivery low affinity for D and D receptors with K shellip1 4 i

Bioactivity Risperidone is a serotonin blocker5-HT receptor2 inhibitor and potent P-Glycoprotein dopamine D receptor2

antagonist with of 48 59 nM for 5-HT and dopamineK si 2AD receptor respectively2

Bioactivity Risperidone hydrochloride is a serotonin receptor5-HT2blocker and a potent receptor antagonistdopamine D2with of 016 14 nM for 5-HT and D receptorK si 2 2respectively

Bioactivity Risperidone mesylate(R 64 766 mesylate) is a serotonin 5-HT2receptor blocker(Ki= 016 nM) and a potent dopamine D2receptor antagonist(Ki= 14 nM)

Promazine hydrochloride Cat No HY-B1225

Quetiapine D4 fumarate Cat No HY-B0031S

Quetiapine fumarate Cat No HY-B0031

Quinagolide hydrochloride (CV205-502 hydrochloride) Cat No HY-13736A

Quinpirole Hydrochloride ((-)-LY 171555) Cat No HY-B1752A

rac-Rotigotine Hydrochloride Cat No HY-15394

Raclopride Cat No HY-103414

Risperidone (R 64 766) Cat No HY-11018

Risperidone hydrochloride (R 64 766 hydrochloride) Cat No HY-11018A

Risperidone mesylate (R 64 766 mesylate) Cat No HY-11018B

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 12: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

Purity 9614Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9931Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 250 mg 500 mg

Purity gt98Clinical Data No Development ReportedSize 10 mg 50 mg

Purity 9988Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

Purity 9998Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Purity 9993Clinical Data LaunchedSize 10mM x 1mL in DMSO

50 mg 100 mg 200 mg

Purity 9889Clinical Data No Development ReportedSize 10mM x 1mL in Water

5 mg 10 mg 50 mg 100 mg

Bioactivity Ro 10-5824 dihydrochloride is a selective dopamine D4 partial agonist with of 52 nMreceptor Ki

Bioactivity Ropinirole hydrochloride(SKF101468 hydrochloride) a selectivedopamine D2 receptor inhibitor with IC50 of 29 nM

Bioactivity Rotigotine is a full agonist of adopamine receptorpartial agonist of the and an antagonist of5-HT1A receptorthe with s of 071nM 4-15nM andα2B-adrenergic receptor Ki83nM for the dopamine D3 receptor and D2 D5 D4 receptorsand dopamine D1 receptor

Bioactivity Rotigotine D7 Hydrochloride is the deuterium labeledRotigotine(N-0923) which is a dopamine D2 and D3 receptoragonist

Bioactivity Rotundine is an antagonist of and dopamine D1 D2 D3 with s of 166 nM 14 μM and 33 μMreceptors IC50

respectively Rotundine is also an antagonist of with5-HT1Aan of 370 nMIC50

Bioactivity SB-277011 is a potent and delective dopamine D3 receptorantagonist (pKi values are 80 60 50 and lt52 for D3D2 5-HT1D and 5-HT1B respectively) brain penetrant

Bioactivity SB-277011 dihydrochloride (SB-277011A dihydrochloride) is apotent selective orally bioavailable and brain penetrate

antagonist with s of 80 60dopamine D receptor3 pKilt52 and 59 for D D 5-HT and 5-HT 3 2 1B 1D

Bioactivity SB269652 is the first drug-like allosteric modulator of thedopamine D2 receptor (D2R) a new chemical probe that candifferentiate D2R monomers from dimers or oligomers dependingon the observed pharmacology

Bioactivity SCH 23390 hydrochloride is a potent D1dopamine receptorantagonist with values of 02 and 03 nM for the D1 and D5Ki

Bioactivity Sertindole a neuroleptic is one of the newer antipsychoticmedications available Target Multi-target In vitro studiesshowed that sertindole exerts a potent antagonism at serotonin5-HT2A 5-HT2C dopamine D2 and αl adrenergic receptorsSertindole offers an alternative treatment option forhellip

12 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Ro 10-5824 dihydrochloride Cat No HY-101384A

Ropinirole hydrochloride (SKF 101468 hydrochloride) Cat No HY-B0623A

Rotigotine (N-0437 N-0923) Cat No HY-75502

Rotigotine D7 Hydrochloride (N-0923 D7 Hydrochloride) Cat No HY-A0007S

Rotundine ((-)-Tetrahydropalmatine L-Tetrahydropalmatine) Cat No HY-N0096

SB-277011 (SB-277011A) Cat No HY-10847

SB-277011 dihydrochloride (SB-277011A dihydrochloride) Cat No HY-10847A

SB269652 Cat No HY-12324

SCH 23390 hydrochloride (R-(+)-SCH23390 hydrochloride) Cat No HY-19545A

Sertindole (Lu 23-174) Cat No HY-14543

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 13: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

wwwMedChemExpresscom 13

Purity gt98Clinical Data LaunchedSize 5 mg 10 mg 50 mg 100 mg

Purity 980Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 25 mg 50 mg 100 mg

Purity 9996Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 9801Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 50 mg

Purity 9995Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 50 mg 100 mg 200 mg 500 mg

Bioactivity SKF 38393 hydrochloride is a selective agonist of the with an of 110 nM dopamine D1 receptor (D1DR) IC50

[1]Bioactivity SKF 82958 is a D1D5 receptor full agonist IC50 value

Target D1D5 receptor in vitro Neuropeptide and immediateearly gene expression in striatonigral neurons of thenormosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity SKF-82958 hydrobromide is a D1D5 receptor full agonist IC50value Target D1D5 receptor in vitro Neuropeptide andimmediate early gene expression in striatonigral neurons ofthe normosensitive striatum is induced by mixed D1 receptorSKF-82958 which induces behavioral activity andhellip

Bioactivity ST-836 is a dopamine receptor ligand Antiparkinsonian agent

Bioactivity ST-836 Hcl is a dopamine receptor ligand Antiparkinsonianagent

Bioactivity Sulpiride is a D2 receptor a antagonist an atypicalantipsychotic drug of the benzamide class used mainly in thetreatment of psychosis associated with schizophrenia and majordepressive disorder and sometimes used in low dosage to treatanxiety and mild depression

Bioactivity Sultopride is a selective antagonist of dopamine D2receptor

Bioactivity Sultopride hydrochloride is a selective antagonist ofdopamine D2 receptor

Bioactivity Sumanirole maleate(PNU 95666E U95666E) is a highly selectiveD2 receptor full agonist with an ED50 of about 46 nM IC50value 46 nM (EC50) Target D2 receptor Sumanirole wasdeveloped for the treatment of Parkinsons disease andrestless leg syndrome While it has never been approved forhellip

Bioactivity Talipexole (B-HT920) is a dopamine agonist that has beenproposed as an antiparkinsonian agent Target DopamineReceptor B-HT920 is a selective alpha 2-adrenoceptor agonistThe effects of B-HT920 have been specified using thealpha-adrenergic antagonists yohimbine and prazosin and thehellip

SKF 38393 hydrochloride ((plusmn)-SKF-38393 hydrochloride SKF-38393A) Cat No HY-12520A

SKF 82958 ((plusmn)-SKF 82958 Chloro-AP) Cat No HY-10435

SKF-82958 hydrobromide ((plusmn)-SKF 82958 hydrobromide Chloro-APB hydrobromide) Cat No HY-10435A

ST-836 Cat No HY-15238

ST-836 hydrochloride Cat No HY-15238A

Sulpiride Cat No HY-B1019

Sultopride (LIN-1418) Cat No HY-42849

Sultopride hydrochloride (LIN-1418 hydrochloride) Cat No HY-42849A

Sumanirole maleate (U-95666E PNU-95666) Cat No HY-70081A

Talipexole (B-HT 920) Cat No HY-A0040

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 14: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

Purity 9912Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

2 mg 5 mg 10 mg 50 mg 100 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg 20 mg

Purity 9970Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 200 mg 500 mg

Purity 9994Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg

Purity 990Clinical Data LaunchedSize 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9982Clinical Data LaunchedSize 100 mg

Purity 9993Clinical Data Phase 4Size 10mM x 1mL in DMSO

100 mg 500 mg

Purity 9907Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity 9970Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

5 mg 10 mg

Purity 9999Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg 100 mg

Bioactivity Talipexole dihydrochloride (B-HT 920 dihydrochloride) is adopamine D2 receptor agonist α2-adrenoceptor agonist and5-HT3 receptor antagonist which displays antiParkinsonianactivity

Bioactivity Tetrahydroberberine is an isoquinoline alkaloid isolated fromcorydalis tuber has micromolar affinity for dopamine D(2)(pK(i) = 608) and 5-HT(1A) (pK(i) = 538) receptors butmoderate to no affinity for other relevant serotonin receptors(5-HT(1B) 5-HT(1D) 5-HT(3) and 5-HT(4) pK(i) lt 500)

Bioactivity Tetrahydropalmatine an active component isolated fromcorydalis acts through inhibition of amygdaloid release of

to inhibit an epileptic attack in ratsdopamine

Bioactivity Thioridazine is an antipsychotic drug used in the treatmentof schizophrenia and psychosis shows D4 selectivity orserotonin antagonism

Bioactivity Tiapride hydrochloride is a drug that selectively blocks D2and D3 dopamine receptors in the brain It is used to treat avariety of neurological and psychiatric disorders includingdyskinesia alcohol withdrawal syndrome

Bioactivity Trifluoperazine Dihydrochloride is a potent dopamine D2receptor inhibitor used as an antipsychotic and an antiemeticTarget Dopamine D2 Receptor Trifluoperazine Dihydrochlorideis a potent dopamine D2 receptor inhibitor used as anantipsychotic and an antiemetic Trifluoperazine inhibited inhellip

Bioactivity Triflupromazine hydrochloride is an antipsychotic medicationwhich are Dopamine D1D2 receptor antagonists

Bioactivity Trimethobenzamide hydrochloride is a blocker of the D2receptor Trimethobenzamide is an antiemetic used to preventnausea and vomiting

Bioactivity U91356 is a agonistdopamine receptor Bioactivity Veralipride is a receptor antagonist It is an alternativeD2antidopaminergic treatment for menopausal symptoms

14 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

Talipexole dihydrochloride (B-HT 920 (dihydrochloride)) Cat No HY-A0008

Tetrahydroberberine (Canadine) Cat No HY-N0925

Tetrahydropalmatine (DL-Tetrahydropalmatine) Cat No HY-N0300

Thioridazine hydrochloride Cat No HY-B0965

Tiapride hydrochloride Cat No HY-B1196

Trifluoperazine dihydrochloride (TFP SKF5019) Cat No HY-B0532A

Triflupromazine hydrochloride Cat No HY-B0909

Trimethobenzamide hydrochloride (Ro 2-9578) Cat No HY-12751A

U91356 Cat No HY-U00227

Veralipride ((plusmn)-Veralipride LIR166) Cat No HY-101797

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163

Page 15: Dopamine Receptor - file.medchemexpress.com · D2 receptor antagonist and 5-HT1A receptor agonist properties. Bioactivity: Alizapride hydrochloride is a dopamine receptor antagonist

wwwMedChemExpresscom 15

Purity 9880Clinical Data No Development ReportedSize 10mM x 1mL in DMSO

50 mg

Purity 9983Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Purity gt98Clinical Data LaunchedSize 10 mg 50 mg

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Purity 9869Clinical Data LaunchedSize 10mM x 1mL in DMSO

10 mg 50 mg

Bioactivity Ziprasidone(CP88059) is a combined 5-HT (serotonin) anddopamine receptor antagonist which exhibits potent effects ofantipsychotic activity

Bioactivity Ziprasidone D8 is deuterium labeled Ziprasidone which is acombined 5-HT (serotonin) and dopamine receptor antagonistwhich exhibits potent effects of antipsychotic activity

Bioactivity Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin)and dopamine receptor antagonist which exhibits potent effectsof antipsychotic activity

Bioactivity Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloridemonohydrate) is a combined 5-HT (serotonin) and dopaminereceptor antagonist which exhibits potent effects ofantipsychotic activity Target 5-HT receptor Dopaminereceptor Ziprasidone hydrochloride monohydrate is the salthellip

Bioactivity Zuclopenthixol is a thioxanthene derivative which acts as amixed antagonistdopamine D1D2 receptor

Ziprasidone (CP-88059) Cat No HY-14542

Ziprasidone D8 (CP-88059 D8) Cat No HY-14542S

Ziprasidone hydrochloride (CP-88059 hydrochloride) Cat No HY-14542A

Ziprasidone hydrochloride monohydrate (CP 88059 (hydrochloride monohydrate)) Cat No HY-17407

Zuclopenthixol ((Z)-Clopenthixol) Cat No HY-A0163