MARCO CANEPA, MD, PhD 1/8

MARCO CANEPA, MD, PhD CURRICULUM VITAE – April 2017

PERSONAL INFORMATION First and last name Marco Canepa Place, date of birth Genova, August 17th1981 Nationality Italian Phone (+39) 010-5555834 E-mail marco.canepa@unige.it; marco.canepa@nih.gov CURRENT APPOINTMENTS Since August 2012 to now

Assistant Professor of Cardiology - Attending Cardiologist School of Medicine, University of Genova, Genova, Italy Cardiovascular Disease Unit, San Martino Hospital - IST Department of Internal Medicine, Genova, Italy Chief: Claudio Brunelli, MD.

• Head of the Hypertrophic Cardiomyopathy Clinic • Co-Head of the Heart Failure Outpatient Clinic

Since July 2013 to now

National Institute of Health Special Volunteer (off site) National Institute on Aging, NIH, Baltimore, MD, USA Longitudinal Study Section/Translational Gerontology Branch PI: Luigi Ferrucci, MD, PhD, Scientific Director

PREVIOUS POSITIONS From March 15th, 2017 to April 18th, 2017

National Institute of Health Special Volunteer (on site) National Institute on Aging, NIH, Baltimore, MD, USA Longitudinal Study Section/Translational Gerontology Branch PI: Luigi Ferrucci, MD, PhD, Scientific Director

From January 8th 2015 to February 6th, 2015

Johns Hopkins University Visiting Scientist Hypertrophic Cardiomyopathy Center of Excellence Department of Medicine, Cardiovascular Division Johns Hopkins University School of Medicine, Baltimore, MD, USA PI: Theodore P. Abraham, MD

From August 1st, 2012 to January 7th, 2015

Johns Hopkins University Research Fellow Hypertrophic Cardiomyopathy Center of Excellence Department of Medicine, Cardiovascular Division Johns Hopkins University School of Medicine, Baltimore, MD, USA PI: Theodore P. Abraham, MD

MARCO CANEPA, MD, PhD 2/8

From September 1st, 2011 to July 3rd, 2013

National Institute of Health Visiting Fellow National Institute on Aging, NIH, Baltimore, MD, USA - Longitudinal Study Section/Translational Gerontology Branch PI: Luigi Ferrucci, MD, PhD, Scientific Director - Human Cardiovascular Study Section/Laboratory of Cardiovascular Sciences PI: Edward G. Lakatta, MD.

From February 2nd, 2011 to June 30th, 2011

National Institute of Health Special Volunteer (on site) National Institute on Aging, NIH, Baltimore, MD, USA Longitudinal Study Section/Translational Gerontology Branch PI: Luigi Ferrucci, MD, PhD, Scientific Director

MEDICAL EDUCATION and TRAINING From January 1st, 2012 to April 14th, 2015

Doctor of Philosophy (PhD) degree in Cardiovascular Biology and Pathophysiology (3 years) School of Clinical and Experimental Internal Medicine, University of Genova, Italy PhD dissertation: “Contribution of arterial stiffening, left ventricular diastolic dysfunction and changes in body composition to cardiovascular aging” Final grade: excellent

From July 2007 to July 2011

Fellowship in Cardiology (4 years) University of Genova, Italy Final grade: 50/50 cum laude

February 2007 Italian Medical License (3 months) Final score: 270/270

From July 2000 to July 2006

Doctor of Medicine (MD) degree (6 years) School of Medicine, University of Genova, Italy Final grade: 110/110 cum laude and merit award

MARCO CANEPA, MD, PhD 3/8

RESEARCH ACTIVITIES CURRENT RESEARCH COLLABORATIONS

− Investigator of the EuroObservational Programme promoted by the European Society of Cardiology, HFA Heart Failure Long-Term Registry. Contact person: Aldo P. Maggioni, MD (1 completed project, 2 ongoing projects)

− Investigator of the GISSI-HF trial (Gruppo Italiano per lo Studio della Sopravvivenza nell Infarto miocardico–Heart Failure). Contact person: Luigi Tavazzi, MD (1 completed project, 1 ongoing project)

− Investigator of the RED-HF trial (Reduction of Events by Darbepoetin Alfa in Heart Failure). Contact person: Karl Swedberg, MD (1 ongoing project)

− Investigator of the Baltimore Longitudinal Study of Aging (BLSA), National Institute on Aging/NIH, Baltimore MD, USA. Contact person: Luigi Ferrucci, MD, PhD (ongoing collaboration, co-administrator of the echocardiography dataset)

− Member of the Heart Failure Working Group of the Italian Cardiovascular Research Institutes Network. Contact person: Edoardo Gronda, MD (1 ongoing project)

− Member of the Working group “Cardiomyopathies and pericardial diseases” promoted by the Italian Society of Cardiology (SIC). Contact person: Francesco Pelliccia, MD

CURRENT RESPONSABILITIES IN CLINICAL TRIALS and REGISTRIES

− Principal Investigator of the NOAH – AFNET 6 trial (Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes) at the San Martino IST Hospital, Genova (active, recruiting)

− Principal Investigator of the BLITZ-Heart Failure registry at the San Martino IST Hospital, Genova (active, recruiting)

− Cardiology consultant for the project “Predictors of rehospitalization in patients with heart failure in the Liguria region” promoted by ALISA (Azienda Ligure Sanitaria della Regione Liguria, Regional Health System Administration)

MARCO CANEPA, MD, PhD 4/8

RESEARCH-RELATED SKILLS and EXPERIENCES

− Advanced experience with SAS (Statistical Analysis System) language and most of the procedures and options used in clinical research, cross-sectional, longitudinal and epidemiology analysis

− Partner of the REDCap (Research Electronic Data Capture) Consortium (project-redcap.org) promoted by the University of Vanderbilt (Nashville, TN, USA) and REDCap Administrator at the University of Genova, Italy

− Peer-reviewer for the following international journals: Circulation, Circulation

Cardiovascular Imaging, Hypertension, the American Journal of Cardiology, the Journal of Clinical Endocrinology & Metabolism, Nutrition Metabolism and Cardiovascular Disease, the International Journal of Cardiology, the Journal of the American Heart Association, PLOS One, the Journal of the American Geriatrics Society and the Journal of Cardiovascular Medicine

− Organizer and contact person of the TEDMEDLive event streaming (http://www.tedmed.com/) at the School of Medicine of the University of Genova, Genova, Italy (years 2015 and 2016)

− English: highly proficient in both spoken and written English (Common European Framework C1)

SELECTED PUBLICATIONS ON PEER-REVIEWED JOURNALS (chronological order)

− Solari D, Bertero E, Miceli R, Brunelli C, Ameri P, Canepa M. Methods, accuracy and clinical implications of atrial fibrillation detection by cardiac implantable electronic devices. Int J Cardiol. 2017 Jan 14. PMID: 28143653.

− Canepa M, Vianello PF, Abraham TP. T1 mapping with cardiovascular magnetic resonance: an emerging clinical biomarker. Heart. 2017 Feb 15;103(4):326. PMID: 28130438.

− Altieri P, Murialdo R, Barisione C, Lazzarini E, Garibaldi S, Fabbi P, Ruggeri C, Borile S, Carbone F, Armirotti A, Canepa M, Ballestrero A, Brunelli C, Montecucco F, Ameri P, Spallarossa P. 5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1. Br J Pharmacol. 2017 Jan 27. PMID: 28127745.

− Gigli L, Ameri P, Secco G, De Blasi G, Miceli R, Lorenzoni A, Torre F, Chiarella F, Brunelli C, Canepa M. Clinical characteristics and prognostic impactof atrial fibrillation in patients with chronic heart failure. World J Cardiol. 2016 Nov 26;8(11):647-656. PMID: 27957251.

MARCO CANEPA, MD, PhD 5/8

− Canepa M, Viazzi F, Strait JB, Ameri P, Pontremoli R, Brunelli C, Studenski S, Ferrucci L, Lakatta EG, AlGhatrif M. Longitudinal Association Between Serum Uric Acid and Arterial Stiffness: Results From the Baltimore Longitudinal Study of Aging. Hypertension. 2017 Feb;69(2):228-235. PMID: 27956574.

− Canepa M, Temporelli PL, Rossi A, Rossi A, Gonzini L, Nicolosi GL, Staszewsky L, Marchioli R, Maggioni AP, Tavazzi L; GISSI-HF Investigators. Prevalence and Prognostic Impact of Chronic Obstructive Pulmonary Disease in Patients with Chronic Heart Failure: Data from the GISSI-HF Trial. Cardiology. 2016 Sep 8;136(2):128-137. PMID: 27618363.

− Lazzarini E, Balbi C, Altieri P, Pfeffer U, Gambini E, Canepa M, Varesio L, Bosco MC, Coviello D, Pompilio G, Brunelli C, Cancedda R, Ameri P, Bollini S. The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity. Sci Rep. 2016 Jul 21;6:29994. PMID: 27444332.

− Ameri P, Bertero E, Meliota G, Cheli M, Canepa M, Brunelli C, Balbi M. Neurohormonal activation and pharmacological inhibition in pulmonary arterial hypertension and related right ventricular failure. Heart Fail Rev. 2016 Sep;21(5):539-47. PMID: 27206576.

− Canepa M, Pozios I, Vianello PF, Ameri P, Brunelli C, Ferrucci L, Abraham TP. Distinguishing ventricular septal bulge versus hypertrophic cardiomyopathy in the elderly. Heart. 2016 Jul 15;102(14):1087-94. PMID: 27122487.

− Fiz F, Morbelli S, Bauckneht M, Piccardo A, Ferrarazzo G, Nieri A, Artom N, Cabria M, Marini C, Canepa M, Sambuceti G. Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk. World J Radiol. 2016 Jan 28;8(1):82-9. PMID: 26834946.

− Altieri P, Barisione C, Lazzarini E, Garuti A, Bezante GP, Canepa M, Spallarossa P, Tocchetti CG, Bollini S, Brunelli C, Ameri P. Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes. J Am Heart Assoc. 2016 Jan 8;5(1). PMID: 26746999.

− Cheli M*, Canepa M*, Brunelli C, Bezante GP, Favorini S, Rollando D, Sivori G, Viani E, Finocchi C, Balbi M. Recurrent and Residual Shunts After Patent Foramen Ovale Closure: Results From a Long-Term Transcranial Doppler Study. J Interv Cardiol. 2015 Dec;28(6):600-8. PMID: 26643006. *equally contributed.

− Canepa M, Bezante G, Vianello P, Ameri P, Milaneschi Y, Aste M, Cavalla F, Bauckneht M, Marini C, Balbi M, Brunelli C, Sambuceti G. Diagnostic value of ischemia severity at myocardial perfusion imaging in elderly persons with suspected coronary disease. J Cardiovasc Med (Hagerstown). 2015 Nov 21. PMID: 26599683.

− Canepa M, AlGhatrif M. From Arterial Stiffness to Heart Failure: Still a Long Way to

MARCO CANEPA, MD, PhD 6/8

Go. J Am Heart Assoc. 2015 Nov 23;4(11). PMID: 26597156.

− Fabbi P, Spallarossa P, Garibaldi S, Barisione C, Mura M, Altieri P, Rebesco B, Monti MG, Canepa M, Ghigliotti G, Brunelli C, Ameri P. Doxorubicin impairs the insulin-like growth factor-1 system and causes insulin-like growth factor-1 resistance in cardiomyocytes. PLoS One. 2015 May 8;10(5):e0124643. PMID: 25955698.

− Pozios I, Corona-Villalobos C, Sorensen LL, Bravo PE, Canepa M, Pisanello C, Pinheiro A, Dimaano VL, Luo H, Dardari Z, Zhou X, Kamel I, Zimmerman SL, Bluemke DA, Abraham MR, Abraham TP. Comparison of Outcomes in Patients With Nonobstructive, Labile-Obstructive, and Chronically Obstructive Hypertrophic Cardiomyopathy. Am J Cardiol. 2015 Sep 15;116(6):938-44. PMID: 26239580.

− Barisione C, Garibaldi S, Brunelli C, Balbi M, Spallarossa P, Canepa M, Ameri P, Viazzi F, Verzola D, Lorenzoni A, Baldassini R, Palombo D, Pane B, Spinella G, Ghigliotti G. Prevalent cardiac, renal and cardiorenal damage in patients with advanced abdominal aortic aneurysms. Intern Emerg Med. 2015 Oct 28. PMID: 26510876.

− Barisione C, Ghigliotti G, Canepa M, Balbi M, Brunelli C, Ameri P. Indoxyl sulfate: a candidate target for the prevention and treatment of cardiovascular disease in chronic kidney disease. Curr Drug Targets. 2015;16(4):366-72. PubMed PMID: 25537654.

− Ameri P*, Canepa M*, Fabbi P, Leoncini G, Milaneschi Y, Mussap M, AlGhatrif M, Balbi M, Viazzi F, Murialdo G, Pontremoli R, Brunelli C, Ferrucci L. Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness. Atherosclerosis. 2014 Oct;236(2):418-25. PMID: 25150940. *equally contributed.

− Canepa M, Malti O, David M, AlGhatrif M, Strait JB, Ameri P, Brunelli C, Lakatta EG, Ferrucci L, Abraham TP. Prevalence, clinical correlates, and functional impact of subaortic ventricular septal bulge (from the Baltimore Longitudinal Study of Aging). Am J Cardiol. 2014 Sep 1;114(5):796-802. PMID: 25129067.

− Canepa M, Ameri P, AlGhatrif M, Pestelli G, Milaneschi Y, Strait JB, Giallauria F, Ghigliotti G, Brunelli C, Lakatta EG, Ferrucci L. Role of bone mineral density in the inverse relationship between body size and aortic calcification: results from the Baltimore Longitudinal Study of Aging. Atherosclerosis. 2014 Jul;235(1):169-75. PMID: 24842457.

− Canepa M, AlGhatrif M, Pestelli G, Kankaria R, Makrogiannis S, Strait JB, Brunelli C, Lakatta EG, Ferrucci L. Impact of central obesity on the estimation of carotid-femoral pulse wave velocity. Am J Hypertens. 2014 Sep;27(9):1209-17. PMID: 24637912.

MARCO CANEPA, MD, PhD 7/8

− Milaneschi Y, Sutin AR, Terracciano A, Canepa M, Gravenstein KS, Egan JM, Vogelzangs N, Guralnik JM, Bandinelli S, Penninx BW, Ferrucci L. The association between leptin and depressive symptoms is modulated by abdominal adiposity. Psychoneuroendocrinology. 2014 Apr;42:1-10. PMID: 24636496.

− David M, Malti O, AlGhatrif M, Wright J, Canepa M, Strait JB. Pulse wave velocity testing in the Baltimore longitudinal study of aging. J Vis Exp. 2014;(87):e5342. PubMed PMID: 24561745.

− Canepa M, Milaneschi Y, Ameri P, AlGhatrif M, Leoncini G, Spallarossa P, Pontremoli R, Brunelli C, Strait JB, Lakatta EG, Ferrucci L. Relationship between inter-arm difference in systolic blood pressure and arterial stiffness in community-dwelling older adults. J Clin Hypertens (Greenwich). 2013 Dec;15(12):880-7. PMID: 24299691.

− Canepa M, Sorensen LL, Pozios I, Dimaano VL, Luo HC, Pinheiro AC, Strait JB, Brunelli C, Abraham MR, Ferrucci L, Abraham TP. Comparison of clinical presentation, left ventricular morphology, hemodynamics, and exercise tolerance in obese versus nonobese patients with hypertrophic cardiomyopathy. Am J Cardiol. 2013 Oct 15;112(8):1182-9. PMID: 24079444.

− Canepa M, Alghatrif M, Strait JB, Cheng HM, Chuang SY, Chen CH, Brunelli C, Ferrucci L, Lakatta EG. Early contribution of arterial wave reflection to left ventricular relaxation abnormalities in a community-dwelling population of normotensive and untreated hypertensive men and women. J Hum Hypertens. 2014 Feb;28(2):85-91. PMID: 24048294.

− AlGhatrif M, Strait JB, Morrell CH, Canepa M, Wright J, Elango P, Scuteri A, Najjar SS, Ferrucci L, Lakatta EG. Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging. Hypertension. 2013 Nov;62(5):934-41. PMID: 24001897.

− Canepa M, Strait JB, Milaneschi Y, AlGhatrif M, Ramachandran R, Makrogiannis S, Moni M, David M, Brunelli C, Lakatta EG, Ferrucci L. The relationship between visceral adiposity and left ventricular diastolic function: results from the Baltimore Longitudinal Study of Aging. Nutr Metab Cardiovasc Dis. 2013 Dec;23(12):1263-70. PMID: 23809149.

− Ameri P*, Canepa M*, Milaneschi Y, Spallarossa P, Leoncini G, Giallauria F, Strait JB, Lakatta EG, Brunelli C, Murialdo G, Ferrucci L. Relationship between vitamin D status and left ventricular geometry in a healthy population: results from the Baltimore Longitudinal Study of Aging. J Intern Med. 2013 Mar;273(3):253-62. PMID: 23061475. *equally contributed.

− Giallauria F, Milaneschi Y, Tanaka T, Maggio M, Canepa M, Elango P, Vigorito C, Lakatta EG, Ferrucci L, Strait J. Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging. J Clin Endocrinol Metab. 2012 Oct;97(10):3717-23.

MARCO CANEPA, MD, PhD 8/8

− Balbi M, Canepa M, Cheli M, Bezante GP, Brunelli C. Sometimes they come back: recurrent noncardiac right-to-left shunt after percutaneous patent foramen ovale closure. J Cardiovasc Med (Hagerstown). 2012 Mar 3. PubMed PMID: 22395026.

− Canepa M, Strait JB, Abramov D, Milaneschi Y, AlGhatrif M, Moni M, Ramachandran R, Najjar SS, Brunelli C, Abraham TP, Lakatta EG, Ferrucci L. Contribution of central adiposity to left ventricular diastolic function (from the Baltimore Longitudinal Study of Aging). Am J Cardiol. 2012 Apr 15;109(8):1171-8. PMID: 22257709.

− Spallarossa P, Altieri P, Barisione C, Passalacqua M, Aloi C, Fugazza G, Frassoni F, Podestà M, Canepa M, Ghigliotti G, Brunelli C. p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells. PLoS One. 2010 Dec 20;5(12):e15583. PMID: 21187925.

ABSTRACT/POSTERS AT INTERNATIONAL and NATIONAL CONFERENCES

− Author of more than 20 abstracts and/or posters presented at international conferences and more than 15 abstracts and/or posters presented at Italian national conferences

− Invited speakers at more than 20 national and international conferences, meetings and workshops

CURRENT PARTICIPATION IN INTERNATIONAL AND NATIONAL SCIENTIFIC SOCIETES

− Gold Member of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC, from 2016 to now)

− Member of the Italian Society of Cardiology (SIC, from 2012 to now)

− Member of the Italian Federation of Cardiology (FIC, from 2009 to now)

As of April 8th, 2017