curriculum vitae robert j. kerns, ph.d. · 2014-08-12 · curriculum vitae – robert j. kerns,...

CURRICULUM VITAE Robert J. Kerns, Ph.D.

University of Iowa Division of Medicinal & Natural Products Chemistry Department of Pharmaceutical Sciences & Experimental Therapeutics 115 S. Grand Ave., S321 Pharmacy Bldg., Iowa City, IA 52242 Phone: W(319)335-8800 C(319)541-5294 Fax: (319)335-8766 E-mail: [email protected]

EDUCATION Institution and Location Degree Year Conferred Field of Study

Iowa State University B.S. 1991 Chemistry Ames, IA University of Iowa Ph.D. 1996 Medicinal and Natural Iowa City, IA Products Chemistry Princeton University Postdoctoral 1996 - 1998 Organic Chemistry, Antibiotic Princeton, NJ Fellow Resistance, Molecular Recognition

PROFESSIONAL & ACADEMIC POSITIONS HELD 7/12-present Professor, Division of Medicinal & Natural Products Chemistry, Department of Pharmaceutical

Sciences & Experimental Therapeutics, University of Iowa, Iowa City, IA 9/10-present Division Head, Division of Medicinal and Natural Products Chemistry, Department of

Pharmaceutical Sciences & Experimental Therapeutics, University of Iowa, Iowa City, IA 7/06-6/12 Associate Professor, Division of Medicinal and Natural Products Chemistry, Univ. of Iowa 7/02-6/06 Assistant Professor, Division of Medicinal and Natural Products Chemistry, Univ. of Iowa 9/98-7/02 Assistant Professor, Department of Pharmaceutical Sciences,

College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI Associate Appt., Dept. of Immunology and Microbiology, WSU School of Medicine

8/96-9/98 Postdoctoral Research Fellow, Organic Chemistry, Department of Chemistry, Princeton University, Princeton, NJ, with Professor Daniel E. Kahne

1/95-5/95 NIH Predoctoral Traineeship in Biotechnology - Research Externship, AMGEN, Thousand Oaks, CA (Supervisor: Andre Venot, Ph.D.)

1/92-7/96 Graduate Research Assistant, Division of Medicinal and Natural Products Chemistry, University of Iowa, Iowa City, IA, with Professor Robert J. Linhardt (Thesis: Chemo-Enzymatic Synthesis of Glycosaminoglycans)

8/91-12/91 Teaching Assistant, Department of Chemistry, Iowa State University, Ames, IA 5/91-8/91 Research Internship, The Ames Laboratory-U.S. Dept. of Energy and Department of Chemistry, Iowa State University, with Professor James Fritz 8/90-12/91 Undergraduate Research Assistant, Department of Chemistry,

Iowa State University, with Professor George Kraus

RESEARCH CENTER AND INSTITUTE AFFILIATIONS 2013-present Member, François M. Abboud Cardiovascular Research Center, U of I, Iowa City, IA 2012-present Member, Fraternal Order of Eagles Diabetes Research Center, U of I, Iowa City, IA 2010-present Member, Institute for Clinical & Translational Science, U of I, Iowa City, IA 2002-present Member, Center for Biocatalysis and Bioprocessing, U of I, Iowa City, IA 2002-present Member/Trainer, Pharmacological Sciences Training Program, U of I, Iowa City, IA 2002-present Member/Trainer, Biotechnology Training Program, U of I, Iowa City, IA 8/02-05/10 Member, Holden Comprehensive Cancer Center, Exp. Therapeutics, U of I, Iowa City, IA 1/00-7/02 Member, Barbara Ann Karmanos Cancer Institute, Developmental Therapeutics

Program, Wayne State University, Detroit, MI 9/98-7/02 Member, The Anti-Infective Research Laboratory, Wayne State University

August 2014

Curriculum Vitae – Robert J. Kerns, Ph.D.

PROFESSIONAL SERVICE AND MEMBERSHIPS

Study Sections and Grant Review

2003 Study Section Member, Chemistry Review Panel, AACP New Investigators Program 2004, 07, 08, 09 Study Section Member, U.S. Army, CDMRP Clinical and Experimental Therapeutics Review Panels, Breast Cancer Concept Award Program 2006 Reviewer, American Chemical Society, Petroleum Research Fund 2007 Reviewer, MD Technology Develop. Corp.; Univ. Technology Development Program 2010 Reviewer, Recovery Act Limited Competition: NIH, ZRG1 IDM-C 2012 Research Grant Review, Portuguese Foundation for Science and Technology 2013, 2014 Ad hoc Study Section Member, NIH, NIAID, DDR 2013 Ad hoc Study Section Member, NIH, NIAID, ZRG1 IDM-S (02) 2013 Ad hoc Study Section Member, NIH, NIAID, ZAI1-SM-M-J2 2001-03, 08-10, 14 Study Section Member, U.S. Army, CDMRP Breast or Prostate Cancer Research

Program, Clinical and Experimental Therapeutics Review Panels

Peer Review of Manuscripts For:

Nature Chemical Biology, Journal of Biological Chemistry, Nature Protocols, Journal of the American Chemical Society, Journal of Medicinal Chemistry, Biochemistry, Organic Letters, Journal of Organic Chemistry, PLOS ONE, Mini Reviews in Organic Chemistry, Expert Opinion on Therapeutic Targets, Analytical Biochemistry, Malaria Journal, Tetrahedron Letters, Tetrahedron, Chemotherapy, Bioorganic and Medicinal Chemistry Letters, Bioorganic and Medicinal Chemistry, Carbohydrate Research, Carbohydrate Polymers, Canadian Journal of Chemistry, Journal of the Brazilian Chemical Society, European Journal of Medicinal Chemistry, Journal of Antimicrobial Chemotherapy, Chemistry Today, Biopolymers, Journal of Pharmaceutical Sciences, ACS Symposium Series, Medicinal Chemistry Communications, Future Medicinal Chemistry, Chemical Reviews.

Professional Societies, Positions and Memberships

2010 - 2012 Executive Committee, Member-at-Large, Division of Carbohydrate Chemistry The American Chemical Society 2003 American Society for Microbiology 2000 Society for Glycobiology 2008 American Association of Pharmaceutical Scientists 1998 American Association for the Advancement of Science 1990 American Chemical Society; Divisions of Organic, Medicinal, & Carbohydrate Chemistry 1998 Rho Chi Honor Society

Consulting and Boards

2011 - Editorial Board, Journal of Pharmaceutical Technology and Drug Research 2011 - 2013 Scientific Advisory Group, PK Biosciences, Ames, IA 2012 - 2013 Coferon Inc., New York, NY 2012 Goodwin Procter LLP 2008 - 2009 Zoll, Kranz & Borgess, LLP 2005 - 2007 Finnegan, Henderson, Farabow, Garrett & Dunner, LLP

HONORS AND AWARDS

2008 Class of 2011 teacher of the year, University of Iowa, College of Pharmacy 2004 Collegiate Teacher of the Year, College of Pharmacy, University of Iowa 2004 Class of 2007 teacher of the year, University of Iowa, College of Pharmacy 2000 - 2001 American Association of Colleges of Pharmacy-New Investigators in Pharmacy Award 2000 - 2003 American Heart Association, Midwest Affiliate, Scientist Development Grant 1997 - 1998 NIH NRSA distributed through the NIAID (F32AI009907) 1994 - 1996 National Institutes of Health Predoctoral Fellowship - A competitive traineeship in Biotechnology (T32GM008365)

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PUBLISHED WORK AND PATENTS

Research Manuscripts

48. Drlica, K.; Mustaev, A; Towle, T.R.; Luan, G.; Kerns, R.J.; Berger, J.M. Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design. ACS Chem. Biol. 2014 (submitted).

47. Aldred, K.J.; Breland, E.J.; Vlčková, V.; Strub, M-P.; Neuman. K.C.; Kerns, R.J.; Osheroff, N. Role of the Water-Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV. Biochemistry 2014 (submitted).

46. Fink, B.D.; Herlein, J.A.; Guo, D.F.; Kulkarni, C.; Weidemann, B.J.; Yu, L.; Grobe, J.L.; Rahmouni, K.; Kerns, R.J.; and Sivitz, W.I. A Mitochondrial-Targeted Coenzyme Q Analog Prevents Weight Gain in High Fat-Fed Mice. J. Pharmacol. Exper. Ther. 2014 (submitted).

45. Malik, M.; Li, L,; Zhao, X.; Kerns, R.J.; Berger, J.M, Drlica, K. Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics. J. Antimicrob. Chemother. 2014 (in press).

44. Mustaev, A.; Malik, M.; Zhao, X.; Kurepina, N.; Luan, G.; Oppegard, L.M.; Hiasa, H.; Marks, K.R.; Kerns, R.J.; Berger, J.M.; Drlica. K. Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding, J Biol. Chem., 2014, 289(18) 12300-12312. PMCID: PMC4007428

43. Aldred, K.J.; Kerns, R.J.; Osheroff, N. Mechanism of Quinolone Action and Resistance, Biochemistry, 2014, 53(10) 1565-1574. PMCID: PMC3985860

42. Aldred, K.J.; Schwanz, H.A.; Li, G.; McPherson, S.A.; Turnbough, C.L.; Kerns, R.J.; Osheroff, N. Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal Ion-Independent Drug-Enzyme Interactions: Implications for Drug Design. ACS Chem. Biol. 2013, 8(12), 2660-2668. PMCID: PMC3870039

41. Fenner, A.M.; Oppegard, L.; Hiasa, H.; Kerns, R.J. Selective inhibition of bacterial and human topoisomerases by N-arylacyl O-sulfonated aminoglycoside derivatives. ACS Med. Chem. Lett. 2013, 4(5), 470-474. PMCID: PMC3694624

40. Towle, T.; Change, I.; Kerns, R.J.; Bhanot, P. Chemical probes of a trisubstituted pyrrole to identify its protein target in Plasmodium sporozoites. Bioorg. Med. Chem. Lett. 2013, 23, 1874-1877. PMID: 23395653

39. Aldred, K.J.; McPherson, S.A.; Turnbough, C.L.; Kerns, R.J.; Osheroff, N. Topoisomerase IV-Quinolone Interactions Are Mediated Through a Water-Metal Ion Bridge: Mechanistic Basis of Quinolone Resistance. Nucleic Acids Research, 2013, 41(8), 4628-4639. PMCID: PMC3632122

38. Fink, B. D.; Herlein, J. A.; Yorek, M. A.; Fenner, A. M.; Kerns, R. J.; Sivitz, W. I. Bioenergetic Effects of Mitochondrial-Targeted Coenzyme Q Analogs in Endothelial Cells. J. Pharmacol. Exper. Ther. 2012, 342(3) 709-719. PMCID: PMC3422527

37. Malik, M.; Chavda, K.; Zhao, X.; Shah, N.; Hussain, S.; Kurepina, N.; Kreiswirth, B. N.; Kerns, R. J.; Drlica, K. Induction of mycobacterial resistance to quinolone-class antimicrobials. Antimicrob. Agents Chemother. 2012, 56(7) 3879-3887. PMCID: PMC3393424

36. Aldred, K. J.; McPherson, S. A.; Wang, P.; Kerns, R. J.; Graves, D. E.; Turnbough, C. L.; Osheroff, N. Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance. Biochemistry, 2012, 51, 370-381. PMCID: PMC3261753

35. Fenner, A. M.; Kerns, R. J. Synthesis, separation, and characterization of amphiphilic sulfated oligosaccharides enabled by reversed-phase ion pairing LC and LC-MS methods. Carbohydrate Research, 2011, 346, 2792–2800. PMCID: PMC3221801

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34. Marks, K.R.; Malik, M.; Mustaev, A.; Hiasa, H.; Drlica, K.; Kerns, R.J. Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones. Bioorg. Med. Chem. Lett. 2011, 21, 4585-4588. PMCID: PMC3138821

33. Malik, M.; Marks, K.R.; Mustaev, A.; Zhao, X.; Chavda, K.; Kerns, R.J.; Drlica, K. Fluoroquinolone and quinazolinedione activity with wild type and gyrase mutants of Mycobacterium smegmatis. Antimicrob. Agents Chemother. 2011, 55(5) 2335-2343. PMCID: PMC3088267

32. Malik, M.; Marks, K.R.; Schwanz, H.A.; German, N.; Drlica, K.; Kerns, R.J. Effect of N-1/C-8 ring fusion and C-7 ring structure on fluoroquinolone lethality. Antimicrob. Agents Chemother. 2010, 54(12) 5214–5221. PMCID: PMC2981251

31. Oppegard, L.M.; Streck, K.R.; Rosen, J.D.; Schwanz, H.A.; Drlica, K.; Kerns, R.J.; Hiasa, H. Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Antimicrob. Agents Chemother. 2010, 54(7) 3011-3014. PMCID: PMC2897325

30. Malik, M.; Hoatam, G.; Chavda, K.; Kerns, R.J.; Drlica, K. Novel approach for comparing the ability of quinolones to restrict the emergence of resistant mutants during quinolone exposure, Antimicrob. Agents Chemother. 2010, 54(1) 149–156. PMCID: PMC2798492

29. Drlica, K.; Hiasa, H.; Kerns, R.J.; Malik, M.; Mustaev, A.; Zhao, X. Quinolones: action and resistance updated, Curr. Top. Med. Chem. 2009, 9, 981-998. PMCID: PMC3182077

28. Rosen, J.; German, N.; Kerns, R.J. Efficient Synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core ring system, Tet. Lett. 2009, 50, 785-789. PMCID: PMC2631556

27. German, N.; Malik, M.; Rosen, J.D.; Drlica, K.; Kerns, R.J. Use of gyrase resistance mutants to guide selection of 8-methoxy-quinazoline-2,4-diones, Antimicrob. Agents Chemother. 2008, 52(11) 3915–3921. PMCID: PMC2573108

26. German, N.; Kaatz, G.W.; Kerns, R.J. Synthesis and evaluation of PSSRI-based inhibitors of Staphylococcus aureus multidrug efflux pumps, Bioorg. Med. Chem. Lett. 2008, 18, 1368-1373.

25. German, N.; Wei, P.; Kaatz, G.W.; Kerns, R.J. Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps, Eur. J. Med. Chem. 2008, 43(11), 2453-2463.

24. Drlica, K.; Malik, M.; Kerns, R.J. Zhao, X. Quinolone-mediated bacterial death, Antimicrobial Agents Chemother. 2008, 52, .385-392. PMCID: PMC2224783

23. Hattan, C.M.; Kerns, R.J. Variability in the Carbazole Assay for N-Desulfonated/N-Acylated Heparin Derivatives, Carbohydr. Res. 2007, 342, 2664–2669.

22. Huang, L.; Fernández, C.; Kerns, R.J. Different protein-binding selectivities for N-acyl heparin derivatives having N-phenylacetyl and heterocycle analogs of N-phenylacetyl substituted in place of N-sulfo groups, Bioorg. Med. Chem. Lett. 2007, 17, 419-423.

21. Zhao, X.; Quinn, B.; Kerns, R.J.; Drlica, K. Bactericidal activity and target preference of a piperazinyl-crosslinked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli. J. Antimicrob. Chemother. 2006,58, 1283-1286.

20. Fernández, C.; Hattan, C.M.; Kerns, R.J. Semi-synthetic heparin derivatives: chemical modifications of heparin beyond chain length, sulfate substitution pattern and N-sulfo/N-acetyl groups. Carbohydr. Res. 2006, 341, 1253-1265.

19. Huang, L.; Kerns, R.J. Diversity-Oriented Chemical Modification of Heparin: Identification of Charge-Reduced N-Acyl Heparin Derivatives Having Increased Selectivity for Heparin-Binding Proteins. Bioorg. Med. Chem. 2006, 14, 2300-2313.

18. Kerns, R.J.; Rybak, M.J.; Cheung, C.M. Susceptibility studies of piperazinyl-cross-linked fluoroquinolone dimers against test strains of Gram-positive and Gram-negative bacteria. Diagn. Microbiol. Infect. Dis. 2006, 54, 305-310.

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17. Wei, P.; Kerns, R.J. Chemoselective deprotection and functional group interconversion of ring-fused 2N,3O-oxazolidinones of N-acetyl-D-glucosamine. Tetrahedron Lett. 2005, 46, 6901-6905.

16. Wei, P.; Kerns, R.J. Factors Affecting Stereocontrol during Glycosidation of 2,3-Oxazolidinone Protected 1-Tolylthio-N-acetyl-D-glucosamine. J. Org. Chem. 2005, 70, 4195-4198.

15. Malik, M.; Lu, T; Zhao, X.; Singh, A.; Hattan, C.M.; Domagala, J.; Kerns, R.J.; Drlica, K. Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol. Antimicrobial Agents Chemother. 2005, 49, 2008-2014. PMCID: PMC1087661

14. Wei, P.; Kaatz, G.W.; Kerns, R.J. Structural Differences Between Paroxetine and Femoxetine Responsible for Differential Inhibition of Staphylococcus aureus Efflux Pumps. Bioorg. Med. Chem. Lett. 2004 14, 3093-3097.

13. Gould, K.A.; Pan, X-S.; Kerns, R.J.; Fisher, L.M. Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae. Antimicrobial Agents Chemother. 2004 48, 2108-2115. PMCID: PMC415600

12. Kerns, R.J.; Zha, C.; Benakli. K.; Liang YZ. Extended Applications and Potential Limitations of Ring-Fused 2,3-Oxazolidinone Thioglycosides in Glycoconjugate Synthesis. Tetrahedron. Lett. 2003, 44, 8069-8072.

11. Kerns, R.J.; Rybak, M.J.; Kaatz, G.W.; Vaka, F.; Cha, R.; Grucz, R.G.; Diwadkar, V.U. Structural Features of Piperazinyl-Linked Ciprofloxacin Dimers Required for Activity Against Drug-Resistant Strains of Staphylococcus aureus. Bioorg. Med. Chem. Lett. 2003, 13(13), 2109-2112.

10. Kerns, R.J.; Rybak, M.J.; Kaatz, G.W.; Vaka, F.; Cha, R.; Grucz, R.G.; Diwadkar, V.U.; Ward, T.D. Piperazinyl-Linked Fluoroquinolone Dimers Possessing Potent Antibacterial Activity Against Drug-Resistant Strains of Staphylococcus aureus. Bioorg. Med. Chem. Lett. 2003, 13(10), 1745-1749.

9. Benakli, K.; Zha, C.; Kerns R.J. Oxazolidinone Protected 2-Amino-2-Deoxy-D-Glucose Derivatives as Intermediates in Stereoselective Oligosaccharide Synthesis and the Formation of Alpha-Linked Glycosides. J. Am. Chem. Soc. 2001, 123, 9461-9462.

8. Kim, Y-S.; Thanawiroon, C.; Bazin, H.; Kerns, R.J.; Linhardt, R.J. Enzymatic Preparation of Heparin Disaccharides as Building Blocks in Glycosaminoglycan Synthesis, Prep. Biochem. Biotech. 2001, 31(2), 113-124.

7. Kerns, R.J.; Dong, S.D.; Fukuzawa, S.; Carbeck, J.; Kohler, J.; Silver, L.; Kahne, D. The Role of Lipids Substituents in the Biological Activity of Glycopeptide Antibiotics, J. Am. Chem. Soc. 2000, 122, 12608-12609.

6. Ge, M.; Chen, Z.; Onishi, H.R.; Kohler, J.; Silver, L.L.; Kerns, R.; Fukuzawa, S.; Thompson, C.; Kahne, D. Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding D-Ala-D-Ala, Science 1999, 284, 507-511.

5. Bazin, H.G.; Kerns, R.J.; Linhardt, R.J. “Regio and Stereoselective Conversion of ∆4-Uronic Acids to L-Ido and D-Glucopyranosiduronic Acids” Tetrahedron Lett. 1997, 38(6), 923-926.

4. Kerns, R.J.; Linhardt, R.J. “Selective N-Sulfation of Glucosamine Derivatives Using Phenyl Chlorosulfate in Non-Aqueous Solvent” Synth. Comm. 1996, 26, 2671-2680.

3. Kerns, R.J.; Toida, T.; Linhardt, R.J. “Synthesis of the Bis-tetrahydropyrano[2,3-b:2’,3’e] piperazine Ring System: A New Tricyclic Heterocycle from D-Glucosamine” J. Carbohydr. Chem. 1996, 15, 581-590.

2. Kerns, R.J.; Vlahov, I.R.; Linhardt, R.J. “Capillary Electrophoresis for Monitoring Chemical Reactions: Sulfation and Synthetic Manipulation of Sulfated Carbohydrates” Carbohydr. Res. 1995, 267, 143-152.

1. Kerns, R.J.; Linhardt, R.J. “Separation of Hydroxyl-Protected Heparin Derived Disaccharides Using Reversed-Phase High Performance Liquid Chromatography” J. Chromatogr. A 1995, 705, 369-373.

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Invited Papers, Book Chapters and Scientific References

5. Kerns, R.J. and Wei, P. “Synthetic Methods to Incorporate α-Linked 2-Amino-2-Deoxy-D-Glucopyranoside and 2-Amino-2-Deoxy-D-Galactopyranoside Residues into Glycoconjugate Structures.” in Glycobiology and Drug Design, Klyosov, A.A. (ed.), ACS symposium series; 1102, Oxford University Press, Washington, D.C., 2012.

4. Karl Drlica, Xilin Zhao, Muhammad Malik, Tal Salz, and Robert J. Kerns; “Fluoroquinolone resistance: mechanisms, restrictive dosing, and anti-mutant screening strategies for new compounds” in Handbook of Antibiotic Discovery and Development (Michael J. Pucci and Thomas J. Dougherty, Eds.), Springer, 2012.

3. Kerns, R.J. and Wei, P. “Synthetic Methods to Incorporate α-Linked 2-Amino-2-Deoxy-D-Glucopyranoside and 2-Amino-2-Deoxy-D-Galactopyranoside Residues into Glycoconjugate Structures.” in Carbohydrate Drug Design, Klyosov, A.A.; Witczak, Z.J.; Platt, D. (eds.), ACS symposium series; 932, Oxford University Press, Washington, D.C., 2006.

2. Kerns, R.J. and Wei, P. “Benzeneselenenyl Trifluoromethansesulfonate, First Update” in Encyclopedia of Reagents for Organic Synthesis, Paquette, L.A.; Fuchs, P.L.; Wipf, P.; Crich, D. (eds.), John Wiley & Sons LTD, 2004.

1. Linhardt, R.J.; Kerns, R.J.; Vlahov, I.R. “Heparin and Heparin Oligosaccharides: Preparation, Analysis, Applications and Biological Activities” in Biochemical Functions and Biotechnology of Natural and Artificial Polymers, Yalpani, M. (ed.), ATL Press, 1996, 45-62.

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Book Reviews and Editorials

Robert J. Kerns; Book Review on “Annual Review of Pharmacology and Toxicology,” Vol. 51, Arthur K. Cho (ed.), J. Med. Chem. 2011, 54, 4934.

Robert J. Kerns; Book Review on “Comprehensive Organic Name Reactions and Reagents,” Zerong Wang, J. Med. Chem. 2010, 53, 2671.

Robert J. Kerns; Book Review on “Annual Review of Pharmacology and Toxicology,” Vol. 49, Arthur K. Cho (ed.), J. Med. Chem. 2009, 52, 3428.

Robert J. Kerns and Amanda M. Fenner; Book Review on “The Synthetic Organic Chemist’s Companion,” M. C. Pirrung, J. Med. Chem. 2008, 51, 1073.

Robert J. Kerns; Book Review on “Combinatorial Synthesis of Natural Product-Based Libraries,” Boldi, A.M. (ed.), J. Natural Products, 2007, 70, 326.

Robert J. Kerns; Book Review on “Organic Synthesis. State of the Art 2003-2005,” By Douglas F. Taber, J. Med. Chem. 2006, 49, 7923.

Robert J. Kerns; Book Review on “Annual Review of Biochemistry,” Vol. 75, Kornberg, Raetz, Rothman & Thorner (eds.), J. Med. Chem. 2006, 49, 7555.

Robert J. Kerns; Book Review on “Annual Review of Pharmacology and Toxicology,” Vol. 46, Arthur K. Cho (ed.), J. Med. Chem. 2006, 49, 5024-5025.

Robert J. Kerns; Book Review on “Annual Review of Biochemistry,” Vol. 74, Kornberg, Raetz, Rothman & Thorner (eds.), J. Med. Chem. 2005, 48, 7500-7501.

Robert J. Kerns; Book Review on “Mechanisms in Organic Reactions” By Richard A. Jackson. The Royal Society of Chemistry, Cambridge, U.K., J. Med. Chem. 2005, 48, 4488.

Patents Issued

Kahne, D., Kerns, R., Fukuzawa, S., Ge, M., Thompson, C. “Glycopeptide Antibiotics, Combinatorial Libraries of Glycopeptide Antibiotics and Methods of Producing Same” US patent No. 7,331,920 B2; issued Feb. 19, 2008.

PRESENTATIONS, INVITED SEMINARS & PUBLISHED ABSTRACTS

Invited Seminars and Research Presentations

“Medicinal chemistry as a tool to solve biological and pharmaceutical problems: from novel anti-infective agents to new modulators of glycosaminoglycan-binding proteins” Iowa State University, Department of Biomedical Sciences (April 11, 2013).

“Medicinal Chemistry Approaches to Solving Biological Problems”, University of Minnesota School of Medicine, Department of Pharmacology, (January 28, 2011).

“New Antibiotics Toward Restricting the Emergence of Resistance”, University of Iowa, Department of Chemistry, (April 13, 2010).

“Derivation of New Therapeutics from the Chemical Modification of Sulfated Polysaccharides”, University of Iowa, Department of Chemical and Biochemical Engineering, (October 16, 2008).

“Pharmacy, Pharmaceutics, Clinical and Administrative Pharmacy, and Medicinal Chemistry: Professional and Graduate Programs that Offer Many Career Options”, University of Northern Iowa, Department of Chemistry and Biochemistry, (April 3, 2008).

“Design and Synthesis of Anti-Infective Agents Toward Overcoming Mutation-Mediated & Efflux-Mediated Resistance to Antibiotics” Brown University, Department of Chemistry, (September 11, 2007).

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“Novel Fluoroquinolone Antibiotics and Charge-Reduced Heparin Derivatives: From Chemical Probes to Anti-Infective Agents” Iowa State University, Department of Veterinary Microbiology and Preventive Medicine, (January 16, 2007).

“Diversity-Oriented Synthesis versus Rational Drug Design: Two Routes towards Novel Anti-Infective Therapeutics” The University of Iowa, (September 2005).

“Derivation of novel therapeutics from the diversity-oriented chemical modification of bioactive polyanions,” 230th American Chemical Society Meeting, Division of Carbohydrate Chemistry, Wolfrom/Isbell New Investigator Award Symposium, Washington, DC, (August 28, 2005).

“From Glycosaminoglycans to Antibiotic Resistance, Odyssey of a CBB Fellow” 12th Annual Center for Biocatalysis and Bioprocessing Conference, “Biocatalysis for Chemical Synthesis”, Iowa City, Iowa, (October 29, 2003).

“Strategy for Preparing Saccharides that Display Unique Protein-Binding Profiles” 2003 Gordon Research Conference, Carbohydrates, Tilton, NH (June 23, 2003).

“Incorporating Structural Diversity into Acidic Polysaccharide Libraries: A Strategy for Identifying Novel Saccharides that Display Unique Protein-Binding Profiles” 225th American Chemical Society National Meeting, Division of Carbohydrate Chemistry, Hudson Awards Symposium, New Orleans, LA, (March 24, 2003).

“Parallel Synthesis and Screening of Structurally Diverse Heparinoid Libraries” Loyola Medical University, Maywood, IL (August 8, 2002). Research Presentations at Scientific Meetings

19. “Quinolone-class antibiotics: Derivatives having unique lethality profiles and activity with resistant mutants” R.J. Kerns, 47th American Chemical Society Midwest Regional Meeting, Drug Discovery and Development Symposium, Omaha, NE, (October 26, 2012)

18. “Derivation of New Therapeutics from the Diversification of Heparin Structure,” R.J. Kerns, 237th American Chemical Society Meeting, Division of Carbohydrate Chemistry, Carbohydrate Based Drugs Symposium, Salt Lake City, UT, (March 24, 2009).

17. “Unique structural requirements for chemically modified reduced-charge heparin derivatives to selectively bind HS-binding proteins” R.J. Kerns, L. Huang, C.M. Hattan, C. Fernandez, Annual Conference of the Society for Glycobiology, Los Angeles, California, November 2006. Glycobiology, 16(11), Abstr. 220, 2006.

16. “Stereoselective synthesis of 2-amino-2-deoxy-D-glucopyranosides employing N-substituted ring-fused 2,3-oxazolidinone protected glycosyl donors, P. Wei and R.J. Kerns, 229th American Chemical Society Meeting, San Diego, California, (March 2005), Abstracts of Papers of the American Chemical Society 2005, Vol 229.

15. “Derivation of novel therapeutics from the diversity-oriented chemical modification of bioactive polyanions,” R.J. Kerns, 230th American Chemical Society Meeting, Washington, DC, (August 2005). Abstracts of Papers of the American Chemical Society 2005, Vol 230.

14. “Incorporating Structural Diversity into Acidic Polysaccharide Libraries: A Strategy for Identifying Novel Saccharides that Display Unique Protein-Binding Profiles”. R.J. Kerns, L Huang and P. Vyas. 225th American Chemical Society Meeting, New Orleans, Louisiana, (March 2003). Abstracts of Papers of the American Chemical Society, Vol 225, U254-U254, 015 Carb Part 1, 2003.

13. “Novel Therapeutics from the Diversification of Heparin Structure” R.J. Kerns and L. Huang, Annual Conference of the Society for Glycobiology, San Diego, California, December 2003. Glycobiology, 13(11), Abstr. 255, 2003.

12. “Parallel Synthesis and Screening of a Structurally Diverse Heparin-Based Library” R.J. Kerns, and L. Huang, Carbohydrates Gordon Conference, Tilton, New Hampshire, June 2003.

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11. “Synthesis and Structure-Activity-Relationships of Fluoroquinolone Dimers Possessing Antibacterial Activity Against Drug-Resistant Bacteria” R.J. Kerns, F. Vaka, R.G. Grucz, G.W. Kaatz, M.J. Rybak, R. Cha, V. Diwadkar 224th American Chemical Society Meeting, Boston, Mass., (August 2002). Abstracts of Papers of the American Chemical Society, Vol 224; 055-MEDI Part 2, 2002.

10. “Incorporating Non-Anionic Structural Diversity Into Heparin Derivatives: Heparin Analogs that Display Unique Protein-Binding and Protease-Inhibiting Profiles Revealed” R.J. Kerns, L.H. Huang and P.M. Vyas, 224th American Chemical Society Meeting, Boston, Mass., (August 2002). Abstracts of Papers of the American Chemical Society, Vol 224; 094-Carb, Part 1, 2002.

9. “Evaluation of Heparanase Activity in Breast Cancer” R.J. Kerns, M.A. Kosir, P. Louden, E. Osborn, C. Zha, V. Diwadkar, G. Tromp, Third Era of Hope Department of Defense Breast Cancer Research Program Meeting, Orlando FL, September, 2002.

8. “Synthesis and Antibacterial Activity of Novel Piperazinyl-Linked Fluoroquinolones” R.J. Kerns, F. Vaka, R.G. Grucz, G.W. Kaatz, M.J. Rybak, 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Illinois, December 2001.

7. “Novel D-Glucosamine Derivatives as Versatile Intermediates in Oligosaccharide Synthesis and the Stereoselective Formation of Alpha-Linked Glycosides” R.J. Kerns, K. Benakli, and C. Zha, Carbohydrates Gordon Conference, Tilton, New Hampshire, June 2001.

6. “New Approach for the Stereoselective Glycosidation of 2-Amino-2-Deoxy-D-Glucose Derivatives” K. Benakli, C. Zha and R.J. Kerns, 221st American Chemical Society Meeting, San Diego, California, (April 2001). Abstracts of Papers of the American Chemical Society, Vol 221; 82-Carb, Part 1, 2001.

5. “Synthesis and Antibacterial Activity of Novel Carbohydrate Modified Derivatives of the Glycopeptide Antibiotic Vancomycin,” R.J. Kerns, S. Fukuzawa, J. Carbeck, and D. Kahne, 216th American Chemical Society Meeting, Boston, Massachusetts, (August 1998). Abstracts of Papers of the American Chemical Society, Vol 216; 250-MEDI Part 2, 1998.

4. “A Method for the Conversion of Enzymatically Prepared Glycosaminoglycan Oligosaccharides to their Non-reducing Terminus C-4 Glycosyl Acceptors,” R.J. Kerns, and R.J. Linhardt, Fifth Annual Biocatalysis and Bioprocessing Conference, The University of Iowa, Iowa City, IA, May, 1996.

3. “Synthesis of Uronic Acid Glycosyl Acceptors from 4-deoxy-α-L-threo-hex-4-enopyranoside Uronic Acids: A Model for the Chemo-Enzymatic Synthesis of Glycosaminoglycan Oligosaccharides,” R.J. Kerns and R.J. Linhardt, Thirty-Fourth Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, March, 1996.

2. “Capillary Electrophoresis for Monitoring Synthetic and Enzymatic Manipulations of Sulfated Carbohydrates,” R.J. Kerns, I.R. Vlahov, and R.J. Linhardt, Fourth Annual Biocatalysis and Bioprocessing Conference, University of Iowa, Iowa City, IA, May, 1995.

1. “Chemo-Enzymatic Synthesis of Heparin and Oligosaccharides from Chiral Synthons,” R.J. Kerns, K. Jandik, R.J. Linhardt, Thirty-Second Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, May, 1994.

Co-authored abstracts and Research Presentations at Scientific Meetings (graduate students under my direction† and co-investigators‡ ) (*graduate student presentations at national and international meetings)

95.* “Novel Neutrophil Serine Protease Inhibitors as Potential Leads to Modulate Inflammatory Lung Disease Ioana Craciun,†

Amanda M. Fenner,† Robert J. Kerns, Medicinal Chemistry Gordon Conference, New London, New Hampshire, August 2014. 94. “Selective Inhibition of Neutrophil Serine Proteases by N-Arylacyl O-Sulfonated Aminoglycosides” Ioana Craciun,† Amanda

M. Fenner,† and Robert J. Kerns, Oral presentation at the Fifty-Second Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April 2014.

93. “Novel Antimutant C7 Pyrrolidine Fluoroquinolones" Benjamin H. Williamson,† Heidi Schwanz,† and Robert J. Kerns, Poster presentation at the Fifty Second Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April 2014.

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92. “Novel N-1 Fluoroquinolone Derivatives and their Inhibition of Type II Topoisomerases” Chaitanya A. Kulkarni,† Tyrell R. Towle,† and Robert J. Kerns, Poster presentation at the Fifty-Second Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April 2014.

91. “Structurally Unique N-Arylacyl O-Sulfonated Aminoglycosides as Potential Leads to Modulate Inflammatory Lung Diseases” Craciun, I.,† Fenner, A.M.† and Kerns, R.J. Poster Presentation at the Twenty-Second Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2013.

90. “Novel N-1 Fluoroquinolones Designed to Combat Bacterial Resistance Due to Mutant Type II Topoisomerases’ Kulkarni, C.A.,† Towle, T.R.† and Kerns, R.J. Poster Presentation at the Twenty-Second Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2013.

89. “Effect of Fluoroquinolone Structure on Activity and Mechanism of Action with Bacterial Topoisomerases” Tyrell R. Towle† and Robert J. Kerns, Oral presentation at the Fifty First Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, April 2013.

88. "Evaluation of N-Arylacyl O-Sulfonated Aminoglycosides for Their Inhibition of Neutrophil Serine Proteases" Ioana Craciun,† Amanda M. Fenner,† and Robert J. Kerns, Poster presentation at the Fifty-First Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, April 2013.

87. “Synthesis and Evaluation of Novel N-1 Substituted Fluoroquinolones Designed to Explore Non-Conventional Binding Contacts in Type-II Topoisomerase Ternary Complex” Chaitanya A. Kulkarni,† Tyrell R. Towle,† and Robert J. Kerns, Poster presentation at the Fifty-First Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, April 2013.

86. “Determining Protein Binding Selectivity of N-Arylacyl O-Sulfonated Aminoglycoside Derivatives” Craciun I.,† Fenner A.M.† & Kerns R.J. Poster Presentation at the 21st Annual Biocatalysis & Bioprocessing Conference, Iowa City, Iowa, October 2012.

85. “Design and Synthesis of Novel N-1 Fluoroquinolones” Kulkarni, C.A.,† Towle, T.R.† and Kerns, R.J. Poster Presentation at the Twenty-First Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2012.

84. "Novel Fluoroquinolone Analogs with Antimutant Activity" Benjamin H. Williamson†, Heidi A. Schwanz†, Robert J. Kerns, Poster Presentation at the Twenty-First Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2012.

83.* “Structural Effects of Fluoroquinolone Class Antibiotics on Lethality” T.R. Towle†, Oral Presentation at the 244th American Chemical Society National Meeting and Exposition, Division of Medicinal Chemistry Fellowship Awards Symposium. Philadelphia, PA, August 2012.

82.* “Synthesis of Novel Fluoroquinolones and Evaluation of Lethality” T.R. Towle,† H.A. Schwanz,† and R.J. Kerns, Medicinal Chemistry Gordon Conference, New London, New Hampshire, August 2012.

81. “Synthesis of Novel Fluoroquinolones and Evaluation of Lethal Activity with Non Growing Bacteria” Tyrell R. Towle,† Heidi A. Schwanz, and Robert J. Kerns, Poster presentation at the Fiftieth Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, April 2012.

80. “Novel Antimutant C-7 Aryl Fluoroquinolones” Benjamin Williamson,† Heidi A. Schwanz,† and Robert J. Kerns, Poster presentation at the Fiftieth Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA April 2012.

79. “Structural Features of N-arylacyl O-sulfonated Aminoglycosides that Determine Protein Binding Selectivity” Ioana Craciun,† Amanda M. Fenner† and Robert J. Kerns, Poster presentation at the Fiftieth Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, April 2012.

78. “Differential Binding of DNA with Fluoroquinolones Affects the Ability of the Fluoroquinolone to Kill Microorgansims” Schwanz, H.A.† and Kerns R.J. Oral Presentation at the Twentieth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2011.

77. “Synthesis of N-Arylacyl O-Sulfonated Aminoglycosides that Bind Heparan Sulfate Binding Proteins” Craciun I.,† Fenner A.M.† and Kerns R.J. Poster Presentation at the Twentieth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2011.

76. “Novel Antimutant C-7 Aryl Fluoroquinolones” Williamson, B.H.†; Schwanz, H.A.†; and Kerns, R.J. Poster Presentation at the Twentieth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2011.

75. “Investigating the Mechanism of Hepatocyte Invasion by Malaria-Causing Plasmodia by Designing and Synthesizing Chemical Probes” Towle T.R.† and Kerns R.J. Poster Presentation at the Twentieth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 2011.

74. “The Role of DNA Binding in the Ability of Different Fluoroquinolones to Rapidly Kill Microorganisms in the Presence and Absence of Protein Synthesis” Heidi A. Schwanz† and Robert J. Kerns. Oral presentation at the Forty-Ninth Annual MIKI Midwestern Medicinal Chemistry Meeting, Lawrence, KS, April 2011.

73. “Synthesis of N-Arylacyl O-Sulfonated Aminoglycosides that Bind Heparan Sulfate Binding Proteins” Ioana Craciun†, Amanda M. Fenner† and Robert J. Kerns. Poster presentation at the Forty-Ninth Annual MIKI Midwestern Medicinal Chemistry Meeting, Lawrence, KS, April 2011.

72. “Synthesis of Chemical Probes for Understanding Invasion of Hepatocytes by Malaria-Causing Plasmodium SPP. Tyrell R. Towle† and Robert J. Kerns. Poster presentation at the Forty-Ninth Annual MIKI Midwestern Medicinal Chemistry Meeting, Lawrence, KS, April 2011.

71. “Novel Antimutant C-7 Aryl Fluoroquinolones” Benjamin H. Williamson†, Heidi A. Schwanz† and Robert J. Kerns. Poster presentation at the Forty-Ninth Annual MIKI Midwestern Medicinal Chemistry Meeting, Lawrence, KS, April 2011.

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70. “Separation and Characterization of Sulfated N-aryl Oligosaccharides by Ion Pairing Liquid Chromatography” A.M. Fenner† and R.J. Kerns, Poster presentation at the Nineteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, IA, October 2010.

69. “Modulation of the Activity of Fluoroquinolones and Quinazolinediones by C-2 Thio Functionalization” Marks, K.R.† and Kerns, R.J. Oral presentation at the 19th Annual Biocatalysis and Bioprocessing Conference, Iowa City, IA, October, 2010.

68. “Activity against mutant E. coli strains and in vitro effects of novel C-7 aryl fluoroquinolones on DNA gyrase and DNA” Heidi A. Schwanz†, Jonathan D. Rosen, Robert J. Kerns, Poster presentation at the Nineteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, IA, October, 2010.

67. “Synthesis of Novel Antimutant C-7 Aryl Fluoroquinoilones” Benjamin H. Williamson†, Heidi A. Schwanz†, Jonathan D. Rosen and Robert J. Kerns. Poster presentation at the Nineteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, IA, October, 2010.

66. “Structural Requirements of Fluoroquinolones for Killing Non Replicating Bacteria” Tyrell R. Towle† and Robert J. Kerns, Poster presentation at the Nineteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, IA, October, 2010.

65.* “Synthesis of Sulfated N-arylacyl Aminoglycosides and Evaluation as Heparin/Heparan Sulfate Mimics” A.F. Fenner†, Oral presentation at the Twelfth Annual Bristol-Myers Squibb Chemistry Award Symposium, Lawrenceville, NJ, April 2010.

64.* “Small Molecule Glycosaminoglycan Mimics” A.F. Fenner†, Oral Presentation at the 240th American Chemical Society National Meeting & Exposition, Division of Medicinal Chemistry Fellowship Awards Symposium. Boston, MA, August 2010.

63. “Design, Synthesis, and Characterization of Sulfated N-aryl Aminoglycosides” A.F. Fenner†, and R.J. Kerns. Poster Presentation at the 240th American Chemical Society National Meeting and Exposition, Division of Carbohydrate Chemistry. Boston, MA, August 2010.

62.* “Influence of a C-2 thioether moiety on the activity of fluoroquinolone antibiotics” Marks, K.R.† and Kerns R.J. Poster Presentation at the 240th American Chemical Society National Meeting and Exposition, Division of Medicinal Chemistry. Boston, MA, August 2010.

61.* “In vitro effects of C-7 Aryl Fluoroquinolones on DNA Gyrase and DNA.” Schwanz, H.A.,† Rosen, J.D., Kerns, R.J. Poster Presentation at the 240th American Chemical Society National Meeting and Exposition. Division of Medicinal Chemistry. Boston, MA. August 2010.

60. “Influence of a C-2 thioether moiety on the activity of fluoroquinolone antibiotics” Marks, K.R.† and Kerns R.J. Oral Presentation at the Forty-Eighth Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April 2010.

59. “Modified Aminoglycosides as Small Molecule Inhibitors of Heparin Binding Proteins” A.F. Fenner† and R.J. Kerns, Oral presentation at the Forty-Eighth Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL. April 2010.

58. “Antimutant Activity of C-7-Aryl Fluoroquinolones.” Schwanz, H.A.,† Rosen, J.D., Kerns, R.J. Poster Presentation at the 48th Annual MIKI Midwestern Medicinal Chemistry Meeting. Chicago, IL. April 2010.

57. “Synthetic Strategies Toward Quinolone-Class Gyrase Inhibitors for Use Against Drug-Resistant Microorganisms.” Schwanz, H.A.,† Rosen, J.D., Kerns, R.J. Poster Presentation at the Eighteenth Annual Biocatalysis and Bioprocessing Conference. Iowa City, Iowa. October 2009.

56.* “Preparation of Novel Quinolone-Class Gyrase Inhibitors to Combat Drug-Resistant Microorganisms.” Schwanz, H.A.,† Rosen, J.D., Kerns, R.J. Poster Presentation at the 44th Midwest Regional meeting of the American Chemical Society. Iowa City, Iowa. October 2009.

55.* “Reducing treatment times: The effect of fluoroquinolone substituents on rapid lethality in bacterial cells” Marks, K.R.† and Kerns, R.J. Poster presentation, American Chemical Society Midwest Regional Meeting, Iowa City, IA, October, 2009.

54. “Reducing treatment times: The effect of fluoroquinolone substituents on rapid lethality in bacterial cells” Marks, K.R.† and Kerns, R.J. Poster presentation at the 18th Annual Biocatalysis and Bioprocessing Conference, Iowa City, IA, October, 2009.

53.* “N-arylacyl O-Sulfonated Aminoglycosides as Heparin and Heparan Sulfate Mimics,” A. M. Fenner† and R. J. Kerns, Poster presentation at the American Chemical Society 44th Annual Midwest Regional Meeting, Iowa City, IA, October 2009.

52. “Targeting Diseases in Panamá with Panamanian Cyanobacteria,” A. M. Fenner† and M. J. Balunas, Poster presentation at The University of Iowa Global Health Conference, Iowa City, IA, October 2009.

51. “N-arylacyl O-sulfonated Aminoglycosides that Bind Select Heparan-Sulfate Binding Proteins,” A. M. Fenner† and R. J. Kerns, Poster presentation Eighteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, IA, October 2009.

50.* “Modulation of Antimicrobial Peptides by Glycosaminoglycans” Beth Miskimins Mills† and Robert J. Kerns. Antimicrobial Peptides Gordon Conference, Ventura, CA, March 2009.

49. “Modulation of Cationic Antimicrobial Peptides by Glycosaminoglycans” Miskimins Mills, B.† and Kerns R.J. Oral Presentation at the Forty-Seventh Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, April 2009.

48. "Synthesis of Sulfated N-arylacyl Aminoglycosides to Selectively Block Heparan Sulfate-Protein Interactions" Amanda M. Fenner† and Robert J. Kerns, Poster presentation at the Forty-Seventh Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, April 2009.

48. "Molecular Interactions of Novel Quinolone-like Gyrase Inhibitors." Schwanz, H.A,† Rosen, J.D., Miskimins Mills,† B. and Kerns, R.J. Poster Presentation at the Forty-Seventh Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, April 2009.

47. "Influence of Substituents on Lethality of Fluoroquinolones" Marks, K.R.† and Kerns, R.J. Poster Presentation at the Forty-Seventh Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, April, 2009.

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46. "Modulation of Cationic Antimicrobial Peptides by Glycosaminoglycans” Miskimins-Mills, B.† and Kerns R.J. Oral Presentation at the Seventeenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 21, 2008.

45. "Sulfated N-arylacyl Aminoglycoside Derivatives: Potential Selective Inhibitors of Heparan Sulfate-Protein Interactions" Fenner, A.M.† and Kerns R.J. Poster Presentation at the Seventeenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 21, 2008.

44. "Evaluation of the Essential Structural Features in Fluoroquinolone-Class Agents for Activity Against Drug Resistant Microorganisms" Schwanz H.A.†, Rosen J.D., and Kerns R.J. Poster Presentation at the Seventeenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 21, 2008.

43. "Probing Structural Requirements of Fluoroquinolones for Lethality in the Absence of Protein Synthesis" Marks K.R.,† German, N., and Kerns R.J. Poster Presentation at the Seventeenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 21, 2008.

42. “Fluoroquinolone Action and Resistance” Drlica, K.,‡ Zhao, X.,‡ Malik, M.,‡ Wang, X., Capecci, J., German, N.,† Kerns, R. DNA topoisomerases in biology and medicine; John Innes Institute, Norwich, UK, July 2008.

41. “Investigations of Aromatic Glycosaminoglycans that Selectively Bind Heparin-Binding Proteins” Hattan, C.M.† and Kerns, R.J. Poster Presentation at the 46th Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, April 2008.

40 “Probing the Structural Requirements of Fluoroquinolones That Cause Rapid Lethality” Marks, K.R.†, German, N.,† and Kerns, R.J. Poster Presentation at the 46th MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, April, 2008.

39 “Sulfated N-arylacyl Aminoglycoside Derivatives: Potential Selective Inhibitors of Heparan Sulfate-Protein Interactions” Fenner, A. M.† and Kerns, R.J. Poster Presentation at the Forty-Sixth Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, April, 2008.

38. “Profiling the Inhibition of Linear Cationic Antimicrobial Peptides by Glycosaminoglycans” Miskimins Mills, B.† and Kerns, R.J. Poster presentation at the 46th Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, April 2008.

37. “Probing the structural requirements of fluoroquinolones for rapid lethality in the absence of protein synthesis” Marks, K. R.,† German, N.,† and Kerns, R. J. Poster presentation at the Sixteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 23, 2007.

36. “Bind and Block Antagonists of Growth Factors” Hattan C.M.† and Kerns R.J. Poster Presentation at the Sixteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 23, 2007.

35. “Profiling the Inhibition of Linear Cationic Antimicrobial Peptides by Glycosaminoglycans.” Miskimins, B.† and Kerns, R J. Poster Presentation at the 16th Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 23, 2007.

34.* “Design and synthesis of Novel Bacterial Efflux Pump Inhibitors: Nadezhda German†, Peng Wei, Glenn W. Kaatz, and Robert J. Kerns Poster presentation at the International Symposium on Advances in Synthetic and Medicinal Chemistry, St. Petersburg, Russia, August 29, 2007.

33. “Differential inhibition of a cationic antimicrobial peptide derived from bovine lactoferricin by glycosaminoglycans” Miskimins Mills, B.† and Kerns, R.J. Poster Presentation at the forty-fifth Annual MIKI Midwestern Medicinal Chemistry Meeting, Lawrence, KS, April 2007.

32. “Aromatic Low Molecular Weight Heparin Amides: Reduced-Charge Heparins that Selectively Bind Heparin-Binding Proteins” Hattan, C.M.† and Kerns, R.J. Oral Presentation at the Forty-Fifth Annual MIKI Midwestern Medicinal Chemistry Meeting, Lawrence, KS, April 2007.

31. “Structural Requirements of Fluoroquinolones Responsible for Chromosome Fragmentation and Rapid Cell Death” Marks, K.R.†, German, N.,† and Kerns, R.J. Poster Presentation at the Forty-Fifth Annual MIKI Midwestern Medicinal Chemistry Meeting, Lawrence, KS, April, 2007.

30. “Differential inhibition of a bovine lactoferricin-derived cationic antimicrobial peptide by glycosaminoglycans” Miskimins Mills B.† and Kerns R.J. Poster presentation at the Fifteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 24, 2006.

29. “Heparin amides: charged-reduced heparins with selectivity for binding to heparin binding proteins” Hattan C.M.† and Kerns, R.J. Poster presentation at the Fifteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 24, 2006.

28. “Fluoroquinolone antibiotics that inhibit bacterial efflux pump systems” Nadezhda German†, Peng Wei and Robert J. Kerns Poster presentation at the Fifteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 24, 2006.

27.* “Heparan Sulfate-Based Inhibitors of Host-Pathogen Interactions” Fernandez-Perez, C.† and Kerns, R.J. Poster presentation at the Thirtieth National Medicinal Chemistry Symposium, Seattle, WA, June, 2006.

26.* “Differential inhibitory activity of glycosaminoglycans against a cationic antimicrobial peptide”. Miskimins B.E.† and Kerns RJ. Poster presentation at the Thirtieth National Medicinal Chemistry Symposium, Seattle, WA, June, 2006.

25.* “Low Molecular Weight Heparin Amides that Selectively Bind Heparin-Binding Proteins” Hattan, C.M.† and Kerns, R.J. Poster presentation at the Thirtieth National Medicinal Chemistry Symposium, Seattle, WA, June, 2006.

24. “Differential inhibition of a cationic antimicrobial peptide by glycosaminoglycans” Miskimins B.E.† and Kerns R.J. Poster Presentation at the Forty-Fourth Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April, 2006.

23. “Low Molecular Weight Heparin Amides that Selectively Bind Heparin-Binding Proteins” Hattan, C. M.† and Kerns, R.J. Poster Presentation at the Forty-Fourth Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April, 2006.

22. “Heparan Sulfate-Based Inhibitors of Host-Pathogen Interactions” Fernandez-Perez, C.† and Kerns, R.J., Oral Presentation at the Forty-Fourth Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April, 2006.

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21. “Substrate-Based Design and Synthesis of Bacterial Efflux Pump Inhibitors” German, N.,† Wei, P.† and Kerns, R.J., Oral Presentation at the Forty-Fourth Annual MIKI Midwestern Medicinal Chemistry Meeting, Chicago, IL, April, 2006.

20.* “Inhibitors of Host-Pathogen Interactions” Fernandez-Perez, C.† and Kerns, R.J. Poster presentation at the 231st American Chemical Society National Meeting and Exposition, Atlanta, GA, March, 2006.

19. “Synthesis of Novel Fluoroquinolone Antibiotic Derivatives Containing Structural Motifs of Bacterial Efflux Pump Inhibitors”, German, N.,† Wei, P.† and Kerns, R.J., Fourteenth Annual Biocatalysis and Bioprocessing Conference, The University of Iowa, Iowa City, IA, October 29, 2005.

18. “Synthesis and Depolymerization of Heparin Amides” Hattan, C.M.† and Kerns, R.J. Fourteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 29, 2005.

17. “Inhibition of short cationic antimicrobial peptide activity by glycosaminoglycans” Miskimins B.E.† and Kerns, R.J. Poster presentation at the Fourteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 29, 2005.

16. “Inhibitors of Host-Pathogen Interactions”, Fernandez-Perez, C.† and Kerns, R.J. Oral presentation at the Fourteenth Annual Biocatalysis and Bioprocessing Conference, Iowa City, Iowa, October 29, 2005.

15. “Synthesis of Fluoroquinolone-Based Probes for Bacterial Efflux Pump Inhibition,” N. German,† P. Wei† and R.J. Kerns, Forty-Third Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, June, 2005.

14. “Study of N-Acyl Heparin Derivatives that Bind Thrombin,” C.M. Hattan† and R.J. Kerns, Forty-Third Annual MIKI Midwestern Medicinal Chemistry Meeting, Minneapolis, MN, June, 2005.

13. “Inhibitors of Host-Pathogen Interactions,” C. Fernández† and R.J. Kerns, Thirteenth Annual Center for Biocatalysis and Bioprocessing Conference, Iowa City, IA, October, 2004.

12. “2N,3O-Oxazolidinones of 2-Amino-2-Deoxy Sugars as Versatile Synthetic Intermediates in Stereoselective Oligosaccharide Synthesis,” C. Fernández† and R.J. Kerns, Forty-Second Annual MIKI Midwestern Meeting-in-Miniature, Iowa City, IA, April, 2004.

11. “Synthesis of Novel Fluoroquinolone Antibiotic Derivatives Containing Structural Motifs of Bacterial Efflux Pump Inhibitors”, N. German† and R.J. Kerns, Forty-Second Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, IA, April, 2004.

10. “Synthesis of Novel Anti-Infective agents containing Structural Motifs of Bacterial Efflux Pump Inhibitors”, N. German,† J. Rees†, R.J. Kerns, 13th Annual Biocatalysis & Bioprocessing Conference, University of Iowa, Iowa City, IA, October, 2004.

9. “Heparin-Derived Direct Inhibitors of Thrombin,” C.M. Hattan† and R.J. Kerns, Thirteenth Annual Biocatalysis and Bioprocessing Conference, The University of Iowa, Iowa City, IA, October 25 – 27, 2004.

8. “Novel Fluoroquinolone Antibiotics Against Drug-Resistant Bacteria,” C.M. Hattan† & R.J. Kerns, Forty-Second Annual MIKI Midwestern Medicinal Chemistry Meeting, Iowa City, Iowa, April 16 – 18, 2004.

7.* “Manipulation of Heparin-Protein Interactions: Parallel Synthesis and Screening of a Structurally Diverse Heparin-Based Library” L. Huang† and R.J. Kerns, 224th American Chemical Society Meeting, Boston, Massachusetts, (August 2002). Abstracts of Papers of the American Chemical Society, Vol 224; 072-Carb, Part 1, 2002.

6. “Invasive and in situ derivatives of breast MCF-10A cells as a model to study the expression of heparanase” Patricia Loudon, Mary A Kosir‡, Elizabeth Osburn, Gerard Tromp, Robert Kerns, 2002 American Association for Cancer Research Annual Meeting in San Francisco, CA; Proceedings of the American Association for Cancer Research 43:2002.

5. “Comparison of the Expression and activity of two Heparanases, Hpa1 and CTAP-III” M.A. Kosir‡, P. Foley-Loudon, E. Osburn, G. Tromp, R.J. Kerns, Presented at Twenty-fifth Annual Meeting, Association of VA Surgeons, 2002.

4.* “2N,3O-Oxazolidinone Derivatives of 2-Amino-2-Deoxy Sugars as Versatile Synthetic Intermediates in Stereoselective Oligosaccharide Synthesis” K. Benakli†, C. Zha† and R.J. Kerns, 84th Canadian Society of Chemistry Conference and Exhibition, Montréal Quebec, May 2001.

3.* “New Strategy for the Synthesis of Repeating units of Glycosaminoglycans” K. Benakli†, and R.J. Kerns, 221st American Chemical Society Meeting, San Diego, California, (April 2001). Abstracts of Papers of the American Chemical Society, Vol 221; 49-Carb, Part 1, 2001.

2. “Regio and stereoselective synthesis of derivatives of L-idopyranosiduronic and D-glucopyranosiduronic acids from 4,5-unsaturated uronates” Bazin, H.G., Kerns, R.J., Linhardt, R.J. 215th American Chemical Society Meeting, Dallas, Texas, (April 1998). Abstracts of Papers of the American Chemical Society, Vol 215; 008-CARB Part 1, 1998.

1. “Synthesis of Heparin Oligosaccharides from Chiral Synthons,” Kerns R.J., Jandic, K., Vlahov, I.R., Pervin, A., Linhardt, R.J. 208th American Chemical Society Meeting, Abstracts of Papers of the American Chemical Society, 208: 50-CARB Part 1, AUG 21, 1994.

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ACTIVE AND PAST GRANT SUPPORT

Current Support:

“Antibacterial Agents that Restrict the Emergence of Resistance” Agency: NIH/NIAID Award Type: Research Project Grant, R01 AI087671 Principal Investigator: Robert J. Kerns, Ph.D. Total Costs: $1,899,430 Annual Direct Costs: $250,000 Period: 05/1/10 – 04/30/15

“Novel fluoroquinolones for killing dormant Mycobacterium tuberculosis” Agency: NIH/NIAID Award Type: R01 AI073491 Principal Investigator: Karl Drlica, Ph.D. (PHRI, Rutgers) Role: Co-I, Consortium Principal Investigator Total support Kerns subcontract = $103,392 Annual Direct Costs = $25,848 Period of Support: 08/01/12 – 07/31/16

“Using Click Chemistry to Identify Potential Drug Targets in Plasmodium” Agency: Department of Defense Award Type: USAMRMC/USAMRAA W81XWH-13-1-0429 Principal Investigator: Purnima Bhanot, Ph.D. (Rutgers) Role: Co-I, Consortium Principal Investigator Total support Kerns subcontract = $22,650 Period of Support: 09/30/2013 – 09/29/2014

“Predoctoral Training in the Pharmacological Sciences” Agency: NIH/NIGMS (T32GM067795) Principal Investigator: Stefan Strack, Ph.D. (UI Dept. of Pharmacology) Role: Trainer Previous trainees in Kerns Lab (Amanda Fenner, Tyrell Towle) Period: 07/1/02 – 06/30/17

“Predoctoral Training Program in Biotechnology” Agency: NIH/NIGMS (T32GM008365) Affiliated with Center for Biocatalysis and Bioprocessing (CBB) Training Program Principal Investigator: Amnon Kohen, Ph.D. (UI Dept. of Chemistry) Role: Trainer (Current CBB Trainee in Kerns Lab, Chaitanya Kulkarni) Past NIH Trainees, Kerns Lab (Cristina Fernandez; Beth Miskimins Mills; Kevin Marks; Heidi Schwanz) Period: 07/1/01 – 06/30/16

Pending Support:

“Augmenting Mitochondrial Respiratory Uncoupling for the Treatment of Obesity Agency: NIH; Type: R01 (1 R01 DK103685-01) Principal Investigators: Kerns & Sivitz Role: Co-PI (Contact PI) Proposed Period of Support: 09/01/14 – 08/31/18

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Past Support:

“Lethal Action of Fluoroquinolones with Non-Growing Mycobacterium Tuberculosis” Agency: NIH/NIAID Award Type: Research Project Grant, R01AI073491 Principal Investigator: Karl Drlica, Ph.D. (PHRI, UMDNJ) Consortium Principal Investigator: Robert J. Kerns, Ph.D. Total support Kerns subcontract = $442,500 Annual Direct Costs = $60,000 Period: 05/15/07 – 04/30/12

“Saccharide-Based Effectors of Cationic Antimicrobial Peptides” Agency: NIH/NIAID Award Type: Exploratory/Developmental, R21AI70939-1 Principal Investigator: Robert J. Kerns, Ph.D. Period: 07/1/06 – 06/30/09; Total support = $368,750

“New Inhibitors of Breast Cancer-Associated Heparanase” Agency: Department of Defense; U.S. Army (CDMRP) Award Type: Breast Cancer Research Program, Idea Award, DAMD17-01-1-0452 Principal Investigator: Robert J. Kerns, Ph.D. Co-Investigators: Mary Kosir, M.D. and Gerard Tromp, Ph.D. WSU School of Medicine Period: 9/1/01 – 8/31/2006; Total support = $446,983

“Inhibitors of Host-Pathogen Interactions” Agency: The University of Iowa Type: Carver Scientific Research Initiative Grant. Principal Investigator: Robert J. Kerns, Ph.D. Period: 1/01/05 - 12/31/05; Total Support = $29,717

“Antibacterial Efflux Pump Inhibitors” Agency: University of Iowa Biological Sciences Funding Program Type: Research Stimulation Grant Principal Investigator: Robert J. Kerns, Ph.D. Period: 1/1/03 – 12/31/03; Total Support = $22,740

“New Glycosaminoglycan-Based Anticoagulants Targeting Protein-Specific Binding and Oral Bioavailability” Agency: American Heart Association, Midwest Affiliate Type: Scientist Development Grant (SDG 0030390Z), Principal Investigator: Robert J. Kerns, Ph.D. Period: 7/1/00 – 6/30/03; Total support = $244,905

“Stable Stereoisomers of Topo IIbeta Inhibitors” Agency: NIH, 1R43CA090088-01 Type: Phase I SBIR. Principal Investigator: Ralph Parchment (SciTech, LLC), Detroit MI. Subcontract PI, Analog Design and Synthetic Chemistry: Robert J. Kerns, Ph.D. Period: 8/1/01 – 7/31/02; Total support = $37,250 plus supplies and reagents to Kerns

“New Modulators of Blood Coagulation Processes via the Exploration of Structural Diversity through Targeted Glycosaminoglycan Libraries” Agency: Wayne State University Type: Competitive Faculty Award for Graduate Student Assistantships Principal Investigator: Robert J. Kerns, Ph.D. Period: 8/19/01 – 8/18/02; Total support = $22,000

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“New Inhibitors of Malignancy Associated Heparan Sulfate-Protein Interactions” Agency: American Cancer Society. Type: Institutional Research Grant through the Barbara Ann Karmanos Cancer Institute, Principal Investigator: Robert J. Kerns Period: 10/99 – 6/00; Total support = $15,870

“New Inhibitors of Heparan Sulfate-Mediated Biological Processes” Agency: The American Association of Colleges of Pharmacy Type: New Investigator Program. Principal Investigator: Robert J. Kerns, Ph.D. Period: 12/1/00 – 11/30/01; Total support = $10,000

“Heparin-Affinity Label Conjugates” Agency: Wayne State University Research Awards Program Type: Competitive Research Stimulation Grant Award Principal Investigator: Robert J. Kerns Period: 5/1/99 – 4/31/00; Total support = $7,000

“New Antibiotics Derived from Glycosylation of Vancomycin” Agency: NIH, NIAID, (1 F32 AIO 9907-1) Type: National Research Service Award to Robert J. Kerns Postdoctoral Sponsor: Daniel E. Kahne, Princeton University

Participation in Funded Instrumentation and Infrastructure Grant Support:

"High-Throughput Drug Screening Robot" Agency: NCRR/NIH PI: Kevin G. Rice, PhD Type: S10 RR029274-01; 8/1/2011-7/31/2012 Role: Project contributor and Medicinal Chemistry support plan The proposal supported the purchase of a High Content Imaging Robot for drug screening and research.

“Acquisition of a 600 MHz Nuclear Magnetic Resonance Spectrometer” Agency: NCRR/NIH PI: James B. Gloer, PhD Type: 1S10RR025500-01; 5/15/2009-5/14/2011 Role: Project contributor The proposal supported the purchase of a 600 MHz NMR.

“Acquisition of a Q-TOF Mass Spectrometer” Agency: NCRR/NIH PI: James B. Gloer, PhD Type: 1S10RR023384-01; 1/15/2007-1/14/2008 Role: Project contributor The proposal supported the purchase of a hybrid quadrupole/orthogonal acceleration time-of-flight (oa- TOF) mass spectrometer.

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THESES/DISSERTATION/TRAINING/RESEARCH PROJECTS DIRECTED

Past Graduate Students Mentored to Degree:

Liusheng Huang: 1/99 - 2/03 (Ph.D., WSU)

Thesis Title: Parallel Synthesis and Screening of Libraries of Heparin-Based Biomimetics Targeting Heparan Sulfate-Mediated Biological Processes

First Position: Postdoctoral Research Associate with Dr. Paul Ortiz de Montellano in the Department of Pharmaceutical Chemistry at UCSF, San Francisco, California

Veena Diwadkar: 9/00 - 7/02 (MS, WSU)

Thesis Title: Chemical Modification of Heparin & Characterization of Heparin Derivatives First Position: Upon my move from WSU to U of I in 2002 Veena left the Department of Pharmaceutical

Sciences with a Master’s degree and enrolled in a Ph.D. program in the WSU School of Medicine.

Cristina Fernández-Pérez: 8/02 – 5/07 (Ph.D., U of I)

Thesis Title: Charge-Reduced Heparin Derivatives: New Antagonists of Glycosaminoglycan-Protein Interactions

First Position: Postdoctoral Research Associate with Dr. William Atkins in the Department of Medicinal Chemistry at the University of Washington, Seattle, Washington

Honors & Awards: Predoctoral Fellowship, Traineeship in Biotechnology (NIH T32) Externship/Internship Experience: Invitrogen (Madison Wisconsin)

Nadia German: 6/03 – 12/07 (Ph.D., U of I)

Thesis Title: Design and Synthesis of Molecules for Overcoming Bacterial Resistance to Fluoroquinolones

First Position: Postdoctoral Research Associate with Dr. Richard Glennon in the Department of Medicinal Chemistry at Virginia Commonwealth University, Richmond, Virginia

Christopher Hattan: 1/04 – 9/08 (Ph.D., U of I)

Thesis Title: Aryl Amides of Uronic Acid Containing Oligosaccharides as Bind and Block Antagonists of Heparin-Binding Proteins

First Position: Postdoctoral Fellowship (appointed to NIH T32 postdoctoral training program) with Dr. Serrine Lau in the Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson Arizona

Honors & Awards: Dissertation Fellowship, U of I College of Pharmacy

Beth Miskimins Mills: 1/05 – 5/10 (Ph.D., U of I)

Thesis Title: Modulatory activities of glycosaminoglycans and other polyanionic polysaccharides on cationic antimicrobial peptides

First Position: Assistant Professor of Medicinal Chemistry, Ferris State University College of Pharmacy, Big Rapids, Michigan Honors & Awards: Predoctoral Fellowship, Traineeship in Biotechnology (NIH T32)

Predoctoral Fellowship, American Foundation for Pharmaceutical Education (AFPE) Externship/Internship Experience: Pfizer Animal Heath (Kalamazoo, Michigan)

Publication from Research Internship: Miskimins Mills, B.; Zaya, M.J.; Walters, R.R.; Feenstra, K.L.; While, J.A.; Gagne, J.; Locuson, C.W. Current Cytochrome P450 Phenotyping Methods Applied to Metabolic Drug-Drug Interaction Prediction in Dogs. Drug Metabolism and Disposition, 2010, 38 (3), 396-404.

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Kevin R. Marks: 1/07 – 5/11 (Ph.D., U of I)

Thesis Title: Investigating the Fluoroquinolone-Topoisomerase Interaction by use of Novel Fluoroquinolone and Quinazoline Analogs

First Position: Research Scientist, Integrated DNA Technologies (Coralville, Iowa)

Honors & Awards: Predoctoral Fellowship, Traineeship in Biotechnology (NIH T32) Dissertation Fellowship, U of I College of Pharmacy

Externship/Internship Experience: Integrated DNA Technologies (Coralville, Iowa) Amanda Fenner: 1/07 – 12/11 (Ph.D., U of I)

Thesis Title: Design, Synthesis, and Evaluation of Small Molecule Glycosaminoglycan Mimics

First Position: Postdoctoral research fellow with Dr. William Gerwick, Scripps Institution of Oceanography, La Jolla, California

Honors & Awards: Predoctoral Fellowship, Pharmacological Sciences Training Program (NIH T32)

Predoctoral Fellowship, American Foundation for Pharmaceutical Education (AFPE)

Predoctoral Fellowship, American Chemical Society, Division of Medicinal Chemistry, Predoctoral Fellowship, sponsored by Bristol-Myers Squibb

Graduate Incentive Fellowship, University of Iowa

Dr. Eunice Schuytema Beam Travel Grant, awarded by the University of Iowa Women in Science and Engineering (WISE) Program

Selected for the Minority Health and Health Disparities International Research Training (MHIRT) Research Training Program in Panama; a five month training program in natural product drug discovery and an additional three month mentorship role training new students in the program

Externship/Internship Experience: Smithsonian Tropical Research Institute (Panama City, Panama)

Publication from External Research Traineeship: Balunas, M.J., Linington, R.G., Tidgewell, K., Fenner, A.M., Ureña, L-D., Togna, G.D., Kyle, D.E., Gerwick, W.H. Dragonamide E, a Modified Linear Lipopeptide from Lyngbya majuscula with Antileishmanial Activity. Journal of Natural Products, 2010, 73 (1) 60-66. PMCID:PMC2834186

Heidi Schwanz: 1/08 – 7/12 (Ph.D. U of I)

Thesis Title: Structural Features of Fluoroquinolone-Class Antibiotics that Affect Lethal Activities and DNA binding.

First Position: Postdoctoral research fellow with Dr. James Hamilton, Boston University School of Medicine, Department of Physiology and Biophysics, Boston, Massachusetts.

Honors & Awards: Predoctoral Fellowship, Center for Biocatalysis & Bioprocessing Predoctoral Fellowship, Traineeship in Biotechnology (NIH T32)


Externship/Internship Experience: Alkermes (Waltham, Massachusetts)

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Tyrell Towle: 1/10 – 8/13 (Ph.D. U of I)

Thesis Title: Synthesis of Novel Fluoroquinolone Derivatives Toward Understanding Aspects of Function.

First Position: Postdoctoral research fellow with Dr. Robert J. Kerns, University of Iowa, Department of Pharmaceutical Sciences & Experimental Therapeutics

Honors & Awards: Predoctoral Fellowship, Pharmacological Sciences Training Program (NIH T32)


Predoctoral Fellowship, The Richard B. Silverman Predoctoral Fellowship in Medicinal Chemistry, American Chemical Society, Division of Medicinal Chemistry

Current Graduate Students:

Ben Williamson: 1/10 – present (Ph.D. candidate)

Honors & Awards: Dissertation Fellowship, U of I College of Pharmacy

Ioana Craciun: 1/11 – present (Ph.D. candidate)

Chaitanya Kulkarni: 1/12 – present (Ph.D. candidate)

Honors & Awards: Predoctoral Fellowship, Center for Biocatalysis & Bioprocessing

Justine Winstead: 1/13 – present (Ph.D. candidate)

Honors & Awards: University of Iowa Dean’s Graduate Research Fellow Predoctoral Fellowship, Traineeship in Biotechnology (NIH T32)

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Postdoctoral Fellows and Research Associates: Current Postdoctoral Fellows & Research Associates:

None currently

Past Postdoctoral Fellows and Research Associates:

Tyrell Towle, Ph.D. (09/2013 – 06/2014) Graduate Degree: Medicinal & Natural Products Chemistry, University of Iowa Position: Independent scientific consultant, Seattle Washington Gangqin Li, MS. (10/10 – 5/12) Graduate Degree: Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China Position: Research scientist, Roche R&D Center (China) Ltd pRED China Dr. Jose Luis Hernández-García, Ph.D. (09/10-5/11) Graduate Degree: Organic Chemistry, Benemérita Universidad Autónoma de Puebla, Mexico Position: Res. Assistant, Department of Pharmacy, CIATEJ, Monterrey, Mexico Dr. Peng Wei, Ph.D. (1/03-10/05) Graduate Degree: Chemistry, University of Missouri, Kansas City Position: Res. Scientist, Adesis Inc., New Castle, DE Dr. YuZeng Liang, Ph.D. (2/02-11/03) Graduate Degree: Chemistry, Peking University, China (2000) Previous Position: Postdoc with Tim Patten at University of California, Davis, 2000-2002 Position: Res. Scientist, Glycomimetics Inc., Gaithersburg, MD Dr. Kamel Benakli, Ph.D. (8/99-1/02) Graduate Degree: Organic Chemistry, University of Aix-Marseille, France (1999) Position: Senior Research Scientist, NéoKimia Inc., Sherbrooke, QC, Canada Dr. Charles Zha, Ph.D. (11/00-7/02) Graduate Degree: Chemistry, University of Alabama at Birmingham (1999) Previous Position: Postdoc with George Kenyon at University of Michigan 1999-2000 Position: Senior Research Scientist, Albany Molecular Research, Inc, Albany, NY Jonathan Rosen, (8/07 – 5/09) Degree: BS, Medicinal Chemistry, State University of New York at Buffalo (1996) Previous Position: Senior Research Chemist, Merck & Co., Inc., 1996-2007 Position: U of I Biostatistics Graduate Program, (MS, 2011).

Other Research Projects and Mentoring Directed:

Undergraduate Thesis : Vaka, Flamur; 4/00-12/01 (BS, Chemistry, WSU) Thesis Project: Synthesis of Novel Fluoroquinolone Dimers

Undergraduate Research Projects: Anna Kovaciny-Ackerman; Summer 2003, U of I (MNPC Summer Undergraduate Research Program)

PharmD Research Projects Carolyn Schneider (WSU, 2001 - 2002) & Research Rotations: Nicki Brogden (U of I, 2004 - 2005) Brandi Lehman (U of I, 2005) Michael Hirsch (U of I, 2006 - 2007) Jung (Glara) Seo (U of I, 2008) Alex Kopelyan (U of I, 2012)

Special Undergraduate Research Rotations: Yong (Caleb) Oh (IBA Program, Spring 2006)

Special Teaching Projects/Programs: 2- hour lecture & discussion, anti-infective drug discovery; Junior Scholars Academy Summer Program, The U of I for Belin-Blank Center (2009 & 2011).

1-hour lab on Pharmaceutical Chemistry, PharmCamp for 5th & 6th grade girls (summer 2012) 20

http://www.education.uiowa.edu/belinblank/


SERVICE ASSIGNMENTS

University of Iowa and College of Pharmacy Service Assignments (2002 – present)

Ongoing Service Assignments (*chair or director positions are indicated with an asterisk)

College of Pharmacy Laboratory Safety Committee (2014 – present) University of Iowa Conflict of Interest in Research Committee (2014 – present) College of Pharmacy Strategic Planning Advisory Committee & Planning Core Group (2014 – present) Search Committee Member, PTT Pharmacogenomics Faculty Search (2014 – present) University of Iowa Division of Sponsored Programs Faculty Advisory Group (2012 – present) *Director of Industrial Internships: T32 Traineeship in Biotechnology (2012 – present) Faculty Advisory Committee, U of I High Throughput Screening Facility (2011 – present) Coordinating Committee: CBB/NIH T32; Traineeships in Biotechnology (2010 – present) College of Pharmacy, College Council (2010 – present) *Director of MNPC Graduate Student Recruiting (2010 – present) Advisory Committee, U of I High Resolution Mass Spectrometry Core Facility (2008 – present)

Completed Service Assignments (*items with an asterisk were chair or director positions)

College of Pharmacy Curriculum Implementation Committee (2014) Search Committee Member; PSET Department Chair Search (2013 – 2014) Search Committee Member, PTT Administrative Services Coordinator (2014) College of Pharmacy Curriculum Transformation Committee (2010 – 2014) COP representative at Batelle Consulting Group meeting with UI Deans & economic development partners (Iowa City; 1/2014) COP representative at Iowa Board of Regents Facilities & Planning Committee meeting (Cedar Falls, IA; 9/2013) Member of PTT Division Consulting Group for Promotion Evaluation (2013) PharmD Curriculum Transformation Foundational Courses Work Group (2013) College of Pharmacy, Executive Committee (2010 – 2013) Division of Pharmacy Practice and Science 5-year Post-Tenure Review Committee (Spring 2013) Faculty Panel for Department of Pharmacology 5-yr Departmental Review (2013) U of I Department of Chemistry External Review, Leaders from Affiliated Centers & Facilities Panel (2012) Search Committee Member, College of Pharmacy Research Support Manager (2012) Ad Hoc Committee to Develop Annual and 5-year Faculty Review Policies (2011 – 2012) Ad Hoc Advisory Group to Select Iowa and National Architects for COP New Building (2011/2012) U of I, HRMS Central Research Facility Review Committee (2010/2011) Search Committee Member; PSET Department Chair Search (2010/2011) Search Committee Member; PSET Administrative Assistant I (2011) *Chair, Probationary Faculty 3rd Review Committee, MNPC 2010/2011 Interviewer, PharmD Admissions Interviews (2004 – 2008, 2011, 2012, 2013) CBB/NIH Biotechnology Traineeship (T32) Fellowship Application Reviews (2010, 2011) College of Pharmacy Admissions Committee (2008 – 2010) Curriculum Subcommittee, College of Pharmacy Re-accreditation Self-Study (2008 – 2010) MNPC Division Consulting Group for Promotion and Tenure (2009) *Chair, College of Pharmacy Teacher of the Year Committee (2008/2009) *Chair, U of I College of Pharmacy PharmD Curriculum Committee (2006 – 2008) MNPC Faculty Search Committee (2007/2008) College of Pharmacy Research Equipment Committee (2007/2008) Seminar on Careers in Pharmacy, Univ. of Northern Iowa (April 2008) Peer Evaluation of Teaching Task Force; Pilot Faculty Review (2008) Mentor, College of Pharmacy Professional Mentoring Program (2006 – 2008) *Director of MNPC course series prerequisite assessment (2005 – 2008) University of Iowa New Faculty Orientation, Tenured Faculty Panel (2007) Division Consulting Group, MNPC Probationary Faculty Review (2007) Participating Editor, TeachingTalk, U of I Center for Teaching (2007 – 2010) College of Pharmacy Dean Search Committee (2006/2007) Division Consulting Group; Promotion and Tenure (2006/2007) *Chair, College of Pharmacy Research Equipment Committee (2006/2007) *Director, MNPC Summer Undergraduate Research Program (2002 - 2007) College of Pharmacy Assessment Committee (2002 - 2006) Task Force to Assess Organizational Structure of the College of Pharmacy (2005) *Chair, 2005 Teacher of the Year Selection Committee (2005) College of Pharmacy Space Utilization Committee (2004/2005) College of Pharmacy Self Study on Graduate Education and Research (2004 - 2005) College of Pharmacy Executive Committee & College Council (2004/2005) Curriculum Committee (2003/2004) MNPC Faculty Search Committee (2003/2004) Pharmacy Practice Faculty Search Committee for PPL Instructor (2003) Curriculum Subcommittee, College of Pharmacy Re-accreditation Self-Study (2002 - 2004)

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Intercollegiate Service Assignments and Service/Learning/Training Programs (2002 – present)

External Dossier Reviews Completed -UCSF – Promotion Dossier Review (2014) -JUST – P & T Dossier Review (2014) -U of MN – Promotion Dossier Review (2013) -UMDNJ – P & T Dossier Review (2012) -UAEU – P & T Dossier Review (2011)

Intercollegiate Leadership Development and Training Programs -Committee on Institutional Cooperation (CIC) DEO Seminars Program, Chicago IL (Oct. 11-13, 2012) -Committee on Institutional Cooperation (CIC) Academic Leaders Program (2014/2015)

Research/Scholarship/Academic Learning Programs, Awards, Seminars &/or Conferences Attended -U of I Career Development Award (July 1 – December 31, 2009) “Development of Novel Antibiotics against Drug-Resistant Microorganisms” -Drug Discovery in Academia Conference, Hosted by Johns Hopkins, Baltimore MD (Oct. 18-19, 2011) -Violent Incident Survival Training; U of I Police Department, Iowa City, IA (Dec. 4, 2012) -NIH Team Science Workshop, Building Successful Research Collaborations; Iowa City, IA (Jan. 14, 2013) -Drug Discovery in Academia Conference, Hosted by Vanderbilt University, Nashville, TN (Oct. 10-11, 2013) -Member, Sloan Center for Exemplary Mentoring, University of Iowa, Iowa City, IA (2013 – present)

Graduate Dissertation/Degree Examination Committees (2002 – present): #denotes external thesis/dissertation examiner

Jenny Lee (Ph.D., 2002, MNPC, Robert J. Linhardt Advisor) Kevin Marks (Ph.D. 2011, MNPC, Robert Kerns Advisor) Aimin He (Ph.D., 2002, MNPC, John P.N. Rosazza Advisor) Kathleen Cornelius (MS 2011, MNPC, Kevin Rice Advisor) Sungwon Lee (Ph.D., 2003, MNPC, John P.N. Rosazza Advisor) Heng Zhang (MS 2011, MNPC, Robert Kerns Admin. Advisor) Tasneem Islam (Ph.D., 2004, Chemistry, Robert J. Linhardt Advisor) Edugie Ekuase (Ph.D. 2011, MNPC, Michael Duffel Advisor) Idil Apak Evans (Ph.D., 2004, MNPC, Michael Duffel Advisor) David Anderson (Ph.D. 2011, MNPC, Jon Doorn Advisor) Atmeja Saxena (Ph.D.; 2004, MNPC, Michael W. Duffel Advisor Erin Allen (Ph.D. 2011, MNPC, Jon Doorn Advisor) Ramya Seshadri (Ph.D., 2005, MNPC, John P.N. Rosazza Advisor) Amanda Fenner (Ph.D. 2011, MNPC, Robert Kerns Advisor) Haining Yu (Ph.D., 2005, MNPC, Robert J. Linhardt Advisor) Enoch Mensah (Ph.D. 2011, Chemistry, Hien Nguyen Advisor) Yiang Kang (Ph.D., 2005, MNPC, Zhendong Jin Advisor) Lydia Mexas (Ph.D. 2012, MNPC, Jon Doorn Advisor) Cristina Fernandez Perez (Ph.D., 2007, MNPC, Robert Kerns Advisor) Heidi Schwanz (Ph.D. 2012, MNPC, Robert Kerns Advisor) Nadia German (Ph.D., 2007, MNPC, Robert Kerns Advisor) Laurie Eckert (Ph.D. 2012, MNPC, Jon Doorn Advisor) Molly Martin (Ph.D., 2007, MNPC, Kevin Rice Advisor) Mark Ericson (Ph.D. 2012, MNPC, Kevin Rice Advisor) Kevin Tidgewell (Ph.D., 2007, MNPC, Tom Prisinzano Advisor) Amninder Kaur (Ph.D. 2012, Chemistry, James B. Gloer Advisor) H. Ozan Gulcan (Ph.D., 2008, MNPC, Michael Duffel Advisor) Koby Kizzire (Ph.D. 2013, MNPC, Kevin Rice Advisor) Rodolfo Tello-Aburto (Ph.D., 2008, MNPC, Horacio Olivo Advisor) Aaron Carlos Monroy (Ph.D. 2013, MNPC, Dave Roman Advisor) Antonio Osorio-Lozada (Ph.D. 2008, MNPC, Horacio Olivo Advisor) Tyrell Towle (Ph.D. 2013, MNPC, Robert Kerns Advisor) Garrett Rettig (Ph.D. 2008, MNPC, Kevin Rice Advisor) Edwin Squirewell (Ph.D. 2014, MNPC, Michael Duffel Advisor) Christopher Hattan (Ph.D. 2008, MNPC, Robert Kerns Advisor) Alyssa Hartung (Ph.D. 2014, Chemistry, David Weimer Advisor) Jennifer Reese (Ph.D. 2009, MNPC, Jon Doorn Advisor) # Jacob Heppell (Ph.D. 2014, LaTrobe University, Victoria Australia) Kevin Anderson (Ph.D. 2009, MNPC, Kevin Rice Advisor) Beth Miskimins-Mills (Ph.D. 2010, MNPC, Robert Kerns Advisor) Patrick Ndungu (data sessions in progress, Chemistry, Hien Nguyen Advisor) David Beyer (data sessions in progress, Biochemistry, Maria Spies Advisor) Joseph C. Cannistra (data sessions in progress, Chemistry, James B. Gloer Advisor) Samuel Thomas Crowley (data sessions in progress, MNPC, Kevin Rice Advisor) Duncan Mackie (data sessions in progress, MNPC, Dave Roman Advisor)

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Graduate Program Predoctoral Qualifying Exam Committees (2002 – present): *Written exam only, did not participate in oral examination.

Zhengmao Hua (2003, MNPC Ph.D. candidate, Zhendong Jin Advisor) Yiang Kang (2003, MNPC Ph.D. candidate, Zhendong Jin Advisor) Molly Sinclair (2004, MNPC Ph.D. candidate, Kevin Rice Advisor) Haining Yu (2004, MNPC Ph.D. candidate, Eric Edens/Robert J. Linhardt Advisor) Yan Mei (2004, MNPC Ph.D. candidate, Zhendong Jin Advisor)

Changgang Lou (2004, MNPC Ph.D. candidate, Zhendong Jin Advisor) Nadia German (2004, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Cristina Fernández-Perez (2004, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Rodolfo Tello-Aburto (2005, MNPC Ph.D. candidate, Horacio Olivo Advisor) Kevin Tidgewell (2005, MNPC Ph.D. candidate, Thomas Prisinzano Advisor) Christopher Hattan (2005, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Garrett Rettig (2005, MNPC Ph.D. candidate, Kevin Rice Advisor) Jason Smart (2005/2006, MNPC Ph.D. candidate, Mike Duffel Advisor) Kevin Anderson (2006, MNPC Ph.D. candidate, Kevin Rice Advisor) Ozan Gulcan (2006, MNPC Ph.D. candidate, Mike Duffel Advisor) Jennifer Reese (2006, MNPC Ph.D. candidate, Jon Doorn Advisor) Antonio Osorio-Lozada (2006, MNPC Ph.D. candidate, Horacio Olivo Advisor) Beth Miskimins (2006, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Mathew Schmidt (2006/2007, MNPC Ph.D. candidate, Thomas Prisinzano Advisor) David Anderson (2007, MNPC Ph.D. candidate, Jon Doorn Advisor) Anthony Lozama (2007/2008, MNPC Ph.D. candidate, Thomas Prisinzano Advisor) Nicholas Baumhover (2007/2008, MNPC Ph.D. candidate, Kevin Rice Advisor) Edugie Ekuase (2007/2008, MNPC Ph.D. candidate, Mike Duffel Advisor) Kevin Marks (2008, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Amanda Fenner (2008, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Erin Gagan-Allen (2008, MNPC Ph.D. candidate, Jon Doorn Advisor) Heidi Schwanz (2009, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Lydia Mexas* (2009, MNPC Ph.D. candidate, Jon Doorn Advisor) Lauri Eckert* (2009, MNPC Ph.D. candidate, Jon Doorn Advisor) Jason Dusky* (2009, MNPC Ph.D. candidate, Kevin Rice Advisor) Mark Ericson* (2009, MNPC Ph.D. candidate, Kevin Rice Advisor) Adam Tordoff* (2009, MNPC Ph.D. candidate, Horacio Olivo Advisor) Koby Kizzire (2010, MNPC Ph.D. candidate, Kevin Rice Advisor) Kathleen Cornelius (2010, MNPC Ph.D. candidate, Kevin Rice Advisor) Aaron Monroy (2010, MNPC Ph.D. candidate, David Roman Advisor) Samuel Thomas Crowley (2011, MNPC Ph.D. candidate, Kevin Rice Advisor) Duncan Mackie (2011, MNPC Ph.D. candidate, David Roman Advisor) Benjamin Williamson (2011, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Tyrell Towle (2011, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Edwin Squirewell (2011, MNPC Ph.D. candidate, Mike Duffel Advisor) Ioana Craciun (2012, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Colin Higgins (2012, MNPC Ph.D. candidate, David Roman Advisor) Eric Rodriguez (2012, MNPC Ph.D. candidate, Mike Duffel Advisor) Brigitte Vanle (2012, MNPC Ph.D. candidate, Jon Doorn Advisor) Aashay Shah (2012, MNPC Ph.D. candidate, Zhendong Jin Advisor) David Beyer (2013, Biochemistry Ph.D. candidate, Maria Spies Advisor) Christopher Bodle (2013, MNPC Ph.D. candidate, David Roman Advisor) Chaitanya Kulkarni (2013, MNPC Ph.D. candidate, Robert J. Kerns Advisor) Josie Schamp (2013, MNPC Ph.D. candidate, Jon Doorn Advisor) Chris White (2014, MNPC Ph.D. candidate, Kevin Rice Advisor) Luis Mullins (2014, MNPC Ph.D. candidate, Mike Duffel Advisor) Michael Hayes (2014, MNPC Ph.D. candidate, Dave Roman Advisor)

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TEACHING ASSIGNMENTS

The University of Iowa (Fall 2002 – Present)

Course Name (Number) Semester Role Contact Hrs. No. Students

Professional Program:

Survey Seminar Series for Pharm.D. Students, (046:012 - Pharm.D. Elective)* Spring 2008 Course Coordinator 19 7 Fall 2007 Course Coordinator 15 6 Spring 2007 Course Coordinator 29 13 Fall 2006 Course Coordinator 17 7 Spring 2006 Course Coordinator 11 4 Fall 2005 Course Coordinator 5 1

MNPC-I (46:128) Spring 2014 Instructor 8 108 Spring 2013 Instructor 20 109 Spring 2012 Instructor 23 108 Spring 2011 Instructor 23 108 Spring 2008, ’09, ‘10 Course Coordinator 23/23/23 109/110/108 Spring 2005, ’06, ‘07 Course Coordinator 30/30/30 111/110/105

Spring 2003 & ‘04 Course Coordinator 20/20 110/110

MNPC-II (46:131) Fall 2003 Instructor 14 110

IPE I (046:001)† 2007/2008 Review Reflection Reports 5 5

IPE I (046:001)† 2007/2008 Student Shadow Rotation 16 2

IPPE 4 (46:004) Fall 2010 PODS South; emotions disc. 1 12

P4 Pharm.D. Advanced Practice Rotation Research Elective (046:199) Fall 2005 Instructor 16 1

Pharmacy Projects (046:101) - Pharm.D. Research Projects in my lab for Credit Spring 2012 Course Coordinator 8 1 Spring 2008 Course Coordinator 8 1 Spring 2007 Course Coordinator 8 1

Fall 2006 Course Coordinator 8 1

Honors Seminar Spring 2003 Instructor 1 10

*Contact hours for the Pharm.D. seminar elective (46:012) covers course management, coordination, communicating seminar announcements and evaluating reports. The course is managed via e-mail after initial course meetings. †Contact hours for the IPE I reflections and rotations cover student contact, reviewing reflections and writing critiques, and other communication and coordination efforts.

MNPC-I (46:128): Doctor of Pharmacy Program Anti-infective agents including anti-microbial, anti-viral, anti-helminthes, anti-parasitics, anti-tuberculosis (24 lectures). Lectures covering fundamentals of prodrugs, anticoagulant agents and other agents used in thrombosis and hemostasis (6 lectures)

MNPC-II (46:131): Doctor of Pharmacy Program Peptide/protein structure and function, peptide-based therapeutics, peptide hormones, agents used to treat diabetes, agents used to treat thyroid conditions (14 lectures).

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Course Name (Number) Semester Role Contact Hrs. No. Students

Graduate Program:

Current Medicinal Chemistry (046:215) Fall 2014 Course Coordinator 45 8 Fall 2012 Course Coordinator 45 7 Fall 2010 Course Coordinator 45 13 Fall 2008 Course Coordinator 45 14 Spring 2006 Course Coordinator 45 8 Spring 2004 Course Coordinator 45 11

Introduction to Pharmaceutical Sciences Research (046:284) Fall 2013 Instructor 2 6

Advanced Problem Solving in Pharmacological Sciences (071:250) Fall 2007 Instructor 6 6

Principles of Scholarly Integrity (650:270/604) Spring 2011 Faculty Facilitator 3 + faculty workshops 8 Fall 2011 Faculty Facilitator 3 + faculty workshops 8 Spring 2012 Faculty Facilitator 3 + faculty workshops 10

Perspectives in Medicinal & Natural Products Chemistry (046:135) Each Fall, 2002 - 2009 Instructor 2 per year 4-6/yr Fall 2010 Course Coordinator/Instructor 2 5 Fall 2011 Course Coordinator/Instructor 2 6 Fall 2012 Course Coordinator/Instructor 2 4 Fall 2013 Course Coordinator/Instructor 2 5 Fall 2014 Course Coordinator/Instructor 2 5

Medicinal & Natural Products Chemistry Research (046:217)* 2002 Research Mentoring 2 2003 Research Mentoring 3 2004 Research Mentoring 5 2005 Research Mentoring 5 2006 Research Mentoring 6 2007 Research Mentoring 9 2008 Research Mentoring 6 2009 Research Mentoring 6 Spring/Summer 2010 Research Mentoring 6 *Fall 2010 Research Mentoring 7 Spring/Summer 2011 Research Mentoring 7/5 *Fall 2011 Research Mentoring 7 Spring/Summer 2012 Research Mentoring 5 *Fall 2012 Research Mentoring 6 Spring/Summer 2013 Research Mentoring 4 *Fall 2013 Research Mentoring 5 Spring/Summer 2014 Research Mentoring 4 *Fall 2013 Research Mentoring 5

*(No. students in fall semesters includes first year rotating graduate students)

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Wayne State University Teaching Assignments (Fall 1998 – Spring 2002)

Pharmaceutical Sciences Graduate Program Winter 1999, Winter 2001: PSC 7010, Principles of Drug Action I Combinatorial Chemistry Approaches (2h)

Fall 2000: PSC 6000, Fundamentals of Drug Design Drugs Targeting DNA and RNA (2h) Anti-Infective Agents/Drug Resistance (2h)

Each Term: PSC 7800, Research Techniques in Medicinal Chemistry

Each Term: PSC 8650, Special Topics: Medicinal Chemistry College of Pharmacy Professional Program

Fall 1998, Fall 1999, Fall 2000, Fall 2001: PSC 3110, Pharmaceutical Biochemistry Carbohydrate Structure and Function (3h) Carbohydrates: Energetics and Metabolism (4h)

Winter 1999, Winter 2000, Winter 2001, Winter 2002: PHA 4210, Infectious Disease; Medicinal Chemistry Lectures Antibiotics (8h), Antituberculosis Agents(2h) Antiprotazoal/Antihelmintic Agents/Antifungal (4h) Antiviral (2)

Fall 1999, Fall 2000, Fall 2001: PHA 4150, Cardiovascular Pharmacotherapeutics; Medicinal Chemistry Lectures

Chemistry of Thrombosis: Anticoagulant/Antithrombotic Drugs (2h)

Winter 2000: PPR 4420, Patient Care Laboratory IV; Directed a group study assignment on discovery and

development of anti-infective agents.

Spring/Summer 2000: PSC 5991, Directed Study in Medicinal Chemistry (B.S.)

Spring/Summer 2001 and each term to present: PSC 7800, Research Techniques in Med. Chem. (Pharm.D. Directed Study) Wayne State University School of Medicine

Fall 1999, Fall 2000, Fall 2001: Immunology/Microbiology, Year 2 Curriculum Antimicrobial Agents (4h) Wayne State University Service Assignments (Fall 1998 – Spring 2002):

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Committee Assignments:

College/Department Committee Membership:

PSC Enhancement Committee (2001-2002) PSC Appointments Committee (1998-2002) Pharm.D. Admissions Committee (1999-2002) PSC Departmental Review Committee (2001) Strategic Planning Action Committee: Basic Research (2000) Departmental Salary Review Committee ('99/'00, '01/'02) Honors Committee (1998-2000)

Wayne State Graduate Dissertation Committees:

Liusheng Huang (Ph.D., Robert J. Kerns Advisor) Veena Diwadkar (M.S., Robert J. Kerns Advisor) Todd Zahn (Ph.D., Richard Gibbs Advisor) Ying Shao (M.S., Richard Gibbs Advisor) Tracy Ward (Ph.D., Patrick Woster Advisor)

Wayne State Inter-Departmental Graduate Dissertation Committees:

Jianwen Fang (Ph.D., Organic Chemistry with Professor George Wang) Qinglin Li (Ph.D., Analytical Chemistry with Professor Colin F. Poole)

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curriculum vitae robert j. kerns, ph.d. · 2014-08-12 · curriculum vitae – robert j. kerns,...

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