COVERLETTER/RESEARCHINTEREST

Much of my experience has been doing the DNA damage and molecular toxicity assessment ofnanoparticles, pesticides and anti-cancer drugs in human lymphocytes, cell lines and animalsmodels.These experiences have strengthened my research and writing skills including careful experimentalplanning,criticalobservations,andmanaginglargepoolofdataforitssuccessfulending.I have ample experience in working with sophisticated instruments and molecular biology assaysemployedfortoxicityassessmentincludingflowcytometricanalysisofcellcycle,apoptosis,Ca2+influx,level of intracellular glutathione, free radicals analysis (including nitric oxide), and dissipation ofmitochondrialmembranepotential,respectively.Usingthecometandcytokinesisblockedmicronucleusassays IcanquantifyDNAdamageandchromosomalbreaks intheabovementionedtestmodels.TheimmunofluorescenceskillsallowsmetovisualizetheexpressionofP53,Bax,Bcl2proteins incell linesundergone oxidative stress and apoptosis as a consequence of toxicant exposure. I also gainedexperience inqPCRarraytoquantitatetheexpressionof84genesresponsible forhumantoxicityandoxidativestress.Since,manyfeaturesofprogrammedcelldeathinplantsresemblewiththoseobservedinanimals,inthisregard,veryrecently,Igotsuccessindecipheringthemechanismofcelldeathinplanttestsystemuponexposurewithdifferentnanoparticles.Inadditiontothebasicandmolecularbiologytechniques,Iamwellversedinthebio-physicalinteractionanalysisofbiologicalmacromolecules,whichincludes the interaction mechanism of binding of exogenous ligands with DNA and human serumalbuminemployingthespectrofluorescencemeasurements,cyclicvoltammetryandcirculardichroism.I have strong passion for scientific research, career oriented, self-motivated, dedicated, hardworkingandIamalwaysexcitedtoembarkonajourneytoeducatemyself.IsuccessfullycompetedatNationalleveltogetfourresearchgrantsfromNationalPlanforSciencesandTechnology(NPST),SaudiArabia,asprincipalinvestigator(PI)andco-investigator(Co-I).

CURRICULUMVITAE

DepartmentofZoology,CollegeofScienceKingSaudUniversity

Riyadh,SaudiArabiaP.O.Box2455,Pin11451

E-mail:quaiser.saquib0@gmail.comQUAISERSAQUIB,Ph.D.qsaquib@ksu.edu.sa

PRESENT STATUS:Working as an Assistant Professor in Department of Zoology, College ofScience,KingSaudUniversity,Riyadh,SaudiArabia.RESEARCH INTERESTS: Molecular Toxicology/Cancer Biology/Bio-physical InteractionStudies• DNAdamagingpotentialofnanoparticles,flameretardants,anticancerdrugs,pesticides

ininvitro(humanlymphocytesandcelllines)andinvivo(mouse/rat)testmodels.• Analysisofinvitroandinvivocellcyclechanges,Ca++influx,esteraseactivity,oxidative

stress, mitochondrial dysfunction, transcriptional and translational changes uponapoptosisinductionbyflameretardants,pesticides,anticancerdrugsandnanoparticles.

• Biophysical interaction analysis of exogenous ligands with biological macromolecules(DNA/proteins).

EDUCATION:

2009:Ph.D.(Ag.Microbiology) (ThrustArea:DNADamageandMolecularToxicology)

Thesis title: Assessment of Genotoxicity of Certain Agrochemicals andTheirMechanismsofInteractionswithBiologicalMacromolecules.AligarhMuslimUniversity,India.

2002:M.Sc.inAg.MicrobiologyDissertation: Biodegradation of Endosulfan by Bacterial Culture IsolatedfromAgricultureSoil.AligarhMuslimUniversity,India.

2000:B.Sc.(Hons.)inZoology AligarhMuslimUniversity,India.

PUBLICATIONS:

1. RizwanWahab,FarheenKhan,YoubingYang,I.H.Hwang,Hyung-ShikShin,JavedAhmad, Sourabh Dwivedi, Shams T. Khan, Maqsood Ahmed Siddiqui, QuaiserSaquib,JavedMusarrat,AbdulazizA.Al-Khedhairy,YogendraK.MishraandBahyA.Ali. (2016). Zinc oxide Quantum Dots: Multifunctional candidates for arresting theC2C12 cancer cells and their role towards Caspase 3 and 7 genes. RSC Adv., 2016,AcceptedManuscriptDOI:10.1039/C5RA25668B.(IF3.84).

2. Saquib Q, Siddiqui MA, Ahmed J, Al-Salim A, Ansari SM, Faisal M, Al-Khedhairy AA,MusarratJ,AlWathnaniHA,AlatarAA,Al-ArifiSA.Hazardsoflowdoseflame-retardants(BDE-47 and BDE-32): Influence on transcriptome regulation and cell death in humanlivercells.JournalofHazardousMaterials(2016)308:37-49.(IF4.52).

3. QuaiserSaquib,MohammadFaisal,AbdulrahmanA.Alatar,AbdulazizA.Al-Khedhairy,MukhtarAhmed,SabihaM.Ansari,HendA.Alwathnani,MohammadK.Okla,SourabhDwivedi, JavedMusarrat, Shelly Praveen, ShamsT. Khan,RizwanWahab,MaqsoodA.Siddiqui, JavedAhmad.Genotoxicityof ferricoxidenanoparticles inRaphanus sativus:Deciphering the role of signalling factors, oxidative stress and cell death. Journal ofEnvironmentalSciences(2016)(Accepted,ArticleinPress).(IF2.0).

4. MohammadFaisal,QuaiserSaquib,AbdulrahmanA.Alatar,AbdulazizA.Al-Khedhairy,Mukhtar Ahmed, Sabiha M. Ansari, Hend A. Alwathnani, Sourabh Dwivedi, JavedMusarrat, Shelly Praveen. Cobalt oxide nanoparticles aggravateDNA damage and celldeath in eggplant via mitochondrial swelling and NO signaling pathway. BiologicalResearch(MinorRevision).(IF1.8).

5. Ahmad J, Alhadlaq HA, Alshamsan A, SiddiquiMA, Saquib Q, Khan ST,Wahab R, Al-Khedhairy AA, Musarrat J, Akhtar MJ, Ahamed M. (2016) Differential cytotoxicity ofcopper ferrite nanoparticles in different human cells. Journal of Applied Toxicology(Accepted)doi:10.1002/jat.3299.(IF2.98).

6. ShamsTabrezKhan,RizwanWahab,JavedAhmad,AbdulazizA.Al-Khedhairy,MaqsoodA.Siddiqui,QuaiserSaquib,BahyA.Ali, JavedMusarrat. (2015).CoOThinNanosheetsExhibitHigherAntimicrobialActivityAgainstTestedGram-positiveBacteriaThanGram-negativeBacteria.KoreanChemicalEngineeringResearch,53(5)565-569.(IF1.69)

7. SM Attia, SF Ahmad, Q Saquib, GI Harisa, AA Al-Khedhairy, SA Bakheet. (2016).Dexrazoxane mitigates epirubicin-induced genotoxicity in mice bone marrow cells.Mutagenesis,2016,31(2),137-145.doi:10.1093/mutage/gev065(IF:2.7).

8. Dwivedi S, Saquib Q, Al-Khedhairy AA, Ahmad J, Siddiqui MA, Musarrat J. (2015).RhamnolipidsfunctionalizedAgNPs-inducedoxidativestressandmodulationoftoxicitypathwaygenes inculturedMCF-7cells.ColloidsandSurfaceB:Biointerfaces.132:290-298.(IF:4.1).

9. Khursheed Ali, Bilal Ahmed, Sourabh Dwivedi, Quaiser Saquib, Abdulaziz A. Al-Khedhairy, JavedMusarrat. (2015).Microwave Accelerated Green Synthesis of StableSilverNanoparticleswith Eucalyptus globulus Leaf Extract and Their Antibacterial andAntibiofilmActivityonClinicalIsolates.PLoSOne.2015Jul1;10(7):e0131178.(IF:3.5).

10. Ebtesam Saad Al-Sheddi,MaiMohammadAl-Oqail,Quaiser Saquib,Maqsood AhmedSiddiqui,JavedMusarrat,AbdulazizAliAl-Khedhairy,NidaNayyarFarshori.(2015).NovelAllTrans-RetinoicAcidDerivatives:Cytotoxicity,InhibitionofCellCycleProgressionandInductionofApoptosisinHumanCancerCellLines.Molecules20(5),8181-8197(IF:2.4).

11. Guanyong Su, Xiaowei Zhang, John P. Giesy, Javed Musarrat, Quaiser Saquib,Abdulaziz A. Alkhedhairy, Hongxia Yu. (2015). Comparison on the molecularresponseprofilesbetweennanozincoxide(ZnO)particlesandfreezincionusingagenome-wide toxicogenomics approach. Environmental Science and PollutionResearch.DOI10.1007/s11356-015-4507-6(IF:2.75).

12. RizwanWahab,FarheenKhan,Lutfullah,R.B.Singh,NagendraKumarKaushik,JavedAhmad, Maqsood A. Siddiqui,Quaiser Saquib, Bahy A. Ali, Shams T. Khan, JavedMusarrat, Abdulaziz A. Al-Khedhairy. (2015). Utilization of photocatalytic ZnOnanoparticles for deactivation of safranine dye and their statistical analyticalapplications.PhysicaE: Low-dimensionalSystemsandNanostructures69,101-108.(IF:1.85).

13. Maqsood A. Siddiqui, Quaiser Saquib, Maqusood Ahamed, Nida N. Farshori, JavedAhmad,RizwanWahab,HishamA.Alhadlaq,JavedMusarrat,AbdulazizA.Al-Khedhairy,AdityaB.Pant(2015).Molybdenumnanoparticles-inducedcytotoxicity,oxidativestress,G2/M arrest, and DNA damage in mouse skin fibroblast cells (L929). Colloids andSurfacesB.125,73-81(IF:4.27).

14. Rizwan Wahab, Maqsood A. Siddiqui, Quaiser Saquib, Sourabh Dwivedi, JavedAhmad, Javed Musarrat, Abdulaziz A. Al-Khedhairy, Hyung-Shik Shin (2014). ZnOnanoparticles induced oxidative stress and apoptosis in HepG2 andMCF-7 cancercellsandtheirantibacterialactivity.ColloidsandSurfacesB,117,267-276.(IF:4.27).

15. Abdelkader E Ashour, Adel R Abd-Allah, Hesham M Korashy, Sabry M Attia,AbdelrahmanZAlzahrani,Quaiser Saquib, SalehABakheet,Hala EAbdel-Hamied,Shazia Jamal, Arun K Rishi, (2014) Thymoquinone suppression of the humanhepatocellularcarcinomacellgrowthinvolvesinhibitionofIL-8expression,elevatedlevels of TRAIL receptors, oxidative stress and apoptosis. Molecular and CellularBiochemistry389:85-98(IF:2.33).

16. Ansari MA, Khan HM, Khan AA, Cameotra SS, Saquib Q, Musarrat J, (2014) Gumarabic capped-silvernanoparticles inhibit biofilm formationbymulti-drug resistantstrainsofPseudomonasaeruginosa.JournalofBasicMicrobiology54,1-12.(IF:1.2).

17. Ansari, M.A., Khan, H.M., Khan, A.A., Cameotra, S.S., Saquib, Q. andMusarrat, J.(2014), Interaction of Al2O3 nanoparticles with Escherichia coli and their cellenvelope biomolecules. Journal of Applied Microbiology, 116: 772–783. doi:10.1111/jam.12423(IF:2.19).

18. Quaiser Saquib; Abdulaziz A Al-Khedhairy; Javed Ahmad; Maqsood A Siddiqui;SourabhDwivedi; Shams T Khan; JavedMusarrat, (2013) Zinc ferrite nanoparticlesactivateIL-1b,NFKB1,CCL21andNOS2signalingtoinducemitochondrialdependentintrinsicapoptoticpathwayinWISHcells.ToxicologyandAppliedPharmacology273,289-297.IF:3.99

19. JavedAhmad,HishamA.Alhadlaq,MaqsoodA.Siddiqui,QuaiserSaquib,AbdulazizA. Al-Khedhairy, Javed Musarrat, Maqusood Ahamed (2013) Concentration-dependent induction of reactive oxygen species, cell cycle arrest and apoptosis inhuman liver cells after nickel nanoparticles exposure. Environmental ToxicologyVolume30,Issue2,pages137–148(doi:10.1002/tox.21879).IF2.70

20. M. A. Siddiqui, J. Ahmad, N. N. Farshori,Q. Saquib, S. Jahan, M. P. Kashyap, M.Ahamed, J.Musarrat, A. A. Al-Khedhairy (2013) Rotenone-inducedoxidative stressandapoptosisinhumanliverHepG2cells.MolecularandCellularBiochemistry(doi10.1007/s11010-013-1781-9).IF2.32

21. M. Faisal*, Q. Saquib*, A.A. Alatar, A.A. Al-Khedhairy, A.K. Hegazy, J. Musarrat.,(2013)PhytotoxichazardsofNiO-nanoparticlesintomato:Astudyonmechanismofcell death. JournalofHazardousMaterials 250-251, 318-332 (*CoFirstAuthor). IF4.17.

22. Saquib,Q.,Attia,S.M.,SiddiquiM.A.,Aboul-Soud,M.,Al-Khedhairy,A.A.,Musarrat,J., (2012) Phorate-induced oxidative stress, DNA damage and transcriptionalactivation of p53 and caspases genes inmaleWistar rats. Toxicology and AppliedPharmacology259(1)54-65.IF4.47

23. Saquib, Q., Musarrat, J., Siddiqui M.A., Dutta, S., Dasgupta, S., Giesy, J.P., Al-Khedhairy, A.A. (2012). Cytotoxic and necrotic responses in human amnioticepithelial (WISH) cells exposed to organophosphate insecticide phorate.MutationResearch/Genetic Toxicology and Environmental Mutagenesis Mutation Research744,125-134.IF3.03

24. Saquib Q., Siddiqui MA., Abou-Tarboush, F.M., Azam, A., Al-Khedhairy, A.A.,Musarrat, J., (2012). Titaniumdioxidenanoparticles induced cytotoxicity, oxidativestressandDNAdamageinhumanamnionepithelial(WISH)cells.ToxicologyInVitro26(2)351-361.IF2.77

25. Dwivedi, S., Saquib, Q*., Al-Khedhairy, A.A., Ali, A.S., Musarrat, J., (2012).CharacterizationofcoalflyashnanoparticlesandinducedoxidativeDNAdamageinhumanperipheralbloodmononuclear cells. Scienceof theTotal Environment437,331-338(*CoFirstAuthor).IF3.28

26. Dwivedi, S., Saquib,Q., Al-Khedhairy,A.A.,Musarrat, J., (2012). Butachlor induceddissipation of mitochondrial membrane potential, oxidative DNA damage andnecrosis in human peripheral bloodmononuclear cells. Toxicology 302, 77- 87. IF3.68

27. Saquib Q, Al-Khedhairy AA, SiddiquiMA, Roy AS, Dasgupta S,Musarrat J. (2011).Preferential binding of insecticide phorate with sub-domain IIA of human serumalbumin induces protein damage and its toxicological significance. Food andChemicalToxicology49,1787-1795.IF2.99

28. Bakheet SA, Attia SM, AL-Rasheed NM, Al-harbiMM, Saquib Q, Al-Khedhairy AA,Musarrat J. (2011). Salubrious effects of dexrazoxane against teniposide-inducedDNAdamageandapoptosisinmurinemarrowcells.Mutagenesis26(4),533-543).IF3.18

29. SiddiquiMA,SaquibQ,AhamedM,AhmadJ,Al-KhedhairyA.A,Abou-TarboushFM,Musarrat J. (2011). EffectofTrans-resveratrolon rotenone-inducedcytotoxicity inhumanbreastadenocarcinomacells.ToxicologyInternational18(2),105-110.

30. Saquib, Q., Al-Khedhairy, A.A., Al-Arifi, Dutta, S., Dasgupta, S.,Musarrat, J. (2010)MethylthiophanateasaDNAminorgroovebinderproducesMT-Cu(II)-DNAternarycomplexpreferablywithAT rich region for initiationofDNAdamage. InternationalJournalofBiologicalMacromolecules47(2010)68–75.IF2.45

31. Saquib,Q.,Al-Khedhairy,A.A.,Al-Arifi,S.,Dwivedi,S.,Mustafa,J.,Musarrat,J.(2010)Fungicidemethyl thiophanatebinding at sub-domain IIAof human serumalbumintriggers conformational change and protein damage. International Journal ofBiologicalMacromolecules47(2010)60–67.IF2.45

32. Saquib,Q.,Al-Khedhairy,A.A.,Singh,B.R.,Arif,J.M,Musarrat,J.Genotoxicfungicidemethyl thiophanate as an oxidative stressor inducing 8-oxo-7,8-dihydro-2’-deoxyguanosineadductsinDNAandmutagenesis.JournalofEnvironmentalScienceandHealth(B)(2010)45,1-6.IF0.88

33. Saquib, Q., Al-Khedhairy, A.A., Al-Arifi, S., Dhawan, A., Musarrat, J. (2009)Assessment of methyl thiophanate-Cu (II) induced DNA damage in humanlymphocytes.ToxicologyInVitro23,848-854.IF2.77

34. Musarrat, J., Saquib, Q., Azam, A., Naqvi, S.A.H. (2009) Zinc oxide nanoparticles-inducedDNAdamageinhumanlymphocytes.InternationalJournalofNanoparticles2,402-415.

RESEARCHPROJECTS:

1) Principal Investigator in project entitled: The Plastics Puzzle on Human Health:Functional Toxicogenomic Study on Effects of Bisphenols to Human Hepatic Cells,projectNo.NPSTProjectNo.15-MED4052-02,FundedbyNationalPlanforSciencesand Technology, King Saud University, Riyadh, KSA (Reviewed by AmericanAssociation for theAdvancementofScience (AAAS),USA,andRecommendedforfunding,Sanctioned,2015).

2) PrincipalInvestigatorinprojectentitled:ToxicogenomicInvestigationonHazardsofOrganophosphorous Flame Retardants (OPFRs): Connections Among GenomeFunction,CellDeathandCarcinogenesis,projectNo.NPSTProjectNo.13-ENV2116-02, Funded by National Plan for Sciences and Technology, King Saud University,Riyadh, KSA (ReviewedbyAmericanAssociation for theAdvancementof Science(AAAS),USA,andHighlyRecommendedforfunding,Sanctioned,2014).

3) Co-Principal Investigator in project entitled: Bio-prospection of Arabian MedicinalPlants for Antiglycation Agents for Developing of a Novel Molecular TherapeuticApproach for Diabetes, project No. NPST Project No. 12-MED2491-02, Funded byNational Plan for Sciences and Technology, King Saud University, Riyadh, KSA(CurrentlyRunning).

4) Co-Principal Investigator in project entitled: Effects of polybrominated flameretardantsfromelectronicwasteonthecellularDNAandcarcinogenesis,projectNo.NPST Project No. 10-ENV-1314-02, Funded by National Plan for Sciences andTechnology,KingSaudUniversity,Riyadh,KSA(Completed2013).

5) Co-Principal Investigator in project entitled: Assessment of DNA Damage andToxicologicalPotentialofNanoparticles,projectNo.NPSTProjectNo.10-NAN1115-02, Funded by National Plan for Sciences and Technology, King Saud University,Riyadh,KSA(Completed2012).

LABORATORYSKILLS:

MolecularBiologyTechniques

• RT2PCRArrayofHumanStressandToxicityPathwayanalysisbyqPCRanalysis.

• Flowcytometry:Cellcycle,apoptosisanalysisusingAnnex-VFITCstaining,measuringmitochondrialmembranepotential, intracellularROSgeneration,Ca2++ influx,nitricoxide(NO)generation,esteraseactivityofhumanandcells.

• AnalysisofhumanapoptoticandoxidativestressgenesbyqPCR.

• Westernblotandimmunofluorescenceanalysisofapoptosisrelatedproteins.

• DNA damage analysis using Comet assay (SCGE) in human lymphocytes, animalorgan,celllinesandplantcells.

• Chromosomal break analysis by cytokinesis blockedmicronucleus (CBMN) assay inhumanlymphocytesandmouse/ratbonemarrowcells.

• CytotoxicityanalysisusingMTTandNRUassays.

• Histopathologicalanalysisofmouse/ratorgansections.

• IsolationandpurificationofHumanSerumAlbuminfromblood.

• AssessmentofDNAandproteindegradationusingagarosegelelectrophoresisandSDSPAGE.

• IsolationandpurificationofbacterialplasmidDNA,mammaliangenomicDNA,RNA,gelelectrophoresis,geldocumentation,ELISA.

• Fluorescencespectrophotometerbasedbio-physical interactionstudiesofDNAandProtein.

Analyticaltechniques

• Fluorescent microscopy, High Performance Liquid Chromatography (HPLC), GasChromatography Maas Spectrophotometry (GC-MS), UV/Vis. Spectrophotometer,CyclicVoltammetry,Nanodrop,FluorescenceMicroplatereader,Lyophilization.

CellcultureandMicrobialtechniques:

• Hand on experience in maintenance of in vitro cell lines (WISH, MCF-7, HepG2),culturinghumanlymphocytesandanimalhandling.Isolationandcharacterizationofbacteria, cultivation and preservation of microbial cultures, Ames mutagenicityassay,EcoliK12genotoxicityassay,plasmidlacZmutagenicityassay,bioremediation

and biodegradation of xenobiotics using selected bacterial strains, plant growthpromotionstudieswithbacterialstrains.

PROFESSIONALTRAININGS:• Organized a workshop on Molecular Tools for Assessment of Genotoxicity for

MastersandPh.D.StudentsonNovember20,2014atKingSaudUniversity.

• OrganizedaworkshoponNanoparticleToxicityforKingSaudUniversityforMastersStudentsonOctober23,2013atKingSaudUniversity.

• OrganizedatrainingcourseontechniquesofPolymeraseChainReaction(PCR)from10-12January2009atKingSaudUniversity.

• Organized theWorkshop entitled “DNA Research Chair: A Gateway to KnowledgeEconomy”on24May2009atKSU.

• Participated in the “The First International Conference in Biotechnology TowardsKnowledge-BasedEconomy”atKSUonFebruary16-18,2009.

FELLOWSHIPS/AWARDSANDHONOURS:• “YoungScientist”awardforbestoralpresentationontheworkentitled“Impactof

MethylthiophanateonDNAStability”in“InternationalSymposiumonthePredictive,PreventiveandMechanisticMutagenesis&XXXIIIEMSIAnnualMeeting”onJanuary1-3,2008,AMU,India.

• Potentialreviewerofpeerreviewedjournals:Chemosphere,EnvironmentalScienceandPollutionResearch.

• Shared the “Best Poster” award on the work entitled “In-silico Analysis andMolecular Modeling of the Phenazine 1-Carboxylic Acid (PCA) Antibioticgenes/Proteins of the Soil Strain NJ-101 of Pseudomonas areuginosa” in“International Symposium on the Predictive, Preventive and MechanisticMutagenesis&XXXIIIEMSIAnnualMeeting”onJanuary1-3,2008,AMU,India.

• Sharedthe“BestPoster”awardontheworkentitled“Evaluationofpendimethalininduced DNA Damage and Cytotoxicity in Human Lymphocytes” in “InternationalSymposium on the Predictive, Preventive and Mechanistic Mutagenesis & XXXIIIEMSIAnnualMeeting”onJanuary1-3,2008,AMU,India.

• Selected as the top10 best paper presenter “Shri Sitaram Joglekar Award” in the“25th Annual Convention of the IACR & Silver Jubilee Symposium on MolecularProfiling”heldatACTREC,NaviMumbai(2006).

ResearchandTeachingExperience:• 2009-Present: Assistant Professor and sharing teaching load of general biology

(Course 145) to B.Sc. students in Department of Zoology, College of Science, KingSaudUniversity,Riyadh,SaudiArabia.

• January 2007 toOctober 2008 as Research Fellow (RF) in project “Assessment ofUnaniMedicinesforToxicHeavyMetalsandtheirProtectiveRoleinEnvironmentalGenotoxicityandMutagenicity”.(CCRUM,DepartmentofAYUSH,MinistryofHealth&FamilyWelfare,GovernmentofIndia.

• March 2003 to October 2006 as Research Fellow (RF) in project “Molecular andBiochemical Characterization of Rhizospheric Bacteria for development of Super-BioinoculantswithCollateralBiocontrolandBioremediationPotential”.DepartmentofBiotechnology,GovernmentofIndia.

• October2002toFebruary2003asResearchAssistant(RA)inproject“AgrichemicalInduced Structural Modification and Oxidative Damage to BiologicalMacromolecules”.TheMuslimAssociationforAdvancementofScience,GovernmentofIndia.

• Summer training on project entitled “Anaerobic Fermentation and production ofSuccinic Acid” at Regional Research Laboratory Jammu (RRL), Council of ScientificandIndustrialResearch,India.

COMPUTERSKILLS:

• Windows 7 (MS office 2010), Statistical Software Instant (Graphpad), Sigma plot11.0, Comet IV Imaging Software (Perceptive Instruments, UK), BAARC CometAnalysis Software,BD-Biosciences Flowcytometry Softwares (CellQuest,ModFit),BeckmanCoulterEPICSflowcytometrysoftware,Photoshop.

OTHERSKILLS:

• Hard working, resourceful, friendly, creative and solution oriented person, I amfrequently able to come up with new and innovative approaches to my assignedproblemsandtofaceupdeadlines.

• Highlymotivated,passionforScience,problemsolving,intuitionandperseverance.

• Capable for interpretation of data and skilled enough to draft manuscript forpublicationinreputedjournal.

AbstractsPublishedinNationalandInternationalConferences/Symposia

1. Q. Saquib, P. Xia, M.A. Siddiqui, J.A Siddiqui, Y. Xie, M. Faisal, J. Zhang, A.A. Al-Khedhairy, X. Zhang, B.A. Ali, S.T. Khan, R. Ahmad, S. Dwivedi, J. Musarrat.Transcriptomic Evidence on the Activation of HIF-1α, TNFSF10, NOS2 Signalling inNickelOxideNanoparticlesInducedApoptosis inHepG2Cells:OxidativeStress,DNADamage, Mitochondrial Dysfunction Are the Key Players. 2015 In Vitro BiologyMeetingatTucson,Arizona,USAfromMay30toJune3,2015.(OralPresentation)

2. JMusarrat,KAli,MAAnsari,QSaquib,MSiddiqui,STKhan,AAAlkhedhairy.(2015).GreenSynthesisofnanoparticlesandtheirroleasnano-antibioticsandanti-biofilmagent.PlantaMedica2015;81-OA44.DOI:10.1055/s-0035-1545126

3. SaquibQ,Al-KhedhairyA.A,AhmadJ,SiddiquiMA,FaisalM,DwivediS,MusarratJ(June10-13,2014).ToxicogenomicInvestigationonNickelOxideNanoparticles(NiO-NPs):ConnectionsamongGeneFunction,DNADamageandCellDeath.ProceedingsofESTIV2014,EgmondannZee,TheNetherlands(OralPresentation).

4. SaquibQ,Al-KhedhairyA.A,SiddiquiMA,AhmadJ,DwivediS,KhanST,Musarrat J(November20-22,2013).ToxicogenomicChanges,OxidativeStressandDNADamageare Key Factors for Nanoparticles Induced Cellular Anomalies: An Insight into theMolecularMechanismofCellDeath.ProceedingsofNanosafety2013,Saarbrucken,Germany(OralPresentation).

5. SaquibQ,Musarrat J,Al-KhedhairyA.A,SiddiquiM,AttiaS.M,FaisalM,Siddiqui J,Dwivedi S, Khan ST. (March 11-18, 2013). Nickel oxide Nanoparticles ProvokeIntrinsicApoptoticPathway inHepG2Cells,MaleWistarRatsandTomatoSeedlingRoots.52ndAnnualMeetingofSocietyofToxicology,SanAntonio,Texas,USA.

6. JMusarrat,QSaquib,SDwivedi,AAl-Salem,MASiddiqui,AAAl-Khedhairy.,(2012).Assessment of DNA Damage, Mutagenesis and Anti-Mutagenic Activity of Unani(Greek)HerbalMedicines.PlantaMedica78-OP18.

7. Q.Saquib, J.Musarrat,A.A.Al-Khedhairy,M.A.Siddiqui, S.Dwivedi, S.M.Attia.Aninsight into the cellular and molecular mechanism of pesticide toxicity. Montreal2012InternationalBiomedicine&ChemistryForum.HeldinMontreal,Canada,April26-27,2012.

8. SM Attia; Bakheet SA; AL-Rasheed NM; Saquib Q; Al-Khedhairy AA; Musarrat J.Salubrious effects of dexrazoxane against teniposide-induced DNA damage and

apoptosis in murine marrow cells. The Annual Meetings of the Society for FreeRadical Research (SFRR) and the 40th Annual Meeting of the EuropeanEnvironmentalMutagenSociety(EEMS).HeldinOslo,Norway.Sept12-18,2010.

9. MASiddiqui,MP,Kashyap,QSaquib,AAAl-Khedhairy,SaudAlarifi, JMusarrat,ABPant (2010) Prophylactic potential of Trans-resveratrol against 4-hydroxynonenal-induceddamages inPC12 cells. Ist InternationalConferenceofBiological Sciences,Cairo,Egypt(September27-29,2010).

10. Javed Musarrat, Q Saquib, Abdulaziz A. Al-Khedhairy, Saud A. Alarifi, MaqsoodSiddiqui (2010) Methyl thiophanate as a DNA minor grove binder produces MT-Cu(II)-DNA ternary complex preferably with AT rich region for initiation of DNAdamage, 2nd International Conference of Biological and Environmental Sciences,(2ndICBES),MansouraUniversity,Egypt(March15-20,2010).

11. MA Siddiqui, AB Pant, Q Saquib, AA Al-Khedhairy, J Musarrat, and S Srivastava.Metabolic fateof4-HydroxyTrans2-Nonenal inculturedPC-12cells in1stAnnualConference of “Society of Professional Biotechnologists (SPB-2009)” duringDecember,1-2,2009atKanpur,India.

12. Saquib, Q., Dhawan, A., Mustafa, J., Singh, B.R., Musarrat, J. (2008) “Impact ofMethylthiophanateonDNAStability”.Proceedingsofthe“InternationalSymposiumon the Predictive, Preventive andMechanisticMutagenesis & XXXIII EMSI AnnualMeeting”.

13. Singh,B.N.,Singh,B.R.,Saquib,Q.,Singh,R.L.,Singh,D.P.,Singhai,P.K.,Musarrat,J.,Singh,H.B(2008)“Antioxidant,AntimutagenicandAnti-quorumSensingActivitiesofredOnion(Alliumcepa)peelExtracts.Proceedingofthe“InternationalSymposiumon the Predictive, Preventive andMechanisticMutagenesis & XXXIII EMSI AnnualMeeting”.

14. Singh,B.R.,Usmani,S.,Saquib,Q.,Dwivedi,S.,Bano,N.,Musarrat,J.(2008)“In-silicoAnalysisandMolecularModelingofthePhenazine1-CarboxylicAcid(PCA)Antibioticgenes/ProteinsoftheSoilStrainNJ-101ofPseudomonasareuginosa”.Proceedingofthe “International Symposium on the Predictive, Preventive and MechanisticMutagenesis&XXXIIIEMSIAnnualMeeting”.

15. Ansari,S.M.,Saquib,Q.,Singh,B.R.,Usmani,S.,Dwivedi,S.,Anwar,S.,Musarrat,J.(2008) “Evaluation of pendimethalin induced DNA Damage and Cytotoxicity in

Human Lymphocytes”. Proceeding of the “International Symposium on thePredictive,PreventiveandMechanisticMutagenesis&XXXIIIEMSIAnnualMeeting”.

16. Saquib, Q., Singh, B.R., Musarrat, J. (2008) “Fluorescence Quenching and In-silicoMolecular Modeling/Docking on Methylthiophanate Induced Fragmentation inHuman Serum Albumin”. Proceeding of the “International Symposium on thePredictive,PreventiveandMechanisticMutagenesis&XXXIIIEMSIAnnualMeeting”.

17. Usmani,S.,Dwivedi,S.,Saquib,Q.,Singh,B.R.,Anwar,S.,Musarrat,J.(2008)“heavyMetals Analysis of certain Unani Medicines and Their Mutagenic Activity Usingbacterial Assay System”. Proceeding of the “International Symposium on thePredictive,PreventiveandMechanisticMutagenesis&XXXIIIEMSIAnnualMeeting”.

18. Haleem,S.,Ansari,M.M.,Singh,B.R.,Saquib,Q.,Usmani,S.,Dwivedi,S.,Ahmed,A.,Musarrat, J. (2008) “Role of TNF-α and CRP as Stress Marker During Open andLaproscopic Cholectectomy in Patients fit for laparoscopic Cholectectomy”.Proceeding of the “International Symposium on the Predictive, Preventive andMechanisticMutagenesis&XXXIIIEMSIAnnualMeeting”.

19. Dwivedi, S., Singh, B.R., Usmani, S., Saquib, Q., Musarrat, J (2007) Molecularcharacterization of Phenazine -1-Carboxylic Acid (PCA) and HCN producingisoproturon degrading rhizospheric bacteria. Proceedings of the “48th AnnualConference of Association of Microbiologists of India, Department ofBiotechnology”,IndianInstituteofTechnology,Chennai,India.

20. Saquib, Q., Singh, B.R., Usmani, S., Dwivedi, S., Ansari, S.M., Musarrat, J. (2007)“Assessment of Pendimethalin-induced chromosomal breaks in humanlymphocytes” Proceeding of the “International Symposium on Genomic InstabilityandCancer”.

21. Saquib,Q., Singh,B.R.,Usmani, S.,Dwivedi, S.,Musarrat, J. (2007) “InteractionofCarbofuran with Biological Macromolecues and DNA damage in humanlymphocytes” Proceeding of the “International Symposium on Genomic InstabilityandCancer”.

22. Singh,B.R.,Saquib,Q.,Dwivedi,S.,Usmani,S.,Musarrat,J. (2007)“AssessmentofCoalFly-ashinducedchromosomalbreaksinhumanlymphocytes”Proceedingofthe“InternationalSymposiumonGenomicInstabilityandCancer”.

23. Usmani, S., Singh, B.R., Dwivedi, S., Saquib, Q., Musarrat, J. (2006) Molecularcharacterization of atrazine resistant plant growth promoting rhizobacteria.Proceedings of the “47th Annual Conference of Association of Microbiologists ofIndia”. Department of Biotechnology & Bioinformatics Center, BarkatullahUniversity,Bhopal.

24. Dwivedi,S.,Singh,B.R.,Usmani,S.,Saquib,Q.,Musarrat,J.(2006)Isolationand16SrDNAbasedcharacterizationof isoproturondegradingrhizosphericbacteriaand itsassessment for plant growth promoting ability. Proceedings of the “47th AnnualConferenceofAssociationofMicrobiologistsofIndia”.DepartmentofBiotechnology&BioinformaticsCenter,BarkatullahUniversity,Bhopal,India.

25. Saquib,Q.,Mustafa, J.,Dhawan,A., Shukla, Y., andMusarrat, J. (2006)MolecularMechanismofMethylthiophanate-Cu(II)InducedDNAalkylationandStrandBreaksFormation. Proceedings of the “International Symposium on EnvironmentalMutagenesis and Public Health and XXXI Annual Conference of EnvironmentalMutagenSociety.

26. Saquib,Q.,Usmani,S.,Shukla,Y.,Dhawan,A.,andMusarrat,J.(2006)Phorateasaputativeinitiatorofcarcinogenesis:aninvitroandinvivoassesmentofproteinandDNA damage. Proceedings of the 25th Annual Convention of the IACR & SilverJubileeSymposiumonMolecularProfilingandCancerManagement.

27. Musarrat, J. and Saquib, Q. (2005) Methylthiophanate-Induced Genotoxicity andDevelopment of Single Strand Breaks in DNA. Proceedings of the 2005 In VitroBiologyMeetingatBaltimore,Maryland,USA.

28. Dwivedi,S.,Singh,B.R.,Usmani,S.,Saquib,Q.,andMusarrat,J.(2005)Isolationand16SrDNA based Characterization of a Novel Butachlor Degrading RhizosphericBacteria. Proceedings of Annual Conference of Association of Microbiologists ofIndia,DepartmentofMicrobiology,OsmaniaUniversity,Hyderabad.

29. Usmani, S., Saquib, Q., Dhawan, A., and Musarrat, J. (2005) Phorate–inducedoxidative stress and damage to biological macromolecules. Proceedings of theInternational Symposium on Diet in Causation and Prevention of Cancer and XXXAnnualConferenceofEnvironmentalmutagenSociety,ITRC,Lucknow,India.

30. Zaidi, S., Saquib,Q., andMusarrat J. (2005) Hyper-accumulation of Ni in Brassicajuncea (Indian mustard) in presence of Ni-tolerant Bacillus sp. as bioinoculant.Proceedingsof92ndIndianScienceCongress,NirmaUniversity,Ahmedabad,India.

31. Saquib,Q.,Bano,N.,andMusarratJ(2004)Assessmentoftopsin-induceddamageinbiologicalmacromolecules. Proceedingsof 91st Indian ScienceCongress, PunjabUniversity,Chandigarh,India.

PERSONAL:

DateofBirth : 14January1979

Nationality : Indian

Sex : Male

MaritalStatus : Married