Comparison of ThinPrep cytology and conventional

cytology in bronchial washing

Gachon University Gil Hospital Seung Yeon Ha

서 론• Diagnosis of Lung Cancer

• Cytology– Bronchial washing– Conventional cytology– ThinPrep

재료 및 방법• 2009.03. – 2011.05. Bronchial wahs-

ing Conventional cytology+ThinPrep = 2551 예

• 임상적 폐암 + 조직검사 = 148 예

결 과 1

• 조직진단 폐암 확진 = 124 예 조직진단 정상 확진 = 24 예 • 세포진단 : 폐암 = 116 예

Cytologic Di-agnosis

Cytospin ThinPrep

Negative 24 9

Atypia 38 31

Malignant 53 79

Cellularity Cytospin ThinPrep

0-1 20 8

2 3 1

3 1 0

Cy-tospin

Thin-Prep

결 과 2

• 조직진단Histologic Diagnosis To-

tal

Cytologic Dx

Squamous cell carcinoma 49 47

Adenocarcinoma 41 39

Small cell carcinoma 20 19

Large cell carcinoma 2 2

Poorly differentiated carci-noma

2 2

Large cell neuroendocrine carcinoma

2 2

Dx(%)

95.9

95.9

95

결 과 3

• 조직 검사에 따른 각 방법의 결과 : Conventional cytology

HistologyNega-tive

Atypi-cal

Malig-nant

Total

Squmaous cell carci-noma

9 20 20 49

Adenocarcinoma 10 11 20 41

Small cell carcinoma 3 7 10 20

Large cell carcinoma 1 0 1 2

Others 0 0 3 3

결 과 3

• 조직 검사에 따른 각 방법의 결과 : ThinPrep

HistologyNega-tive

Atypi-cal

Malig-nant

Total

Squmaous cell carci-noma

2 16 31 49

Adenocarcinoma 2 10 29 41

Small cell carcinoma 0 4 16 20

Large cell carcinoma 0 0 2 2

Others 0 0 3 3

Cy-tospin

결 과 4

• Conventional Cytology 결과 : Atypical 38 예

Histologic Dx Cytologic Dx(ThinPrep)Normal Atypical Ma-lignant

Squamous cell carci-noma

1 11 8

Adenocarcinoma 0 7 5

Small cell carcinoma 0 2 3

Large cell neuroen-docrine carcinoma

0 0 1

Total 1 20 17

결 과 4

• ThinPrep 결과 : atypical 31 예

Histologic Dx Cytologic DxNormal Atypical Ma-lignant

Squamous cell carci-noma

5 11 0

Adenocarcinoma 4 7 0

Small cell carcinoma 1 2 1

Total 10 20 1

결 과 4

• Sensitivity and Specificity

Conventional Cytology

Sensitivity (%) Speici-ficity(%)

ThinPrep

Sensitivity (%) Speici-ficity(%)

79.1 96.9 95.7 94.1

논 문 1• 209 명 , SurePath

논 문 2• 197 명 , ThinPrep

감사의 말씀

THANK YOU!!