DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Download DNA Repair. Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS

Post on 20-Dec-2015

221 views

Category:

Documents

3 download

Embed Size (px)

TRANSCRIPT

<ul><li> Slide 1 </li> <li> DNA Repair </li> <li> Slide 2 </li> <li> Cell Cycle Checkpoint activation DNA Repair: Base Excision Repair Nucleotide excision repair Mismatch repair DSB repair SENESCENCE / APOPTOSIS CANCER </li> <li> Slide 3 </li> <li> Source of Damage Endogenous: Replication Errors Reactive Oxygen Species Exogenous: UV radiation, IR.. Mutagenic chemicals </li> <li> Slide 4 </li> <li> Type of Damage- Endogenous Oxidation of bases Methylation of bases Hydrolysis of bases Mismatch of bases Damage mostly on DNA bases, causing point mutations: </li> <li> Slide 5 </li> <li> Type of Damage- Exogenous UV light- pyrimidine dimers IR- Breaks in DNA strands Chemicals (found in smoke, soot and tar)- diversity of DNA damages including crosslinking of DNA. Damage mostly on helix structure: </li> <li> Slide 6 </li> <li> Slide 7 </li> <li> DNA MutationDNA Damage </li> <li> Slide 8 </li> <li> The cellular DNA damage response Transducers Mediators Sensors Effectors Cell cycle arrest DNA repairApoptosisDNA repair DNA damage </li> <li> Slide 9 </li> <li> DNA Repair Mechanisms </li> <li> Slide 10 </li> <li> DNA Mismatch repair </li> <li> Slide 11 </li> <li> Slide 12 </li> <li> Slide 13 </li> <li> Slide 14 </li> <li> Base Excision Repair </li> <li> Slide 15 </li> <li> Nucleotide excision repair </li> <li> Slide 16 </li> <li> Nucleotide Excision Repair in Eukaryotes </li> <li> Slide 17 </li> <li> Xeroderma Pigmentosum </li> </ul>

Recommended

View more >