currently funded projects 2015 - alzheimer's … · currently funded projects 2015 ... anthony...

Currently funded projects 2015

Type Title Institution Lead Applicant

ARUK and CSO Project Grant into Translational Dementia Research

Targeting tau to prevent Abeta mediated synapse degeneration in Alzheimer’s

University of Edinburgh

Tara Spires-Jones

Clinical Research Fellowship

Investigating the role of the microglial receptor TREM2 in Alzheimer's disease

University College London, Institute of Neurology

Pablo Garcia Reitboeck

Clinical Research Fellowship

Systemic and central inflammation in Dementia with Lewy Bodies

University of Southampton

Jay Amin

Emergency support grant

Calcium abnormalities associated with neurodegeneration in Alzheimer’s disease

King's College London Wendy Noble

Equipment grant High-throughput and high-resolution digital slide scanner Nanozoomer-XR for studies in dementia


Delphine Boche

Equipment grant

Ensuring High Quality DNA and RNA isolation from the Brains for Dementia Research (BDR) Resource using the Agilent 2200 TapeStation Nucleic Acid System.

University of Nottingham

Keeley Brookes

Equipment grant Confocal laser scanning microscope for dementia researchers in Southampton


Roxana Carare

Equipment grant The use of a histology slide scanner to aid in the understanding of disease progression and mechanisms in dementia


Janice Holton

Equipment grant Phenotyping the immune response in Alzheimer’s disease by flow cytometry


Diego Gomez-Nicola

Extension grant THE ROLE OF ASTROCYTES IN TAU-RELATED NEURONAL CELL DEATH

University of Cambridge

Maria Grazia Spillantini


Extension grant Using network analysis to understand why patients with small vessel disease suffer cognitive impairment – extension


Hugh Markus

Interdisciplinary Research Grant

The molecular basis of the innate response to oligomers of beta amyloid and alpha synuclein


Clare Bryant


PSK kinases and tau pathology in Alzheimer's disease

King's College London Jonathan Morris


Neurovascular dysfunction in Alzheimer’s disease: the search for early biomarkers

University of Sheffield Jason Berwick


Determining the role of lysosomal Ca2+ signalling in the pathogenesis of Alzheimer's disease

Cardiff University Emyr Lloyd-Evans

Major project The ARUK supplement for the JPND funded PERADES consortium

Cardiff University Julie Williams

Major project Endoplasmic reticulum-mitochondria interactions and Alzheimer's disease

King's College London, Institute of Psychiatry

Chris Miller

Major project Evaluating the relationship between ischaemia and neurodegeneration in post-mortem brain tissue

University of Bristol Seth Love

Major project Live cell tracking of amyloidogenic species related to Alzheimer’s disease


Clemens Kaminski

Major project The role of Dkk1 in Amyloid-beta mediated effects on dendritic spines and long-term depression

University College London

Patricia Salinas

Major project Evaluation of tau aggregation detected by novel tau tracer, [18F]T807 PET in mild cognitive impairment subjects: a preliminary collaborative PET study.

Imperial College London

Paul Edison

Major project Combinatorial biomarkers for dementia prodromes, prediction, pathology and progression

University of Oxford Simon Lovestone


Major project Determining the causes and consequences of brain amyloidosis, atrophy and cerebrovascular disease


Nick Fox

Major project Using network analysis to understand why patients with small vessel disease suffer cognitive impairment.


Hugh Markus

Major project An Investigation of the role of the ageing process in Alzheimer’s Disease


Linda Partridge

Major project A cell surface, lipid raft-based signalling complex links amyloid-beta to tau via Fyn

University of Manchester

Nigel Hooper

Major project Imaging amyloid and neuroinflammation in subjects "at risk" for Alzheimer's disease


David J Brooks

Major project Automated subcortical brain segmentation using multispectral MRI for improved AD diagnosis and disease tracking


Josephine Barnes

Major project Title: Alpha-Synuclein and Cellular Iron Reduction University of Bath David Brown

Major project Investigation into the impact of systemic inflammation due to infection on microglial phenotype and its contribution to Alzheimer’s disease neuropathology


Delphine Boche

Major project Phosphorylation of kinesin light chain and calsyntenin-1/alcadein mediated axonal transport and processing of APP in Alzheimer’s disease


Chris Miller

Major project Enabling high-throughput genomic approaches in Alzheimer’s disease.


Kevin Morgan

Major project Mechanisms of neurodegeneration in an animal model of cerebral hypofusion

Newcastle University Raj Kalaria

Major project Targeting perivascular innervation and vascular tone for improved clearance of ß-amyloid from the brain

The Open University Cheryl Hawkes


Major project

The impact of the accumulation of brain beta-amyloid and tau with ageing on the development of Alzheimer's disease in Down's syndrome adults: a cross-sectional and longitudinal study.


Anthony Holland

Major project Causes and consequences of dystrophic axons University of Cambridge

Michael Coleman

Major project Hypertension, hypoperfusion and neurodegeneration in Alzheimer's disease

University of Bristol Seth Love

Major project 123I-MIBG Scintigraphy Utility as a biomarker for Prodromal DEmentia with Lewy Bodies (SUPErB)

Newcastle University Alan Thomas

Network Centre Alzheimer's Research UK Manchester and North West Network Centre Grant


Nigel Hooper

Network Centre Alzheimer's Research UK Yorkshire Network Centre Grant

University of Leeds John Boyle

Network Centre Alzheimer's Research UK University College London Network Centre Grant


Sebastian Crutch

Network Centre Alzheimer's Research UK King's College London Network Centre Grant

King's College London Wendy Noble

Network Centre Alzheimer's Research UK Scotland Network Centre Grant

University of Dundee Mike Ashford

Network Centre Alzheimer's Research UK Cardiff Network Centre Grant

Cardiff University Lesley Jones

Network Centre Alzheimer's Research UK Oxford Network Centre Grant

University of Oxford Richard Wade-Martins

Network Centre Alzheimer's Research UK Midlands Network Centre Grant - Year 1

Aston University Eric Hill

Network Centre Alzheimer's Research UK Northern Ireland Network Centre Grant

Queen's University Belfast

Brian Green


Network Centre Alzheimer's Research UK Cambridge Network Centre Grant

The Babraham Institute

Michael Coleman

Network Centre Alzheimer's Research UK Imperial College London Network Centre Grant


Paul Edison

Network Centre Research into early-onset dementia University College London, Institute of Neurology

Nick Fox

Network Centre Alzheimer's Research UK South West Network Centre Grant - Year 1

University of Plymouth Oleg Anichtchik

Network Centre Alzheimer's Research UK Bristol and Bath Network Centre Grant

University of Bristol Patrick Kehoe

Network Centre Alzheimer's Research UK South Coast Network Centre Grant


Amrit Mudher

Network Centre Alzheimer's Research UK Newcastle Network Centre Grant

Newcastle University Raj Kalaria

Network Centre Alzheimer's Research UK South West Network Centre - Year 2

University of Exeter Katie Lunnon

Network Centre Alzheimer's Research UK Midlands Network Centre Grant - Year 2

Loughborough University

Eef Hogervorst

Network cooperation grant

Functional deficits in a novel murine model of frontotemporal lobar degeneration

University of Bristol Andrew Randall


A biological resource for metagenomic studies of dementia

King's College London John Powell


Next Generation Sequencing of Alzheimer's Disease (AD) Genes in non-familial early-onset AD (EOAD).


Kevin Morgan

Network Support Grant

Characterisation of the unfolded protein response, apoptosis and autophagy in human AD cases

University of Aberdeen Bettina Platt


Other Canadian Consortium on Neurodegeneration in Aging Canadian Institutes of Health Research (CIHR)

CIHR Canadian Institutes of Health Research

Other Alzheimer's Research UK Drug Discovery Institute 2015: University College London


Giampietro Schiavo

Other Identifications of druggable pathways that influence tau toxicity


David Rubinsztein

Other Alzheimer's Research UK Drug Discovery Institute 2015: University of Oxford

University of Oxford Simon Lovestone

Other CRACK IT - UnTangle Challenge University College London

Selina Wray

Other Alzheimer's Research UK Drug Discovery Institute 2015: University of Cambridge


David Rubinsztein

Other Pharmacological modulation of CSF1R activation to control microglial proliferation in Alzheimer’s disease


Diego Gomez-Nicola

Other Alzheimer's Research UK Stem Cell Research Centre University of Cambridge

Frederick Livesey

Other Moving autophagy inducers into the clinic for tauopathies


David Rubinsztein

Other ALS disease models and therapeutic drug screen International Centre for Genetic Engineering and Biotechnology

Marco Baralle

PhD Scholarship Molecular mechanisms of C9ORF72 repeat expansion toxicity in frontotemporal dementia

King's College London Jean-Marc Gallo

PhD Scholarship Differential production of amyloid-beta from the APP isoforms


Nigel Hooper

PhD Scholarship O-GlcNAc as a strategy for the treatment of tauopathies

University of York Gideon Davies


PhD Scholarship The role of TREM2 in neurodegeneration University College London

Tammaryn Lashley

PhD Scholarship Investigating the effect of ApoE genotype on synaptic dysfunction using sporadic Alzheimer’s disease patient iPSC-derived cells

University of Oxford Colin Akerman

PhD Scholarship Impaired Tight Junction Protein Signalling in Astrocytes In Alzheimer's Disease

University of Sheffield Stephen Wharton

PhD Scholarship

Title: Identification of the Alzheimer pre-protein as a potential regulator of endosomal phosphoinositide metabolism; a novel mechanistic pathway to neurodegeneration?

Aston University Thomas Wassmer

PhD Scholarship Emergence of cognitive impairment in an Alzheimer's Disease mouse model: the role of NMDA receptor currents.


Mariana Vargas-Caballero

PhD Scholarship Convergence of Abeta and tau pathogenic mechanisms on axonal transport

The Babraham Institute

Michael Coleman

PhD Scholarship Understanding Alzheimer's disease using mouse models of Down syndrome


Frances Wiseman

PhD Scholarship Imaging cerebral vascular alterations and their modulation in experimental models: a translational approach


Karen Horsburgh

PhD Scholarship Fe65/APP signalling and brain-derived neurotrophic factor in Alzheimer's disease


Chris Miller

PhD Scholarship Modelling hexanucleotide expansion repeats of C9ORF72 in Frontotemporal Dementia


Frank Hirth


PhD Scholarship Altered Heparan Sulfate in Ageing and Dementia: a Potential Axis for Dysregulation of BACE-1 in Alzheimers Disease

University of Liverpool Jeremy Turnbull

PhD Scholarship

Using genetic variability in whole transcriptome expression in the hippocampus and temporal cortex to understand the pathogenesis of Alzheimer's disease


John Hardy

PhD Scholarship Characterisation of a novel in vivo model of human tauopathy


Diane Hanger

PhD Scholarship Investigation of the mechanism by which the C9ORF72 intronic repeat expansion causes frontotemporal dementia


Adrian Isaacs

PhD Scholarship NeuroTraffic: Orientated neuronal networks for investigating mechanisms of tau propagation


Katrin Deinhardt

PhD Scholarship Hippocampal sclerosis – a poorly understood cause of dementia among the older old


Carol Brayne

PhD Scholarship Using iPSC-derived neurons to study homeostatic control of aSyn by the E3-ubiquitin ligase and co-chaperone CHIP


Kathryn Ball

PhD Scholarship Contribution of TREM2 and neuroinflammation to neurodegeneration and cognitive dysfunction in response to chronic cerebral hypoperfusion


Barry McColl

PhD Scholarship Alterations in autophagy in frontotemporal lobar degeneration: identifying new targets for therapeutic intervention

University of Salford Gemma Lace-Costigan

Pilot project grant A PK11195 PET Study of neuroinflammation in dementia with Lewy bodies


John O'Brien


Pilot project grant Developing a new biomarker for the early diagnosis of dementia; a novel nonlinear signal processing approach using resting state EEG.

University of Sheffield Daniel Blackburn

Pilot project grant Understanding oligodendrocyte progenitor dynamics and myelin loss in Alzheimer's Disease


Diego Gomez-Nicola

Pilot project grant Epigenetic modification of mitochondrial genes in Alzheimer's disease (AD)

University of Exeter Katie Lunnon

Pilot project grant Imaging copper trafficking in Alzheimer’s disease with PET: potential clinical applications

King's College London Philip Blower

Pilot project grant Harnessing the Ubiquitin-Proteasome System in the Brain: Implications for Dementia

University of Bath Julien Licchesi

Pilot project grant Super resolution microscopy in human brain white matter

St. George's University of London

Atticus Hainsworth

Pilot project grant Identification of unfolded protein response, apoptosis and autophagy markers in human AD

University of Aberdeen Bettina Platt

Pilot project grant The role of TMEM106B and CHMP2B in neuronal lysosomal trafficking in frontotemporal dementia


Adrian Isaacs

Pilot project grant CARASIL - a window into Alzheimer's disease? Institute of Neurology, University College London

Rita Guerreiro

Pilot project grant Exploring endogenous mediators regulating blood brain barrier functionality in Alzheimer’s disease

Barts and The London School of Medicine and Dentistry, Queen Mary University of London

Egle Solito

Pilot project grant Cellular modelling of C9orf72 di-peptide repeat proteins


Stuart Pickering-Brown


Pilot project grant Rare variants in inflammatory pathways in Alzheimer's disease

King's College London Angela Hodges

Pilot project grant Complement and microglial activation in mouse models of dementia

Cardiff University Paul Morgan

Pilot project grant Validation of an O-GlcNAcase inhibitor as a novel therapeutic agent against Alzheimer pathology

University of Bradford Ritchie Williamson

Pilot project grant Interhemispheric processing in Alzheimer Disease University of Leeds Jean-Francois Delvenne

Pilot project grant Ultra-high field MRI in early Alzheimer’s disease: characterising iron deposition

University of Oxford Klaus Ebmeier

Pilot project grant

Double-blind randomised crossover placebo-controlled pilot trial with intra-nasal Oxytocin to increase social cognitive function and reduce carer burden in frontotemporal dementia.


Michael Hornberger

Pilot project grant Characterisation of enteric nervous system function of the intestine in Alzheimer’s disease

University of Portsmouth

Jerome Swinny

Pilot project grant Cortico-striatal contributions to symptomology in dementia: new targets for therapy


Michael Hornberger

Pilot project grant

Repressor Element 1-Silencing Transcription Factor (REST): A blood-based biomarker for Alzheimer’s disease linking molecular neuropathology with psychological stress

King's College London Richard Killick

Pilot project grant Testing a new diagnostic tool for Alzheimer's disease and Dementia with Lewy Bodies


David Klenerman

Pilot project grant Development of small molecule Usp8 inhibitors as therapeutics in Lewy body dementia

University of Oxford George Tofaris

Pilot project grant Investigating the role of kinesin motor proteins in a human neuronal cell model of Alzheimer’s Disease: a new drug discovery target?


Isabel M Palacios


Preparatory Clinical Research Fellowship

Fronto-thalamic effective connectivity in familial Alzheimer’s disease

Dementia Research Centre, UCL Institute of Neurology

Kirsi Kinnunen

Preparatory Clinical Research Fellowship

Evaluation of microglial activation in Alzheimer’s disease and mild cognitive impairment subjects using a novel TSPO marker, GE180


Valeria Calsolaro

Research Fellowship

The role of the nuclear transport system in frontotemporal dementia.

University of London Tammaryn Lashley

Research Fellowship

Astrocytes influence interactions between Abeta and tau to cause synaptotoxicity in AD


Beatriz Gomez Perez-Nievas

Research Fellowship

Selective vulnerability to Alzheimer’s disease – understanding changes in white matter connectivity of the visual system in Posterior Cortical Atrophy


Tim Shakespeare

Research Fellowship

Investigating the role of BIN1 in tau missorting and secretion


Elizabeth Glennon

Research Fellowship

Dysfunctional synaptic and neuronal network encoding in tauopathy-associated dementia

University of Bristol Jonathan Witton

Sabbaticals/Secondments

Mapping the cellular relationship between RNA metabolism and endosome dysfunction in Frontotemporal Dementia

University of York Sean Sweeney

Senior Research Fellowship

Regulation of iron homeostasis by beta-amyloid precursor protein in health and disease.

University of Leeds James Duce


Interaction of systemic and central apolipoproteins in the pathogenesis and treatment of cerebral amyloid angiopathy

The Open University Cheryl Hawkes


Identifying functional molecular pathways that underlie the earliest changes associated with Alzheimer’s Disease


Dervis Salih



Therapeutic potential of boosting astrocytic Nrf2-mediated antioxidant signalling in combating white matter damage, amyloid pathology and cognitive deficits caused by chronic cerebral hypoperfusion


Jill Fowler


Measuring, Tracking and Disentangling the Impact of White Matter Disease in AD and Mixed Disease: A Longitudinal MRI and CSF Study


Josephine Barnes


Neuronal network disruptions in a model of tauopathy University of Exeter Jon Brown


Alzheimer’s disease and posterior cortical atrophy: cognitive and neuroimaging studies of visual dysfunction


Sebastian Crutch


Are multiple mechanisms involved in FTLD-TDP pathogenesis; will one drug fit all?

Institute of Neurology, University College London

Tammaryn Lashley

Travelling Research Fellowship US

High-throughput genotyping of rare variants identified through next-generation sequencing of Alzheimer's disease candidate genes


Christopher Medway

currently funded projects 2015 - alzheimer's … · currently funded projects 2015 ... anthony...

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