Disruptive  Change  and  the  Implications  for    

Our  Industry    

2015  Spring  Senior  Executives  Meeting  

 

Mandarin  Oriental  Hotel  Boston,  Massachusetts  May  3-­‐5,  2015  

   

 

 2015  Spring  Senior  Executives  Meeting  2  

 

Harvard  Business  School  Professor  Clay  Christensen  popularized  the  concept  of  market  disruption  and  coined  the  term  “disruptive  innovation”  (a  product  or  service  that  creates  a  new  market,  often  initially  for  a  different  set  of  consumers,  and  a  unique  value  network  that  eventually  displaces  an  existing  market  and  value).  However,  disruption  is  broader  than  technology  and  encompasses  “any  influence  that  drastically  alters  or  destroys  the  existing  structure.”    In  the  life  science,  analytical  and  diagnostics  space,  several  influences  threaten  to  fundamentally  disrupt  the  future  direction  and  growth.  These  influences  include:  technology  such  as  Next  Gen  Sequencing  with  its  many  dimensions  and  applications,  and  the  challenges  associated  with  aggregating  and  interpreting  big  sets  of  data;  geographical  as  the  global  economy/geopolitical  dynamics  and  markets  especially  in  China  and  the  BRIC  countries  evolve;  business  model  as  companies  grow,  expand  internationally  and  develop  business  in  the  diagnostics  and  research  space;  and  government  due  to  regulation,  e.g.,  of  LDTs  as  technology  migrates  from  life  science  to  diagnostics,  and  compliance,  enforcement,  and  import/export  barriers.    Our  2015  Spring  Senior  Executives  Meeting  will  offer  strategic  insights  and  advice  on  several  potentially  disruptive  influences.  We’ll  examine  some  breakthrough  technologies  that  will  transform  business,  society  and  our  industry  over  the  next  several  years.  Ian  Bremmer,  who  was  impressive  at  our  2013  Spring  Meeting,  will  update  the  geopolitical  outlook  and  assess  influences  shaping  the  global  markets.    Other  speakers  will  examine  disruptive  technologies  including  Next  Generation  Sequencing  and  how  they  will  change  medicine,  and  the  impact  of  the  changing  regulatory  landscape  on  our  industry’s  markets  and  products.      Completing  our  program  will  be  a  presentation  from  a  highly  regarded  author  on  how  the  next  15  years  will  transform  competition,  customers  and  companies,  and  the  highlights  of  his  recent  book,  “Resilience:  Why  Things  Bounce  Back”.  

2015  Spring  Senior  Executives  Meeting  Program  

 

 2015  Spring  Senior  Executives  Meeting  3  

A  highly  regarded  speaker  at  our  2013  Spring  Meeting,  Dr.  Ian  Bremmer,  President  of  the  Eurasia  Group,  will  return  and  lead  off  Monday’s  program  with  an  assessment  of  the  global  geopolitical  outlook  with  a  focus  on  geographies  and  user  markets  of  special  interest  to  members  of  ALDA.    Founded  by  Dr.  Bremmer  in  1998,  the  Eurasia  Group  is  a  leading  global  political  risk  research  and  consulting  firm.  With  a  network  of  experts  and  resources  in  90  countries,  the  firm  provides  analysis  and  expertise  on  how  political  developments  and  national  security  dynamics  move  markets  and  shape  investments  across  the  globe.  As  the  firm’s  president  and  most  active  public  voice,  Dr.  Bremmer  advises  leading  executives,  money  managers,  diplomats  and  heads  of  state.    Among  other  achievements,  Dr.  Bremmer  created  Wall  Street's  first  global  political  risk  index,  and  has  authored  nine  books,  including  national  bestsellers,  Every  Nation  for  Itself:  Winners  and  Losers  in  a  G-­‐Zero  World  and  The  End  of  the  Free  Market:  Who  Wins  the  War  Between  States  and  Corporations?  Former  U.S.  Treasury  Secretary  Larry  Summers  has  said,  “Global  political  economy  has  no  sharper  or  more  prescient  analyst  than  Ian  Bremmer.”        

A  Strategic  View  of  the  Healthcare  Landscape  and  Disruptive  Changes  That  Are  Likely  to  Reshape  Healthcare  and  Medicine  

 Jake  Henry  Director  McKinsey  &  Company  

 In  this  presentation,  Jake  Henry,  a  senior  partner  at  McKinsey,  and  leader  of  the  firm’s  Medical  Products  Practice  in  the  Americas,  will  present  a  high  level  and  strategic  view  of  the  future  of  the  healthcare  landscape  and  examine  the  disruptive  changes  that  are  likely  to  take  place  in  that  space  and  the  implications  for  members  of  ALDA  as  suppliers  of  life  science  tools  and  diagnostic  testing  technologies.    12:00  Noon   Luncheon  

 

Sunday,  May  3,  2015  5:00  PM   Registration    6:00  PM   Reception  and  Dinner    8:00  PM   Breakthrough  Technologies  that  Will  

Transform  Business  and  Society       Jason  Pontin  

Editor  in  Chief  and  Publisher    MIT  Technology  Review  

 For  more  than  100  years,  the  MIT  Technology  Review  has  identified  important  emerging  technologies  and  provided  insight  on  their  practical  impact.    Since  1999,  that  mission  has  been  complemented  by  the  annual  EmTech  Conference,  gathering  the  sharpest  minds  in  technology,  engineering,  academia  and  management  to  explore  innovations  that  will  shape  the  world  in  the  future.  Jason  Pontin  has  served  as  Editor  of  the  MIT  Technology  Review  since  2004  where  he  leads  the  organization’s  mission  and  also  is  responsible  for  the  editorial  direction,  media  platforms  and  business  strategy,  including  websites,  print  magazines,  videos,  and  live  events  such  as  EmTech.    In  our  Sunday  evening  presentation,  Mr.  Pontin  will  lead  attendees  on  a  fascinating  journey  exploring  several  breakthrough  technologies  and  market  changes  that  have  the  potential  to  significantly  transform  business,  society,  politics  and  healthcare  in  the  future.   Monday,  May  4,  2015  9:00  AM   Welcome  and  Program  Introduction    

The  Global  Geopolitical  Outlook    Ian  Bremmer,  Ph.D.  Author  and  President  Eurasia  Group  

   

 2015  Spring  Senior  Executives  Meeting  4  

 

1:30  PM   Disruptive  Technologies  in  Genomic  Medicine    

Jochen  Lennerz,  M.D.,  Ph.D.  Assistant  Professor,  Harvard  Medical  School,  and  Department  of  Pathology  &  Center  for  Integrated  Diagnostics,  Mass  General  Hospital  

 Next  generation  sequencing  is  expected  be  a  disruptive  technology  in  healthcare,  and  has  many  dimensions.  Contending  “we  are  far  from  recognizing  the  full  potential  of  next-­‐gen  sequencing”,  Dr.  Jochen  “Joe”  Lennerz,  an  Assistant  Professor  at  Harvard  Medical  School  and  a  member  of  the  Center  for  Integrated  Diagnostics  team  at  Mass  General  Hospital,  will  review  NGS  and  examine  the  components  required  for  clinical  next-­‐generation  testing.  These  components  range  from  wet-­‐lab  and  microfluidics,  via  server-­‐technologies  and  non-­‐relational  databases,  to  integrated  reporting  tools  and  hospital  information  systems.  Integrating  these  components  into  a  functioning  unit  results  in  a  clear  outline  of  the  discovery  potential  in  routine  diagnostics,  the  future  capabilities,  and  a  good  handle  on  what’s  currently  missing.        The  Changing  Regulatory  Landscape  as  a  Potential  Disruptive  Force       Lakshman  Ramamurthy,  Ph.D.     Director     Avalere  Health  LLC    Dr.  Ramamurthy  advises  pharmaceutical,  device  and  diagnostics  companies  on  medical  device  regulation  issues  and  how  to  incorporate  a  FDA  regulatory  strategy  into  business  planning.    In  addition,  he  provides  analysis  and  advice  to  pharma  and  device  companies  as  well  as  to  financial  entities  investing  in  device  and  diagnostics  companies.  Previously  he  worked  in  several  senior  level  and  policy  positions  at  FDA,  and  is  currently  serving  as  an  Industry  Representative  on  the  CMS-­‐Medicare  Evidence  Development  and  Coverage  Advisory  committee.    In  this  presentation,  Dr.  Ramamurthy  will  offer  a  high  level  and  strategic  view  of  the  future  of  the  changing  regulation  landscape  including  LDTs  and  the  implications  for  companies  in  our  industry.      4:00  PM    End  of  Monday’s  Program    6:00  PM    Reception  and  Dinner    

Tuesday,  May  5,  2015  8:00  AM   Welcome  and  Introduction  of  Tuesday’s  

Presentation    

Resilience  and  Transformation:  Thriving  in  an  Age  of  Volatility  

    Andrew  Zolli  

Author,  “Resilience:  Why  Things  Bounce  Back”  

 Andrew  Zolli  works  at  the  intersection  of  global  innovation,  foresight,  social  change  and  resilience.    A  central  thrust  of  his  work  is  how  to  harness  the  power  of  networks  for  collaborative  discovery,  innovation  and  change.  Mr.  Zolli  also  spends  much  of  his  time  advancing  a  global  dialogue  on  resilience  –  how  to  help  people  and  systems  persist,  recover  and  thrive  amid  disruption.  For  several  years,  he  traveled  from  the  coral  reefs  of  Palau  to  the  back  streets  of  Palestine  exploring  these  issues  –  the  results  are  encapsulated  in  his  book,  Resilience:  Why  Things  Bounce  Back.  His  work  since  has  focused  on  bringing  together  coalitions  of  interested  practitioners  and  leaders  from  many  resilience-­‐related  fields.      From  2003-­‐2014,  Andrew  was  the  primary  creative  and  curatorial  force  behind  PopTech,  a  renowned  innovation  and  social  change  network.  The  group  brings  together  innovators  from  many  different  fields  to  share  ideas  and  to  work  on  new  approaches  to  some  of  the  world’s  toughest  problems.          In  our  Tuesday  presentation,  Mr.  Zolli  will  explore  how  the  next  15  years  will  transform  competition,  customers  and  companies,  and  present  the  highlights  of  his  most  recent  book,  “Resilience:  Why  Things  Bounce  Back”.      10:00  AM   Wrap-­‐Up  and  Adjournment