What is What is

““detoxing” Or detoxing” Or

“cleansing“cleansing””

Is Detox right for you?Is Detox right for you?Detoxification can be beneficial for

those with one or more of the following conditions:  

Parasite infestationRecurring headachesBad breathHemorrhoidsIrritabilityFrequent coldsProtruding belly

Seasonal AllergiesFood allergiesChronic constipationFrequent gas & bloatingExcess weightFrequent fatigueImpaired digestionIrritable Bowel Syndrome (IBS)Candida infection 

Common Signs & Symptoms Common Signs & Symptoms Linked to Linked to

Chronic Toxicant ExposureChronic Toxicant Exposure

• Marked sensitivity to environmental chemicals, odors, medications, &/or nutritional supplements

• Chronic, debilitating fatigue & lethargy• Depression, anxiety &/or mood swings• Cognitive dysfunction (poor memory and

concentration; learning disorders)

The Liver is the MajorThe Liver is the MajorDetoxifying OrganDetoxifying Organ

The liver utilizes a two-phase system in detoxifying the body of harmful substances:

• 11stst:: Transforms toxins into more water-soluble compounds that are then carried through the blood to the liver for further processing, or to the kidney for elimination.

• 22nd:nd: Completing the detoxification in the liver and sending the toxins back to the kidney for elimination, or into the bile for elimination via the GI tract.

Phase I & Phase IIPhase I & Phase II

• The congested or sluggish liver is characterized by a diminished bile flow, while impaired liver (hepatic) detoxification refers to decreased phase I and/or phase II enzyme activity.

• Phase I detoxification rates that are in excess of phase II activity will also cause toxicity problems due to excessive accumulation of activated intermediates.

Imbalanced DetoxificationImbalanced Detoxification

Phase ICYP P450

Phase IIConjugation

Damage to DNA, RNA, Proteins

Reactive IntermediateNon-Polar Xenobiotic

InertWater-Soluble

Metabolite

Phase 2Phase 2

• Phase 2 enzymes are highly dependent on energy and on adequate dietary protein.

• Phase 2 enzymes can be induced by numerous substances found in fruits, vegetables, spices and herbs.

• Both phase 1 and 2 are highly dependent on adequate nutritional status for their activity

excretoryderivatives

Supportive Nutrients for Detoxification Pathways Supportive Nutrients for Detoxification Pathways

Lipid-soluble molecule

polarwater-soluble( )

Bile

Feces/stools

Serum

Kidneys

Urine

ATPglutathioneglycinetaurineglutamineornithineargininemethyl donorsN-acetylcysteinecysteinemethionine

riboflavin (vit. B2)niacin (vit. B3)pyridoxine (vit. B6)folic acidvitamin B12glutathionebranched-chain amino

acidsflavonoidsphospholipids

Phase II[conjugation

pathways]

Phase I[cytochrome P450

enzymes]

ActivatedIntermediates

Genetic VariationsGenetic Variations

• There are numerous genetic variations in the activity of both phase 1 and phase 2 enzymes.

• This, along with nutritional status and total toxic load may help explain why detoxification abilities for a particular substance may vary as much as 100-fold or more between different individuals.

Causes of Impaired Causes of Impaired Detoxication: SummaryDetoxication: Summary

• Overwhelming toxic load (exogenous + endogenous)

• Impaired excretion (constipation or increased transit time; renal dysfunction)

• Inefficient fuels (macronutrient imbalance)• Deficiency of detoxifying substances

(antioxidants, cofactors, conjugating agents)

• Genetic Variation

Common Signs & Symptoms Common Signs & Symptoms Linked to Linked to

Chronic Toxicant ExposureChronic Toxicant Exposure

• Recurrent headaches• Muscle aching & weakness• Paresthesias and neuropathic pain• Recurrent infections• Infertility

Disorders Linked ToDisorders Linked To Toxicant Exposure Toxicant Exposure

• Chronic Fatigue Syndrome• Fibromyalgia• Multiple Chemical

Sensitivity• Allergies, Asthma • Atherosclerosis• Cancer

[ The Road to Immunity By Stephen Bock]

Potential Benefits of Potential Benefits of the Detoxification Programthe Detoxification Program

• Increased Energy & Vitality• Weight Loss• Breaking Weight Loss Plateaus• Better gut function• Clearer thinking• Improved Skin• Better Sleep• Improved Mood

What are you waiting for?

How to get started on your own Detoxification Program:

Join our Quarterly Group Cleanses and Bring a friend!!

(Individual programs also available)

Contact Lisa Saslove at 805-305-0774 or

lisasasloverd@gmail.com