correlations between clinical and microscopic features of premalignant

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  • 1. CORRELATIONS BETWEENCLINICAL ANDMICROSCOPIC FEATURESOF PREMALIGNANTLESIONS Done by : Ahmed Ali Al-Asmari

2. Idiopathic Leukoplakia : Clinical features :Asymptomatic white patch; cannot be wiped off; males affected more than females- AgeUsually over 40 years- High-Risk Sites for Malignant Transformation Floor > tongue > lip > palate > buccal > vestibule > retromolar 3. Microscopic Diagnoses At First DiagnosisHyperkeratosis80%Dysplasia12%In situ carcinoma3%Squamous cell carcinoma5% 4. Erythroplakia : Clinical features :Asymptomatic red velvety patch; red lesions may have foci or white hyperkeratosis (speckled erythroplakia)- Age typically between 50 and 70 years- High-risk sitesfloor of mouth, tongue, retromolar mucosa, soft palate 5. HistopathologySquamous cell carcinoma (50%)Severe dysplasia or in situ carcinoma (40%)Mild-to-moderate dysplasia (10%) 6. Lichen planus : Clinical features :asymptomatic except when erosions are present;occasionally present and are purple pruriticpapules; forearm and lower leg most common skinareas- Ageseen in middle age- High-risk sitesbuccal mucosa most commonly affected, withlesions occasionally on tongue, gingiva, and palate;skin lesions 7. Possible Risk of Carcinoma TransformationMay be slightly increased with erosive form (0.4%2.5% of cases) 8. Reference : Oral Pathology : Clinical PathologicCorrelations by Joseph A. Regezi , James J.Sciubba , and Richard C.K. Jordan , 5th ed2007 , Saunders Company , Chapter 4 , Page100-130