department of chemistry - sci.osaka-u.ac.jp€¦ · department of chemistry department of chemistry...

Department of Chemistry


Graduate School of Science2018-2019

IntroductionChemistry is a science dealing with the structure, synthesis,and properties of substances, particularly at the molecularlevel. We are surrounded by chemical products; e.g., food,clothing, housing, drugs, and so on. In addition, newmaterials such as those supporting computer memorystorage and superconductivity have been playing anessential role in the recent progress of technology andculture. Some chemicals, on the other hand, tend to giverise to serious environmental problems, whose solutionswill depend upon chemistry research and education in future.Thus, chemistry and related sciences are much closer to usthan one imagines, extensively contributing to thedevelopment of science and human society.

The department of chemistry, graduate school of science,Osaka University, comprises the following four divisionscovering inorganic, physical, organic, and interdisciplinarychemistry. In addition, the department has cooperative withthirteen research groups of other research institutes.

Inorganic Chemistry DivisionAnalytical Chemistry, Inorganic Chemistry, CoordinationChemistry and Radiochemistry laboratories are included inthis division.

Analytical Chemistry laboratory is developing nano-chemistry of liquid-liquid interfaces to elucidate specific roleof the interface in chemistry. The diffusion dynamics ofsingle molecules and the reaction mechanisms of metal-complex aggregations at the interface are investigated inrelation to the separation mechanisms. New principles formigration analysis of biological micro-particles are alsodeveloped utilizing specific forces generated by a laser, anelectric field and a magnetic field.

The main subject in both laboratories of InorganicChemistry is to explore novel transition metal complexesshowing unique structures and properties. Various new typesof mononuclear and polynuclear metal complexes have beensynthesized and the relationship between their structures andchemical properties is elucidated in solid and solution statesby means of electronic spectroscopy, NMR, X-raydiffraction, and magnetic measurements. Furthermore, newspectroscopic phenomena induced by a magnetic field arealso investigated.

In the Radiochemistry laboratory, superheavy elements andactinide elements are synthesized and their chemicalproperties are studied by some unique techniques. A newchemistry on artificial atoms composed of pion and muon,called an exotic atom, is developed in this laboratory.Nuclear reaction mechanisms of heavy ions and a finding ofnew nuclear phenomena, together with their applicationto physical and chemical researches, are also of theirsubjects.

In the Laboratory for bioinorganic chemistry, they study onrelationships between structures and functions ofmetalloproteins, playing important roles in the biologicalsystems. Furthermore, metal complexes are synthesized as a



biomimetic model compound of the active site ofmetalloproteins, and the model complexes are structurallyand functionally compared with the active site of proteins.

Physical Chemistry DivisionIn the physical chemistry division, our research andeducational activities cover experimental studies of structure,properties and reactivity of molecules and condensed matterand their theoretical analysis.

In the Condensed Matter Physical Chemistry Group,electronic properties of molecular conductors, molecularmagnets, metal complexes and their network magneticsystems are studied by calorimetry, transport, and magneticmeasurements. Novel features originated from thecooperative effects of spins, charges and molecular motionsare discussed.

The Surface Chemistry Group is concerned withelectronic properties of molecules adsorbed on solid surfacesby means of fs-laser and electron spectroscopy. Micro-spottwo-photon photoemission spectroscopy has beendeveloped to probe unoccupied states in energy, time, andspatial domains.

Chemical Kinetics and Dynamics Group aims atunderstanding chemical reactions at single molecule ornano-level using novel methods of scanning probemicroscopy. The investigation for devices consisting ofsmall number of molecules based on single molecularreaction and/or properties develops novel features differingfrom that of bulk molecular materials.

Biophysical Chemistry Group maintains as its primaryfocus the development and use of laser-based technologiesto measure atomic level features of the biological systems.The results of these efforts are contributing to a deeperunderstanding of the nature of proteins' motions andrelating the dynamics to biological function.

In the Quantum and Theoretical Chemistry Group,Computers are utilized for theoretical analysis andprediction of properties and reactivity of chemicalsubstances, design of functional materials. Development ofnew methodologies for computation is also the subject inthisgroup.

The Research Center for Structural Thermodynamics isdevoted specifically to chemical thermodynamics dealingwith various types of condensed matter, including hardmaterials such as high-TC superconductors, soft materialssuch as liquid crystals, and rather complex systems such asadsorbed monolayers. We are particularly interested in“Order and Disorder” created by subtle balance of variousintermolecular interactions.

A physical chemistry group in the Museum of OsakaUniversity is mainly working on the structure and dynamicsof molecules confined in the nano-space constructed in thesolid- state materials, by means of high-resolution solid-stateNMR and ESR with other physico-chemical measurements.We also aim to develop a new analytical method for thecultural properties in Osaka University.

The Advanced Research System Development Groupmainly focuses on surface chemistry explored with newlydeveloped original experimental techniques and their relatedequipment. Particularly, the group is developing molecular-beam and ion- beam facilities for the studies of theelementary processes of surface-chemical reactions and ofthe surface modification including sputtering.

Organic Chemistry DivisionIn the Division of Organic Chemistry, we observe naturalphenomena through the structures and chemical behaviors oforganic molecules, and try to discover the underlyingprinciples operating in the life systems. We also activelyextend our knowledge through theoretical considerations ofthe structures and properties of molecules and molecularinteractions. These efforts will allow us to interpretate thesophisticated natural system and enable further creation offunctionally interesting organic compounds. Division ofOrganic Chemistry consists of the following fourindependent research groups.

The research in Laboratory for Physical OrganicChemistry is directed toward molecular design andsynthesis of artificial novel compounds with theoretical andfunctional interests in the solid state properties. Such effortsmay lead to an ultimate goal to realize self-organized singlemolecular electronics. Major research projects ofLaboratory for Structural Organic Chemistry are related tosynthesis of novel extended π-electron systems and artificialsupramolecules. New synthetic procedures for moleculeswith conjugated electronic systems are also investigatedthere. Systematic studies of properties for such varioussynthetic compounds are expected to result in discovery ofnovel classes of functionally interesting and versatilecompounds.

Laboratory for Natural Products Chemistry mainlyfocuses on the functions of glycoconjugates consisting ofcarbohydrates linked to other structural units such as fattyacids and phosphates. Isolation of unknown bioactivecompounds from natural sources, their structural, syntheticand functional studies are being intensively undertaken. Theresearch purpose in Laboratory for Organic Biochemistry isto clarify the functions of oligosaccharides in the living cell.Chemical synthesis of glycoproteins, glycopeptides andoligosaccharides are potentially performed and then used itfor several bioassays in order to elucidate oligosaccharidefunctions. Several new reactions to construct suchbiomolecular are also studied.

Interdisciplinary Chemistry DivisionIn this Division research works are oriented towards novelfields of both bioorganic and bioinorganic chemistry. Marinetoxins and other biologically active compounds such as lipidsand hormones are dealt with in Laboratory for BiomolecularChemistry. New methodologies based mainly on NMRspectroscopy are being elaborated for investigation of three-dimensional structures and functions of complexbiomolecules. The purpose of Laboratory of CoordinationChemistry is to prepare novel mononuclear, polynuclear,and metallosupramolecular complexes and to elucidatetheir molecular structures, electronic states, andfunctionalities. In particular, our current interest is directedtoward the development of fundamental coordinationchemistry by utilizing multifunctional metalloligandsinstead of classical inorganic/organic ligands.

ResearchProjects

Inorganic Chemistry Division

1. Laboratory for AnalyticalChemistry2. Laboratory for Radiochemistry3. Laboratory for Inorganic Chemistry4. Laboratory for Bioinorganic Chemistry

Physical Chemistry Division

5. Laboratory for Condensed Matter PhysicalChemistry6. Laboratory for Surface Chemistry7. Laboratory for Quantum Chemistry8. Laboratory for ReactionDynamics9. Laboratory for BiophysicalChemistry

Advanced Research System Development Group

Organic Chemistry Division

10. Laboratory for Structural OrganicChemistry11. Laboratory for Physical OrganicChemistry12. Laboratory for Natural Product Chemistry13. Laboratory for OrganicBiochemistry

Interdisciplinary Chemistry Division

14. Laboratory for Biomolecular Chemistry15. Laboratory for Coordination Chemistry16. Research Center for StructuralThermodynamics17. Laboratory for High-Technology Research for theAnalysis

and Utilization of Materials

18. Center for Education in LiberalArts and Sciences19. Radio Isotope ReseachCenter

The Institute of Scientific and Industrial Research (CooperativeDivision)

20. Laboratory for Semiconductor Materials andProcesses21. Laboratory for Bio-Nanotechnology22. Laboratory for Regulatory Bioorganic Chemistry23. Laboratory for Synthetic OrganicChemistry

Institute for Protein Research (Cooperative Division)

24. Laboratory of Protein OrganicChemistry25. Laboratory for Molecular Biophysics26. Laboratory of Protein Profiling and Functional Proteomics

Cooperative Adjunct Division

27. National Institute of Advanced Industrial Science and Technology (AIST) Inorganic Functional Materials Research Institute

28. National Institute of Advanced Industrial Science and Technology (AIST) Inorganic Functional Materials Research Institute

29. National Institute of Advanced Industrial Science and Technology (AIST) Research Institute of Electrochemical Energy

30. Peptide Institute, Inc.31. Suntory Foundation for Life Sciences, BioorganicResearch

Institute


[Research Interests]1) Metal complex aggregation at liquid/liquid interfaces and

its high sensitive spectroscopic analysis2) Measurements and analysis of denaturation of proteins at

hydrophobic interfaces3) Measurements of transport kinetics of substances through

liquid/liquid interfaces and development of high selective interfaces

4) Development of magneto-optical microscope under pulsed magnetic field

5) Development of analytical separation methods for microparticles exploiting external field

6) Structural analysis of chiral molecules in solutions based on Raman optical activity spectroscopy

Measurements of chemical reactions and phenomenaoccurring at liquid/liquid interfaces and analysis ofnanoparticles and microparticles relating to biological andenvironmental systems are much important and attractivesubjects in Analytical Chemistry. We have invented newmethods to measure absorption spectra of metal complex

Satoshi TSUKAHARA (Professor), Takao FUKUMOTO (Assistant Professor), Masayori SUWA (Assistant Professor), Shigeki YAMAMOTO (Assistant Professor)

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aggregates formed at liquid/liquid interfaces with polarizedlight; the thickness of the aggregates is only a fewnanometers. We also measured reversible adsorption ofproteins to hydrophobic interfaces by total internalreflection technique, and investigated the denaturation ofproteins there. We have also invented novel analyticalmethods for microparticles by using magnetic field.Magneto-optical imaging microscopy and analyticalseparation method are being developed in order to detectparamagnetic compounds in microparticles.




Atsushi SHINOHARA (Professor), Yoshitaka KASAMATSU (Associate Professor), Kazuhiko NINOMIYA (Assistant Professor)

[ResearchArea]1) Chemistry of superheavyelements2) Chemistry of exotic atoms3) Development of radionuclides for medical use (mainly on

targeted alpha therapy)4) Environmental radioactivity of Fukushima Nuclear accident

origin5) Chemistry related with radioactive elements and nuclear

properties

Chemistry of superheavy elements: The chemistry oftransactinide elements – which can also be termed superheavyelements – has now reached element 108. We have beenstudying the chemical properties of heavy-actinide andtransactinide elements. Our interests have concentrated on thequestion how well the Periodic Table of the Elementsaccommodates the transactinide elements as transition metalsin the 7th period. Development of apparatus for “single atomchemistry” and the related tracer experiment are also making

progress for the project above.Chemistry of exotic atoms: The goal of this theme liesin comprehensively understanding the formation mechanismand behavior of pionic/muonic atoms and molecules in orderto apply the phenomenon to analytical chemistry and materialscience, and to develop a new chemistry of the 2nd generationsubstance.

http://www.chem.sci.osaka-u.ac.jp/lab/shinohara/index_e.html


Members Naoto ISHIKAWA (Professor), Takamitsu FUKUDA (Associate Professor), Akira FUYUHIRO (Assistant Professor)

Inorganic Chemistry Group

［Research Interests］

1) Electronic structure and molecular magnetism of thesystems containing 4f electrons.2) New molecular devises such as single-4f-ionic singlemolecule magnets3) Time-domain behavior of quantum states of the systemscontaining multiple single molecule magnets4) Chemical and physical manipulation of ligand fieldpotential, magnetic anisotropy and molecular magnetism

“Metal complexes” and “supramolecules” can containunpaired electrons of several different kinds. The unpairedelectrons have magnetic moments which are responsible forvarious intriguing magnetic properties. Atomic nuclei alsohave magnetic moments whose strength varies from nucleusto nucleus. Such magnetic moments interact to constructcomplicated quantum states. One of our research aims is tounderstand such quantum states through experimental andtheoretical analysis. For some unsolved problems, such as

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sub-structure of the ground states of lanthanide complexeshaving 4f-electronic systems, we develop computationaltools to solve them. Solving such unsolved problems sometimes leads to discovery of new properties of molecules. Oneof such properties is the “Single Molecule Magnet (SMM)”behavior of mono-nuclear lanthanide-phthalocyaninecomplexes, which had been considered possible only forpolynuclear metal complexes. At present the lanthanide-phthalocyanine complexes are regarded as the mostpromising SMMs for future applications. Our research targethas been extended to understanding and controlling of time-domain behavior of 4f-electronic systems, including mono-and multiple-nuclear SMMs.

L




Laboratory for Bioinorganic Chemistry

［Research Interests］1) Synthesis of dinuclear and multinuclear

metal complexes activating molecules2) Synthesis of heterometallic multinuclear

complexes activating molecules3) Synthesis of novel metal complexes as a

photosensitizer4) Development of artificial metalloenzymes

activating molecules5) Investigation of relationships between

structures and functions of metalloprotein6) Synthetic and mechanistic study on metal

complexes with anticancer activity

The photosynthetic energy transduction andmetabolism involve photo-excitationcoupled with electron transfer process,and activation of substrates including smallmo

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Members Yasuhiro FUNAHASHI (Professor), Masaki NOJIRI (Associate Professor), Tsubasa HATANAKA (Assistant Professor)

molecules such as O2 and N2. The 1st transitionmetals are frequently essential trace elementsfor organisms, working at the active sites in theproteins. The metal complexes sometimesshow pharmaceutical activity. We study onmetals in biology, and we newly developrelevant metal complexes and metalloenzymes.




Members Hiroyuki S. KATO (Associate Professor), Takashi YAMADA (Assistant Professor)

Laboratory for Surface Chemistry

[Research Interests](1) Photoemission microspectroscopy for

organic films(2) Electronically excited states of adsorbed

molecules

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[Research Area]Unoccupied electronic states play crucial roles in

functionality and chemical reactions at surfaces. Weare concerned with spectroscopy and dynamics of theunoccupied states by means of two-photonphotoemission (2PPE) spectroscopy. Upon adsorptionof molecules on a surface, adsorption-inducedoccupied and unoccupied states are formed in thevicinity of the Fermi level. The adsorption-inducedstates are probed with 2PPE spectroscopy providinginsights on chemical properties of surface covered withmolecules. A microbeam photoemission spectrometerwas developed by use of coherent radiation at awavelength of 140 nm. The micro-spectrometer, whichachieved an energy resolution of 30 meV and a lateralresolution of 0.3 mm, is applied to reveal lateralinhomogeneity of electronic structures of organic films.


Members Mitsutaka OKUMURA (Professor), Shusuke YAMANAKA (Associate Professor), Takashi KAWAKAMI (Assistant Professor)

Laboratory for Quantum Chemistry

［Research area］1) Theoretical studies on molecular and electronic

structures for atoms, molecules and theirclusters.

2) Theoretical studies on chemical reaction.3) Theoretical studies on electronic, magnetic and

photo properties.4) Theoretical studies on functional, informatics

and mathematical systems.

In this laboratory the investigations depending on only theory and calculation are performed for many chemical subjects. We employ quantum mechanics, statistics and informatics as fundamental theory for investigation of electronic and molecular structures.

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Moreover, ab initio MO program packages based onour own theory are developed to challenge cluster,biological sciences and etc., which expand possibilitiesof chemical subjects.

Accurate and huge calculations as well asvisualization of their results using super-computers arealso applied to the elucidation of intriguing chemicalphenomena before experimental studies.



[ResearchArea]1) Structural chemistry on allostericproteins.2) Energy flow in proteins.3) Allostery and functionality of proteins.4) Development of techniques for time-resolved spectroscopy.

Our research focuses on functionally-important proteindynamics to elucidate mechanism how they function. Proteindynamics are intimately connected to the structure/functionrelationship of biological systems. In numerous biologicalprocesses, the ensuing protein structural changes accompanying areaction at a specific site must spatially extend to the mesoscopicdimensions of the protein to achieve a biological function. Proteindynamics span over a wide range of time scales. To answerquestions on protein dynamics, we need the concatenation ofexperimental results recorded over many orders of magnitude oftime. In this regard it is important that a single experimentaltechnique can examine protein structures evolving from the earliestmoments, such as the picosecond regime, toward time scales that

are highly relevant to biological functions, such as the microsecondor millisecond regimes. We are studying protein dynamics in thewide time window by using various time-resolved spectroscopictechniques, such as resonance Raman, absorption, and fluorescencespectroscopy.


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Laboratory for Reaction Dynamics

[Research Interests]1)Time-resolved electrostatic force microscopy for

electron- transfer dynamics.2)Molecular recognition force microscopy for

receptor-ligand reaction.3)Molecular electronics based on redox-active

molecular array.4)Multi-dimensional stereodynamics in the

molecular-molecular reactions.5)Stereodynamics in the molecular-radical reactions.

The chemistry of individual molecules has been achemist’s dream for long time, but today, it isrealized by scanning probe microscopy. Themethod enables us to observe, measure, andmanipulate individual molecules in nano-scale.

Members Takuya MATSUMOTO (Professor), Hiroshi OHYAMA (Associate Professor), Dock-Chil CHE (Associate Professor), Youichi OTSUKA (Assistant Professor)

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We are studying molecular recognition andelectron transfer using scanning probemicroscopy in single molecule level, andinterested in finding novel phenomena whichdiffer from those of bulk molecular materials.Along this line, the devices consisting of smallnumber of molecules are also developed from aperspective of molecular electronics.




Laboratory for Structural Organic Chemistry

[Research Interests]1) Synthesis and solid-state properties of open-shell molecules2) Development of proton and electron transfer system3) Design, synthesis, and properties of molecular-based 2D-

sheet materials4) Synthesis and functions of π-compressed molecules5) Synthesis, structures, and properties of overcrowded quinones

π-Electrons in conjugated molecules play decisive roles forthe electronic and photo- physical properties of organiccompounds. We have been studying designs, syntheses,structures, and physical properties of novel extended π-conjugated systems, with particular emphasis on functionalproperties such as electron-transport, magnetism,supramolecular chemistry, photo-switching, and chiro-optics.Work in these areas is highly synthesis-driven, and is alsostrongly based on physical organic chemistry. Our widevariety of chemistry will lead to discovery of new class ofelectronic- and photonic-materials as well as of fundamentalscientific ideas.

Members Takashi KUBO (Professor), Yasukazu HIRAO (Assistant Professor), Tomohiko NISHIUCHI (Assistant Professor)

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Members Michio OKADA (Professor)

Laboratory for Beam Chemistry

[Research Interests]1) Stereodynamics of surface chemical reactions

induced by molecular beams2) Surface chemical reactions explored with

various surface-spectroscopy techniques3) X-ray photoemission spectroscopy at SPring-8

for surface chemistry4) Surface phase transition induced by the low

dimensionality5) Tuning of surface reactivity with surface alloying6) Development of new type of secondary ion mass

spectroscopy with very low-energy ions

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We mainly focus on surface chemistry exploredwith newly developed original experimentaltechniques and their related equipments.

Particularly, our group is developing molecular-beam and ion-beam facilities for the studies ofthe elementary processes of surface-chemicalreactions and of the surface modificationincluding sputtering.




Members Takuji OGAWA (Professor), Ken-ichi YAMASHITA (Associate Professor), Yosuke TANI (AssistantProfessor)

Laboratory for Physical Organic Chemistry

［Research Interests］

1. Single-molecule Science: molecularelectronics & single-molecule chemicalreaction

2. Development of novel application ofantiaromatic molecules

3. Development of the new chemistry ofstacked (anti)aromatic molecules.

4. Luminescent molecules: solid-stateemission & mechanochromism

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≡

+ H+

- H+ + e-

- e-

Excellent SMM Poor SMMNot SMM

Single molecule magnets (SMMs)

Single-molecule rectifier

Single-molecule chemical reactions


Members Koichi FUKASE (Professor), Kazuya KABAYAMA (Associate Professor),Atsushi SHIMOYAMA (Assistant Professor), Yoshiyuki MANABE (Assistant Professor)

Laboratory for Natural Product Chemistry Group

［Research Interests］• Chemistry and function of immunomodulating substances

from microbes and hosts• Efficient and selective methods for glycosylation and

oligosaccharide synthesis• Bio-imaging of glycans and proteins for the new functional

studies• Targeted a-radiation therapy for cancer

We have studied the syntheses andbiofunctions of microbial and host-derivedmolecules related to important biologicalphenomena such as immunity, infection,allergy, cancer, and etc. In particular, we haveinvestigated glycans and glyco-conjugates inorder to identify the active principle,elucidate the action mechanism, and controlthe biological responses.

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Bio-imaging study of glycans, peptides, andproteins have been investigated by usingfluorescent microscopy. Targeted a-particletherapy for cancer is also important project.




Members Michio MURATA (Professor), Shinya HANASHIMA (Associate Professor), Hiroshi TSUCHIKAWA (Assistant Professor)

Laboratory for Biomolecular Chemistry

［Research Interests ］

1. Action of drugs and natural products inbiological membranes

2. Dynamic lipid conformations in bilayermembranes

3. Lipid-lipid and lipid-protein interaction atlipid rafts

4. Synthesis of complex natural products

We are interested in the membrane activedrugs and toxins, as well as theendogenous lipids and sterols to elucidatethe active molecular assemblages.Chemical synthesis assisted NMR analysis

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works out the channel structure of thepolyene antibiotics-lipids assembly, dynamiclipid conformations and lipid interactionsoccurring in bilayer membrane.


Members Yasuhiro Kajihara (Professor), Ryo Okamoto (Associate Prof.), Yuta Maki (Assistant Prof.)

Laboratory for Organic Biochemistry

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[Research Interests]1)Chemical synthesis of oligosaccharides2)Chemical synthesis of glycoproteins and

glycopeptides3)Elucidation of oligosaccharide functions

The oligosaccharides of protein have beenthought to concern with protein conformation,dynamics, protein trafficking and glycoproteinlifetime in blood. We have examined synthesisof homogeneous glycoproteins having humancomplex type oligosaccharide in order toevaluate oligosaccharide functions. We havesynthesized several small glycoproteins (amino

Acids 40-76 residues), erythropoietinanalogue (amino acids 166 residues), and co-stimulate glycoprotein of T-cell (amino acids120 residues). We have also evaluated theeffect of oligosaccharide during proteinfolding process.




Members Takumi KONNO (Professor), Nobuto YOSHINARI (Associate Professor), Naoto KUWAMURA (Assistant Professor), Tatsuhiro KOJIMA (Assistant Professor)

Laboratory for Coordination Chemistry

［Research Interests］1) Exploitation of coordination molecular

technology that leads to the creation ofnew conceptual ionic solids with newfunctionalities.

2) Stepwise construction of heterometallicpolynuclear and metallosupramolecularstructures based on multifunctionalmetalloligands.

3) Studies on the chiral recognition and self-assembly of metal complexes.

4) Studies on the control of structures andproperties of sulfur-bridged polynuclearcomplexes.

The purpose of our research projects is toprepare novel mononuclear, polynuclear, and

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metallosupramolecular complexes and toelucidate their molecular structures,electronic states, and functionalities. Ourcurrent interest is directed toward thedevelopment of fundamental coordinationchemistry by utilizing multifunctionalmetalloligands by using simple ligands.


Members Motohiro NAKANO (Professor), Yuji MIYAZAKI (Associate Professor), Yatsuhisa NAGANO (Associate Professor), Daisuke TAKAJO (Assistant Professor)

Research Center for Structural Thermodynamics

[Research Interests]1) Thermodynamic investigation of molecule-based magnets.2) Thermodynamic investigation on biomolecules and

macromolecules in aqueous solutions.3) Thermodynamic approach to biological phenomena.4) Thermochemical approach to chemical bonds.5) Structure and thermodynamics of molecular monolayers.6) Characterization of solutions in terms of higher derivatives of

thermodynamic potentials.

We are particularly interested in "Order and Disorder" createdby subtle balance of various intermolecular interactions. Amongmany experimental techniques used in chemical science, ourspecialty is to measure the "Energy and Entropy" very accuratelyby means of calorimetry. Our goal is to combine all theinformation obtained from both the microscopic and macroscopicinvestigations to uncover the nature of condensed matter, whichleads us to harmonize "molecular" sciences and chemical

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"thermodynamics". Applicability of thermodynamics allows us totarget at hard samples including metals, ceramics, and molecularcrystals in addition to soft ones like biopolymers, solutions,monolayers, and living things.

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Center for Educationin Liberal Arts and Sciences

Members Kazuya YAMAGUCHI (Professor)

Tel Tel: +81-6-6850-6963 e-mail [email protected]

[Research Interests]1)Effect of reaction field on the function of model

complexes for the active site of metalloenzyme2)Function conversion of dinuclear metalloenzymes3)Preparation of new functional materials with

biological metal complexes

Metal ions play important roles to maintain structures and functions in biological systems. Our current works are focused on (1) studies of structures and functions of metal proteins (Cu, Ni, Fe etc.) by various spectroscopy, and (2) syntheses and structural and functional characterization of transition metal complexes as models for the active sites of metalloproteins. Specially, we investigate

Members Takahiro UEDA (Professor), Jiro TOYODA (Associate Professor), Keisuke MIYAKUBO (Associate Professor)

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[Research Interests]1) Physicochemical properties and intermolecular interactions of

guest molecules confined innanospace2) Construction of new molecular assembly using a uniquely

restricted nanospace and investigation of their novel properties3) Development of new porosimetry based on NMRspectroscopy4) Development of a new analytical method for the cultural

properties using magnetic resonance spectroscopy5) Construction of the Database for the Museum of Osaka

University

Our laboratory is working on the structure and dynamics ofmolecules confined in nano space constructed in the solid-statematerials, by means of state-of-the-art high-resolution solid-stateNMR spectroscopy with other physico-chemical measurements. Wealso examine the new molecular assembly using a uniquelyrestricted nanospace and investigate their novel properties.

Furthermore, we also aim to develop a new analytical method forthe cultural properties using NMR spectroscopy, as well as toconstruct a database and develop a network system for the exchangeof information about the primary materials in OsakaUniversity.

Laboratory forHigh-Technology Research for the Analysis and Utilization of Materials

(The Museum of Osaka University)


The local structure of benzene confined in Zn-basedporous coordination polymer, IRMOF-1, obtained bymolecular dynamics simulation.

the effect of reaction filed on the function of metalcomplexes. Moreover, we challenge the functionconversion of metalloenzyme with the metal ionsubstitution and recombinant DNA methods. Webelieve that the studies will give the importantinformation for preparation of new functionalmaterials with biological metal complexes.




Members Takashi YOSHIMURA (Professor), Kojiro NAGATA (Assistant Professor)

Laboratory for Isotope Chemistry

［Research Interests］1) Synthesis of new chelate agents for nuclear medicine2) Synthesis and photoluminescent properties of metal

complexes3) Synthesis and properties of actinide complexes4) Development of agents for separation of lanthanides

and actinides Radioactive elements account for nearlyone third of the elements of the periodictable. In order to elucidate the periodic lawof the elements in more detail, knowledge ofthe chemistry of radioactive elements isimportant. Recent our research project is tosynthesize new chelating agent for nuclearmedicine. We are interested in synthesis ofnew photoluminescent metal complexes.

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Laboratory for Semiconductor Materials and Processes (The Institute of Scientific and Industrial Research)

(Institute for Radiation Sciences)

It is interesting to separate trivalent actinidesand lanthanides because the chemicalproperties are very similar. We havestudied about synthesis of new chelatingligands to separate them and structuralproperties of the lanthanides complexes.


Members Hikaru KOBAYASHI (Professor), Taketoshi MATSUMOTO (Associate Professor), Kentaro IMAMURA (Assistant Professor)

［Research Interests］1) High efficiency Si solar cells by use of new

chemical methods.2) Si nanoparticles for application to next

generation materials.

Although theoretical limit of energyconversion efficiency for silicon solar cells isabout 30%, energy conversion efficiencies ofcommercial silicon solar cells are only 15~18%due to reflection at Si surfaces andrecombination of electrons and holes at defects.New chemical methods to prevent reflection atSi surfaces and recombination of electrons andholes have been developed to overcome theseissues.

We are also studying effects of hydrogengenerated with a silicon-containing medicine on

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human body in collaboration with GraduateSchool of Medicine of Osaka University. Siliconis a hydrogen source by reaction with water.High capacity anodes for lithium ion batterieshave also been developed with silicon swarf.




[Research Interests]1) Chemical Biology of trinucleotide repeats2) Regulation of gene expression by synthetic smallmolecule3) Development of small molecule targeting functional RNAs4) Development of really useful method for genetic diagnosis

With the technique of accurate synthetic organic chemistry andthe knowledge and sense for treating nucleic acids as organicmolecules, we focused our research attention on small moleculestargeting DNA and RNA that regulates biological functions. Mostpart of human genome (76%) is transcribed into RNA that does notencode any protein. These non-coding but functional RNAs areimportant targets for small molecules to regulate biologicalfunction. With these studies, we may achieve to develop newtechnology for human society and to open a new ear in genomescience. Toward this end, we have set very challenging research

themes. Two approaches, one is from synthetic chemistry and theother is from molecular biology were effectively combined tolaunch creative studies on theseprojects.

Members Kazuhiko NAKATANI (Professor), Chikara DOHNO (Associate Professor), Asako MURATA (Assistant Professor)

HomePage http://www.sanken.osaka-u.ac.jp/labs/rbc/english/index_e.html


3% Protein

DNA

76% RNA

Fate of human genome (over 3 billion base pairs)


[Research Interests]1）Electrical and thermal properties in single-molecule junctions2) Single-molecule electrical sequencing of DNA, RNA, and

peptide based on quantumchemistry3) Single-molecule fluid dynamics and its controlling method4) Single-molecule observations with atomic resolutions

We are challenging biology through the development and use ofsingle-molecule science and technology based on chemicalphysics. In an effort to explore single-molecule science, we arestudying electrical and thermal properties of single-moleculejunctions formed by metal electrodes and single molecules. Inaddition, we are attempting to elucidate biological behaviors usingquantum-chemistry-based, single-molecule electrical sequencingof DNA, RNA, and peptides because the central dogma ofmolecular biology explains the genetic information flow within abiological system. Moreover, we are investigating single-moleculefluid dynamics in solutions and developing methods for controlling

fluid dynamics because biomolecules exist and function in thesolutions. Furthermore, to better understand single-moleculebehaviors deduced from electrical measurements, we observesingle molecules at atomic resolutions using optical and scanningtunneling microscopes. Our primary goal is to develop single-molecule science and technologies, which are expected torevolutionize molecular biology, medical sciences, and drugdevelopment.

Members Masateru TANIGUCHI (Professor), Makusu TSUTSUI (Associate Professor), Hiroyuki TANAKA (Assistant Professor), Kazumichi YOKOTA (Assistant Professor)

HomePage http://www.bionano.sanken.osaka-u.ac.jp/


Laboratory for Bio-Nanotechnology(The Institute of Scientific and Industrial Research)

Fig. Shematic of single-moleculesequencing method.

Laboratory for Regulatory Bioorganic Chemistry (The Institute of Scientific and Industrial Research)




[Research Interests]1) Establishment of practical enantioselective reactions based on a

new concept2) Development of multifunctional organocatalysts and their

application to environmentally benign process3) Development of green sustainable organic reactions using

reusable solid-supportedcatalysts4) Efficient synthesis of advanced materials utilizing chiral spiro

compounds

The goal of this laboratory is to develop catalyticasymmetric processes that produce optically active organiccompounds with high selectivity. We have already developedheterobimetallic complexes that promote a variety ofasymmetric reactions in a manner analogous to enzymaticreactions. Now, we engage in the design and synthesis ofnovel optically active catalysts and reaction media based on anew concept, and their application to the energy-saving andenvironment-conscious reactions directed towardspractically useful processes. Theoretical studies on design ofcatalysts and reaction mechanism are also conducted.

Members Hiroaki SASAI (Professor), Shinobu TAKIZAWA (Associate Professor),Makoto SAKO (Assistant Professor)

HomePage http://www.sanken.osaka-u.ac.jp/labs/soc/socmain_english.html


Laboratory for Synthetic Organic Chemistry(The Institute of Scientific and Industrial Research)


MembersHironobu HOJO (Professor), Toru KAWAKAMI (Associate Professor), Yuya ASAHINA (Assistant Professor)

Laboratory of Protein Organic Chemistry

［Research Interests］1. General studies on a chemical protein synthesis2. Development of methods for ligation3. Synthesis, structural and functional studies

of membrane proteins4. Synthetic studies of post-translationally

modified proteins

Tel・Fax

Home Page

e-mailTel: +81-6-6879-8601・Fax: +81-6-6879-8603

http://www.protein.osaka-u.ac.jp/organic/english.html

[email protected]

(Institute for Protein Research)

Chemical methods enable the synthesis of proteins, whichcan not be prepared by the recombinant method, such assite-specifically labeled, glycosylated and phosphorylatedproteins. Laboratory of Protein Organic Chemistry isaiming to promote new protein researches using thesesynthetic proteins. Thus, our laboratory is developing facilemethods for protein synthesis based on ligation chemistries.In addition, the synthetic method is applied for thesynthesisof membrane proteins and their partial sequences

to elucidate the signal transduction mechanism bysolid state NMR and IR. Modified histones and theirpartial sequences, glycosylated proteins are alsobeing synthesized for the functional analyses.

NH2 Peptide 2

Peptide 1O

SR

NH

Peptide 2Peptide 1O

Chemoselective ligation

Deprotection &folding

General procedure for chemical protein synthesis.




Members Toshimichi FUJIWARA (Professor), Yoh MATSUKI (Associate Professor),Yohei MIYANOIRI (Associate Professor, concurrent)

Laboratory for Molecular Biophysics(Institute for Protein Research)

［Research Interests］1) Structure of membrane proteins pHtrII for transmitting

light signal and halorhodopsin for light-driven ion pumping2) Development of high-sensitivity NMR using

hyperpolarization by terahertz wave irradiation3) Structure analysis by NMR bioinformatics4) Elucidation of the correlation between structure, dynamics

and function of large molecular proteins using NMR

NMR reveals structure and function of biologicallyimportant molecular complexes that not amenable to X-raycrystallography and electron microscopy. These systemsinclude proteins bound to lipid bilayers and noncrystallinelarge molecular complexes, such as membrane protein pHtrIIfor the transmission of light signal, halorhodopsin for light-driven ion pumping, amyloid protein fibers, and model G-protein-receptor complexes.

Tel・Fax

Home Page

e-mailTel: +81-6-6879-8598 Fax: +81-6-6879-8599

http://www.protein.osaka-u.ac.jp/biophys/

[email protected]

We are also developing NMR methods by usingadvanced technologies for NMR experiments,bioinformatics and molecular biology. Two NMRspectrometers features high-power terahertz wavesources, gyrotron for enhancing the sensitivity byusing electron spin polarization.




[Research Programs]1) Latticecomposites2) Organic-inorganic hybrid materials3) Development of high performance gas sensors by novel

materials

4) Preparation process of metal oxide nanoparticles

We have proposed the concept of ‘lattice composite’, and weare developing new gas sensing materials based on the concept.Crystal lattice is recognized as a smallest unit which can generatea function. The composites of different kind of lattices can beexpected to generate a new function or an advanced function bysynergetic effects of the lattices. In order to develop novel gassensing materials, we have expanded the concept not only toinorganic compounds but also to organic compounds. Gas sensingmaterials have two elemental functions, molecule recognition andtransducer. The shearing of the elemental functions by both the

components can realize high performance sensing properties in the lattice compositematerials.

Tel: +81-72-751-8360・Fax: +81-72-751-9970

Ichiro MATSUBARA (Guest Professor)

[email protected]


Members Kenji Kamada

National Institute of Advanced Industrial Science and Technology (AIST), Kansai CenterInorganic Functional Materials Research Institute

［Research Topics］1) Highly-sensitive TPA materials and their

structure-property relationship.2) Photon upconversion materials operating at

the sunlight-level intensity and tripletexciton dynamics, especially in solid.

We are working in a new field, so-called ‘Two-Photon Photochemistry’ which will open newfunctionalities of materials by two photons butcannot be achieved by one photon. One ofsuch topics is Two-Photon Absorption (TPA)and another is Photon Upconversion viatriplet excited state, allowing a new way to usephoton energy efficiently.

Tel・Fax e-mailTel: +81-72-751-8609・Fax:+81-72-751-9637 [email protected]

Members

Tel・Fax e-mail

National Institute of Advanced Industrial Science and Technology (AIST), Kansai CenterInorganic Functional Materials Research Institute

TPASpatial selective photo-excitation by two-photon absorption (above).

Crystalline solid showing blue emission by green excitation at sunlight level, (from long to short wave-length conversion, below).

TTA Upconversion




Peptide Institute, Inc.

[Research Interests]1) Chemical Synthesis of Protein and Their Structure-Function

Relationships.2) Synthesis of Carbohdrate Conjugates and Evaluation of Their

Functions.3) Chemical Synthesis of Biologically Active Peptides and

Elucidation of Their Structure-ActivityRelationships.4) Design and Chemical Synthesis of the Enzyme Substrates and

Inhibitors.

Our laboratory has been mainly involved in the development ofsynthetic methodology of large peptides, proteins, andcarbohydrate conjugates. For the synthesis of large peptides orproteins, we utilize the segment condensation method applying themaximum protection strategy in solution. The peptide segmentscan be synthesized by our solid phase synthetic strategy, and eachsegment is coupled in solution to obtain long protected peptideswhich are then treated with anhydrous hydrogen fluoride to obtainfree peptides. In order to overcome the problems encounteredduring synthesis, we are developing protecting groups and/orsolvent systems that are available to our synthetic strategy. For themultiple cystine-containing peptides, the various disulfide bond

formations in one molecule are analyzed and the relationshipbetween conformation and the ratio of disulfide isomers areinvestigated. For the synthesis of the carbohydrate conjugates, weare evaluating the stability of glycoside bonds in several kinds ofsugar under the deprotecting conditions and developing syntheticstrategy of carbohydrate moiety.

In order to elucidate the mechanism of biological phenomenon,we are always making efforts to supply reliable synthetic samplesof peptides and carbohydrate conjugates for the collaboration withmany researchers.

Members Hideki NISHIO (Guest Professor), Kumiko YOSHIZAWA-KUMAGAYE (Guest Professor), Toshihiro YAMAMOTO (Guest Associate Professor)

Tel・Fax Tel: +81-72-643-4411・Fax: +81-72-643-4422 Home Page http://www.peptide.co.jp/en

e-mail [email protected] [email protected] [email protected]




[Research Interests]1) Function of Novel Glycolipids2) Function of Lipids inBiomembranes3) Chemical Syntheses of BioactiveProbes

Many biological events involve not only proteins but also non-proteinaceous molecules such as small bioactive compounds,carbohydrates, and lipids. In order to elucidate the mode of action,it is necessary to identify the involved molecules by means ofadvanced instrumental analysis such as NMR and MS, and todevelop molecular probes chemicallysynthesized.

Biomembranes include small amounts of glycolipids as well asphospholipids, however, the roles of such minor components andtheir biological significance remain unsolved. The difficulty inmolecular biological approach is one of the reasons for the delayof elucidation of biomembrane functions. By using techniques oforganic chemistry, we identified the structure of a novel glycolipid,

MPIase, essential for the membrane protein integration. We studyon the activity mechanisms of MPIase by chemically synthesizingmolecular probes and by building simple model system foranalyses of the interaction between membranes and theglycolipid.

Tel: +81-50-3182-0693・Fax: +81-774-98-6262

Keiko SHIMAMOTO (professor)

Suntory Foundation for Life Sciences, Bioorganic Research Institute

[email protected]

http://www.sunbor.or.jp/

Members

Tel・Fax

Home Page

e-mail



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