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    Developmental Cognitive Neuroscience 17 (2016) 5767

    Contents lists available at ScienceDirect

    Developmental Cognitive Neuroscience

    j o ur nal ho me pa ge: ht tp : / /www.e lsev ier .com/ locate /dcn

    eview

    opaminergic reward sensitivity can promote adolescent health: Aew perspective on the mechanism of ventral striatum activation

    va H. Telzera,b,c,

    Psychology Department, University of Illinois, Urbana Champaign, United StatesBeckman Institute for Science and Technology, University of Illinois, Urbana Champaign, United StatesNeuroscience Program, University of Illinois, Urbana Champaign, United States

    r t i c l e i n f o

    rticle history:eceived 20 June 2015eceived in revised form6 September 2015ccepted 26 October 2015vailable online 24 November 2015

    a b s t r a c t

    The prevailing view in the field of adolescent brain development is that heightened activity in themesolimbic dopaminergic reward system serves as a liability, orienting adolescents toward risky behav-iors, increasing their sensitivity to social evaluation and loss, and resulting in compromised well-being.Several findings inconsistent with this deficit view challenge the perspective that adolescent reward sen-sitivity largely serves as a liability and highlights the potential adaptive function that heightened striatalreactivity can serve. The goal of this review is to refine our understanding of dopaminergic reward sensi-

    eywords:dolescenceewardsisk takingealth

    tivity in adolescence. I review several studies showing that ventral striatum activation serves an adaptivefunction for adolescents health and well being relating to declines in both risk taking and depressionand increases in cognitive persistence and achievement.

    Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

    rain development

    ontents

    1. Adolescent peaks in reward sensitivity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .582. Dopaminergic changes in the adolescent brain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 583. Deficit perspective on dopaminergic reactivity in adolescence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 594. A potential adaptive role of dopaminergic reactivity in adolescence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 595. The ventral striatum and reward: reverse inference . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 606. Evidence that dopaminergic sensitivity can promote adolescent health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60

    6.1. Ventral striatum sensitivity to prosocial decisions predicts declines in risk-taking behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 606.2. Ventral striatum sensitivity to different types of rewards predicts both increases and decreases in depression over time . . . . . . . . . . . . . . . . . . 606.3. Maternal presence redirects adolescent ventral striatum sensitivity away from risky behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 616.4. Extrinsic and intrinsic rewards can promote improved cognitive persistence via heightened ventral striatum activation . . . . . . . . . . . . . . . . . . 616.5. Increased striatal reactivity during cognitive control predicts positive peer influence effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 626.6. Increased striatal reactivity can serve a regulatory role . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 626.7. Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62

    7. Can we take advantage of adolescent ventral striatum sensitivity in ways that promote adaptive decision making? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 628. The complexity of ventral striatum reactivity in adolescence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63

    8.1. Functional heterogeneity supporting different psychological processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 638.2. Structural heterogeneity supporting different psychological processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63

    9. Future directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9.1. Develop novel and innovative tasks that tap diverse contexts and9.2. Focus on individual and cultural differences to identify youth mo

    Correspondence to: Department of Psychology, University of Illinois, 603 East Daniel E-mail address: ehtelzer@illinois.edu

    ttp://dx.doi.org/10.1016/j.dcn.2015.10.010878-9293/Published by Elsevier Ltd. This is an open access article under the CC BY-NC-N

    . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 allows comparison of reward sensitivity across situations . . . . . . . . . . . . . 64st at risk . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64

    Street, Champaign, IL 61820, United States.

    D license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

    dx.doi.org/10.1016/j.dcn.2015.10.010http://www.sciencedirect.com/science/journal/18789293http://www.elsevier.com/locate/dcnhttp://crossmark.crossref.org/dialog/?doi=10.1016/j.dcn.2015.10.010&domain=pdfhttp://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/mailto:ehtelzer@illinois.edudx.doi.org/10.1016/j.dcn.2015.10.010http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/4.0/

  • 58 E.H. Telzer / Developmental Cognitive Neuroscience 17 (2016) 5767

    9.3. Use neural sensitivity to predict changes in real-life health outcomes and behaviors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6510. Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65

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    References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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