dasatinib ( nm ) 0 0 0.1 0.5 1 5

2
Dasatinib (nM ) 0 0 0.1 0.5 1 5 M-CSF - + + + + + WB: Phospho-Erk WB: Erk WB: Phospho- Akt WB: Akt B Dasatinib (nM) 0 0 0.5 1 5 10 M-CSF - + + + + + WB: Phospho- FMSY708 WB: FMS Dasatinib (nM ) 0 0 0.1 0.5 1 5 M-CSF - + + + + + Wb: Phospho-Akt Akt Figure S1 Side scatter 0 50K100K150K200K250K 0 50K 100K 150K 200K 250K Forward scatter 0 CD14- FITC 10 2 10 3 10 4 10 5 0 40 80 120 160 200 Cell event count 88.6 C D b (nM) 0 0 0.5 1 5 10 - + + + + + WB: Phospho- FMS Y708 WB: FMS A

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250K. 200K. Dasatinib (nM) 0 0 0.5 1 5 10 M-CSF - + + + + +. 88.6. WB: Phospho- FMS Y708 WB: FMS. 150K. 100K. 50K. 0. Dasatinib (nM) 0 0 0.5 1 5 10 - PowerPoint PPT Presentation

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Page 1: Dasatinib ( nM )              0          0      0.1    0.5   1     5

Dasatinib (nM ) 0 0 0.1 0.5 1 5 M-CSF - + + + + +

WB: Phospho-Erk

WB: Erk

WB: Phospho-Akt

WB: Akt

B Dasatinib (nM) 0 0 0.5 1 5 10M-CSF - + + + + + WB: Phospho- FMSY708

WB: FMS

Dasatinib (nM ) 0 0 0.1 0.5 1 5 M-CSF - + + + + +

Wb: Phospho-Akt

Akt

Figure S1Si

de s

catte

r

0 50K 100K150K200K250K 0

50K

100K

150K

200K

250K

Forward scatter0

CD14- FITC102 103 104 105

0

40

80

120

160

200

Cel

l eve

nt c

ount

88.6

C D

Dasatinib (nM) 0 0 0.5 1 5 10M-CSF - + + + + +

WB: Phospho-FMS Y708

WB: FMS

A

Page 2: Dasatinib ( nM )              0          0      0.1    0.5   1     5

20

406080

100120

No M-CSF

0 0.5 1Imatinib (μM)

20406080

100120

0 0.5 1Imatinib (μM)

% m

acro

phag

e su

rviv

al

TA

M p

er m

m2

G H

I J

E

F