crossing the bridge from microfluidics to connected health ... · digital health funding hit a new...

Crossing the Bridge from Microfluidics to Connected Health & Blended Reality for Life

Dr. Ali Tinazli – Head of Healthcare Strategy CTO Office – Vision, Strategy & IncubationDecember 13th 2016

©2016 HP, Inc. | HP Confidential1

© Copyright 2016 HP Development Company, L.P. The information contained herein is subject to change without notice.2

Our heritage:• Founded in 1939 by engineers

Bill Hewlett and Dave Packard• Start-up capital: $538• First product: Model 200A audio oscillator• Earliest customer: Walt Disney Studios

History of innovation

3

*Source: Guinness World Record for fastest time to print 500 sheets by an office color desktop printer, April 2012. Record set on HP X576dw models.© Copyright 2016 HP Development Company, L.P. The information contained herein is subject to change without notice.

HP Model 200A audio oscillator

used to test sound equipment

Launch of LaserJet and

thermal, miniaturized

inkjet printing technology

HP invented the first scientific

hand-held calculator,the HP-35

The HP 9100A, the world’s first

desktop computer

HP launches the world's

fastest desktop printer*

HP unveils the future of 3D printing and immersive computing

HP reinvents printing

delivering Ink, Laser, and PageWide,

technologies

HP launches the world’s

thinnest laptop

The Compaq Portable, one

of the first laptops

Jet Fusion 3D

1939 1968 2014 20161972 20131984201

51983 2016

HPtoday

© Copyright 2016 HP Development Company, L.P. The information contained herein is subject to change without notice.4

1 Total net revenue is based on non-GAAP segment reporting for fiscal year 2015. Total net revenue is calculated based on total segment revenue, which does not include intercompany eliminations.

Fortune 100company

$52.7B revenuerevenue in FY15 1

Operations in 170 countries

~50,000employees

Fortune Most Admired#7 in technology

250,000+channel partners

18,000+patents

Technology Convergence

©2016 HP, Inc. 6

We are in the Age of Technology Convergence

7

Healthcare has been undergoing a transformation similar to manufacturing

8

From a 1-to-1 art to digital mass industrialization & scale, transforming to personalized and democratized applied science

Leve

l of T

echn

olog

y

Ancient times

• Healthcare 1.0– Rudimentary

– Highly personal 1-to-1

– Access: Exclusive

Pre 20th Century

• Healthcare 2.0– Foundation of modern

medicine

– Shift to scientifically-based medicine

– Access: Limited

20th Century

• Healthcare 3.0– Industrialization,

centralization & standardization

– Rise of complexity & specialization

– Technologies challenge healthcare economics

– Access: Benefit

Next

• Healthcare 4.0– Decentralization

enabled by microfluidics

– Focus on prevention

– Personalized treatments

– Big data, AI and machine learning

– Access: Democratized

Healthcare Timeline Key trends shaping Healthcare

Shift towarddecentralized,

connected,preventive, and

personalizedtreatment

models

Convergence ofTechnologies

Empoweredand engaged customers

Regulatorychanges

Digital Revolution: Internet-of-Things

71627243

73247404

74847562

2013 2014 2015 2016 2017 2018

Total world population

Shortage of doctors and nursing staff put pressure on healthcare system

699,100 709,700 735,600 759,800

706,500 723,400798,500

851,300

2008 2010 2015 2020

Supply Demand

Projected Supply & Demand of Physicians in the US

90kshortage

European health professionals or other health workers Estimated shortage by 2020

Physicians 230,000

Dentists, pharmacists, and physiotherapists 150,000

Nurse 59000

Total 970,000

Doctors (per 1,000 population) as compared with the total world population (millions)

1.7 1.7

Doctors per 1,000

Popu

latio

n (m

illio

n)

Doctors

6

5

4

3

2

1

Source: European Commission

Pressure to contain costs and demonstrate value is coming from all sides

Cost Increase Factors

Higher premiums Affordable Care Act Overuse of services Coverage expansion Austerity measures

Life sciences companiesHealth plansProvidersGovernments Consumers

Expanding healthcare and lowering costs requires eliminating waste of resources & adding value

Medical advances — Unraveling the human genome, emergence of precision medicineCase in point — Cures for diseases like hepatitis C, but costs are substantialPersonalized care — Shifting clinical offerings from mass generalization to mass customization

Telemedicine mHealth EMR Wearable

Combining big data, analytics, and machine learning can create efficiencies and increase speed of care

Source: Deloitte, 2016

With doctors and healthcare workers now using machines to provide efficiency, better care and take on more complex tasks

Source: Accenture, 2015

Today

• Phone apps are helping doctors and patients calculate the risk of heart surgery

• Mental patients in the U.K. are using social media to anonymously interact

• A software-based Alzheimer’s diagnostic test can detect impairments on the hippocampus (the first area of the brain to be affected) by evaluating your eye movement

• Ingestible or implantable devices collect newfound levels of data that can better inform a doctor’s care plan

• Develop caregiving teams/connect with peers using social media• Surgeons using wearables have real-time access to data from

monitoring equipment, so they can make more informed decisions about the patient during a procedure

Tomorrow

SocialMedia

Alzheimer’s Diagnostic test

Phone apps Caregiving team Implantable

device

Real-time data

Technology Trigger

Peak of Inflated Expectations

Plateau of Productivity

Many of the emerging digital health technologies are at the beginning of the hype cycle which is not surprising given digital health is still in its infancy

Slope of Enlightenment

Trough of Disillusionment

Source: Digital Health Hype Cycle by Bionicly (not Gartner), 2014

Digital Health

Digital health funding hit a new high in 2015, reaching nearly $6B

Growing healthcare challenges from rise in patients with chronic diseases,

healthcare cost and doctor shortage

Source: Partnership to Fight Chronic Disease and A.D. Little

190M

$42T

90,000 U.S. Doctor shortfall by 2025

Total cost of chronic disease from 2016-2030 in U.S.

Number of Americans affected by 1 or more chronic diseases

Digital healthcare a large and growing market

Source: A.D. Little, 2016

60.8

135.9

233.3

2013 2017 2020

Predictive

Preventative

Personalized

Participatory

4Ps of Healthcare

Digital Health Market 2013-2020 ($bn)

Prevention to elimination is plausible thanks to exponential

technology growth

Sources: Sparks & Honey, Millennial Branding, Salt

Faster, Cheaper Genomics

Sequence a genome in a day @ $1000

Managing Big Data

Healthcare data doubles every

24 months

Increasing Connectivity

Sensors increase data accuracy & frequency

for improved care

Reduced Drug Development Time

Data analysis reduced from 2 days to 1 min

Healthcare 2.0:Computing + AI + Machine Learning

+ Big Data+ Sensors

Precision Medicine

©2016 HP, Inc. 14

15

Today’s Reality - Imprecision Medicine

Towards Precision Medicine

Precision Medicine © InnVentis

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Needed: Blood to Personal Molecular Profile

Personal Molecular ProfileMachine learningbased on

longitudinal, multi-omic data

Blood sample

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PRECISION MEDICINE: Integrating multi-omics, clinical and real world data

Creation of topological mapsof health/disease

Eric Topol, CELL,Volume 157, Issue 1, 27 March 2014, Pages 241–253 Precision Medicine © InnVentis

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Precision Medicine causes Paradigm Shift

Symptom-based Cohort-based Algorithm-based

Yesterday

Intuition Medicine

Today

Evidence-based Medicine

Tomorrow

Precision Medicine

DAT

AAC

TIO

NS

Application of rules, algorithms and reference databases enables ACTIONABLE clinical decision support & PRECISE/EFFICIENT care

Reference Databases

(Rules & Algorithms)

PersonalMolecular Profiles

(PMP, multi-omics)

Molecular Imaging

Non-molecular content (waveforms)

Precision Medicine(prevention,

diagnosis, treatment)

MobileInformation

CommunicationTechnologies

Big DataAnalytics


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Pattern Diagnostics:• Is independent from baselines

• Reveals “hidden” disturbances

• The more data the better the analysis; i.e. precise patter recognition from “different angles”

• Machine learning recognizes “fragments” of a pattern

Molecular patterns are like memorable “skylines“

Pattern discovery, Machine Learning in Precision Medicine:FDA calls this “complementary“ diagnostics


©2016 HP, Inc. | HP Confidential20

Personal Molecular Profiles (PMP) will assess patients with unprecedented precision

Personal Molecular Profile

Accurate and actionable diagnostics Disease and patient

stratification Prevention and early

intervention Complementary Diagnostics Personalized products

(pharma, neutraceutical)

Health/Disease management Personalized health/disease

status monitoring Compliance management Disease stage classification Disease vs. non‐disease

events Medication dosage and

timing

! Value creation For patients For pharma and biotech

industry For payers/providers For society

+

Machine learningbased on longitudinal, multi-omic data

Blood sample

Adapted from Precision Medicine © InnVentis

Precision Fluidics for Precision Medicine

©2016 HP, Inc. 21

22

The Hype Cycle

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History & Trajectories of Microfluidics Chip Markets

HP’s Technology Framework addresses unmet Needs in the Industry

Reliable, cost-effective microfluidic solutions at scale to enable a wide use point-of-care testing.

Microfluidics consumables

HP is the world’s largest microfluidics company

Stable, contractual supply of microfluidic consumables business with long lifecycle.

Razor/Blade consumables business

Print business is a supplies businessof prefilled microfluidic cartridges

Mobile Compute, processing, communication and data capture for telemedicine and digital health.

Computing and mobility

Computing, commercial mobility, dataprocessing & connectivity is in our DNA

The One Device

©2016 HP, Inc. All rights reserved. | The information contained herein is subject to change without notice. |24

Mar

ket

Nee

dH

P Co

re E

xper

tise

& IP

Emerging needs in healthcare for decentralization/democratization of diagnostics will drive the “Medical Office of the Future”

© Copyright 2015 Hewlett-Packard Development Company, L.P. The information contained herein is subject to change without notice.25

Building Blocks for the Tools in Precision MedicinePrecision dispense, microfluidics, novel sensing combine with supply chain, manufacturing & compute

Microfluidics MEMS Scale


High Precision Microfluidics Hardware and Consumables Solutions

HP MEMS Microaccuracy Manufacturing Scale

Ink jet print heads are the ultimate success of integrating electronics with microfluidics(!)Embedding electronics in microfluidics (or vice versa) is a key step to extracting the data from the ‘wet stuff’…

Application: Consumables

Application + Device:Consumables +

Mobile Platform

Application + Solution:Consumables +

Mobile Platform +

Cloud Storage & Analytics

HP’s modular Platform Technology Architecture

27

From application-specific consumables to a fully-integrated Cloud Solution

©2016 HP, Inc. All rights reserved. | The information contained herein is subject to change without notice. l

Next Dimension: A mobile Communications Platform for PoC Diagnostics

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• Addresses immediate market needs as expressed by pharma companies and government organizations: seeking for a mobile MS Windows platform which is state-of-the-art.

• Security advantages of a Win 10 platform vs. other devices (i.e. Android and iOS)

Smart Phone are revolutionizing the ways of how patients and healthcare professionals engage – establishing standards are needed for safety and security reasons.


Liquid Biopsy: An emerging market for radically improved cancer management and more…A cancer diagnosis to being about as eventful as having the flu!

Data are getting as important as actual clinical chemistry in diagnostics!

New value creation: DNA analysis will become a • cloud-based node in the • Internet of Things, • with subscription software, for both control and processing.



HP’s Microfluidics & Machine learning capabilities for predictive cancer diagnostics

Big Data

Decentralized data capture units

Mobile Point-of-Care (PoC) Platform

CloudAnalyticsData Processing


A healthcare-IoT system which connects, combines and integrates healthcare data

Healthcare subscription models + IoT will form a new category

WearableDevice

TelehealthDevice

GatewayDevice

CloudPlatform

Micro Services

• Platform• Patient• Provider• System• Specialists


Everything imbued with intelligence

Anticipates our needs

Deliver information, products and services when needed

AI assistants and friends

Enabling new experiences

Becoming a utility

Omni intelligence

crossing the bridge from microfluidics to connected health ... · digital health funding hit a new...

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